58,699 research outputs found

    Gain control of saccadic eye movements is probabilistic

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    Saccades are rapid eye movements that orient the visual axis toward objects of interest to allow their processing by the central, highacuity retina. Our ability to collect visual information efficiently relies on saccadic accuracy, which is limited by a combination of uncertainty in the location of the target and motor noise. It has been observed that saccades have a systematic tendency to fall short of their intended targets, and it has been suggested that this bias originates from a cost function that overly penalizes hypermetric errors. Here we tested this hypothesis by systematically manipulating the positional uncertainty of saccadic targets. We found that increasing uncertainty produced not only a larger spread of the saccadic endpoints but also more hypometric errors and a systematic bias toward the average of target locations in a given block, revealing that prior knowledge was integrated into saccadic planning. Moreover, by examining how variability and bias co-varied across conditions, we estimated the asymmetry of the cost function and found that it was related to individual differences in the additional time needed to program secondary saccades for correcting hypermetric errors, relative to hypometric ones. Taken together, these findings reveal that the saccadic system uses a probabilistic-Bayesian control strategy to compensate for uncertainty in a statistically principled way and to minimize the expected cost of saccadic errors

    Exploring the evidence base for acupuncture in the treatment of Meniereā€™s Syndrome ā€” A systematic review

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    Meniereā€™s syndrome is a long-term, progressive disease that damages the balance and hearing parts of the inner ear. To address the paucity of information on which evidence-based treatment decisions should be made, a systematic review of acupuncture for Meniereā€™s syndrome was undertaken. The method used was a systematic review of English and Chinese literature, from six databases for randomized, non-randomized and observational studies. All studies were critically appraised and a narrative approach to data synthesis was adopted. Twenty-seven studies were included in this review (9 in English and 18 in Chinese languages): three randomized controlled trials, three non-randomized controlled studies and four pre-test, post-test designs. All but one of the studies was conducted in China. The studies covered body acupuncture, ear acupuncture, scalp acupuncture, fluid acupuncture point injection and moxibustion. The studies were of varying quality. The weight of evidence, across all study types, is of beneficial effect from acupuncture, for those in an acute phase or those who have had Meniereā€™s syndrome for a number of years. The review reinforces the importance of searching for studies from English and Chinese literature. The transferability of the findings from China to a Western context needs confirmation. Further research is also needed to clarify questions around the appropriate frequency and number of treatment/courses of acupuncture. The weight of evidence suggests a potential benefit of acupuncture for persons with Meniereā€™s disease, including those in an acute phase and reinforces the importance of searching for published studies in the Chinese language

    Caldolysin, a highly active protease from an extremely Thermophilic Bacterium

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    Proteases comprise a significant proportion of those proteins which have been subject to detailed characterisation (amino acid sequence and high resolution crystallographic analysis). The extent of research interest in proteolytic enzymes reflects both their historical status, and the practical advantages of proteases as research subjects (available in quantity, extracellular etc.) widely occurring

    Sex- and season-dependent behaviour in a flightless insect, the Auckland tree weta (Hemideina thoracica)

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    In a polygynous mating system, males frequently compete by locating and defending sites with resources essential to female survival and reproduction. We investigated seasonal changes in site occupancy in a sexually dimorphic, harem-forming insect, the Auckland tree weta (Hemideina thoracica). First we established artificial cavities as diurnal refuge cavities and potential harem guarding sites. We then examined cavity occupancy changes, and, based on our knowledge of prior occupants, determined sex-specific patterns of arrival, departure, and aggregation at a population level throughout the year. Both season and the sex of prior occupants influenced weta occupancy patterns. Most observations were of single females. However, both males and females moved into cavities previously occupied by a weta of the opposite sex more often than expected by chance alone. Females avoided cavities where other females were present, except during summer when most harems formed. In early summer, male and female tree weta previously living apart began co-habiting. Generally there was little relationship between the number and sex of the weta inside cavities and female departure rates from cavities. Males who were sharing with other males departed cavities more frequently than single males, as might be expected in a polygynous species with male-male combat. Males were less likely to depart if they were sharing a cavity with a harem of more than two females during the summer-autumn period. Analysis of departure rates from artificial cavities indicates males are more mobile than females only in winter and spring. Based on our arrival and departure data, and high occupancy of artificial cavities, we suggest that female weta at this site are mobile and may search for mates during the summer. The data are consistent with a polygynandrous mating system as inferred for other tree weta species (Hemideina spp.)

    The industrial potential of enzymes from extremely thermophilic bacteria

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    The thermal regions of the central North Island of New Zealand are some of the most extensive in the world. In addition, they are readily accessible and contain a diversity of ecological habitats, including a large number at 100Ā°C. These areas are regarded as an important tourist attraction, and as a source of geothermal power, It is now clear that they also contain an important and unique genetic resource
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