Comparison of Different Levels of Vitamin Premix on Meat Lipid Oxidation in Floor and Battery Cage Broiler Raising Systems

A total of 1260 male broiler chicks (Ross 308) were allocated to 7 treatment groups (different levels and access time to vitamin premix (VP)) at 29 to 42 days of age, in floor system (Experiment 1) and battery cage system (Experiment 2). The oxidative stability was evaluated by thiobarbituric acid reactive substances (TBARS) on the thigh yield that were storage for 180 days in -20˚C. Results of experiment 1 showed that VP reduction and withdrawal from 29 d of age did not impair body weight, feed intake and feed conversion ratio during the final period of treatments (29-42d).Results of experiment 2 showed that there were no significant differences in the birds’ performance with reduction or withdrawal of VP from diets in 29-35 days among the experimental groups, but in 36-42 days of age, the performance of the group of birds fed with diet without VP (T1) was significantly lower than other groups. The results of experiment 2 showed that the performance of birds fed with diet without VP was significantly lower than other treatments in 36-42 days of age. The results of TBARS values in experiment 1 for thigh meat samples of birds slaughtered at 42 days of age showed that TBARS values of treatments without VP were significantly higher than other treatments. However in experiment 2, TBARS values of treatments without VP and with 33% VP were significantly higher than other treatments for birds slaughtered at 42 days of age. Finally, the results of this study demonstrate firstly that it is not possible to withdraw but it can be possible to reduce VP in finisher broiler's diets without negative effects on performance and meat quality during the time of freezing in both methods of rearing. Secondly, it is possible to reduce the VP levels in diet of broilers reared in floor system more than battery cage system

Nonlinear aeroelastic stability analysis of a two-stage axially moving telescopic wing by using fully intrinsic equations

During the process of span extension for an aircraft wing equipped with a telescopic morphing mechanism, the wing aspect ratio increases, and hence, the geometrical nonlinearities might become more significant. In this regard, this paper aims to investigate the effect of structural nonlinearity on the aeroelasticity of span morphing wings using the exact fully intrinsic equations for the first time. Furthermore, the effects of various parameters such as thrust force, engine location, chord size, flight altitude, initial angle of attack, and overlapping mass on the aeroelasticity of the wing are studied. The applied aerodynamic loads in an incompressible flow regime are determined using Peters’ unsteady aerodynamic model. In order to check the stability of the system, first the resulting nonlinear partial differential equations are discretized by using the central finite difference method and then linearized about the static equilibrium. Finally, by obtaining the eigenvalues of the linearized system, the stability of the wing is evaluated. It is observed that by using the fully intrinsic equations, the instability of the axially moving telescopic wing can be determined more accurately. Moreover, the results show that the morphing length and overlapping mass have significant effects on the aeroelastic stability of the telescopic wing

Parametric study on the dynamic aeroelastic analysis of a two-stage axially deploying telescopic wing

In this paper, the flutter instability of a conventional two-stage axially moving telescopic UAV wing is investigated. To this aim, and to be as close as possible to the reality, the effects of temporal variation of mass and length, due to the movement of stages and their overlapping, along with the effects of morphing speed are considered for the first time. The bending-torsional dynamics of the two-stage wing is modeled by modifying the Euler–Bernoulli beam theory to take into account the effects of morphing speed and variations of mass and length. Furthermore, the aerodynamic loads are simulated using Peters' unsteady aerodynamic model. The governing aeroelastic equations are discretized using a finite element approach, and a length-based stability analysis is proposed to investigate the aeroelasticity of the wing. The obtained results are compared with those available in the literature, and a good agreement is observed. It is found that the aeroelastic stability of a telescopic wing is more sensitive to the fixed part parameters than the moving part. Also, it is shown that the wing critical length is sensitive to the morphing speed. Therefore, by selecting the telescopic wing morphing parameters properly, the aeroelastic stability of the system can significantly be improved

Zespół Brucka — rzadki zespół charakteryzujący się kruchością kości, przykurczami stawowymi i nowoodkrytą homozygotyczną mutacją FKBP10

Bruck syndrome is an autosomal recessive syndrome consisting of bone fragility and congenital joint contractures. According to the genotype, it has been classified into types 1 and 2. Recently, mutations in FKBP10, localised to chromosome 17q21, have been identified in some patients of Bruck syndrome. Twenty-seven patients of this syndrome have been reported so far. We present a new patient of this syndrome, with frequent fractures, congenital joint contractures, kyphoscoliosis, bilateral clubfoot, and pectus carinatum. The clinical and genetic features of all previously reported cases are also reviewed. (Endokrynol Pol 2015; 66 (2): 170–174)Zespół Brucka jest autosomalną chorobą recesywną, na którą składa się kruchość kości i wrodzone przykurcze stawowe. Zgodnie z genotypem zespół ten można podzielić na typ 1 i 2. Ostatnio, u niektórych pacjentów z zespołem Brucka wykryto mutacje FKBP10, genu zlokalizowanego na chromosomie 17q21. Do tej pory zarejestrowano 27 pacjentów z tym zespołem. Autorzy przedstawiają nowego pacjenta ze zdiagnozowanym zespołem Brucka, z częstymi złamaniami, wrodzonymi przykurczami stawowymi, kifoskoliozą kręgosłupa, obustronną stopą końsko-szpotawą i klatką piersiową kurzą. Przytoczymy również kliniczne i genetyczne cechy wszystkich wcześniej potwierdzonych przypadków. (Endokrynol Pol 2015; 66 (2): 170–174

