1,970 research outputs found
Book Notes: Lowering the Wall: Religion and the Supreme Court in the 1980s. by Gregg Ivers.
Book notes: Lowering the Wall: Religion and the Supreme Court in the 1980s. By Gregg Ivers. Antidefamation League: New York. 1991. Pp. vii, 108. Reviewed by: Rikke A. Dierssen-Morice
Carrier prayer-book : containing, together with the usual formularies, a complete collection of hymns, catechisms, directions relative to various points of Catholic life / by A.G. Morice.
Carrier Catholic Prayer Book from Stuart Lake Mission written in 1901. Written in Carrier, prefaced in English and French. 338 pages. Leather covers, blind stamped, upper cover blind stamped with cruciform design, spine in gold, with floral decorations between raised bands. End papers decorated with gilt stamped design of repeating fleurons
N-cinnamoylanthranilates as human TRPA1 modulators: Structure-activity relationships and channel binding sites
The transient receptor potential ankyrin 1 (TRPA1) channel is a non-selective cation channel, which detects noxious stimuli leading to pain, itch and cough. However, the mechanism(s) of channel modulation by many of the known, non-reactive modulators has not been fully elucidated. N-cinnamoylanthranilic acid derivatives (CADs) contain structural elements from the TRPA1 modulators cinnamaldehyde and flufenamic acid, so it was hypothesized that specific modulators could be found amongst them and more could be learnt about modulation of TRPA1 with these compounds. A series of CADs was therefore screened for agonism and antagonism in HEK293 cells stably transfected with WT-human (h)TRPA1, or C621A, F909A or F944A mutant hTRPA1. Derivatives with electron-withdrawing and/or electron-donating substituents were found to possess different activities. CADs with inductive electron-withdrawing groups were agonists with desensitizing effects, and CADs with electron-donating groups were either partial agonists or antagonists. Site-directed mutagenesis revealed the CADs do not undergo conjugate addition reaction with TRPA1 and reveal that F944 is a key residue involved in the non-covalent modulation of TRPA1 by CADs, as well as many other structurally distinct non-reactive TRPA1 ligands already reported
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An investigation into the impact of using various techniques to estimate Arctic surface air temperature anomalies
Time series of global and regional mean Surface Air Temperature (SAT) anomalies are a common metric used to estimate recent climate change. Various techniques can be used to create these time series from meteorological station data. The degree of difference arising from using five different techniques, based on existing temperature anomaly dataset techniques, to estimate Arctic SAT anomalies over land and sea ice were investigated using reanalysis data as a testbed. Techniques which interpolated anomalies were found to result in smaller errors than non-interpolating techniques relative to the reanalysis reference. Kriging techniques provided the smallest errors in estimates of Arctic anomalies and Simple Kriging was often the best kriging method in this study, especially over sea ice. A linear interpolation technique had, on average, Root Mean Square Errors (RMSEs) up to 0.55 K larger than the two kriging techniques tested. Non-interpolating techniques provided the least representative anomaly estimates. Nonetheless, they serve as useful checks for confirming whether estimates from interpolating techniques are reasonable. The interaction of meteorological station coverage with estimation techniques between 1850 and 2011 was simulated using an ensemble dataset
comprising repeated individual years (1979-2011). All techniques were found to have larger RMSEs for earlier station coverages. This supports calls for increased data sharing and data rescue, especially in sparsely observed regions such as the Arctic
Absorption imaging of a quasi 2D gas: a multiple scattering analysis
Absorption imaging with quasi-resonant laser light is a commonly used
technique to probe ultra-cold atomic gases in various geometries. Here we
investigate some non-trivial aspects of this method when it is applied to in
situ diagnosis of a quasi two-dimensional gas. Using Monte Carlo simulations we
study the modification of the absorption cross-section of a photon when it
undergoes multiple scattering in the gas. We determine the variations of the
optical density with various parameters, such as the detuning of the light from
the atomic resonance and the thickness of the gas. We compare our results to
the known three-dimensional result (Beer-Lambert law) and outline the specific
features of the two-dimensional case.Comment: 22 pages, 5 figure
Lipid laden macrophages in respiratory disease
Letter to the edito
Aging, jamming, and the limits of stability of amorphous solids
Apart from not having crystallized, supercooled liquids can be considered as
being properly equilibrated and thus can be described by a few thermodynamic
control variables. In contrast, glasses and other amorphous solids can be
arbitrarily far away from equilibrium and require a description of the history
of the conditions under which they formed. In this paper we describe how the
locality of interactions intrinsic to finite-dimensional systems affects the
stability of amorphous solids far off equilibrium. Our analysis encompasses
both structural glasses formed by cooling and colloidal assemblies formed by
compression. A diagram outlining regions of marginal stability can be adduced
which bears some resemblance to the quasi-equilibrium replica meanfield theory
phase diagram of hard sphere glasses in high dimensions but is distinct from
that construct in that the diagram describes not true phase transitions but
kinetic transitions that depend on the preparation protocol. The diagram
exhibits two distinct sectors. One sector corresponds to amorphous states with
relatively open structures, the other to high density, more closely-packed
ones. The former transform rapidly owing to there being motions with no free
energy barriers; these motions are string-like locally. In the dense region,
amorphous systems age via compact activated reconfigurations. The two regimes
correspond, in equilibrium, to the collisional or uniform liquid and the so
called landscape regime, respectively. These are separated by a spinodal line
of dynamical crossovers. Owing to the rigidity of the surrounding matrix in the
landscape, high-density part of the diagram, a sufficiently rapid pressure
quench adds compressive energy which also leads to an instability toward
string-like motions with near vanishing barriers. (SEE REST OF ABSTRACT IN THE
ARTICLE.)Comment: submitted to J Phys Chem
Multifocal Aggressive Squamous Cell Carcinomas Induced by Prolonged Voriconazole Therapy: A Case Report
Voriconazole is a treatment for severe fungal infections. Prolonged voriconazole therapy may induce skin reactions, with 1% of severe photosensitivity accidents. Recently the imputability of voriconazole in skin carcinogenesis has been suggested. This report concerns a 55-year-old man suffering from pulmonary aspergillosis who presented a phototoxic reaction a few months after introduction of voriconazole, followed by multiple squamous cell carcinomas of sun-exposed skin areas. After voriconazole discontinuation, no new carcinoma was observed. The detection of EBV and HPV in skin lesions was negative. Exploration of gene mutations involved in skin carcinogenesis showed two variants of the MICR gene. The occurrence of multiple, recurrent, aggressive squamous cell carcinomas is rare with voriconazole, but its imputability is strongly suggested. A plausible hypothesis is that several factors including voriconazole uptake, immunosuppression, and genetic background could explain the phenotype of fast-developing skin carcinomas. Voriconazole therapy should be accompanied by stringent photoprotection and skin monitoring
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