The use of GIS in Brownfield redevelopment

In recent years, the issue of Brownfield site development - the re-use of previously used urban land - has gained a significant place in the planning agenda. However, not all Brownfield sites are derelict or contaminated land, some are significant as environmental amenities - be it part of wider ecosystem or a green area for the local population. The growing concern to include environmental aspects into the public debate have lead the Environment Agency, the Jackson Environment Institute and the Centre for Advanced Spatial Analysis to commission a short term pilot study to evaluate the contribution of a GIS for decision support and for "discussion support".In this paper, we describe how the state-of-the-art in geographic information (GI) and GI Science (GISc) can be used in a short term and limited project to achieve a practical and usable system. We are drawing on developments in information availability, as made accessible through the World Wide Web and research themes in GISc ranging from Multimedia GIS to Public Participation GIS

The Brown-dwarf Atmosphere Monitoring (BAM) Project II: Multi-epoch monitoring of extremely cool brown dwarfs

With the discovery of Y dwarfs by the WISE mission, the population of field brown dwarfs now extends to objects with temperatures comparable to those of Solar System planets. To investigate the atmospheres of these newly identified brown dwarfs, we have conducted a pilot study monitoring an initial sample of three late T-dwarfs (T6.5, T8 and T8.5) and one Y-dwarf (Y0) for infrared photometric variability at multiple epochs. With J-band imaging, each target was observed for a period of 1.0h to 4.5h per epoch, which covers a significant fraction of the expected rotational period. These measurements represent the first photometric monitoring for these targets. For three of the four targets (2M1047, Ross 458C and WISE0458), multi-epoch monitoring was performed, with the time span between epochs ranging from a few hours to ~2 years. During the first epoch, the T8.5 target WISE0458 exhibited variations with a remarkable min-to-max amplitude of 13%, while the second epoch light curve taken ~2 years later did not note any variability to a 3% upper limit. With an effective temperature of ~600 K, WISE0458 is the coldest variable brown dwarf published to-date, and combined with its high and variable amplitude makes it a fascinating target for detailed follow-up. The three remaining targets showed no significant variations, with a photometric precision between 0.8% and 20.0%, depending on the target brightness. Combining the new results with previous multi-epoch observations of brown dwarfs with spectral types of T5 or later, the currently identified variables have locations on the colour-colour diagram better matched by theoretical models incorporating cloud opacities rather than cloud-free atmospheres. This preliminary result requires further study to determine if there is a definitive link between variability among late-T dwarfs and their location on the colour-colour diagram.Comment: 9 pages, 6 figures, 3 tables, accepted for publication in MNRA

The Histone 3'-Terminal Stem-Loop-Binding Protein Enhances Translation through a Functional and Physical Interaction with Eukaryotic Initiation Factor 4G (eIF4G) and eIF3

Metazoan cell cycle-regulated histone mRNAs are unique cellular mRNAs in that they terminate in a highly conserved stem-loop structure instead of a poly(A) tail. Not only is the stem-loop structure necessary for 3'-end formation but it regulates the stability and translational efficiency of histone mRNAs. The histone stem-loop structure is recognized by the stem-loop-binding protein (SLBP), which is required for the regulation of mRNA processing and turnover. In this study, we show that SLBP is required for the translation of mRNAs containing the histone stem-loop structure. Moreover, we show that the translation of mRNAs ending in the histone stem-loop is stimulated in Saccharomyces cerevisiae cells expressing mammalian SLBP. The translational function of SLBP genetically required eukaryotic initiation factor 4E (eIF4E), eIF4G, and eIF3, and expressed SLBP coisolated with S. cerevisiae initiation factor complexes that bound the 5' cap in a manner dependent on eIF4G and eIF3. Furthermore, eIF4G coimmunoprecipitated with endogenous SLBP in mammalian cell extracts and recombinant SLBP and eIF4G coisolated. These data indicate that SLBP stimulates the translation of histone mRNAs through a functional interaction with both the mRNA stem-loop and the 5' cap that is mediated by eIF4G and eIF3

