Peripartum antidepressant use is associated with an increased risk of postpartum hemorrhage

Dissertação de mestrado em Treino Desportivo para Crianças e Jovens, apresentada à Faculdade de Ciências do Desporto e Educação Física da Universidade de CoimbraEste estudo teve como objetivo avaliar os fatores determinantes do rendimento e da contribuição metabólica numa competição de 1000m em Kayak ergómetro, em jovens atletas praticantes de canoagem na variante “regatas em linha”. A amostra foi constituída por 12 atletas jovens de canoagem com experiencia desportiva. Verificou-se também a associação dos parâmetros morfológicos e maturacionais com a performance num teste máximo de 1000m e em segmentos de 250m desses 1000m. Este estudo ganha pertinência pela determinação da associação da intensidade relativa, identificada com os parâmetros ventilatórios, com o resultado de uma prova critério – 1000m em kayak ergómetro, em jovens praticantes. Metodologia: O desenho do estudo consistiu num levantamento de dados antropométricos da amostra, após este levantamento foi realizado um protocolo progressivo e após 48 horas foi realizado um teste máximo de 1000 metros. Dados da amostra: idade decimal 16,0 ± 1,1; massa corporal (kg) 63,8 ± 7,2; estatura (centímetros) 174,9 ± 7,2; estatura matura predita (Khamis-Roche) 100,1 ± 5,7; prática semanal (horas) 10,5 ± 2,4; com experiencia desportiva (anos) 2,7 ± 0,7. Utilizámos: adipômetro, estadiómetros, Bod Pod, Balança, estação meteorológica, analisador de gases, kayak ergómetro, ciclo ergómetro e analisador de lactato portátil. Resultados: No protocolo incremental alcançaram um valor de VO2 max abs (L.min-1) 3,4 ± 0,6; sendo o Lv1 (58,8 ± 11,8%) e o Lv2 (88 ± 14,7%), e um valor de potência 138,5 ± 24,5 watt. O teste máximo de 1000m teve duração de 292,25 ± 15 segundos, uma percentagem da VAM 97,0 ± 2,8, uma percentagem VO2 max de 90,0 ± 6,5 e uma percentagem da PAM de 96,3. Conseguindo um modelo preditivo. Discussão: Verificámos a existência de correlação entre as seguintes variáveis e a performance no teste máximo: idade, PAM, Cadência, VO2 max abs, VAM, VLv1, VLv2 e FC Lv1. O que é uma novidade pois na literatura sobre esta temática apenas são apresentados com frequência o VO2 max abs, a idade, cadência e a VAM. Estes novos indicadores necessitam de maior aprofundamento para perceber numa amostra com um N maior a sua resposta e dessa forma perceber a sua importância como preditores. Conclusão: A realização do protocolo progressivo pode ser preditor de um teste máximo de 1000m, contribuindo também para o planeamento de treino para a preparação de competições desta distância. Além disso os limiares ventilatórios são uma das novas tendências da prescrição do treino. iii ABSTRACT Coelho, AB (2015). Predictive value of a progressive protocol on a Kayak ergometer for the 1,000 metre race in Kayak ergometer. Master's Thesis on Children and Teenage Sport Training - Faculty of Sport Sciences and Physical Education, University of Coimbra. Introduction: The aim of this study was to evaluate the determinants of efficiency and metabolic contribution in a 1,000 metre race in Kayak ergometer in young athletes practicing canoeing in the variant flat water. The sample contained 12 young canoeing athletes with competitive sporting experience. The association of morphological and maturation parameters with the performance of a maximum 1,000 metre test and 250 metre segments within the 1,000 metres was verified. This study gains relevance from the determination of the association of relative intensity , identified with the ventilation parameters, with the result of a test criterion – 1,000 metre kayak ergometer in young sportsmen. Methodology: The study consisted of a survey of the anthropometric data of sample. After this survey a progressive protocol was conducted and after 48 hours a maximal test of 1,000 metres at full speed was performed. Sample data: decimal age 16.0 ± 1.1; body mass (kg) 63.8 ± 7.2; height (centímetros) 174.9 ± 7.2; predicted mature height (Khamis-Roche) 100.1 ± 5.7; weekly practice (hours) 10.5 ± 2.4; with sports experience (years) 2.7 ± 0.7. We used: adipometer, stadiometers, Bod Pod, weighing scale, weather station, gas analyzer, kayak ergometer, ergometer cycle and portable lactate analyzer. Results: In the incremental protocol they reached a value of VO2 max abs (L.min-1) 3.4 ± 0.6; being VT1 (58.8 ± 11.8%) and VT2 (88 ± 14.7%), and a power value of 138.5 ± 24.5 watts. The maximum 1,000 m test race lasted 292.25 ± 15 seconds, a 97.0 ± 2.8 MAV percentage, a 90.0 ± 6.5 maximum VO2 percentage and a 96.3 MAP percentage. A predictive model was reached. Discussion: We found a correlation between the following variables and the maximum performance in the test: age, MAP, Cadence, VO2 max abs, MAV, VVT1, VVT2 and HR VT1. This is new because in the literature on this subject only VO2 max abs, age, cadence and MAV are presented frequently. These new indicators need to be deeper clarified to understand in a sample with a higher N their answer and, thus, understand its importance as predictors. Conclusion: The performance of the progressive protocol can be a predictor of a maximum 1000m test, also contributing to the training plan for the preparation of competitions of this distance. In addition, the ventilatory thresholds are one of the new trends in the training prescription

