You Are What You Drink—a Rockst*r or a Monster?: An Enviga-rating Regulatory Question

This paper briefly examines the regulation of caffeine in energy drinks. The FDA does not have specific regulations pertaining to the use of caffeine in energy drinks. Caffeine is generally safe, but may pose dangerous health risks to children, pregnant women, and people with caffeine sensitivities. I suggest that the Food and Drug Administration require energy drink companies to list the amount of caffeine on the product labels of energy drinks to facilitate informed product comparison

Amphetamine users and crime in Western Australia, 1999–2009

This current study aims to examine the relationship between amphetamine use and crime among police detainees in Western Australia. Further, the study provides a brief profile of detainee amphetamine users and compares this with the profile of a non-user. Amphetamines have been increasingly available on Australian drug markets since the early 1990s (National Drug Research Institute 2007). Clandestine laboratory detections increased from 50 in 1996 to 250 in 2002 (Ministerial Council on Drugs Strategy 2004), although use decreased slightly in the general population between 2004 (3.2%) and 2007 (2.3%) (Australian Institute of Health and Welfare 2008). There has also been an increase in the amount of high-grade amphetamine detected by Customs and the Australian Federal Police (AFP). Amphetamine use has been associated with psychological, physical and social harm, criminal behaviour and violence (Dyer & Cruickshank 2005; Lynch, Kemp, Krenske, Conroy & Webster 2003; Wickes 1993). The Drug Use Monitoring in Australia (DUMA) project has collected data since 1999. This current study aims to examine the relationship between amphetamine use and crime among police detainees in Western Australia. Further, the study provides a brief profile of detainee amphetamine users and compares this with the profile of a non-user

Shrimp Allocation Policies and Regional Development Under Conditions of Environmental Change: Insights for Nunatsiavutimmuit

This report is part of a larger research program examining the relationship between fisheries policy and regional development in Atlantic Canada’s northern shrimp fisheries. Since the extension of Canadian jurisdiction over its 200 mile Exclusive Economic Zone in 1977, federal policy makers have allocated shrimp licenses and quotas to cooperatives, community based organizations, inshore fish harvesters, large fishing companies as well as Indigenous groups. However, our knowledge of the relationship between fisheries policy and regional development outcomes in this fishery remains very limited, with the exception of case studies of a few organizations and regions in southeast Labrador and in Newfoundland. Despite the long history of substantial allocations of shrimp in northern Labrador/Nunatsiavut, we know little about how effective allocation policies have been in meeting regional development goals for Indigenous communities in the region. The objective of this research is to build on and extend our larger research project by identifying allocation policies that have enabled Nunatsiavut communities, and people to benefit from the shrimp fishery and to identify those development benefits in a systematic way. The research findings help us meet two further practical objectives: to provide research evidence to inform federal, provincial, and municipal policymaking and decision-making and to assist regional bodies and community groups in their decision-making and activities aimed at improving social, economic, cultural, and environmental conditions

Antigen-presenting genes and genomic copy number variations in the Tasmanian devil MHC

