Observation of Two New Excited Ξb0 States Decaying to Λb0 K-π+

Two narrow resonant states are observed in the Λb0K-π+ mass spectrum using a data sample of proton-proton collisions at a center-of-mass energy of 13 TeV, collected by the LHCb experiment and corresponding to an integrated luminosity of 6 fb-1. The minimal quark content of the Λb0K-π+ system indicates that these are excited Ξb0 baryons. The masses of the Ξb(6327)0 and Ξb(6333)0 states are m[Ξb(6327)0]=6327.28-0.21+0.23±0.12±0.24 and m[Ξb(6333)0]=6332.69-0.18+0.17±0.03±0.22 MeV, respectively, with a mass splitting of Δm=5.41-0.27+0.26±0.12 MeV, where the uncertainties are statistical, systematic, and due to the Λb0 mass measurement. The measured natural widths of these states are consistent with zero, with upper limits of Γ[Ξb(6327)0]<2.20(2.56) and Γ[Ξb(6333)0]<1.60(1.92) MeV at a 90% (95%) credibility level. The significance of the two-peak hypothesis is larger than nine (five) Gaussian standard deviations compared to the no-peak (one-peak) hypothesis. The masses, widths, and resonant structure of the new states are in good agreement with the expectations for a doublet of 1D Ξb0 resonances

FCC Physics Opportunities: Future Circular Collider Conceptual Design Report Volume 1

We review the physics opportunities of the Future Circular Collider, covering its e+e-, pp, ep and heavy ion programmes. We describe the measurement capabilities of each FCC component, addressing the study of electroweak, Higgs and strong interactions, the top quark and flavour, as well as phenomena beyond the Standard Model. We highlight the synergy and complementarity of the different colliders, which will contribute to a uniquely coherent and ambitious research programme, providing an unmatchable combination of precision and sensitivity to new physics

Immunoglobulin, glucocorticoid, or combination therapy for multisystem inflammatory syndrome in children: a propensity-weighted cohort study

Background Multisystem inflammatory syndrome in children (MIS-C), a hyperinflammatory condition associated with SARS-CoV-2 infection, has emerged as a serious illness in children worldwide. Immunoglobulin or glucocorticoids, or both, are currently recommended treatments. Methods The Best Available Treatment Study evaluated immunomodulatory treatments for MIS-C in an international observational cohort. Analysis of the first 614 patients was previously reported. In this propensity-weighted cohort study, clinical and outcome data from children with suspected or proven MIS-C were collected onto a web-based Research Electronic Data Capture database. After excluding neonates and incomplete or duplicate records, inverse probability weighting was used to compare primary treatments with intravenous immunoglobulin, intravenous immunoglobulin plus glucocorticoids, or glucocorticoids alone, using intravenous immunoglobulin as the reference treatment. Primary outcomes were a composite of inotropic or ventilator support from the second day after treatment initiation, or death, and time to improvement on an ordinal clinical severity scale. Secondary outcomes included treatment escalation, clinical deterioration, fever, and coronary artery aneurysm occurrence and resolution. This study is registered with the ISRCTN registry, ISRCTN69546370. Findings We enrolled 2101 children (aged 0 months to 19 years) with clinically diagnosed MIS-C from 39 countries between June 14, 2020, and April 25, 2022, and, following exclusions, 2009 patients were included for analysis (median age 8·0 years [IQR 4·2–11·4], 1191 [59·3%] male and 818 [40·7%] female, and 825 [41·1%] White). 680 (33·8%) patients received primary treatment with intravenous immunoglobulin, 698 (34·7%) with intravenous immunoglobulin plus glucocorticoids, 487 (24·2%) with glucocorticoids alone; 59 (2·9%) patients received other combinations, including biologicals, and 85 (4·2%) patients received no immunomodulators. There were no significant differences between treatments for primary outcomes for the 1586 patients with complete baseline and outcome data that were considered for primary analysis. Adjusted odds ratios for ventilation, inotropic support, or death were 1·09 (95% CI 0·75–1·58; corrected p value=1·00) for intravenous immunoglobulin plus glucocorticoids and 0·93 (0·58–1·47; corrected p value=1·00) for glucocorticoids alone, versus intravenous immunoglobulin alone. Adjusted average hazard ratios for time to improvement were 1·04 (95% CI 0·91–1·20; corrected p value=1·00) for intravenous immunoglobulin plus glucocorticoids, and 0·84 (0·70–1·00; corrected p value=0·22) for glucocorticoids alone, versus intravenous immunoglobulin alone. Treatment escalation was less frequent for intravenous immunoglobulin plus glucocorticoids (OR 0·15 [95% CI 0·11–0·20]; p<0·0001) and glucocorticoids alone (0·68 [0·50–0·93]; p=0·014) versus intravenous immunoglobulin alone. Persistent fever (from day 2 onward) was less common with intravenous immunoglobulin plus glucocorticoids compared with either intravenous immunoglobulin alone (OR 0·50 [95% CI 0·38–0·67]; p<0·0001) or glucocorticoids alone (0·63 [0·45–0·88]; p=0·0058). Coronary artery aneurysm occurrence and resolution did not differ significantly between treatment groups. Interpretation Recovery rates, including occurrence and resolution of coronary artery aneurysms, were similar for primary treatment with intravenous immunoglobulin when compared to glucocorticoids or intravenous immunoglobulin plus glucocorticoids. Initial treatment with glucocorticoids appears to be a safe alternative to immunoglobulin or combined therapy, and might be advantageous in view of the cost and limited availability of intravenous immunoglobulin in many countries. Funding Imperial College London, the European Union's Horizon 2020, Wellcome Trust, the Medical Research Foundation, UK National Institute for Health and Care Research, and National Institutes of Health

