The nature of mind

Three public lectures delivered in the Physics Amphitheatre of the Rice Institute, January 6, 13, and 20, 1929, by Charles William Morris, Ph.D., Assistant Professor of Philosophy at the Rice Institute.I. The problem of mind and its historical setting -- II. Three theories of mind -- III. The functional view of min

Uma maneira prática de distinguir abelhas africanizadas (Apis mellifera L.) de abelhas européias usando o estado excitatório central, a mobilidade dos membros e viabilidade do ferrão

A key to understanding the expansion of Africanized honey bees (Apis mellifera) is distinguishing this aggressive form from its European relative. Current identification techniques have a degree of success, but each has its own set of problems, prohibiting wide-spread adoption and use. This study examined aspects of central excitatory state, persistence of mobile appendages, and a viable sting after decapitation for their use in distinguishing between these two races. Central excitatory state was not useful in distinguishing the Africanized honey bee from the European honey bee; however, appendage mobility and sting viability were significantly different between the two subspecies. Appendage mobility and sting viability are useful techniques for distinguishing the two subspecies, and alleviate the issues of expense, application, and accuracy.Uma chave para o entendimento da expansão da abelha africanizada (Apis mellifera) é distinguir esta abelha agressiva de sua equivalente européia. Técnicas de identificação atual têm um grau de sucesso, mas cada método tem seu próprio conjunto de problemas, tornando-se proibitivo sua adoção e uso em larga escala. Este estudo examinou aspectos do estado excitatório central, persistência de mobilidade de apêndices e viabilidade da ferroada após decapitação como ferramenta na distinção entre essas duas raças. O estado excitatório central não foi útil na distinção entre a abelha africanizada e a européia; todavia, a mobilidade de apêndices e a viabilidade do ferrão foram significativamente diferentes entre essas duas raças. A mobilidade de apêndices e a viabilidade do ferrão são técnicas úteis na distinção das duas raças e atenua os aspectos relacionados a gastos, aplicação e precisão

A metadata-aware application for remote scoring and exchange of tissue microarray images.

BACKGROUND: The use of tissue microarrays (TMA) and advances in digital scanning microscopy has enabled the collection of thousands of tissue images. There is a need for software tools to annotate, query and share this data amongst researchers in different physical locations. RESULTS: We have developed an open source web-based application for remote scoring of TMA images, which exploits the value of Microsoft Silverlight Deep Zoom to provide a intuitive interface for zooming and panning around digital images. We use and extend existing XML-based standards to ensure that the data collected can be archived and that our system is interoperable with other standards-compliant systems. CONCLUSION: The application has been used for multi-centre scoring of TMA slides composed of tissues from several Phase III breast cancer trials and ten different studies participating in the International Breast Cancer Association Consortium (BCAC). The system has enabled researchers to simultaneously score large collections of TMA and export the standardised data to integrate with pathological and clinical outcome data, thereby facilitating biomarker discovery.RIGHTS : This article is licensed under the BioMed Central licence at http://www.biomedcentral.com/about/license which is similar to the 'Creative Commons Attribution Licence'. In brief you may : copy, distribute, and display the work; make derivative works; or make commercial use of the work - under the following conditions: the original author must be given credit; for any reuse or distribution, it must be made clear to others what the license terms of this work are

First Science Observations with SOFIA/FORCAST: Properties of Intermediate-Luminosity Protostars and Circumstellar Disks in OMC-2

We examine eight young stellar objects in the OMC-2 star forming region based on observations from the SOFIA/FORCAST early science phase, the Spitzer Space Telescope, the Herschel Space Observatory, 2MASS, APEX, and other results in the literature. We show the spectral energy distributions of these objects from near-infrared to millimeter wavelengths, and compare the SEDs with those of sheet collapse models of protostars and circumstellar disks. Four of the objects can be modelled as protostars with infalling envelopes, two as young stars surrounded by disks, and the remaining two objects have double-peaked SEDs. We model the double-peaked sources as binaries containing a young star with a disk and a protostar. The six most luminous sources are found in a dense group within a 0.15 x 0.25 pc region; these sources have luminosities ranging from 300 L_sun to 20 L_sun. The most embedded source (OMC-2 FIR 4) can be fit by a class 0 protostar model having a luminosity of ~50 L_sun and mass infall rate of ~10^-4 solar masses per year.Comment: Accepted by ApJ Letter

Commemorative Air Force: Dixie Wing

Prepared by the Fall 2016 Interpretive Planning Class. This interpretive plan evaluates the existing conditions of the Dixie Wing\u27s membership, resources, management and opportunities to enable the administration to monitor, review and implement policies and processes going forward. Comprehensive analysis of administration and membership goals, in addition to delineating a series of guiding themes for the exhibit, are included in the interpretive plan. Policy and initiative recommendations are also included as a sustainable model in the areas of environment, experience and community which emphasize membership input, resource management, logistical, fiscal and administrative structures for future growth.https://scholarworks.gsu.edu/history_heritagepreservation/1015/thumbnail.jp

Bostonia: The Boston University Alumni Magazine. Volume 10

Founded in 1900, Bostonia magazine is Boston University's main alumni publication, which covers alumni and student life, as well as university activities, events, and programs

Structure of Tagatose-1,6-bisphosphate Aldolase. Insight into chiral discrimination, mechanism, and specificity of class II aldolases

Tagatose-1,6-bisphosphate aldolase (TBPA) is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phosphate to produce tagatose 1,6-bisphosphate. The high resolution (1.45 Å) crystal structure of the Escherichia coli enzyme, encoded by the agaY gene, complexed with phosphoglycolohydroxamate (PGH) has been determined. Two subunits comprise the asymmetric unit, and a crystallographic 2-fold axis generates the functional tetramer. A complex network of hydrogen bonds position side chains in the active site that is occupied by two cations. An unusual Na(+) binding site is created using a interaction with Tyr(183) in addition to five oxygen ligands. The catalytic Zn(2+) is five-coordinate using three histidine nitrogens and two PGH oxygens. Comparisons of TBPA with the related fructose-1,6-bisphosphate aldolase (FBPA) identifies common features with implications for the mechanism. Because the major product of the condensation catalyzed by the enzymes differs in the chirality at a single position, models of FBPA and TBPA with their cognate bisphosphate products provide insight into chiral discrimination by these aldolases. The TBPA active site is more open on one side than FBPA, and this contributes to a less specific enzyme. The availability of more space and a wider range of aldehyde partners used by TBPA together with the highly specific nature of FBPA suggest that TBPA might be a preferred enzyme to modify for use in biotransformation chemistry

Incidental findings on brain magnetic resonance imaging: systematic review and meta-analysis

Objective To quantify the prevalence of incidental findings on magnetic resonance imaging (MRI) of the brain