Improved measurement for mothers, newborns and children in the era of the Sustainable Development Goals.

BACKGROUND: An urgent priority in maternal, newborn and child health is to accelerate the scale-up of cost-effective essential interventions, especially during labor, the immediate postnatal period and for the treatment of serious infectious diseases and acute malnutrition.  Tracking intervention coverage is a key activity to support scale-up and in this paper we examine priorities in coverage measurement, distinguishing between essential interventions that can be measured now and those that require methodological development. METHODS: We conceptualized a typology of indicators related to intervention coverage that distinguishes access to care from receipt of an intervention by the population in need.  We then built on documented evidence on coverage measurement to determine the status of indicators for essential interventions and to identify areas for development. RESULTS: Contact indicators from pregnancy to childhood were identified as current indicators for immediate use, but indicators reflecting the quality of care provided during these contacts need development. At each contact point, some essential interventions can be measured now, but the need for development of indicators predominates around interventions at the time of birth and interventions to treat infections. Addressing this need requires improvements in routine facility based data capture, methods for linking provider and community-based data, and improved guidance for effective coverage measurement that reflects the provision of high-quality care. CONCLUSION: Coverage indicators for some essential interventions can be measured accurately through household surveys and be used to track progress in maternal, newborn and child health.  Other essential interventions currently rely on contact indicators as proxies for coverage but urgent attention is needed to identify new measurement approaches that directly and reliably measure their effective coverage

Pan-Cancer Analysis of lncRNA Regulation Supports Their Targeting of Cancer Genes in Each Tumor Context

Long noncoding RNAs (lncRNAs) are commonly dys-regulated in tumors, but only a handful are known toplay pathophysiological roles in cancer. We inferredlncRNAs that dysregulate cancer pathways, onco-genes, and tumor suppressors (cancer genes) bymodeling their effects on the activity of transcriptionfactors, RNA-binding proteins, and microRNAs in5,185 TCGA tumors and 1,019 ENCODE assays.Our predictions included hundreds of candidateonco- and tumor-suppressor lncRNAs (cancerlncRNAs) whose somatic alterations account for thedysregulation of dozens of cancer genes and path-ways in each of 14 tumor contexts. To demonstrateproof of concept, we showed that perturbations tar-geting OIP5-AS1 (an inferred tumor suppressor) andTUG1 and WT1-AS (inferred onco-lncRNAs) dysre-gulated cancer genes and altered proliferation ofbreast and gynecologic cancer cells. Our analysis in-dicates that, although most lncRNAs are dysregu-lated in a tumor-specific manner, some, includingOIP5-AS1, TUG1, NEAT1, MEG3, and TSIX, synergis-tically dysregulate cancer pathways in multiple tumorcontexts

Genomic, Pathway Network, and Immunologic Features Distinguishing Squamous Carcinomas

This integrated, multiplatform PanCancer Atlas study co-mapped and identified distinguishing molecular features of squamous cell carcinomas (SCCs) from five sites associated with smokin

Gestión administrativa y clima organizacional del personal administrativo de un gobierno regional del Perú - 2023

La presente tesis se enmarcó en la línea de investigación Reforma y modernización del Estado, siendo el objetivo de la investigación fue determinar relación entre la gestión administrativa y clima organizacional del personal administrativo de un gobierno regional del Perú, 2023, asimismo, la investigación fue de tipo básico, con diseño no experimental, de corte transversal, correlacional, en tanto, la población estuvo conformada por los trabajadores de un gobierno regional y la muestra estuvo conformada por 80 trabajadores, la técnica utilizada para la recolección de información fue la encuesta y el instrumento fue el cuestionario, el instrumento de recolección para medir la variable gestión administrativa estuvo conformado por 20 ítems y para medir la variable clima organizacional por 20 ítems, los resultados de la investigación determinaron que la variable gestión administrativa se relaciona directa, significativamente con la variable clima organizacional, con un coeficiente de correlación Rho Spearman de 0,689 ** con un p_valor calculado de 0.000, concluyendo que existe regular falta de claridad en los objetivos y estrategias de la organización, si bien los empleados no están claros en lo que se espera de ellos, es probable que se sientan desmotivados y descontentos con su trabajo

Spatio-temporal analysis of Texas shoreline changes using GIS technique

One of the most important aspects of coastal management and planning programs that needs to be investigated is shoreline dynamics. Long-term coastal analysis uses historical data to identify the sectors along the coast where the shoreline position has changed. Among the information that can be obtained from these studies are the general trend of coasts, either advancing or retreating. The erosion or accretion rates at each location can be used to forecast future shoreline positions. The current techniques used to study shoreline evolution are generally based on transects perpendicular to a baseline at selected points. But these techniques proved to be less efficient along more complex shorelines, and need to be refined. A new and more reliable method, the topologically constrained transect method (TCTM), was developed for this study and tested using data available for three sectors of the Texas Gulf Coast. Output data generated from TCTM also allowed performing shoreline evolution analysis and forecasting based on historical positions. Using topological constrained transects, this study provides a new method to estimate total areas of accretion or erosion at each segment of the coastline. Reliable estimates of future gains or losses of land along the coast will be extremely useful for planning and management decisions, especially those related to infrastructure and environmental impacts, and in the development of coastal models. Especially important is the potential to quickly identify areas of significant change, which eliminates the need for preliminary random sample surveying, and concentrate higher-resolution analyses in the most significant places. The results obtained in this research using the new methodology show that the Texas coast generally experiences erosion, with anthropogenic factors responsible for accretion. Accretion areas are located near coastal infrastructure, especially jetties that block the along shore sediment transport. The maximum erosion rate obtained in the study area is 5.48 m/year. This value helps make us aware of the powerful dynamic of the sector

