Exercises to increase auditory discrimination in retarded readers of grades four, five, and six.

Thesis (Ed.M.)--Boston Universit

A highly optimized vectorized code for Monte Carlo simulations of SU(3) lattice gauge theories

New methods are introduced for improving the performance of the vectorized Monte Carlo SU(3) lattice gauge theory algorithm using the CDC CYBER 205. Structure, algorithm and programming considerations are discussed. The performance achieved for a 16(4) lattice on a 2-pipe system may be phrased in terms of the link update time or overall MFLOPS rates. For 32-bit arithmetic, it is 36.3 microsecond/link for 8 hits per iteration (40.9 microsecond for 10 hits) or 101.5 MFLOPS

Love and love of self in early modern French writing

This is a pre-print version of an article which was published in Seventeenth Century French Studies Volume 35, Number 1, July 2013 , pp. 80-97(18) and is available online at http://www.ingentaconnect.com/content/maney/c17/2013/00000035/00000001/art00007

Transition-metal interactions in aluminum-rich intermetallics

The extension of the first-principles generalized pseudopotential theory (GPT) to transition-metal (TM) aluminides produces pair and many-body interactions that allow efficient calculations of total energies. In aluminum-rich systems treated at the pair-potential level, one practical limitation is a transition-metal over-binding that creates an unrealistic TM-TM attraction at short separations in the absence of balancing many-body contributions. Even with this limitation, the GPT pair potentials have been used effectively in total-energy calculations for Al-TM systems with TM atoms at separations greater than 4 AA. An additional potential term may be added for systems with shorter TM atom separations, formally folding repulsive contributions of the three- and higher-body interactions into the pair potentials, resulting in structure-dependent TM-TM potentials. Towards this end, we have performed numerical ab-initio total-energy calculations using VASP (Vienna Ab Initio Simulation Package) for an Al-Co-Ni compound in a particular quasicrystalline approximant structure. The results allow us to fit a short-ranged, many-body correction of the form a(r_0/r)^{b} to the GPT pair potentials for Co-Co, Co-Ni, and Ni-Ni interactions.Comment: 18 pages, 5 figures, submitted to PR

Transport and Fate of Sediment on the Waipaoa River Continental Shelf: Implications for the Formation and Reworking of Flood Deposits

As part of a large interdisciplinary study, particulate fluxes in the Waipaoa River sedimentary system in New Zealand have been studied from the terrestrial headlands of the catchment to the oceanic basin over timescales spanning storm events, seasons, and the Holocene. Here, we complement prior efforts by evaluating the formation and reworking of riverine deposits during episodic flood and wave events, and considering their role in accumulation patterns created over longer timescales on the Waipaoa shelf. Using a numerical hydrodynamic and sediment transport model, sediment fluxes and deposition were analyzed from January 2010 through February 2011. A version of the three dimensional ROMS-CSTMS (Regional Ocean Modeling System – Community Sediment Transport Modeling System) was used to investigate the spatial and temporal variability of sediment fluxes on the Waipaoa shelf. The model could account for river input, waves, winds, larger-scale currents, tides, multiple sediment classes and a multi-layered seabed. Sediment sources to the water column included both the river plume and resuspension from the seabed. For model stability and to prevent the reflection of the river plume at the open boundary, the Waipaoa shelf model was nested within a larger-scale New Zealand ocean model. Model inputs were based on observations and model estimates, depending on availability

Monte Carlo Hamiltonian of lattice gauge theory

We discuss how the concept of the Monte Carlo Hamiltonian can be applied to lattice gauge theories.Comment: "Non-Perturbative Quantum Field Theory: Lattice and Beyond", Guangzhou, China 200

Functional Analysis of MicroRNA-10b in Breast Carcinoma: A Dissertation

MicroRNAs (miRNAs) represent a class of small noncoding RNAs that regulate gene expression. Recent studies have shown that miRNAs are mis-expressed in various human cancers and that some miRNAs have the potential to act as tumor suppressors or oncogenes. MiR-10b is one miRNA that has been shown to be deregulated in breast cancer. However, current findings regarding miR-10b’s role in breast cancer are controversial. MiR-10b was originally reported to be downregulated in breast cancer compared to normal breast tissue. Subsequently, miR-10b was argued to be upregulated in metastatic breast cancer cell lines, acting as a potent pro-metastatic agent via regulation of HOXD10. This report was soon challenged by another group who reported that miR-10b expression in a large patient cohort correlated inversely and significantly with tumor size, grade, and vascular invasion, but did not correlate with development of distant metastases or survival. These latter data suggest that miR-10b may impede specific functions associated with breast cancer progression. In this thesis, I present my analysis of miR-10b function in breast carcinoma cells, which revealed that it suppresses their migration and invasion. To define a mechanism that accounts for this suppressive function, I identified T-lymphoma invasion and metastasis 1 (TIAM1), a guanine nucleotide exchange factor for Rac1, as a miR-10b target and demonstrated that miR-10b inhibits TIAM1-dependent Rac1 activation, migration, and invasion. In addition, I identified the VEGF receptor fms-related tyrosine kinase 1 (FLT-1) as a second target of miR-10b and discovered a novel function for FLT-1 in promoting breast carcinoma cell migration and invasion. My results show, for the first time, that Rac activation can be regulated by a specific miRNA and provide a novel mechanism for the regulation of TIAM1 and FLT-1 in breast cancer. These data support the conclusion from clinical data that miR-10b expression correlates inversely with breast cancer progression, and suggest that miR-10b functions to impede breast carcinoma progression by regulating key target genes involved in cell motility