A Microcontroller Based System for Controlling Patient Respiratory Guidelines

The need of making improvements in obtaining (in a non-invasive way) and monitoring the breathing rate parameters in a patient emerges due to (1) the great amount of breathing problems our society suffer, (2) the problems that can be solved, and (3) the methods used so far. Non-specific machines are usually used to carry out these measures or simply calculate the number of inhalations and exhalations within a particular timeframe. These methods lack of effectiveness and precision thus, influencing the capacity of getting a good diagnosis. This proposal focuses on drawing up a technology composed of a mechanism and a user application which allows doctors to obtain the breathing rate parameters in a comfortable and concise way. In addition, such parameters are stored in a database for potential consultation as well as for the medical history of the patients. For this, the current approach takes into account the needs, the capacities, the expectations and the user motivations which have been compiled by means of open interviews, forum discussions, surveys and application uses. In addition, an empirical evaluation has been conducted with a set of volunteers. Results indicate that the proposed technology may reduce cost and improve the reliability of the diagnosis.Ministerio de Economía y Competitividad TIN2016-76956-C3-2-RMinisterio de Economía y Competitividad TIN2015-71938-RED

Towards an Approach for Applying Early Testing to Smart Contracts

Immutability -  the ability for a Blockchain (BC) Ledger to remain an unalterable, permanent and indelible history of transactions - is a feature that is highlighted as a key benefit of BC. This ability is very important when several companies work collaboratively to achieve common objectives. This collaboration is usually represented by using business process models. BC is considered as a suitable technology to reduce the complexity of designing these collaborative processes using Smart Contracts. This paper discusses how to combine Model-based Software Development, modelling techniques, such as use cases models and activity diagram models based on Unified Model Languages (UML) in order to simplify and improve the modelling, management and execution of collaborative business processes between multiple companies in the BC network. This paper includes the neccessity of using transformation protocols to obtain Smart Contract code. In addition, it presents systematic mechanisms to evaluate and validate Smart Contract, applying early testing techniques, before deploying the Smart Contract code in the BC network.Ministerio de Economía y Competitividad TIN2016-76956-C3-2-R (POLOLAS

Systematic Development of ERP Modules using a Model-Driven Strategy Focusing on the Users

ERP systems are composed of different functional modules on which each one addresses a different business area. Developments on these modules are managed independently on each one, which allow to handle and address the management of many related information requirements. In this context the startup G7Innovation works for its product iMEDEA. In this study we have combined two methodologies, Design Sprint and NDT 4.0; and systematized the development of ERP system modules. This combination allows you to use Design Sprint to generate and validate prototyping, and NDT 4.0 to do the study, analysis, and design of the software to be developed. In addition, according to the specifications defined in NDT, the code generation of the ERP module can be automated. This proposal has been validated in a case study in collaboration with the startup G7Innovation, where we have applied both methodologies on Odoo, an open source ERP system based in Python language. Thanks to the use of these two methodologies we have produced a module related to the needs of the clinic by reducing costs, times and human failures.Ministerio de Ciencia e Innovación TIN2016-76956-C3-2-

A Model Oriented Approach for Managing Traceability of Biological Samples and Tests of Patients in Assisted Reproduction Clinics

Assisted reproduction has become a service that more and more people access. Current problems such as the delay in the age of motherhood, single-parent couples, etc. they have proliferated the options and the different treatments that are put at the service of society. A fundamental part of these processes lies in the work of laboratories, in the samples that are handled in clinical processes and then be implanted in future mothers. The management of the samples is a critical aspect that requires all the opportune mechanisms that guarantee the traceability of said samples, avoiding fatal errors. The correct identification, monitoring and control of them is a fundamental aspect and of special relevance. However, the systems currently offered to clinics present important problems. On the one hand, they offer little security, are very expensive or very independent of a specific provider, so that the traceability system cannot be connected to the hospital central management system, or they are very intrusive control systems in the daily work of the laboratory technicians. In this paper a software solution based on the definition of automatic models and protocols is proposed. It includes the appropriate devices, to manage the traceability of the samples in parallel to the work of the laboratory technician.Ministerio de Economía y Competitividad TIN2016-76956-C3-2-R (POLOLAS

