The Mediterranean Diet from Ancel Keys to the UNESCO Cultural Heritage. A Pattern of Sustainable Development between Myth and Reality

Abstract This paper deals with the Mediterranean Diet as a potential tool for increasing knowledge and promoting a sustainable development especially in least developed and developing regions. The confirmation of the MD as an Intangible Heritage of Humanity, recognized by UNESCO in 2010, is producing a significant social effect in the seven nations and communities involved. In addition in 2012 the MD has been included by the FAO at the top of the list of the most sustainable diets in the planet. The double recognition of this life style is generating a new approach to this cultural heritage by the stakeholders who are progressively recognizing that it may become a new tool to develop green economy and eco-tourism. To this end the author analyses the real and mythological genealogy of the MD in order to bring out its cultural, economic and social potentiality

LA DIETA MEDITERRANEA UNESCO. UN MODELLO DI SVILUPPO SOSTENIBILE TRA MITO E REALTÀ

This paper deals with the Mediterranean Diet as a potential tool for increasing knowledge and promoting a sustainable development especially in least developed and developing regions. The confirmation of the MD as an Intangible Heritage of Humanity, recognized by UNESCO in 2010, is producing a significant social effect in the seven nations and communities involved. In addition in 2012 the MD has been included by the FAO at the top of the list of the most sustainable diets in the planet. The double recognition of this life style is generating a new approach to this cultural heritage by the stakeholders who are progressively recognizing that it may become a new tool to develop green economy and eco-tourism. To this end the author analyses the real and mythological genealogy of the MD in order to bring out its cultural, economic and social potentiality.DOI: http://dx.medra.org/10.19254/LaborEst.12.03         

Nascita di un nome. Esercizi di memoria sul patrimonio immateriale della dieta mediterranea

L’autrice riscostruisce la genealogia del termine “dieta mediterranea” e la sua introduzione nel lessico scientifico e nel senso comune occidentali. Questa espressione, infatti, risale solo alla seconda metà del Novecento. Attraverso una serie di testimonianze dirette e un’analisi delle fonti, Moro mette in evidenza il fatto che ad inventare questa fortunata espressione sono stati Ancel Keys e Margaret Haney Keys, scopritori di questo stile di vita, che attraverso il Seven Countries Study (1958) ne hanno dimostrato per primi i benefici sulla salute. Con il libro How to Eat Well and Stay Well. The Mediterranean Way (USA 1975) i Keys introducono nel lessico occidentale il nome dieta mediterranea. Tale termine entra invece ufficialmente nel lessico scientifico grazie ad una ricerca sul rapporto tra dieta e colesterolo, fortemente voluta da Ancel Keys, condotta da Anna Ferro-Luzzi et all. in Cilento-Italia (oggi comunità UNESCO della dieta mediterranea) e pubblicata nel 1984 sul prestigioso American Journal of Clinical Nutrition AJCN.The author reconstructs the genealogy of the term “Mediterranean diet” and its introduction into the scientific lexicon and in the western general sense. Indeed, this expression dates back only to the second half of the twentieth century. After collecting witnesses and analyzing the sources, Moro points out that Ancel Keys and Margaret Haney Keys, the discoverers of this way of life, invented this successful expression. They showed the health benefits of the Mediterranean Diet through the Seven Countries Study (1958). Thanks to the book How to Eat Well and Stay Well. The Mediterranean Way (USA 1975) the Keys introduced the expression “Mediterranean diet” into the western lexicon. However, this term officially enters into the scientific lexicon thanks to research carried out on the relationship between diet and cholesterol. The study was strongly desired by Ancel Keys and performed by Anna Ferro-Luzzi et all. in Cilento-Italy (today one of the UNESCO communities of the Mediterranean diet). This research was published in 1984 in the prestigious American Journal of Clinical Nutrition AJCN

L-MOMENTS BASED ASSESSMENT OF A MIXTURE MODEL FOR FREQUENCY ANALYSIS OF RAINFALL EXTREMES.

