An accumulation of climatic stress events has led to years of reduced growth for sugar maple in southern Quebec, Canada

Understanding the influence of climatic variation on forest dynamics is of great ecological and economic interest, and is essential to prescribe silvicultural interventions that will facilitate ecosystem acclimation to global change. However, the retrospective identification of climatic events responsible for the inter-annual variation of tree growth is challenging, notably because both their duration and their subsequent effects can be highly variable in time. In this study, we aimed to (1) quantify empirically the effect of climatic stress events on the short- and long-term growth dynamics of sugar maple trees; (2) compare the effects of different types of climatic events, that is, drought and thaw–freeze; and (3) compare the effects of climatic stress events to those of traditional monthly level climate metrics. To achieve this, we paired cross-dated tree-ring series to monthly and daily-level climate metrics over more than 50 yr in two distinct regions of southern Quebec. While the analysis from monthly level metrics first suggested a weak and non-stationary relationship between climatic conditions and tree growth, the analysis from daily-level metrics showed that climatic stress events, and more particularly thaw–freeze events, were strongly related to the growth of sugar maple trees. Our results suggest that the synergic influence of cumulative climatic stress events, which was exacerbated by insect outbreaks during the early 1980s, induced an important shift in the growth dynamics of sugar maple and in its response to variation in climatic conditions. These results highlight the potential negative impact of global climate change on our capacity to predict stand productivity accurately, especially if climate-sensitive growth models are based on projections of future monthly metrics. Because adverse climatic events are expected to increase both in frequency and in severity over the next decades, a general decrease in the growth rate of sugar maple is apprehended in southern Quebec

Imaging spatiotemporal Hong-Ou-Mandel interference of biphoton states of extremely high Schmidt number

We report the experimental observation of a spatiotemporal Hong-Ou-Mandel (HOM) interference of biphoton states of extremely high Schmidt number. Two-photon interference of 1500 spatial modes and a total of more than 3 × 10 6 spatiotemporal modes is evidenced by measuring momentum spatial coincidences, without any prior selection of the photons in time and space coincidence, between the pixels of the far-field images of two strongly multimode spontaneous parametric down-conversion (SPDC) beams propagating through a HOM interferometer. The outgoing SPDC beams are recorded on two separate detector arrays operating in the photon-counting regime. The properties of HOM interference are investigated both in the time and space domains. We show that the two-photon interference exhibits temporal and two-dimensional spatial HOM dips with visibilities of 60% and widths in good agreement with the spatiotemporal coherence properties of the biphoton state. Moreover, we demonstrate that maxima of momentum spatial coincidences are evidenced within each image, in correspondence with these dips

Impacts of climatic variation on the growth of black spruce across the forest-tundra ecotone : positive effects of warm growing seasons and heat waves are offset by late spring frosts

Climate strongly limits the physiological processes of trees near their range limits, leading to increased growth sensitivity. Northeastern North America is experiencing considerable warming, so the growth of trees near the northern treeline represents a key indicator of forest responses to climate change. However, tree-ring series and corresponding climatic data are scarce across the forest-tundra ecotone when compared to southern boreal regions, resulting in fewer studies on growth-climate relationships focused on this ecotone. Using daily climatic data, we identified trends in growing season heat accumulation and the intensity of acute climatic events over the last several decades in the southern and the northern parts of the forest-tundra ecotone in northeastern North America, and investigated their influence on black spruce radial growth. We found that black spruce trees responded positively to the increase in growing season temperatures and heat wave intensity, suggesting that growth is currently limited by suboptimal temperatures. While tree growth in the southern region generally benefited from warm spring temperatures, vulnerability to late spring frosts reduced tree growth in the northern region and increased probability of abrupt growth decline. In this region, late spring frosts offset approximately half of the additional growth that would otherwise occur over the course of a warm growing season. This vulnerability of northern trees may result from local adaptations to short growing seasons, which initiate biological activities at colder temperatures in the spring. Overall, our results highlight the need to explicitly incorporate acute climatic events into modeling efforts in order to refine our understanding of the impact of climate change on forest dynamics