Traceability Management of Systems of Systems: A Systematic Review in the Assisted Reproduction Domain

Over last decade, Assisted Reproductive Treatment (ART) has becomea very used health service by more and more people around the worldbecause of problems such as the delay in the maternity age, single-parent couples, etc. In this context, health agencies have performedinnovations to improve healthcare processes of ARTs, to optimize theperformance of health professionals who work in fertilization laborato-ries and to improve Biological Sample Management (BSM) and sampletraceability in ART. However, there are important handicaps in ARTprocesses from the point of view of quality, safety and management.On the one hand, these processes are mainly based on manual executiontasks and manual control tasks. This excess of manual tasks could lead to fatal traceability and safety errors during BSM. On the other hand, ARTprocesses require real, interoperable and traceable communicationsbetween different software systems that have to collaborate together(health information systems, biological sample management systems,patient management systems, etc.), but, at present, it is possible toidentify some limitations in this domain, that is, the domain of systemsof systems (SoS). This paper aims to conduct an exhaustive study wascarried out both in the research community and in the commercial fieldto identify and analyze SoS solutions and theoretical proposals for BSMin ART processes. We have applied the Systematic Literature Review(SLR) methodology to carry out our study and we conclude it is a veryyoung research line that shows a growing trend and that in the actualitythere are very few technologies that deal with the problem of the BSMin ART.After analyzing the results, this paper presents as future workan initial Model-Driven conceptual solution to improve BSM in ART.2019-2

Effects of acute unilateral ovariectomy to pre-pubertal rats on steroid hormones secretion and compensatory ovarian responses

In the present study we analyzed the existence of asymmetry in the secretion of steroid hormones in pre-pubertal female rats treated with unilateral ovariectomy (ULO) or unilateral perforation of the abdominal wall (sham-surgery). Treated rats were sacrificed at different times after surgery. Since sham-surgery had an apparent effect on the age of first vaginal estrous (FVE) and serum levels hormone, the results of the sham surgery groups were used to assess the effects of their respective surgery treatment groups. On the day of FVE, compensatory ovulation (CO) and compensatory ovarian hypertrophy (COH) were similar in animals with ULO, regardless of the ovary remaining in situ. In ULO treated animals, progesterone (P4) levels were higher than in animals with sham-surgery one hour after treatment but lower in rats sacrificed at FEV. Left-ULO resulted in lower testosterone (T) concentration 48 and 72 hours after surgery. In rats with Right-ULO lower T concentrations were observed in rats sacrificed one or 72 hours after surgery, and at FVE. ULO (left or right) resulted in lower estradiol (E2) concentrations one or 72 hours after treatment. In rats with Left-ULO, E2 levels were higher 48 hours after surgery and at FVE. Left-ULO resulted in higher levels of follicle stimulating hormone (FSH) five hours after surgery and at FVE. FSH levels were higher in rats with Right-ULO sacrificed on FVE. The present results suggest that in the pre-pubertal rat both ovaries have similar capacities to secrete P4, and that the right ovary has a higher capacity to secrete E2. Taken together, the present results support the idea that the effects of ULO result from the decrease in glandular tissue and changes in the neural information arising from the ovary

Applying Model-Driven Web Engineering to the Testing Phase of the ADAGIO Project

The Model-Driven Engineering (MDE) has been used in recent years to promote better results in the development of Web Applications, in the field that has been called Model-Driven Web Engineering (MDWE). One of the advantages of applying MDWE is that it offers a solution to reduce the cost of the tests without affecting their quality execution. This paper presents the application of a MDWE methodology (Navigational Development Techniques, NDT) that provides support for all the phases of the lifecycle of a software project development proposing transformations between these phases, to manage the test phase of a real-world case study named ADAGIO. This project, among other goals, proposes the development of a web application whose main objective is to offer researchers the possibility of integrating and consolidating heterogeneous data sources, showing a unified vision of them, allowing to simplify the search task in different repositories as well as the relationship between the sources found.Ministerio de Economía y Competitividad TIN2016- 76956-C3-2-

Una estrategia centrada en el usuario y guiada por modelos para el desarrollo sistemático de módulos ERP