BACKGROUND The Tasmanian devil (Sarcophilus harrisii) is currently under threat of extinction due to an unusual fatal contagious cancer called Devil Facial Tumour Disease (DFTD). DFTD is caused by a clonal tumour cell line that is transmitted between unrelated individuals as an allograft without triggering immune rejection due to low levels of Major Histocompatibility Complex (MHC) diversity in Tasmanian devils. RESULTS Here we report the characterization of the genomic regions encompassing MHC Class I and Class II genes in the Tasmanian devil. Four genomic regions approximately 960 kb in length were assembled and annotated using BAC contigs and physically mapped to devil Chromosome 4q. 34 genes and pseudogenes were identified, including five Class I and four Class II loci. Interestingly, when two haplotypes from two individuals were compared, three genomic copy number variants with sizes ranging from 1.6 to 17 kb were observed within the classical Class I gene region. One deletion is particularly important as it turns a Class Ia gene into a pseudogene in one of the haplotypes. This deletion explains the previously observed variation in the Class I allelic number between individuals. The frequency of this deletion is highest in the northwestern devil population and lowest in southeastern areas. CONCLUSIONS The third sequenced marsupial MHC provides insights into the evolution of this dynamic genomic region among the diverse marsupial species. The two sequenced devil MHC haplotypes revealed three copy number variations that are likely to significantly affect immune response and suggest that future work should focus on the role of copy number variations in disease susceptibility in this species.This work was funded by an ARC Future Fellowship to KB (FT0992212), the Eric Guiler fund and the Tasmanian Department of Primary Industries, Parks, Water and the Environment. YC was supported by an Endeavour International Postgraduate Research Scholarship, KM by an Australian Postgraduate Award and an ARC Linkage Grant

Lessons of Corporate Entrepreneurship for Motivating Public Sector Employees

This paper aims to contribute to the field of public entrepreneurship by addressing the question of what can public sector organizations learn from corporate entrepreneurship to create a more motivating work environment. The study develops a scale developed to measure key organizational work environment factors that influence employee discretionary work effort behaviours in public organizations. In doing so, it uses concepts from Morris & Douglas (2005; 2004) and expands on the work of Eisenhauer (1995) and Douglas & Shepherd (2000) by further unpacking the perceived psychic benefits and costs of working conditions associated with employment. While the relevance of corporate entrepreneurship to the public sector has been questioned (Terry, 1993; Frederickson, 1997 for example), the need for public organizations to be more entrepreneurial is also strongly espoused (Bellone & Goerl, 1992; Osborne & Gaebler, 1994; Morris & Jones, 1999). Today public institutions are perhaps in greater need of corporate renewal than many large established private sector firms. In the face of tight fiscal constraints, rising public demands and tight labour market conditions, new ways of acquiring revenues, combining resources, retaining talented employees and achieving better outcomes within statutory constraints are needed. This study supports the view that valuable lessons can be learned from corporate entrepreneurship in assisting public organizations to be more responsive and to provide higher quality public services. To find ways of doing business better public organizations need to not only foster entrepreneurial behaviours amongst their employees but also more generally motivate greater discretionary work effort, that is voluntary effort above and beyond what is minimally required for the benefit of the organization. The importance of contextual factors in influencing entrepreneurial behaviour at both the organizational and individual levels is well documented in the entrepreneurship literature (e.g. Hornsby, Kuratko & Zahra, 2002; Amabile, 1996; Zahra, 1993; Covin & Slevin, 1991; Kuratko, Montagno & Hornsby, 1990; Kant, 1988). The study focuses on how to create an internal environment to better motivate employees to contribute greater levels of discretionary effort, which includes initiative and proactive behaviours. As its emphasis is on individual level behaviour within organisations, this study follows the approach to corporate entrepreneurship used by Kuratko, Hornby and others (1990, 1993, 2002) which uses the ''initiative from below'' definition of corporate entrepreneurship (Vesper, 1984) to develop a measure for an effective internal entrepreneurial corporate environment

Antigen-presenting genes and genomic copy number variations in the Tasmanian devil MHC.