Broad-scale wood degradation dynamics in the face of climate change : a meta-analysis

In the context of global change, a better understanding of the dynamics of wood degradation, and how they relate to tree attributes and climatic conditions, is necessary to improve broad-scale assessments of the contributions of deadwood to various ecological processes, and ultimately, for the development of adaptive post-disturbance management strategies. The objective of this meta-analysis was to review the effects of tree attributes and local climatic conditions on the time since death of coarse woody debris ranging in decomposition states. Results from our meta-analysis showed that projected warming will likely accelerate wood decomposition and significantly decrease the residence time in decay stages. By promoting such a decrease in residence time, further climate warming is very likely to alter the dynamics of deadwood, which in turn may affect saproxylic biodiversity by decreasing the temporal availability of specific habitats. Moreover, while coarse woody debris has been recognized as a key resource for bioenergy at the global scale, the acceleration of decay-stages transition dynamics indicates that the temporal window during which dead trees are available as feedstock for value-added products will shrink. Consequently, future planning and implementation of salvage harvesting will need to occur within a short period following disturbance, especially in warmer regions dominated by hardwood species. Another important contribution of this work was the development of a harmonized classification system that relies on the correspondence between the visual criteria used to characterize deadwood decomposition stages in locally developed systems the literature. This system could be used in future investigations to facilitate direct comparisons between studies. Our literature survey also highlights that most of the information on wood decay dynamics comes from temperate and boreal forests, whereas data from subtropical, equatorial and subarctic forests are scarce. Such data are urgently needed to allow broader-scale conclusions on global wood degradation dynamics

Opportunities and limitations of thinning to increase resistance and resilience of trees and forests to global change

We reviewed recent literature to identify the positive and negative effects of thinning on both stand- and tree-level resistance and resilience to four stressors that are expected to increase in frequency and/or severity due to global change: (1) drought, (2) fire, (3) insects and pathogens, and (4) wind. There is strong evidence that thinning, particularly heavy thinning, reduces the impact of drought and also the risk and severity of fire when harvest slash is burned or removed. Thinning also increases the growth and vigor of residual trees, making them less susceptible to eruptive insects and pathogens, while targeted removal of host species, susceptible individuals and infected trees can slow the spread of outbreaks. However, the evidence that thinning has consistent positive effects is limited to a few insects and pathogens, and negative effects on root rot infection severity were also reported. At this point, our review reveals insufficient evidence from rigorous experiments to draw general conclusions. Although thinning initially increases the risk of windthrow, there is good evidence that thinning young stands reduces the long-term risk by promoting the development of structural roots and favouring the acclimation of trees to high wind loads. While our review suggests that thinning should not be promoted as a tool that will universally increase the resistance and resilience of forests, current evidence suggests that thinning could still be an effective tool to reduce forest vulnerability to several stressors, creating a window of opportunity to implement longer term adaptive management strategies such as assisted migration. We highlight knowledge gaps that should be targeted by future research to assess the potential contribution of thinning to adaptive forest management. One of these gaps is that studies from boreal and tropical regions are drastically underrepresented, with almost no studies conducted in Asia and the southern hemisphere. Empirical evidence from these regions is urgently needed to allow broader-scale conclusions

High rate, fast timing Glass RPC for the high η\eta CMS muon detectors

The HL-LHC phase is designed to increase by an order of magnitude the amount of data to be collected by the LHC experiments. To achieve this goal in a reasonable time scale the instantaneous luminosity would also increase by an order of magnitude up to $6 \cdot 10^{34}$ cm$^{-2}$s$^{-1}$. The region of the forward muon spectrometer ($|\eta| > 1.6$) is not equipped with RPC stations. The increase of the expected particles rate up to 2 kHz/cm$^2$ ( including a safety factor 3 ) motivates the installation of RPC chambers to guarantee redundancy with the CSC chambers already present. The actual RPC technology of CMS cannot sustain the expected background level. A new generation Glass-RPC (GRPC) using low resistivity glass (LR) is proposed to equip at least the two most far away of the four high eta muon stations of CMS. The design of small size prototypes and the studies of their performances under high rate particles flux is presented.Comment: 5 pages, 5 figures, proceeding for the conference VCI 201