Los sistemas ERP están compuestos por diferentes módulos funciona les en el que cada uno aborda un área de negocio distinta. Los desarrollos que se llevan a cabo sobre estos módulos se gestionan de manera independiente por cada uno, lo que permite abordar de forma controlada un gran número de requisitos de información relacionados. En este contexto trabaja la startup G7Innovation para su producto iMEDEA. En este estudio hemos combinado dos metodologías, De sign Sprint y NDT 4.0; consiguiendo sistematizar el desarrollo de módulos de sistemas ERP. Esta combinación permite usar Design Sprint para generar y vali dar el prototipado, y NDT 4.0 para hacer el estudio, análisis y diseño del software a desarrollar. Además, de acuerdo a las especificaciones definidas en NDT, se puede automatizar la generación de código del módulo ERP. Esta propuesta se ha validado en un caso de estudio en colaboración con la startup G7Innovation donde hemos aplicado ambas metodologías sobre Odoo, un sistema ERP de có digo abierto escrito en lenguaje Python. Gracias al uso de estas dos metodologías hemos producido un módulo afín a las necesidades de la clínica reduciendo cos tos, tiempos y fallos humanos.Ministerio de Economía y Competitividad TIN2016-76956-C3-2-R (POLOLAS

Demostración de TRABIS (TRAzabilidad de Muestras BIológicaS de Reproducción Humana Asistida)

El control y trazabilidad de muestras biológicas es un problema a resolver en un gran número de ámbitos, pero en lo que se refiere a laboratorios de reproducción humana asistida, existen una serie de factores ambientales y del propio contexto de trabajo que hace que la práctica esté expuesta a múltiples posibles incidentes. En este contexto, se ha colaborado en un proyecto de transferencia tecnológica denominado “TRABIS - TRAzabilidad de muestras BIológicaS de reproducción humana asistida”. TRABIS es una solución tecnológica e innovadora que permite la ejecución y la monitorización de procesos de reproducción humana asistida, de manera integrada con dispositivos físicos de laboratorio para mejorar el control, salvaguarda y trazabilidad de muestras biológicas de paciente. Para verificar y validar la solución tecnológica, se ha realizado el pilotaje de la solución en Inebir (clínica privada de Reproducción Asistida).Ministerio de Economía y Competitividad PID2019-105455GB-C31 (proyecto NICO

Hacia una metodología para el desarrollo guiado y sistemático de los Trabajos Fin de Grado

El Trabajo Fin de Grado (TFG) juega un papel muy importante en el proceso formativo de los grados en Ingeniería Informática, ya que, a través de la ejecución satisfactoria de un proyecto, se pretende que el alumno/a tenga su primera experiencia profesional tutorada como ingeniero/a en proyectos de ingeniería y tecnología del Software. En este artículo se presenta una propuesta de metodología de trabajo seguida por nuestro grupo de investigación a la hora de tutorar, dirigir y ejecutar los TFG de las titulaciones de grado relacionadas con la Ingeniería Informática. Esta metodología, está compuesta por tres fases principales: la fase de diseño del producto (basada en metodología Design Sprint), la fase de análisis de la solución (basada en la metodología NDT) y el diseño, implementación y pruebas de la solución (basada en metodologías ágiles de desarrollo). Gracias a esta forma de trabajo, el alumno es capaz de ejecutar el TFG de una forma sistemática, ordenada y teniendo una visión clara del producto y solución que debe desarrollar.The final project plays a very important role in the formative process of the degrees in Computer Engineering, because, the satisfactory execution of a project, intends that the student has his first professional tutored experience as real engineer in projects of software engineering and technology. In this paper we present a proposal of work methodology followed by our research group when it comes to tutoring, directing and executing the final project in the degree programs related to Computer Engineering. This methodology is composed of three main phases: the design phase of the product (based on Design Sprint methodology), the solution analysis phase (based on the NDT methodology) and the design, implementation and testing of the solution phase (based on in agile development methodologies). Thanks to this kind of working, the student is able to execute the final project in a systematic and orderly way, having a clear vision of the product and solution to be developed.Este trabajo también ha sido apoyado por el Proyecto Pololas (TIN2016-76956-C3-2-R) del Ministerio de Economía y Competitividad y el VPPI de la Universidad de Sevilla