The management of acute venous thromboembolism in clinical practice. Results from the European PREFER in VTE Registry

Venous thromboembolism (VTE) is a significant cause of morbidity and mortality in Europe. Data from real-world registries are necessary, as clinical trials do not represent the full spectrum of VTE patients seen in clinical practice. We aimed to document the epidemiology, management and outcomes of VTE using data from a large, observational database. PREFER in VTE was an international, non-interventional disease registry conducted between January 2013 and July 2015 in primary and secondary care across seven European countries. Consecutive patients with acute VTE were documented and followed up over 12 months. PREFER in VTE included 3,455 patients with a mean age of 60.8 ± 17.0 years. Overall, 53.0 % were male. The majority of patients were assessed in the hospital setting as inpatients or outpatients (78.5 %). The diagnosis was deep-vein thrombosis (DVT) in 59.5 % and pulmonary embolism (PE) in 40.5 %. The most common comorbidities were the various types of cardiovascular disease (excluding hypertension; 45.5 %), hypertension (42.3 %) and dyslipidaemia (21.1 %). Following the index VTE, a large proportion of patients received initial therapy with heparin (73.2 %), almost half received a vitamin K antagonist (48.7 %) and nearly a quarter received a DOAC (24.5 %). Almost a quarter of all presentations were for recurrent VTE, with >80 % of previous episodes having occurred more than 12 months prior to baseline. In conclusion, PREFER in VTE has provided contemporary insights into VTE patients and their real-world management, including their baseline characteristics, risk factors, disease history, symptoms and signs, initial therapy and outcomes

La comunidad de cristianos en Wašqa. Nuevas apreciaciones acerca de su organización y lugares de culto

This paper analyzes the existence of a Christian community in Huesca between 711 and 1096, as well as the question concerning the vacancy of the episcopal see and the location of their place of worship in the church of San Pedro el Viejo. Both Arabic and Latin texts –written prior to and after the Islamic conquest– will be examined, along with archeological sources. In order to understand the main issues regarding Christians in Huesca, the information drawn from these sources will be contrasted with the historical events in the outlying Pyrenees area. A new interpretation is advanced which demonstrates the viability of this community from the perspective of Islamic law: This allows for other forms of community organization beyond episcopal mediation and may cast light on the place of worship of this community.SSe analiza la existencia de la comunidad cristiana de Huesca entre el 711 y el 1096, así como la problemática existente respecto a la sede episcopal vacante y su congregación en torno a San Pedro el Viejo. Para ello se estudian conjuntamente textos árabes y latinos, tanto anteriores como posteriores a la conquista, así como los registros materiales y se establecen comparativas con los acontecimientos históricos de las áreas circumpirenaicas. Se concluye con una nueva propuesta interpretativa que establezca la posible viabilidad de esta comunidad desde el punto de vista del derecho islámico, que plantee otras posibilidades organizativas de la comunidad más allá de la mediación episcopal o que resuelva las dudas en torno al lugar de reunión de esta comunidad

e-Civitas. Database of Medieval Cities

Proyecto en curso, continuará en próximos años.El proyecto de innovación docente e.-Civitas Base de datos sobre las ciudades medievales tiene por objetivo crear un espacio de encuentro entre la investigación sobre mundo urbano y la docencia en los grados de Historia y Arqueología. El objetivo del mismo es sistematizar información sobre ciudades medievales en una base de datos como resultado de las actividades del proyecto y la formación de los alumnos en herramientas TIC.The teaching innovation project e.-Civitas Database on medieval cities aims to create a meeting point between research on the urban world and teaching in History and Archaeology degrees. The aim of the project is to systematise information on medieval cities in a database as a result of the activities of the project and the training of students in ICT tools.Le projet d'innovation pédagogique e.-Civitas Database on medieval cities vise à créer un point de rencontre entre la recherche sur le monde urbain et l'enseignement dans les diplômes d'histoire et d'archéologie. L'objectif du projet est de systématiser les informations sur les villes médiévales dans une base de données, grâce aux activités du projet et à la formation des étudiants aux outils TIC.Depto. de Historia de América y Medieval y Ciencias HistoriográficasFac. de Geografía e HistoriaFALSEUniversidad Complutense de MadridComunidad de Madridsubmitte

e.Civitas. Medieval Cities Data Base.