Metodología STEAM y habilidades técnicas de estudiantes de un tecnológico universitario de Guayaquil, 2024

Este estudio, llevado a cabo en el Tecnológico Universitario de Guayaquil en 2024, se enfocó en determinar la relación entre la metodología STEAM y las habilidades técnicas de los estudiantes, contando con la participación de 120 estudiantes. Se utilizó un diseño de investigación básica correlacional. Los resultados muestran que la mayoría de los estudiantes (83%) están en un nivel bueno de implementación de la metodología STEAM, mientras que un 73% se encuentra en un nivel bueno de habilidades técnicas. Esto sugiere que la metodología STEAM impacta positivamente en el desarrollo de habilidades técnicas. No hay estudiantes en el nivel bajo en ambas categorías, lo que indica una base sólida en ambos aspectos. Un 18% de los estudiantes están en un nivel regular de implementación de STEAM y un 28% en un nivel regular de habilidades técnicas, señalando una mayor necesidad de apoyo en el desarrollo de habilidades técnicas en comparación con la implementación de STEAM. La diferencia en los porcentajes en el nivel regular (18% en STEAM vs. 28% en habilidades técnicas) sugiere que algunos estudiantes podrían beneficiarse de un enfoque más integrado y práctico en la enseñanza de habilidades técnicas utilizando la metodología STEAM

Spatial Organization and Molecular Correlation of Tumor-Infiltrating Lymphocytes Using Deep Learning on Pathology Images

Beyond sample curation and basic pathologic characterization, the digitized H&E-stained images of TCGA samples remain underutilized. To highlight this resource, we present mappings of tumorinfiltrating lymphocytes (TILs) based on H&E images from 13 TCGA tumor types. These TIL maps are derived through computational staining using a convolutional neural network trained to classify patches of images. Affinity propagation revealed local spatial structure in TIL patterns and correlation with overall survival. TIL map structural patterns were grouped using standard histopathological parameters. These patterns are enriched in particular T cell subpopulations derived from molecular measures. TIL densities and spatial structure were differentially enriched among tumor types, immune subtypes, and tumor molecular subtypes, implying that spatial infiltrate state could reflect particular tumor cell aberration states. Obtaining spatial lymphocytic patterns linked to the rich genomic characterization of TCGA samples demonstrates one use for the TCGA image archives with insights into the tumor-immune microenvironment

Pan-cancer Alterations of the MYC Oncogene and Its Proximal Network across the Cancer Genome Atlas

Although theMYConcogene has been implicated incancer, a systematic assessment of alterations ofMYC, related transcription factors, and co-regulatoryproteins, forming the proximal MYC network (PMN),across human cancers is lacking. Using computa-tional approaches, we define genomic and proteo-mic features associated with MYC and the PMNacross the 33 cancers of The Cancer Genome Atlas.Pan-cancer, 28% of all samples had at least one ofthe MYC paralogs amplified. In contrast, the MYCantagonists MGA and MNT were the most frequentlymutated or deleted members, proposing a roleas tumor suppressors.MYCalterations were mutu-ally exclusive withPIK3CA,PTEN,APC,orBRAFalterations, suggesting that MYC is a distinct onco-genic driver. Expression analysis revealed MYC-associated pathways in tumor subtypes, such asimmune response and growth factor signaling; chro-matin, translation, and DNA replication/repair wereconserved pan-cancer. This analysis reveals insightsinto MYC biology and is a reference for biomarkersand therapeutics for cancers with alterations ofMYC or the PMN

Aplicativo para personas de 18 a 40 años que tengan problemas con su autoestima y dificultad para expresar sus emociones Thinkup ( Aumenta tu confianza)

El presente “PROYECTO DE INNOVACIÓN TECNOLÓGICA titulado APLICATIVO PARA PERSONAS QUE TIENEN PROBLEMAS CON SU AUTOESTIMA Y DIFICULTAD PARA EXPRESAR SUS EMOCIONES “THINKUP (AUMENTA TU CONFIANZA)”, tuvo como finalidad proponer un programa para mejorar la autoestima de las personas. Para está investigación se seleccionó un grupo de 60 personas entre hombres y mujeres, entre las edades de 18 a 40 años. Material y método: se utilizó encuestas y Focus Group, dónde se obtuvo como resultado que más del 50% presenta problemas de baja autoestima. Se seleccionó un grupo de personas que se muestran con situaciones desfavorables con su autoestima, por consiguiente, se le invitó a una sala virtual, donde se realizó una entrevista, manifestando, los problemas que se desarrollen en su entorno, tanto laboral como personal. Los resultados obtenidos reflejan que la Aplicación para personas que tienen problemas con su autoestima y expresar sus emociones, ayudo en su relaciones interpersonales y personales