In the framework of the regional analysis of hydrological extreme events, a probabilistic mixture model, given by a convex combination of two Gumbel distributions, is proposed for rainfall extremes modelling. The papers concerns with statistical methodology for parameter estimation. With this aim, theoretical expressions of the L-moments of the mixture model are here defined. The expressions have been tested on the time series of the annual maximum height of daily rainfall recorded in Tuscany (central Italy)

Novel missense mutations in PNPLA2 causing late onset and clinical heterogeneity of neutral lipid storage disease with myopathy in three siblings

Neutral lipid storage disease with myopathy (NLSD-M) is a rare autosomal recessive disorder characterised by an abnormal accumulation of triacylglycerol into cytoplasmic lipid droplets (LDs). NLSD-M patients are mainly affected by progressive myopathy, cardiomyopathy and hepatomegaly. Mutations in the PNPLA2 gene cause variable phenotypes of NLSD-M. PNPLA2 codes for adipose triglyceride lipase (ATGL), an enzyme that hydrolyses fatty acids from triacylglycerol. This report outlines the clinical and genetic findings in a NLSD-M Italian family with three affected members. In our patients, we identified two novel PNPLA2 missense mutations (p.L56R and p.I193F). Functional data analysis demonstrated that these mutations caused the production of ATGL proteins able to bind to LDs, but with decreased lipase activity. The oldest brother, at the age of 38, had weakness and atrophy of the right upper arm and kyphosis. Now he is 61 years old and is unable to raise arms in the horizontal position. The second brother, from the age of 44, had exercise intolerance, cramps and pain in lower limbs. He is currently 50 years old and has an asymmetric distal amyotrophy. One of the two sisters, 58 years old, presents the same PNPLA2 mutations, but she is still oligo-symptomatic on neuromuscular examination with slight triceps muscle involvement. She suffered from diabetes and liver steatosis. This NLSD-M family shows a wide range of intra-familial phenotypic variability in subjects carrying the same mutations, both in terms of target-organs and in terms of rate of disease progression

Long-term continuous monitoring of the preterm brain with diffuse optical tomography and electroencephalography: A technical note on cap manufacturing

open12noDiffuse optical tomography (DOT) has recently proved useful for detecting whole-brain oxygenation changes in preterm and term newborns' brains. The data recording phase in prior explorations was limited up to a maximum of a couple of hours, a time dictated by the need to minimize skin damage caused by the protracted contact with optode holders and interference with concomitant clinical/nursing procedures. In an attempt to extend the data recording phase, we developed a new custom-made cap for multimodal DOT and electroencephalography acquisitions for the neonatal population. The cap was tested on a preterm neonate (28 weeks gestation) for a 7-day continuous monitoring period. The cap was well tolerated by the neonate, who did not suffer any evident discomfort and/or skin damage. Montage and data acquisition using our cap was operated by an attending nurse with no difficulty. DOT data quality was remarkable, with an average of 92% of reliable channels, characterized by the clear presence of the heartbeat in most of them.openopenAlfonso Galderisi; Sabrina Brigadoi; Simone Cutini; Sara Basso Moro; Elisabetta Lolli; Federica Meconi; Silvia Benavides-Varela; Eugenio Baraldi; Piero Amodio; Claudio Cobelli; Daniele Trevisanuto; Roberto Dell'AcquaGalderisi, Alfonso; Brigadoi, Sabrina; Cutini, Simone; BASSO MORO, Sara; Lolli, Elisabetta; Meconi, Federica; Silvia, Benavides-Varela; Baraldi, Eugenio; Amodio, Piero; Cobelli, Claudio; Trevisanuto, Daniele; Dell'Acqua, Robert

Risk perception, knowledge about SARS-CoV-2, and perception towards preventive measures in Italy: a nationwide cross-sectional study

