WATER QUALITY DURING TWO HIGH-FLOW YEARS ON THE LOWER MISSOURI RIVER: THE EFFECTS OF RESERVOIR AND TRIBUTARY CONTRIBUTIONS

Complex socioeconomic and ecological issues, ranging from impaired streams to Gulf of Mexico hypoxia, have made nutrient management an increasingly important issue across the USA. High flows during 2010 and 2011 provided a unique opportunity to investigate trends in discharge, total nitrogen, nitrate/nitrite, total phosphorus, orthophosphorus, suspended sediment and total suspended solids during two distinct high-flow years on the Missouri River. We compared collections taken during 2010 and 2011 at 12 lower Missouri River locations (river kilometers 1212 to 71) and 22 Missouri River tributary locations. During 2011, average concentrations for all sampled parameters were significantly lower, despite significantly higher total discharge, than 2010 concentrations. Differences in water chemistry between years are likely attributed to the primary source of water. Tributary inflow created high flows during 2010, whereas record releases from Gavin’s Point Dam created high flows during 2011. Analysis of flow estimated the contribution of these releases at each site and revealed strong positive relationships between the percentage of estimated tributary flow at each site and the concentrations of total nitrogen, total phosphorus and total suspended solids. These monitoring efforts underline the contrasting impacts that tributary streams and reservoir releases have on nutrient export of the Missouri River during high-flow events and reveal a larger trend of increased nutrient concentrations as the proportion of Missouri River tributary flow increased

Altered functional brain network connectivity and glutamate system function in transgenic mice expressing truncated Disrupted-in-Schizophrenia 1

Considerable evidence implicates DISC1 as a susceptibility gene for multiple psychiatric diseases. DISC1 has been intensively studied at the molecular, cellular and behavioral level, but its role in regulating brain connectivity and brain network function remains unknown. Here, we utilize a set of complementary approaches to assess the functional brain network abnormalities present in mice expressing a truncated Disc1 gene (Disc1tr Hemi mice). Disc1tr Hemi mice exhibited hypometabolism in the prefrontal cortex (PFC) and reticular thalamus along with a reorganization of functional brain network connectivity that included compromised hippocampal–PFC connectivity. Altered hippocampal–PFC connectivity in Disc1tr Hemi mice was confirmed by electrophysiological analysis, with Disc1tr Hemi mice showing a reduced probability of presynaptic neurotransmitter release in the monosynaptic glutamatergic hippocampal CA1–PFC projection. Glutamate system dysfunction in Disc1tr Hemi mice was further supported by the attenuated cerebral metabolic response to the NMDA receptor (NMDAR) antagonist ketamine and decreased hippocampal expression of NMDAR subunits 2A and 2B in these animals. These data show that the Disc1 truncation in Disc1tr Hemi mice induces a range of translationally relevant endophenotypes underpinned by glutamate system dysfunction and altered brain connectivity

Recent progress in biohydrometallurgy and microbial characterisation

Since the discovery of microbiological metal dissolution, numerous biohydrometallurgical approaches have been developed to use microbially assisted aqueous extractive metallurgy for the recovery of metals from ores, concentrates, and recycled or residual materials. Biohydrometallurgy has helped to alleviate the challenges related to continually declining ore grades by transforming uneconomic ore resources to reserves. Engineering techniques used for biohydrometallurgy span from above ground reactor, vat, pond, heap and dump leaching to underground in situ leaching. Traditionally biohydrometallurgy has been applied to the bioleaching of base metals and uranium from sulfides and biooxidation of sulfidic refractory gold ores and concentrates before cyanidation. More recently the interest in using bioleaching for oxide ore and waste processing, as well as extracting other commodities such as rare earth elements has been growing. Bioprospecting, adaptation, engineering and storing of microorganisms has increased the availability of suitable biocatalysts for biohydrometallurgical applications. Moreover, the advancement of microbial characterisation methods has increased the understanding of microbial communities and their capabilities in the processes. This paper reviews recent progress in biohydrometallurgy and microbial characterisatio

A control on quantum fluctuations in 2+1 dimensions

A functional method is discussed, where the quantum fluctuations of a theory are controlled by a mass parameter and the evolution of the theory with this parameter is connected to its renormalization. It is found, in the framework of the gradient expansion, that the coupling constant of a N=1 Wess-Zumino theory in 2+1 dimensions does not get quantum corrections.Comment: Comments adde

Whirl mappings on generalised annuli and the incompressible symmetric equilibria of the dirichlet energy

In this paper we show a striking contrast in the symmetries of equilibria and extremisers of the total elastic energy of a hyperelastic incompressible annulus subject to pure displacement boundary conditions.Indeed upon considering the equilibrium equations, here, the nonlinear second order elliptic system formulated for the deformation u=(u1,…,uN) : EL[u,X]=⎧⎩⎨⎪⎪Δu=div(P(x)cof∇u)det∇u=1u≡φinX,inX,on∂X, where X is a finite, open, symmetric N -annulus (with N≥2 ), P=P(x) is an unknown hydrostatic pressure field and φ is the identity mapping, we prove that, despite the inherent rotational symmetry in the system, when N=3 , the problem possesses no non-trivial symmetric equilibria whereas in sharp contrast, when N=2 , the problem possesses an infinite family of symmetric and topologically distinct equilibria. We extend and prove the counterparts of these results in higher dimensions by way of showing that a similar dichotomy persists between all odd vs. even dimensions N≥4 and discuss a number of closely related issues