Relationship between chemical composition and standardized ileal digestible amino acid contents of corn grain in broiler chickens

This experiment was conducted to evaluate the chemical composition and standardized ileal amino acid digestibility of corn grain and to use these data to develop prediction equations for estimating total amino acids (TAAs) and standardized ileal digestible amino acids (SIDAAs) for broiler chickens. Four types of corn grains were obtained from different origins (Brazil, Ukraine, Russia, and Iran). Eighty-day-old Ross 308 male broiler chicks were fed a standard diet until day 18, and experimental diets were fed from 19 to 24 D of age. Five dietary treatments consisted of 4 semi-purified diets containing corn from each origin as the only source of amino acid (AA) and a N-free diet for determination of basal endogenous AA losses. Assay diets contained 939 g of test corn/kg. The concentration of crude protein and gross energy ranged from 7.58 to 8.39% (coefficient of variation [CV] = 4.72%) and 4,121 to 4,621 kcal/kg (CV = 5.09%), respectively. There was significant variation among the 4 corn grains in standardized ileal digestibility (SID) for CP, Phe, Leu, Asp, Glu, Ser, Gly, Ala, and Tyr (P ≤ 0.05). The results of linear regression showed that linear prediction equations based on protein content can be used to predict the TAA and SIDAA contents (e.g., TLys = 0.041 × CP, adj R2 = 95.9, standard error of prediction [SEP] = 0.05; SIDLys = 0.0356 × CP, adj R2 = 96, SEP = 0.051). Inclusion of other proximate components of test samples into the regression equation increased the R2 value and decreased the SEP value (e.g., TLys = 0.329 × crude fiber [CF] ‒ 0.209 × Ash, adj R2 = 99.9, SEP = 0.005; SIDLys = ‒1.1591 + 0.836 × CF ‒ 0.055 × Ash, adj R2 = 99.9, SEP = 0.001). The concentration of TAA and SIDAA was highly correlated (adj R2 > 89%) for most AA and showed that the amount of SIDAA could be predicted from its total concentration with a high degree of accuracy (e.g., SIDLys = 0.0023 + 0.861 × TLys, adj R2 = 99.9, SEP = 0.0001). In conclusion, this in vitro assays and equations accurately predicted TAA and SIDAA corn grain samples for broiler chickens and can serve as a reference analysis to develop calibration equations for rapid feed quality evaluation methods such as near-infrared reflectance spectroscopy.info:eu-repo/semantics/publishedVersio

Effects of the Problem Solving Technique in Type 2 Diabetic Patients with Cognitive Impairment: A Randomized Clinical Trial

Background: Diabetes mellitus is a common metabolic disorder, one of the lesser known of whose consequences is cognitive disorder. This study aimed to evaluate the effects of problem-solving technique in type 2 diabetic patients with cognitive impairment. Methods: This randomized clinical trial was conducted in the south of Iran between December 2014 and April 2015. 96 type 2 diabetic patients with cognitive impairment were randomly divided into two groups. The patients in the intervention group attended classes on problem-solving skills, while the patients in the control group attended the usual classes in the clinic. The quality of life, self-management profile, metabolic indexes of the patients in both groups were measured before and three months after the experiment. Data were analyzed using SPSS version 16.0. Paired t-test, independent t-test, Wilcoxon, Mann-Whitney and Chi-Square tests were used. Results: The differences between the groups’ levels of HbA1c (P=0.02) and HDL (P=0.02) were significant, but the differences between their FBS, cholesterol, triglycerides and LDL were not significant (P>0.05). The mean difference of the changes in the quality of life (P<0.001) between the intervention and control groups was significant. The differences between the two groups in the area of self-management were as follows: patient’s anxiety management (P<0.001), patient’s capability in using medicine (P<0.001), healthy eating (P<0.001), weight management (P=0.02), and confidence in one’s ability to manage his/her diabetes (P<0.001). Conclusion: Applying problem-solving technique significantly enhanced self-management, quality of life and metabolic indexes in type 2 diabetic patients with cognitive impairment. Trial Registration Number: IRCT2014041517283N

Effect of mitomycin-C on corneal endothelial cell parameters after refractive surface ablation procedures

