8,584 research outputs found

    Pathways to "opportunity and excellence": collaborative curriculum innovation in South Yorkshire

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    This paper reports on two aspects of a large-scale curriculum project currently taking place in four LEAs in South Yorkshire. The first of these is concerned with the positive and negative influences on effective curriculum innovation and is addressed from the perspective of the LEA project managers who are managing the delivery of the project in the region's schools. The second aspect considers what the pupils (Year 10, age 14-15) think about the new learning opportunities. The project is set in the context of regional regeneration. The paper concludes that the extremely positive responses from the sample of pupils in all three strands of the programme indicate that the greater emphasis on vocational work and work experience in schools is having a strong motivational effect on pupils who are responding with improved attendance, behaviour and achievement.</p

    "Meniscal" scar as a landmark for the joint line in revision total knee replacement

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    AIM\textbf{AIM}: To determine whether tissue identified at the joint line was actually remnant "meniscal" scar tissue or not. METHODS\textbf{METHODS}: Nine patients undergoing revision knee surgery following informed consent had meniscal scar tissue sent to the histology department for analyses. All revisions were performed where joint line had been raised or lowered at earlier surgery. Although preoperative radiographic evaluations suggested that the joint line had been altered, intraoperatively there was scar tissue at the level of the recreated joint line. This scar tissue has traditionally been described as meniscal scar, and to identify the origins of this tissue, samples were sent for histological analyses. The tissue samples were stored in formalin, and embedded and sectioned before undergoing histochemical staining. All samples underwent macroscopic and microscopic examination by a histopathologist who was blind to the study aims. The specific features that were examined included tissue organisation, surface and central composition, cellular distribution including histiocytes, nuclear ratio and vasculature. Atypical and malignant features, inflammation and degeneration were specifically looked for. A statistical review of the study was performed by a biomedical statistician. RESULTS\textbf{RESULTS}: The histological findings for the nine patients showing the macroscopic and microscopic findings, and the conclusion are outlined in a Table. The histological analyses were reviewed to determine whether the tissue samples were likely to be meniscal scar tissue. The response was yes (2, 22%), no (6, 67%) and maybe (1, 11%) based on the conclusions. The results were "yes" when on macroscopy, firm cream tissue was identified. In these two "yes" samples, microscopic analyses showed organised fibrous tissue with focal degenerative areas with laminated pattern associated with histiocytes peripherally but no inflammation. The "no" samples were assessed macroscopically and microscopically and were deemed to have appearances representing fibrous synovial tissue and features in keeping with degenerate scar tissue or connective tissue. One sample was indeterminate and microscopically contained fibro-collagenous tissue with synovial hyperplasia. It also contained some degenerate hyalinised tissue that may represent cartilage, but the appearances were not specific. CONCLUSION\textbf{CONCLUSION}: Based on our pilot study, we recommend reliance on a number of markers to identify the joint line as outlined above, and to exercise caution in using the "meniscal" scar

    Connections between propulsive efficiency and wake structure via modal decomposition

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    We present experiments on oscillating hydrofoils undergoing combined heaving and pitching motions, paying particular attention to connections between propulsive efficiency and coherent wake features extracted using modal analysis. Time-averaged forces and particle image velocimetry (PIV) measurements of the flow field downstream of the foil are presented for a Reynolds number of Re=11×\times103^3 and Strouhal numbers in the range St=0.16-0.35. These conditions produce 2S and 2P wake patterns, as well as a near-momentumless wake structure. A triple decomposition using the optimized dynamic mode decomposition (opt-DMD) method is employed to identify dominant modal components (or coherent structures) in the wake. These structures can be connected to wake instabilities predicted using spatial stability analyses. Examining the modal components of the wake provides insightful explanations into the transition from drag to thrust production, and conditions that lead to peak propulsive efficiency. In particular, we find modes that correspond to the primary vortex development in the wakes. Other modal components capture elements of bluff body shedding at Strouhal numbers below the optimum for peak propulsive efficiency and characteristics of separation for Strouhal numbers higher than the optimum.Comment: 28 pages, 14 figure

    Indicator system provides complete data of engine cylinder pressure variation

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    Varying reference pressure used together with a balanced pressure pickup /a diaphragm switch/ to switch the electric output of the pressure transducer in a reference pressure line obtains precise engine cylinder pressure data from a high speed internal combustion engine

