6 research outputs found
Treatment of Large Liver Cyst Evaluated with CA19-9 in the Cystic Fluid
A middle-aged woman was admitted with a diagnosis of liver cysts. The patient was symptomatic and was
treated by injecting absolute ethanol into the largest cyst every week, but the secretion from the cyst
persisted. The patient was then treated by absolute ethanol injection every day with good results.
CA 19-9 was measured in the cystic fluid. The secretion was related to CA 19-9 activity
Clinical experiences with left gastric vena caval shunt in patients with esophageal varices
Phase II study of IRInotecan treatment after COmbined chemoâimmunotherapy for extensiveâstage small cell lung cancer: Protocol of IRICO study
Abstract Introduction Combined treatment using antiâprogrammed deathâligand 1 antibody (antiâPDâL1) and platinumâetoposide is the current standard firstâline treatment for patients with extensiveâstage (ES) small cell lung cancer (SCLC). However, the best treatment for relapsed ESâSCLC after the firstâline treatment remains unclear. There are some approved chemotherapeutic agents that can be used against ESâSCLC, and treatment with irinotecan is well established as both a monotherapy and a combined therapy, in combination with platinum. Therefore, we conduct a phase II study with irinotecan in the secondâ or laterâline setting for patients with ESâSCLC who have been previously treated with combined treatment. Methods Our study will enroll total 30 patients who are diagnosed with ESâSCLC and have experienced disease progression after the combined treatment. Patients will receive irinotecan on days 1, 8, and 15, which will be repeated every 4âweeks. Doses of irinotecan (100/80/60âmg/m2) will be determined according to the type of UGT1A1 gene polymorphism, and the treatment will be discontinued following disease progression, intolerance, withdrawal of patient consent, and based on the investigator's decision. The primary endpoint of the study is the response rate, and the secondary endpoints are overall survival, progressionâfree survival, and safety. Discussion Since the present firstâline treatment has been changed to the combined treatment, the secondâ or laterâline treatment should be reâevaluated for patients with relapsed SCLC. Irinotecan is a major chemotherapeutic agent used for SCLC. This study demonstrates and reâevaluates the clinical benefits of irinotecan after combined treatment with antiâPDâL1 and platinumâetoposide for patients with ESâSCLC. Registration details This study was registered in the Japan Registry of Clinical Trials (no. jRCT s071210090) on November 4, 2021