Treating vaginal candidiasis for the prevention of preterm birth: protocol for a systematic review and meta-analysis

NHMR

Reversible Capture and Release of a Ligand Mediated by a Long-Range Relayed Polarity Switch in a Urea Oligomer

[Image: see text] Ethylene-bridged oligoureas characterized by a continuous, switchable chain of hydrogen bonds and carrying a binding site (an N,N′-disubstituted urea) for a hydrogen-bond-accepting ligand (a phosphine oxide) were synthesized. These oligomers show stronger ligand binding when the binding site is located at the hydrogen-bond-donating terminus than when the same binding site is at the hydrogen-bond-accepting terminus. An acidic group at the terminus remote from the binding site allows hydrogen bond polarity, and hence ligand binding ability, to be controlled remotely by a deprotonation/reprotonation cycle. Addition of base induces a remote conformational change that is relayed through up to five urea linkages, reducing the ability of the binding site to retain an intermolecular association to its ligand, which is consequently released into solution. Reprotonation returns the polarity of the oligomer to its original directionality, restoring the function of the remote binding site, which consequently recaptures the ligand. This is the first example of a synthetic molecular structure that relays intermolecular binding information, and these “dynamic foldamer” structures are prototypes of components for chemical systems capable of controlling chemical function from a distance

Economic and Fiscal Impacts of Proposed LNG Facility in Robbinston, Maine

The purpose of this study is to examine the economic and fiscal impacts of the proposed Downeast LNG facility on the Town of Robbinston, Washington County, and the State of Maine. The economic impact analysis focuses on the employment and income that are associated with the LNG facility construction and operations. The fiscal impact analysis considers additional local and state tax revenues associated with the facility, as well as increased local government expenditures that are projected to result from the LNG project. This report does not address the environmental, homeland security, or energy security impacts of the LNG facility. In addition, this report does not estimate any changes in the price of delivered natural gas in Maine that could potentially result from a new major energy supplier

Treating vaginal candidiasis for the prevention of preterm birth: protocol for a systematic review and meta-analysis

NHMR

Do Industrial Relations Affect Plant Performance?: The Case of Commercial Aircraft Manufacturing

This study analyzes the impact of major industrial relations variables on productivity within a plant that assembles large commercial aircraft. The analysis combines the deep firm- specific knowledge of management and labor typical of the best of traditional industrial relations with formal statistical tests. We use a before and after research design over an 18-year period with monthly data, as well as information from the participants in the industrial relations events. Our approach is unusual in showing that by focusing only on managerial factors or the learning curve, and omitting factors such as union leadership and related labor relations events, estimates may mis-specify impacts on firm performance. Strikes, slowdowns, and tough union leaders influenced the productivity of this plant by both large percentages and absolute dollar amounts during the period they were occurring. In contrast with much of the firm performance literature, we find small initial productivity impacts of movements from traditional adversarial management, which is the norm in this industry, to total quality management (TQM) and back again. How and why TQM is adopted may be just as important as whether it is adopted. Finally, simulations from a counterfactual case show that major industrial relations events like strikes, slowdowns, and the TQM program did not have long term productivity effects, and that the firm we studied returned to pre-event levels of production within one to four months.