Deep Architectures on Drifting Concepts: A Simple Approach

Many real-world problems may vary over time. These non stationary problems have been widely studied in the literature, often called drifting concepts problems. Recently, deep architectures have drawn a growing attention, given that they can easily model functions that are hard to approximate with shallow ones and an effective way of training them have been discovered. In this work we adapt a deep architecture to problems that present concept drift. To this end we show a way of combining them with a widely known drifting concept technique, the Streaming Ensemble Algorithm. We evaluate the new method using appropriate drifting problems and compare its performance with a more traditional approach. The results obtained are promising and show that the proposed variation is effective at combining the expressive power of a deep architecture with the adaptability of SEA.Sociedad Argentina de Informática e Investigación Operativ

Deep Architectures on Drifting Concepts: A Simple Approach

Many real-world problems may vary over time. These non stationary problems have been widely studied in the literature, often called drifting concepts problems. Recently, deep architectures have drawn a growing attention, given that they can easily model functions that are hard to approximate with shallow ones and an effective way of training them have been discovered. In this work we adapt a deep architecture to problems that present concept drift. To this end we show a way of combining them with a widely known drifting concept technique, the Streaming Ensemble Algorithm. We evaluate the new method using appropriate drifting problems and compare its performance with a more traditional approach. The results obtained are promising and show that the proposed variation is effective at combining the expressive power of a deep architecture with the adaptability of SEA.Sociedad Argentina de Informática e Investigación Operativ

Mitochondrial Supercomplexes: Physiological Organization and Dysregulation in Age-Related Neurodegenerative Disorders

Several studies suggest that the assembly of mitochondrial respiratory complexes into structures known as supercomplexes (SCs) may increase the efficiency of the electron transport chain, reducing the rate of production of reactive oxygen species. Therefore, the study of the (dis)assembly of SCs may be relevant for the understanding of mitochondrial dysfunction reported in brain aging and major neurodegenerative disorders such as Alzheimer's disease (AD) and Parkinson's disease (PD). Here we briefly reviewed the biogenesis and structural properties of SCs, the impact of mtDNA mutations and mitochondrial dynamics on SCs assembly, the role of lipids on stabilization of SCs and the methodological limitations for the study of SCs. More specifically, we summarized what is known about mitochondrial dysfunction and SCs organization and activity in aging, AD and PD. We focused on the critical variables to take into account when postmortem tissues are used to study the (dis)assembly of SCs. Since few works have been performed to study SCs in AD and PD, the impact of SCs dysfunction on the alteration of brain energetics in these diseases remains poorly understood. The convergence of future progress in the study of SCs structure at high resolution and the refinement of animal models of AD and PD, as well as the use of iPSC-based and somatic cell-derived neurons, will be critical in understanding the biological relevance of the structural remodeling of SCs.Fil: Novack, Gisela Vanina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; ArgentinaFil: Galeano, Pablo. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; ArgentinaFil: Castaño, Eduardo Miguel. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; ArgentinaFil: Morelli, Laura. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; Argentin

A Novel Decisionâ Making Process for Tooth Retention or Extraction

Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/141780/1/jper0476.pd

Letter to the Editor: Authors’ Response

Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/141379/1/jper1202a.pd

Deep Architectures on Drifting Concepts: A Simple Approach

Many real-world problems may vary over time. These non stationary problems have been widely studied in the literature, often called drifting concepts problems. Recently, deep architectures have drawn a growing attention, given that they can easily model functions that are hard to approximate with shallow ones and an effective way of training them have been discovered. In this work we adapt a deep architecture to problems that present concept drift. To this end we show a way of combining them with a widely known drifting concept technique, the Streaming Ensemble Algorithm. We evaluate the new method using appropriate drifting problems and compare its performance with a more traditional approach. The results obtained are promising and show that the proposed variation is effective at combining the expressive power of a deep architecture with the adaptability of SEA.Sociedad Argentina de Informática e Investigación Operativ

GRADE Evidence to Decision (EtD) frameworks : A systematic and transparent approach to making well-informed healthcare choices. 1. Introduction

Funding: Work on this article has been partially funded by the European Commission FP7 Program (grant agreement 258583) as part of the DECIDE project. Sole responsibility lies with the authors; the European Commission is not responsible for any use that may be made of the information contained therein.Peer reviewedPublisher PD

Transcriptional regulation of insulin-degrading enzyme modulates mitochondrial amyloid β (Aβ) peptide catabolism and functionality