Computer-aided communication satellite system analysis and optimization

The capabilities and limitations of the various published computer programs for fixed/broadcast communication satellite system synthesis and optimization are discussed. A satellite Telecommunication analysis and Modeling Program (STAMP) for costing and sensitivity analysis work in application of communication satellites to educational development is given. The modifications made to STAMP include: extension of the six beam capability to eight; addition of generation of multiple beams from a single reflector system with an array of feeds; an improved system costing to reflect the time value of money, growth in earth terminal population with time, and to account for various measures of system reliability; inclusion of a model for scintillation at microwave frequencies in the communication link loss model; and, an updated technological environment

A clinical analysis of vertical fixation disparity graphs

Historically, vertical fixation disparity curves have been described as straight lines. This suggests minimal prism adaptation to vertical prism stress. There have been reports in the literature, and it has been our clinical experience, that while many vertical fixation disparity curves are straight lines, many others are sigmoidal. This study evaluated the slopes of thirty vertical fixation disparity curves from non-asthenopic subjects to see if the magnitude of the change in slope is striking enough to identify the curves as something other than a straight line. The results indicate that the majority of the graphs are straight lines, as most literature suggests, with a total of twenty straight line curves and ten sigmoid shaped. However, two sigmoidal curves show a large magnitude of change across the slope suggesting vertical prism adaptation is indeed possible

Characterising a tunable, pulsed atomic beam using matter-wave interferometry

We describe the creation and characterisation of a velocity tunable, spin-polarized beam of slow metastable argon atoms. We show that the beam velocity can be determined with a precision below 1% using matter-wave interferometry. The profile of the interference pattern was also used to determine the velocity spread of the beam, as well as the Van der Waals (VdW) co-efficient for the interaction between the metastable atoms and the multi-slit silicon nitride grating. The VdW co-efficient was determined to be C_{3} = 1.84 ± 0.17 a.u., in good agreement with values derived from spectroscopic data. Finally, the spin polarization of the beam produced during acceleration of the beam was also measured, demonstrating a spatially uniform spin polarization of 96% in the m = +2 state

Flow cytometric characterization and clinical outcome of CD4+ T-cell lymphoma in dogs: 67 cases.

BackgroundCanine T-cell lymphoma (TCL) is conventionally considered an aggressive disease, but some forms are histologically and clinically indolent. CD4 TCL is reported to be the most common subtype of TCL. We assessed flow cytometric characteristics, histologic features when available, and clinical outcomes of CD4+ TCL to determine if flow cytometry can be used to subclassify this group of lymphomas.ObjectiveTo test the hypothesis that canine CD4+ T-cell lymphoma (TCL) is a homogeneous group of lymphomas with an aggressive clinical course.AnimalsSixty-seven dogs diagnosed with CD4+ TCL by flow cytometry and treated at 1 of 3 oncology referral clinics.MethodsRetrospective multivariable analysis of outcome in canine CD4+ TCL including patient characteristics, treatment, and flow cytometric features.ResultsThe majority of CD4+ TCL were CD45+, expressed low class II MHC, and exhibited an aggressive clinical course independent of treatment regimen (median survival, 159 days). Histologically, CD4+ TCL were classified as lymphoblastic or peripheral T cell. Size of the neoplastic lymphocytes had a modest effect on both PFI and survival in this group. A small number of CD4+ TCL were CD45- and class II MHC high, and exhibited an apparently more indolent clinical course (median survival not yet reached).Conclusions and clinical importanceAlthough the majority of CD4+ TCL in dogs had uniform clinical and flow cytometric features and an aggressive clinical course, a subset had a unique immunophenotype that predicts significantly longer survival. This finding strengthens the utility of flow cytometry to aid in the stratification of canine lymphoma