PENGARUH TERPAAN BERITA PERKOSAAN DI TRIBUNNEWS.COM TERHADAP SIKAP WASPADA MAHASISWI

The research problem in this research includes whether there is the influence of rape news of UGM female student in Tribunnews.com towards female students vigilant attitude in interact and how the influence imposed. Variable X in this research is rape news, while vigilant attitude of female students in interact is variable Y. Quantitative research is implemented by means of associative type. In addition, the basic research is survey method. The population in this study is female students second period of KKN 2018/2019 University of Muhammadiyah Malang and 36 of them become the research sample. Questionnaires and documentation are implemented as data collection techniques. Validity and reliability test are also implemented as the research instrument test. Furthermore, the researcher conducts simple linear regression and hypothesis testing using the t test as data analysis techniques. The coefficient of variable X is 0.716 (positive). From the analysis results obtained that R square result (the coefficient of determination) is 0.130. R value (the correlation coefficient) is 0.361, it shows the correlation between news rape of UGM female student in Tribunnews.com towards female students vigilant attitude in interact (Y) are included in a weak category. On the other hand, t table (α = 0.05; df residual = 34) is 1.690. Since t arithmetic > t table is 2.255 > 1.690 or sig. t value (0.031) < α = 0.05, the influence of X (rape news of UGM female student in Tribunnews.com) towards Y (female students vigilant attitude in interact) is significant. In accordance with the analysis above, it can be concluded that 13% of female students vigilant attitude in interact variable (Y) is influenced by independent variable, namely rape news of UGM female student in Tribunnews.com, and yet 87% of female students vigilant attitude in interact variable is influenced by other variables

On a class of stationary loops on SO(n) and the existence of multiple twisting solutions to a nonlinear elliptic system subject to a hard incompressibility constraint

For full abstract please refer to http://dx.doi.org/10.1186/s13661-018-1047-

Applicability and Cost Implications for Proprotein Convertase Subtilisin/Kexin Type 9 Inhibitors Based on the ODYSSEY Outcomes Trial: Insights From the Department of Veterans Affairs

In the recently presented ODYSSEY Outcomes: Evaluation of Cardiovascular Outcomes After an Acute Coronary Syndrome During Treatment With Alirocumab trial, alirocumab use in patients with acute coronary syndrome (ACS) and low-density lipoprotein cholesterol (LDL-C) ≥70 mg/dL (or non–high-density lipoprotein cholesterol ≥100 mg/dL or apolipoprotein B ≥80 mg/dL) resulted in a 15% relative (1.6% absolute) reduction in the risk of major adverse cardiovascular events. We evaluated what proportion of patients in the VA Health Care System would qualify for alirocumab on the basis of ODYSSEY Outcomes criteria, how they are currently treated with LDL-C–lowering medications, and the cost implications if other evidence-based medications were used first before a proprotein convertase subtilisin/kexin type 9 inhibitor was considered

A framework for predicting X-nuclei transmitter gain using 1H signal

Commercial human MR scanners are optimised for proton imaging, containing sophisticated prescan algorithms with setting parameters such as RF transmit gain and power. These are not optimal for X-nuclear application and are challenging to apply to hyperpolarised experiments, where the non-renewable magnetisation signal changes during the experiment. We hypothesised that, despite the complex and inherently nonlinear electrodynamic physics underlying coil loading and spatial variation, simple linear regression would be sufficient to accurately predict X-nuclear transmit gain based on concomitantly acquired data from the proton body coil. We collected data across 156 scan visits at two sites as part of ongoing studies investigating sodium, hyperpolarised carbon, and hyperpolarised xenon. We demonstrate that simple linear regression is able to accurately predict sodium, carbon, or xenon transmit gain as a function of position and proton gain, with variation that is less than the intrasubject variability. In conclusion, sites running multinuclear studies may be able to remove the time-consuming need to separately acquire X-nuclear reference power calibration, inferring it from the proton instead

Very High-Risk ASCVD and Eligibility for Nonstatin Therapies Based on the 2018 AHA/ACC Cholesterol Guidelines

The 2018 American Heart Association/American College of Cardiology Multisociety Cholesterol Guidelines recommend risk stratification among patients with atherosclerotic cardiovascular disease (ASCVD) to identify “very high-risk ASCVD patients.” These patients have characteristics associated with a higher risk of recurrent ASCVD events; consequently, they derive a higher net absolute benefit from addition of ezetimibe and/or a proprotein convertase subtilisin/kexin type 9 inhibitor (PCSK9i) to statin therapy. From a clinical and payer’s perspective, we assessed the proportion of patients with ASCVD who will qualify as very high-risk based on the guideline criteria, their current lipid management, and how this will change with maximizing statin therapy and stepwise use of ezetimibe before consideration for a PCSK9i, as recommended by the 2018 cholesterol guideline