173 research outputs found
Multi-messenger signals of heavy axionlike particles in core-collapse supernovae: two-dimensional simulations
Core-collapse supernovae are a useful laboratory to probe the nature of
exotic particles. If axionlike particles (ALPs) are produced in supernovae,
they can affect the transfer of energy and leave traces in observational
signatures. In this work, we present results from two-dimensional supernova
models including the effects of the production and the absorption of ALPs that
couple with photons. It is found that the additional heating induced by ALPs
can enhance the diagnostic energy of explosion, E_diag. For example, for
moderate ALP-photon coupling, we find explosion energies ~0.6*10^51 erg
compared to our reference model without ALPs of ~0.4*10^51 erg in the first
~0.5 s postbounce explored in this work. Our findings indicate that when the
coupling constant is sufficiently high, the neutrino luminosities and mean
energies are decreased because of the additional cooling of the proto-neutron
star via ALPs. The gravitational wave amplitude is also reduced because the
mass accretion on the proto-neutron star is suppressed. Although the ALP-photon
coupling can foster explodability, including enhancing the explosion energy
closer to recent observations, more long-term simulations in spatially
three-dimension are needed to draw robust conclusionsComment: 12 pages, 8 figures, accepted for publication in PR
Molecular Alterations Associated with Osteosarcoma Development
Osteosarcoma is the most frequent malignant primary bone tumor characterized by a high potency to form lung metastases which is the main cause of death. Unfortunately, the conventional chemotherapy is not fully effective on osteosarcoma metastases. The progression of a primary tumor to metastasis requires multiple processes, which are neovascularization, proliferation, invasion, survival in the bloodstream, apoptosis resistance, arrest at a distant organ, and outgrowth in secondary sites. Consequently, recent studies have revealed new insights into the molecular mechanisms of metastasis development. The understanding of the mechanism of molecular alterations can provide the identification of novel therapeutic targets and/or prognostic markers for osteosarcoma treatment to improve the clinical outcome
Chromosome 8-14 translocation in a non-African Burkitt's lymphoma with leukemic conversion.
A specific chromosome translocation, t(8q-; 14q+), was observed in a 43-year-old female with non-African Burkitt's lymphoma in which leukemic conversion had occurred. The chromosome studies used cells from ascites. The ascites was apparently the result of a primary tumor involving the ovaries and contained 68% of lymphoma cells. The frequent occurrence of abnormalities related to chromosomes 1, 8 and 14 in African and non-African Burkitt's lymphomas was emphasized.</p
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