    Muscle Protein Turnover and Tenderness in Broiler Chickens Fed Cimaterol

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    To investigate the impact of cimaterol (CIM) on muscle protein turnover, carcass and muscle composition, muscle cathepsin B+L activity and meat tenderness, 21-d-old broiler chickens (n = 88) were assigned to dietary treatments of either 0 or 1 ppm CIM. Fractional synthesis rates (FSR), fractional accretion rates (FAR), proximate composition and collagen content were determined in the breast muscle (BM; pectoralis major) and a group of leg muscles (LM; gastrocnemius and peroneous longus) from groups of six birds per treatment within each of two time periods (age = 38 or 56 d). Whole body composition,\u27 serum hydroxyproline content and BM cathepsin B+L activity also were measured. Fractional degradation rates (FDR) were calculated as the difference between FSR and FAR. Feeding CIM increased (P \u3c .01) whole body protein content. Weights of LM and percentage of body weight as BM and LM were increased (P \u3c .05) when CIM was included in the diet. Although FSR was)lot significantly reduced by CIM feeding, it decreased (P \u3c .05) with increasing age. Due to decreases in FAR, FDR thereby was reduced by CIM 31.5% and 11.9% in BM and 38.2% and 37.4% in LM at 38 d and 56 d of age, respectively. Cathepsin B+L activities also were reduced 33.6% (P \u3c .01) and shear forces were increased by 41% (P c .05) by CIM feeding. For chickens fed CIM, the correlation between cathepsin B+L activity and shear force was -.63 (P \u3c .01). Feeding CIM improved carcass leanness and muscling due to reductions in FDR and proteolytic enzyme activity. Feeding CIM also reduced meat tendernes

    Muscle Protein Turnover and Tenderness in Broiler Chickens Fed Cimaterol

    Get PDF
    To investigate the impact of cimaterol (CIM) on muscle protein turnover, carcass and muscle composition, muscle cathepsin B+L activity and meat tenderness, 21-d-old broiler chickens (n = 88) were assigned to dietary treatments of either 0 or 1 ppm CIM. Fractional synthesis rates (FSR), fractional accretion rates (FAR), proximate composition and collagen content were determined in the breast muscle (BM; pectoralis major) and a group of leg muscles (LM; gastrocnemius and peroneous longus) from groups of six birds per treatment within each of two time periods (age = 38 or 56 d). Whole body composition,\u27 serum hydroxyproline content and BM cathepsin B+L activity also were measured. Fractional degradation rates (FDR) were calculated as the difference between FSR and FAR. Feeding CIM increased (P \u3c .01) whole body protein content. Weights of LM and percentage of body weight as BM and LM were increased (P \u3c .05) when CIM was included in the diet. Although FSR was)lot significantly reduced by CIM feeding, it decreased (P \u3c .05) with increasing age. Due to decreases in FAR, FDR thereby was reduced by CIM 31.5% and 11.9% in BM and 38.2% and 37.4% in LM at 38 d and 56 d of age, respectively. Cathepsin B+L activities also were reduced 33.6% (P \u3c .01) and shear forces were increased by 41% (P c .05) by CIM feeding. For chickens fed CIM, the correlation between cathepsin B+L activity and shear force was -.63 (P \u3c .01). Feeding CIM improved carcass leanness and muscling due to reductions in FDR and proteolytic enzyme activity. Feeding CIM also reduced meat tendernes

    Debridement for periprosthetic joint infections: future therapies

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    Deep Woodchip Litter: Hygiene, Feeding, and Behavioral Enhancement in Eight Primate Species

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    Sixty-seven animals from eight primate species were used to assess improved husbandry techniques. The presence of woodchips as a direct-contact litter decreased inactivity and fighting and increased time spent on the ground. Placing food in the deep litter led to further behavioral improvement. Frozen foods improved distribution and reduced fighting in most situations, especially when buried in the litter. With time, the litter became increasingly inhibitory to bacteria. The results suggest that inexpensive ways of increasing environmental complexity are effective in improving housing for primates

    Urban streets: generating design options, in Better Streets for Better Cities: A Handbook for Active Street Planning, Design and Management - Chapter 8

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    Using examples from the MORE cities, this chapter describes and illustrates the process of applying the MORE option generation and co-creation design tools (as introduced in Chapter 5) to develop design options. It also covers post-appraisal stakeholder engagement
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