Studies of post-mortem brains from Alzheimer disease patients suggest that oxidative damage induced by mitochondrial amyloid β (mitAβ) accumulation is associated with mitochondrial dysfunction. However, the regulation of mitAβ metabolism is unknown. One of the proteases involved in mitAβ catabolism is the long insulin-degrading enzyme (IDE) isoform (IDE-Met(1)). However, the mechanisms of its expression are unknown, and its presence in brain is uncertain. We detected IDE-Met(1) in brain and showed that its expression is regulated by the mitochondrial biogenesis pathway (PGC-1α/NRF-1). A strong positive correlation between PGC-1α or NRF-1 and long IDE isoform transcripts was found in non-demented brains. This correlation was weaker in Alzheimer disease. In vitro inhibition of IDE increased mitAβ and impaired mitochondrial respiration. These changes were restored by inhibition of γ-secretase or promotion of mitochondrial biogenesis. Our results suggest that IDE-Met(1) links the mitochondrial biogenesis pathway with mitAβ levels and organelle functionality.Fil: Leal, Maria Celeste. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; ArgentinaFil: Magnani, Natalia Daniela. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; ArgentinaFil: Villordo, Sergio. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; ArgentinaFil: Marino, Cristina Ester. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; ArgentinaFil: Evelson, Pablo Andres. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; ArgentinaFil: Castaño, Eduardo Miguel. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; ArgentinaFil: Morelli, Laura. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; Argentin

The fragility of thin discs in galaxies -- II. Thin discs as tracers of the assembly history of galaxies

Thin galactic discs and nuclear stellar discs (NSDs) are fragile structures that can be easily disturbed by merger events. By studying the age of the stellar populations in present-day discs, we can learn about the assembly history of galaxies and place constraints on their past merger events. Following on the steps of our initial work, we explore the fragility of such disc structures in intermediate-mass-ratio dry encounters using the previously constructed $N$-body model of the Fornax galaxy NGC 1381 (FCC 170), which hosts both a thin galactic disc and a NSD. We dismiss major and minor encounters, as the former were previously shown to easily destroy thin-disc structures, whereas the latter take several Hubble times to complete in the specific case of FCC 170. The kinematics and structure of the thin galactic disc are dramatically altered by the mergers, whereas the NSD shows a remarkable resilience, exhibiting only a smooth increase of its size when compared to the model evolved in isolation. Our results suggest that thin galactic discs are better tracers for intermediate-mass-ratio mergers, while NSDs may be more useful for major encounters. Based on our simulations and previous analysis of the stellar populations, we concluded that FCC 170 has not experienced any intermediate-mass-ratio dry encounters for at least $\sim$10 Gyr, as indicated by the age of its thin-disc stellar populations.Comment: 11 pages, 10 figure

Adult hippocampal neurogenesis impairment at preplaque stage in a transgenic rat model of Alzheimer like amyloid pathology

The contribution of adult hippocampal neurogenesis (AHN) impairment on cognitive decline in early Alzheimer disease (AD) remains poorly understood. This can be ascribed to the technical difficulties to measure AHN in postmortem brains and patients. Furthermore, most animal models of AD exhibit an aggressive neuropathology at early age and harbor gene mutations and express transgenes that disrupts AHN by pathways not directly involved in AD pathology. To overcome some of these limitations, we studied AHN at preplaque stage (6 month old) in hemizygous (Tg+/-) and homozygous (Tg+/+) McGill-R-Thy1-APP transgenic rats. This model exhibits a much less aggressive neuropathology that nevertheless is associated with a marked cognitive impairment from early age. Our results revealed that Tg+/+ rats showed a reduced number of PCNA+ cells, DCX+ immature neurons and BrdU+/NeuN+ colabed neurons in dorsal and ventral dentate gyrus. Moreover, dendritic arborization was less developed. AHN was not impaired in Tg+/- rats, although dendritic arborization was slightly decreased. On the other hand, both hemizygous and homozygous rats exhibited spatial memory impairments in the Morris water maze. These results suggest that 1) AHN is dysregulated from the preplaque stage in homozygous rats, 2) AHN impairment is dependent on APP transgene copy numbers since hemizygous rats did not show it, 3) Dysregulation of AHN is not directly associated with spatial memory impairments since hemizygous rats exhibited spared neurogenesis despite showing spatial memory deficits. Funding: International Society for Neurochemistry CAEN Grant and Andalucia TECH-ICE (PG), and PICT-2015-0285 (LM).Fil: Galeano, Pablo. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; ArgentinaFil: Dalmasso, María Carolina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; ArgentinaFil: Prestia, Federico Ariel. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; ArgentinaFil: Castaño, Eduardo Miguel. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; ArgentinaFil: Cuello, Augusto Claudio. McGill University; CanadáFil: Santín Nuñez, Luis Javier. Universidad de Málaga; EspañaFil: Morelli, Laura. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; ArgentinaThe International Society for Neurochemistry and the American Society for Neurochemistry MeetingMontrealCanadáInternational Society for NeurochemistryAmerican Society for Neurochemistr