RIGHTS : This article is licensed under the BioMed Central licence at http://www.biomedcentral.com/about/license which is similar to the 'Creative Commons Attribution Licence'. In brief you may : copy, distribute, and display the work; make derivative works; or make commercial use of the work - under the following conditions: the original author must be given credit; for any reuse or distribution, it must be made clear to others what the license terms of this work are.BACKGROUND: The Tasmanian devil (Sarcophilus harrisii) is currently under threat of extinction due to an unusual fatal contagious cancer called Devil Facial Tumour Disease (DFTD). DFTD is caused by a clonal tumour cell line that is transmitted between unrelated individuals as an allograft without triggering immune rejection due to low levels of Major Histocompatibility Complex (MHC) diversity in Tasmanian devils. RESULTS: Here we report the characterization of the genomic regions encompassing MHC Class I and Class II genes in the Tasmanian devil. Four genomic regions approximately 960 kb in length were assembled and annotated using BAC contigs and physically mapped to devil Chromosome 4q. 34 genes and pseudogenes were identified, including five Class I and four Class II loci. Interestingly, when two haplotypes from two individuals were compared, three genomic copy number variants with sizes ranging from 1.6 to 17 kb were observed within the classical Class I gene region. One deletion is particularly important as it turns a Class Ia gene into a pseudogene in one of the haplotypes. This deletion explains the previously observed variation in the Class I allelic number between individuals. The frequency of this deletion is highest in the northwestern devil population and lowest in southeastern areas. CONCLUSIONS: The third sequenced marsupial MHC provides insights into the evolution of this dynamic genomic region among the diverse marsupial species. The two sequenced devil MHC haplotypes revealed three copy number variations that are likely to significantly affect immune response and suggest that future work should focus on the role of copy number variations in disease susceptibility in this species

The Cellar Door Report: Margaret River Region Winery / Tourism Research

The Margaret River tourist is a well educated, professional person who visits the region to tour the wineries, enjoy the scenery and the beach, relax and go to the restaurants. The tourist considers the wineries one of the prime tourist destinations in the region and goes to the wineries primarily to taste and buy wine

Drug use monitoring in Australia: An expansion into the Pilbara

The relationship between alcohol, illicit drugs and offending is complex and dynamic. Substance misuse both nationally and internationally has been found to be prevalent in detained populations (Bennett & Holloway 2007, Pernanen, Cousineau, Brochu & Sun 2002, Sweeney & Payne 2012). With the cost of crime in Australia estimated to be $36 billion per annum (AIC 2009), it is important to establish some of the links that, if addressed, may reduce the level of commissions of crime and increase the wellbeing of Australians

Deriving accurate microbiota profiles from human samples with low bacterial content through post-sequencing processing of Illumina MiSeq data

BackgroundThe rapid expansion of 16S rRNA gene sequencing in challenging clinical contexts has resulted in a growing body of literature of variable quality. To a large extent, this is due to a failure to address spurious signal that is characteristic of samples with low levels of bacteria and high levels of non-bacterial DNA. We have developed a workflow based on the paired-end read Illumina MiSeq-based approach, which enables significant improvement in data quality, post-sequencing. We demonstrate the efficacy of this methodology through its application to paediatric upper-respiratory samples from several anatomical sites.ResultsA workflow for processing sequence data was developed based on commonly available tools. Data generated from different sample types showed a marked variation in levels of non-bacterial signal and ‘contaminant’ bacterial reads. Significant differences in the ability of reference databases to accurately assign identity to operational taxonomic units (OTU) were observed. Three OTU-picking strategies were trialled as follows: de novo, open-reference and closed-reference, with open-reference performing substantially better. Relative abundance of OTUs identified as potential reagent contamination showed a strong inverse correlation with amplicon concentration allowing their objective removal. The removal of the spurious signal showed the greatest improvement in sample types typically containing low levels of bacteria and high levels of human DNA. A substantial impact of pre-filtering data and spurious signal removal was demonstrated by principal coordinate and co-occurrence analysis. For example, analysis of taxon co-occurrence in adenoid swab and middle ear fluid samples indicated that failure to remove the spurious signal resulted in the inclusion of six out of eleven bacterial genera that accounted for 80% of similarity between the sample types.ConclusionsThe application of the presented workflow to a set of challenging clinical samples demonstrates its utility in removing the spurious signal from the dataset, allowing clinical insight to be derived from what would otherwise be highly misleading output. While other approaches could potentially achieve similar improvements, the methodology employed here represents an accessible means to exclude the signal from contamination and other artefacts