Novel 8-nitroquinolin-2(1H)-ones as NTR-bioactivated antikinetoplastid molecules:Synthesis, electrochemical and SAR study

International audienceTo study the antiparasitic 8-nitroquinolin-2(1H)-one pharmacophore, a series of 31 derivatives was synthesized in 1-5 steps and evaluated in vitro against both Leishmania infantum and Trypanosoma brucei brucei. In parallel, the reduction potential of all molecules was measured by cyclic voltammetry. Structure-activity relationships first indicated that antileishmanial activity depends on an intramolecular hydrogen bond (described by X-ray diffraction) between the lactam function and the nitro group, which is responsible for an important shift of the redox potential (+0.3 V in comparison with 8-nitroquinoline). With the assistance of computational chemistry, a set of derivatives presenting a large range of redox potentials (from -1.1 to -0.45 V) was designed and provided a list of suitable molecules to be synthesized and tested. This approach highlighted that, in this series, only substrates with a redox potential above -0.6 V display activity toward L. infantum. Nevertheless, such relation between redox potentials and in vitro antiparasitic activities was not observed in T. b. brucei. Compound 22 is a new hit compound in the series, displaying both antileishmanial and antitrypanosomal activity along with a low cytotoxicity on the human HepG2 cell line. Compound 22 is selectively bioactivated by the type 1 nitroreductases (NTR1) of L. donovani and T. brucei brucei. Moreover, despite being mutagenic in the Ames test, as most of nitroaromatic derivatives, compound 22 was not genotoxic in the comet assay. Preliminary in vitro pharmacokinetic parameters were finally determined and pointed out a good in vitro microsomal stability (half-life > 40 min) and a 92% binding to human albumin

8-Aryl-6-chloro-3-nitro-2-(phenylsulfonylmethyl)imidazo[1,2-a]pyridines as potent antitrypanosomatid molecules bioactivated by type 1 nitroreductases

Based on a previously identified antileishmanial 6,8-dibromo-3-nitroimidazo[1,2-a]pyridine derivative, a Suzuki-Miyaura coupling reaction at position 8 of the scaffold was studied and optimized from a 8-bromo-6-chloro-3-nitroimidazo[1,2-a]pyridine substrate. Twenty-one original derivatives were prepared, screened in vitro for activity against L infantum axenic amastigotes and T. brucei brucei trypomastigotes and evaluated for their cytotoxicity on the HepG2 human cell line. Thus, 7 antileishmanial hit compounds were identified, displaying IC50 values in the 1.1-3 mu M range. Compounds 13 and 23, the 2 most selective molecules (SI = >18 or >17) were additionally tested on both the promastigote and intramacrophage amastigote stages of L donovani. The two molecules presented a good activity (IC50 = 1.2-1.3 mu M) on the promastigote stage but only molecule 23, bearing a 4-pyridinyl substituent at position 8, was active on the intracellular amastigote stage, with a good IC50 value (2.3 mu M), slightly lower than the one of miltefosine (IC50 = 4.3 mu M). The antiparasitic screening also revealed 8 antitrypanosomal hit compounds, including 14 and 20, 2 very active (IC50 = 0.04-0.16 mu M) and selective (SI = >313 to 550) molecules toward T brucei brucei, in comparison with drug-candidate fexinidazole (IC50 = 0.6 & SI > 333) or reference drugs suramin and eflornithine (respective IC50 = 0.03 and 13.3 mu M). Introducing an aryl moiety at position 8 of the scaffold quite significantly increased the antitrypanosomal activity of the pharmacophore. Antikinetoplastid molecules 13, 14, 20 and 23 were assessed for bioactivation by parasitic nitroreductases (either in L donovani or in T. brucei brucei), using genetically modified parasite strains that over-express NTRs: all these molecules are substrates of type 1 nitroreductases (NTRI), such as those that are responsible for the bioactivation of fexinidazole. Reduction potentials measured for these 4 hit compounds were higher than that of fexinidazole (-0.83 V), ranging from -0.70 to -0.64 V