Efeitos da Reeducação Postural Global em escolares com escoliose Global Posture Reeducation effects in students with scoliosis

O objetivo deste estudo foi analisar o efeito do método da Reeducação Postural Global (RPG) em escolares com diagnóstico de escoliose torácica não estrutural (ETNE). Os escolares com indicativo de ETNE ao exame postural e teste de Adams negativo foram encaminhados ao exame radiográfico para comprovação diagnóstica. Foram selecionados 20 participantes (11 meninos e 9 meninas, com 10±3 anos), divididos randomicamente em dois grupos homogêneos: o que realizou o RPG (GRPG) durante 12 semanas com duração de 25 a 30 minutos cada sessão, de acordo com o que aguentou permanecer na postura; e o grupo controle (GC), sem intervenção. Após três meses, os dois grupos repetiram a avaliação postural e o exame radiográfico. Para avaliação das estatísticas, foi utilizada análise de variância (ANOVA) univariada, com medidas repetidas, seguida do Post Hoc de Tukey para identificar as possíveis diferenças intra e intergrupos. O valor de &#945; foi de 0,05. O GRPG apresentou redução significativa no ângulo de Cobb na comparação intragrupo (&#916;%=-35,100; p=0,009), mas o GC não (&#916;%=9,520; p=0,789). Pode-se concluir que escolares submetidos ao método da RPG apresentaram melhora do quadro de escoliose torácica não estrutural.<br>The aim of this study was to analyze the effect of Global Reeducation Postural (RPG) method in scholars diagnosed with thoracic nonstructural scoliosis (ETNE). Scholars with indicative of ETNE to postural exam and Adams test negative were directed to radiographic exam to diagnostic. Twenty participants were selected (11 boys and 9 girls, 10±3 years old) and randomly divided in two homogeneous groups: group treated by RPG (GRPG) and control group (CG). The GRPG was submitted a RPG treatment during 12 weeks in sessions from 25 to 30 minutes in agreement with each student tolerance at posture. The CG didn't suffer intervention. After three months, both groups repeated the postural and radiographic exam. For statistics, it was used ANOVA univariated with repeated measures, followed by Tukey Post Hoc Test to identify the possible differences intra and intergroups. The &#945; value used was 0.05. The GRPG present significant reduction at Cobb angle between pre and posttest (&#916;%=-35.100; p=0.009), but the CG didn´t show (&#916;%=9.520; p=0.789). It was concluded that scholars submitted to RPG method presented improvement in thoracic nonstructural scoliosis