Introduction: After COVID-19 outbreak, governments adopted several containment measures. Risk perception and knowledge may play a crucial role since they can affect compliance with preventive measures. This study aimed to explore the extent and the associated factors of risk perception, knowledge regarding SARS-CoV2, and perception towards preventive measures among the Italian population. Methods: A nationwide cross-sectional study involving adults was conducted in April-May 2021: an online survey was distributed through social media. The outcomes were: Knowledge Score (KS) (0 to 100%: higher scores correspond to higher COVID-19-related knowledge); Risk Perception Score (RPS) (1 to 4: higher values indicate higher concern); Preventive measures Perception Score (PPS) (1 to 4: higher values indicate higher confidence). Multivariable regression models were performed. Results: A total of 1120 participants were included. Median KS was 79.5%  (IQR=72.7%-86.4%). Lower education and poor economic conditions were negatively associated with the KS.  Median RPS was 2.8 (IQR=2.4-3.2). Female gender, sharing house with a fragile person, suffering from a chronic disease, having a family member/close friend who contracted SARS-CoV-2 infection were positively associated with the RPS. Median PPS was 3.1 (IQR=2.8-3.4). Lower educational level was negatively associated with the PPS. Vaccine hesitancy was negatively associated with all three outcomes. The three scores were positively associated with each other. Conclusions: Fair levels of knowledge, risk perception and perception towards preventive measures were reported. Reciprocal relationships between the outcomes and a relevant relationship with vaccine hesitancy were highlighted. Further investigations should be focused on studying underlying determinants and consequences

Novel missense mutations in PNPLA2 causing late onset and clinical heterogeneity of neutral lipid storage disease with myopathy in three siblings

Neutral lipid storage disease with myopathy (NLSD-M) is a rare autosomal recessive disorder characterised by an abnormal accumulation of triacylglycerol into cytoplasmic lipid droplets (LDs). NLSD-M patients are mainly affected by progressive myopathy, cardiomyopathy and hepatomegaly. Mutations in the PNPLA2 gene cause variable phenotypes of NLSD-M. PNPLA2 codes for adipose triglyceride lipase (ATGL), an enzyme that hydrolyses fatty acids from triacylglycerol. This report outlines the clinical and genetic findings in a NLSD-M Italian family with three affected members. In our patients, we identified two novel PNPLA2 missense mutations (p.L56R and p.I193F). Functional data analysis demonstrated that these mutations caused the production of ATGL proteins able to bind to LDs, but with decreased lipase activity. The oldest brother, at the age of 38, had weakness and atrophy of the right upper arm and kyphosis. Now he is 61. years old and is unable to raise arms in the horizontal position. The second brother, from the age of 44, had exercise intolerance, cramps and pain in lower limbs. He is currently 50. years old and has an asymmetric distal amyotrophy. One of the two sisters, 58. years old, presents the same PNPLA2 mutations, but she is still oligo-symptomatic on neuromuscular examination with slight triceps muscle involvement. She suffered from diabetes and liver steatosis. This NLSD-M family shows a wide range of intra-familial phenotypic variability in subjects carrying the same mutations, both in terms of target-organs and in terms of rate of disease progression

Neuronal desertification after a direct lightning strike: a case report

Background: Lightning strike is a rare but dramatic cause of injury. Patients admitted to intensive care units (ICUs) with lightning strike frequently have a high mortality and significant long-term morbidity related to a direct brain injury or induced cardiac arrest (CA). Case presentation: A 50-year-old Caucasian man was admitted to our hospital after being struck by lightning resulting in immediate CA. Spontaneous circulation was initially restored, and the man was admitted to the ICU, but ultimately died while in hospital due to neurological injury. The computer tomography scan revealed a massive loss of grey-white matter differentiation at the fronto-temporal lobes bilaterally. Somatosensory-evoked potentials demonstrated bilateral absence of the cortical somatosensory N20-potential, and the electroencephalogram recorded minimal cerebral electrical activity. The patient died on day 10 and a post-mortem study revealed a widespread loss of neurons. Conclusion: This case study illustrates severe brain injury caused by a direct lighting strike, with the patient presenting an extraordinary microscopic pattern of neuronal desertification

SCL-90 empirical factors predict post-surgery weight loss in bariatric patients over longer time periods

This longitudinal study examined how pre-intervention psychological health helps predict bariatric surgery (BS) success as percentage of expected body mass index loss (ëMIL) over shorter to longer periods