Impactos da Precarização do Trabalho na Segurança Alimentar e Nutricional: contribuições para o debate sobre saúde e alimentação de trabalhadores terceirizados em Unidades de Alimentação e Nutrição

No Brasil, a garantia da Segurança Alimentar e Nutricional (SAN) ainda é um desafio, sobretudo para grupos populacionais mais vulneráveis, dentre os quais, os trabalhadores com rendimentos até cinco salários mínimos. Mudanças no mundo do trabalho, desde os anos 90, alinhadas à precarização do trabalho, com destaque para jornadas laborais flexíveis e baixos salários, desafiam a promoção da saúde dos trabalhadores, como, por exemplo, assegurar uma alimentação saudável e adequada. Assim, objetivou-se analisar a relação entre processo de trabalho e SAN de trabalhadores terceirizados em uma Unidade de Alimentação e Nutrição (UAN). Foi realizado um estudo qualitativo em UAN de uma Instituição Pública Federal de Ensino Superior, onde a observação participante e a entrevista semiestruturada foram empregadas para compreender a tríade trabalho, saúde e alimentação. A organização da produção de refeições na UAN apontou para a intensificação do ritmo de trabalho; para fragmentação do coletivo de trabalhadores; e para prejuízos à saúde dos trabalhadores de ordem física e psíquica. Ficou sinalizado que, na atualidade, no contexto de precarização no mundo do trabalho, as correlações de força desfavoráveis à classe trabalhadora submetem os trabalhadores a uma carga de doenças progressiva e a instabilidade na garantia do Direito Humano à Alimentação Adequada

Contributions of the Brazilian Network of Information in Health Sciences for the construction of a Latin American thematic repository: practices and lessons learned

Thematic repositories are used as one of the main tools for the implementation of Open Access in the world and as a mechanism for memory preservation and information management. This work seeks to systematize the strategies used by the Brazilian Network of Health Sciences Information on the processes of cooperation and decentralization of technical-scientific information, from the perspective of the key actors involved, seeking to understand the challenges, limits and possibilities of providing equitable access to knowledge and updated scientific evidence. Learning from mistakes and right answers is fundamental to the life of any human being and in teaching and research institutions it is no different since they have a tendency to forget the past. The methodology of this study will be based on the qualitative approach, in the light of case studies, through the application of semistructured questionnaires, whose objective is to collect information about the participants’ perception and content and document analysis. The implications of these lessons are fundamental for the elaboration of networking strategies for the construction of a Latin American thematic repository, with the idea of scientific information as a concept of citizenship and public communication of science as a fundamental value

Minicircle kDNA microheterogeneity in Endotrypanum indicate diversity within this genus.

A comparison of kDNA restriction-endonuclease fragment patterns from strains representing selected Endotrypanum zymodemes was done by schizodeme analysis. As the degree of heterogeneity within mini-circles varied among species or strains of Endotrypanum, the fingerprint obtained with each of the restriction enzymes was unique for each of these parasites. The data have revealed that this trypanosomatid genus is much more complex than it was originally thought to be

Clonal chromosomal mosaicism and loss of chromosome Y in elderly men increase vulnerability for SARS-CoV-2

The pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2, COVID-19) had an estimated overall case fatality ratio of 1.38% (pre-vaccination), being 53% higher in males and increasing exponentially with age. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, we found 133 cases (1.42%) with detectable clonal mosaicism for chromosome alterations (mCA) and 226 males (5.08%) with acquired loss of chromosome Y (LOY). Individuals with clonal mosaic events (mCA and/or LOY) showed a 54% increase in the risk of COVID-19 lethality. LOY is associated with transcriptomic biomarkers of immune dysfunction, pro-coagulation activity and cardiovascular risk. Interferon-induced genes involved in the initial immune response to SARS-CoV-2 are also down-regulated in LOY. Thus, mCA and LOY underlie at least part of the sex-biased severity and mortality of COVID-19 in aging patients. Given its potential therapeutic and prognostic relevance, evaluation of clonal mosaicism should be implemented as biomarker of COVID-19 severity in elderly people. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, individuals with clonal mosaic events (clonal mosaicism for chromosome alterations and/or loss of chromosome Y) showed an increased risk of COVID-19 lethality