Background: The effect of mitomycin-C (MMC) on the reduction of endothelial cell count in the cornea remains controversial. We aimed to evaluate the effect of MMC on corneal endothelial cell parameters after refractive surface ablation procedures, including photorefractive keratectomy (PRK) and laser epithelial keratomileusis (LASEK). Methods: In this interventional, comparative, follow-up study, 342 eyes of 171 patients were followed up for 6 months. Patients undergoing PRK or LASEK were included and were divided into two groups: group one (188 eyes of 94 patients) with an ablation depth of ? 65 µm and who received intraoperative 0.02% MMC for 30 s, and group two (154 eyes of 77 patients) with an ablation depth of &lt; 65 µm and who received balanced salt solution for 30 s. Changes in endothelial cell density (ECD), central corneal thickness (CCT), coefficient of variation (CV), and hexagonality values were compared between the groups at 3 and 6 months after surgery. Results: The mean ± standard deviaiton (SD) age of the patients was 28.11 ± 6.56 years. The mean ± SD ECD did not change significantly in either group between the baseline and at 3 and 6 months postoperatively. The baseline mean ECD was significantly higher in group one than that in group two (P &lt; 0.001) and remained so at 3 (P = 0.002) and 6 months (P = 0.022) postoperatively. The baseline hexagonality value was lower in group one (P = 0.173), with a gradual decrease during the postoperative follow-up as compared with that in group two (P = 0.016 and 0.001 at 3 and 6 months postoperatively, respectively). Group one had a significantly lower CCT at 3 and 6 months postoperatively (both P &lt; 0.001) and a higher mean CV (3 months: P = 0.028; 6 months: P = 0.328). Conclusions: A single intraoperative application of MMC for 30 s as prophylaxis for corneal haze development during refractive surface ablation procedures had no significant effect on ECD up to 6 months postoperatively. Future studies with a contralateral-eye design (to neutralize factors specific to the individual patient), a larger sample size, and longer follow-up are necessary to confirm or disprove our observations

Prediction of the total and standardized ileal digestible amino acid contents from the chemical composition of soybean meals of different origin in broilers

The objective of this experiment was to determine total amino acid (TAA) content, standardized ileal digestibility (SID) of crude protein, and standardized ileal amino acid digestibility in 9 sources of soybean meal (SBM) of different origin and to subsequently establish equations for predicting the TAA content and concentration of standardized ileal digestible amino acids (SIDAA) based on their protein content and other proximate components. Concentration of SIDAA of the samples was also predicted using TAA values. A total of 160 1-day-old male broiler chicks were randomly assigned to 10 dietary treatments consisted of 9 semipurified diets containing one SBM (200 g of crude protein/kg) as the only source of dietary amino acid (AA) and one N-free diet to determine endogenous ileal AA flow. The birds were fed with a standard diet from 0 to 18 D of age, and experimental diets were fed from 19 to 24 D of age. The fitness of the models of the study was tested using the adjusted coefficient of determination (R2) value, P-value regression and coefficients, and standard error of prediction (SEP). The coefficient of SID for Lys and Cys among SBM varied from 86.7 to 96.3 and 74.1 to 89.3, respectively, with significant difference (P < 0.05). In equations based on protein content, the adjusted R2 value ranged from 40.7 (Ile) to 99.6 (Met) and 37.2 (Met + Cys) to 99.6 (Met) for TAA content and concentration of SIDAA, respectively. Inclusion of other proximate components of test samples (e.g., crude fiber, neutral detergent fiber, acid detergent fiber, ash, gross energy, and so on) into the regression equation increased the adjusted R2 value and decreased the SEP. The results of linear regression revealed that it is possible to satisfactorily estimate the TAA content and concentration of SIDAA of SBM through its protein content and other proximate components, but the prediction equations based on other proximate components were more accurate in terms of reflecting the measured results; however, additional time and costs were associated with this approach. It is also possible to estimate the concentration of SIDAA through TAA values with reasonable accuracy and lower SEP.info:eu-repo/semantics/publishedVersio

The Effect of Mesenchymal Stem Cells on the Expression of IDOand Qa2 Molecules in Dendritic Cells

Purpose: Mesenchymal stem cells (MSCs) have been shown to reduce the activity of immunecells, including dendritic cells (DCs). But the exact mechanism of mesenchymal inhibitionof DCs is still unknown. In this study, the effect of mesenchymal cells on the expression ofindoleamine dioxygenase (IDO) and Qa2 molecules in DCs was evaluated.Methods: MSCs and DCs were respectively isolated from the bone marrow and spleen of BALB/cmice. Then DCs were co-cultured with MSCs in the present and absence of lipopolysaccharides(LPS). Then the expression of mRNA and protein of IDO and Qa2 molecules were investigatedin DCs that were treated with MSCs.Results: The expression of IDO and Qa2 mRNA in DCs that were treated with MSCs did notsignificantly differ from the control group. The expression of IDO protein in DCs that were coculturedwith MSCs (in 1:10 and 1:50 ratios) in absence of LPS was increased, although theywere not statistically significant (P values: 0.24 and 0.18, respectively). The expression of Qa2protein in DCs that were co-cultured with MSCs (in 1:10 and 1:50 ratios) in presence of LPS wasincreased, although they were not statistically significant (P-values: 0.09 and 0.33, respectively).Conclusion: Our results denied the possibility that MSCs led to the induction of tolerogenic DCsby increasing the expression of the IDO and Qa2 immunomodulatory molecules