El estudio del mundo urbano en el periodo medieval es un área de investigación que cuenta con tradición historiográfica europea y que en la UCM es desarrollada por los miembros del equipo que forman la propuesta e-Civitas. La propuesta se desarrolla en el cruce disciplinar entre las Humanidades Digitales y la Historia Urbana con especial atención en la edad media. La creación de la base de datos va más allá de la transferencia de conocimiento en el binomio investigación / difusión, sino que supone la sistematización de contenidos y la creación de nuevos interrogantes.The study of the urban world in the medieval period is a Research topic with solid tradition in European Universities, and some members of e-Civitas teams have developed their expertise research concerning the topic. The project e.Civitas involves the disciplinary crossing of Digital Humanities and Medieval Urban History , the creation of the data Base e-civitas, goes beyond of transference of information / new contents; in fact the new data base involves a refection on the origin of medieval cities and open new perspectives and new questions.Depto. de Historia de América y Medieval y Ciencias HistoriográficasFac. de Geografía e HistoriaFALSEUCMsubmitte

The management of patients with venous thromboembolism in Italy: insights from the PREFER in VTE registry

Venous thromboembolism (VTE) is the third most common cardiovascular disease. Real-life data on the clinical presentation, risk factors, diagnosis, and treatment of VTE in Italy and Europe are required to optimize the management of this disease. The PREFER in VTE registry, a prospective non-interventional real-life study, was designed to assess clinical characteristics and management of patients with VTE, use of health care resources, and on-treatment patient quality of life. Eligible consecutive patients with objectively diagnosed VTE were enrolled in the registry and followed up for 12 months. Between January and December 2013, 816 Italian and 1027 patients from 6 European countries other than Italy (European patients) were enrolled in the registry, and followed up until December 2014. Italian patients were the oldest (mean age 65.7 years) among the European patients. The Italian patients with a history of cancer were 24.6 % of whom 63.2 % had an active cancer (18.2 and 57.0 %, respectively, in Europe). Parenteral heparin was given, as initial treatment, in 73.8 % of Italian patients (66.4 % in Europe); VKA in combination with other treatments in 45.8 % (34.7 % in Europe); and VKA as the only anticoagulant treatment in 24.4 % (17.2 % in Europe). Of the Italian patients, 43.2 and 90.6 % of patients were hospitalized for deep vein thrombosis and pulmonary embolism, respectively; 65.4 % were admitted to the hospital through the emergency department. Following a real world approach, PREFER in VTE shows that the Italian patients, among and compared to the European patients, are the oldest, have a history of cancer more commonly, receive an initial treatment with heparin more commonly, and are more commonly hospitalized, particularly if affected by PE

The management of acute venous thromboembolism in clinical practice - study rationale and protocol of the European PREFER in VTE Registry

Background: Venous thromboembolism (VTE) is a major health problem, with over one million events every year in Europe. However, there is a paucity of data on the current management in real life, including factors influencing treatment pathways, patient satisfaction, quality of life (QoL), and utilization of health care resources and the corresponding costs. The PREFER in VTE registry has been designed to address this and to understand medical care and needs as well as potential gaps for improvement. Methods/design: The PREFER in VTE registry was a prospective, observational, multicenter study conducted in seven European countries including Austria, France Germany, Italy, Spain, Switzerland, and the UK to assess the characteristics and the management of patients with VTE, the use of health care resources, and to provide data to estimate the costs for 12 months treatment following a first-time and/or recurrent VTE diagnosed in hospitals or specialized or primary care centers. In addition, existing anticoagulant treatment patterns, patient pathways, clinical outcomes, treatment satisfaction, and health related QoL were documented. The centers were chosen to reflect the care environment in which patients with VTE are managed in each of the participating countries. Patients were eligible to be enrolled into the registry if they were at least 18 years old, had a symptomatic, objectively confirmed first time or recurrent acute VTE defined as either distal or proximal deep vein thrombosis, pulmonary embolism or both. After the baseline visit at the time of the acute VTE event, further follow-up documentations occurred at 1, 3, 6 and 12 months. Follow-up data was collected by either routinely scheduled visits or by telephone calls. Results: Overall, 381 centers participated, which enrolled 3,545 patients during an observational period of 1 year. Conclusion: The PREFER in VTE registry will provide valuable insights into the characteristics of patients with VTE and their acute and mid-term management, as well as into drug utilization and the use of health care resources in acute first-time and/or recurrent VTE across Europe in clinical practice. Trial registration: Registered in DRKS register, ID number: DRKS0000479