1,696 research outputs found
Spatial Distributions of Tropical Cyclone Tornadoes by Intensity and Size Characteristics
Tropical cyclones that make landfall often spawn tornadoes. Previous studies have shown that these tornadoes are not uniformly distributed in the United States or in the tropical cyclone environment. They show that tornadoes tend to occur relatively close to the coastline and that they tend to cluster to the east-of-center in the tropical cyclone environment, particularly in the northeast and east-of-center quadrants. This study contributes to these studies by analyzing the spatial distributions of tropical cyclone tornadoes by intensity, path length, path width, and the damage potential index. The analyses confirm that most tornadoes occur relatively close to the coastline, but show that stronger tornadoes with larger paths are disproportionately common farther inland. They also confirm that the highest amount of activity is located within the northeast and east-of-center quadrants and show that the most potentially damaging tornadoes cluster in a sub region near the intersection of these two quadrants
Hitting time for quantum walks on the hypercube
Hitting times for discrete quantum walks on graphs give an average time
before the walk reaches an ending condition. To be analogous to the hitting
time for a classical walk, the quantum hitting time must involve repeated
measurements as well as unitary evolution. We derive an expression for hitting
time using superoperators, and numerically evaluate it for the discrete walk on
the hypercube. The values found are compared to other analogues of hitting time
suggested in earlier work. The dependence of hitting times on the type of
unitary ``coin'' is examined, and we give an example of an initial state and
coin which gives an infinite hitting time for a quantum walk. Such infinite
hitting times require destructive interference, and are not observed
classically. Finally, we look at distortions of the hypercube, and observe that
a loss of symmetry in the hypercube increases the hitting time. Symmetry seems
to play an important role in both dramatic speed-ups and slow-downs of quantum
walks.Comment: 8 pages in RevTeX format, four figures in EPS forma
Quantum walks with infinite hitting times
Hitting times are the average time it takes a walk to reach a given final
vertex from a given starting vertex. The hitting time for a classical random
walk on a connected graph will always be finite. We show that, by contrast,
quantum walks can have infinite hitting times for some initial states. We seek
criteria to determine if a given walk on a graph will have infinite hitting
times, and find a sufficient condition, which for discrete time quantum walks
is that the degeneracy of the evolution operator be greater than the degree of
the graph. The set of initial states which give an infinite hitting time form a
subspace. The phenomenon of infinite hitting times is in general a consequence
of the symmetry of the graph and its automorphism group. Using the irreducible
representations of the automorphism group, we derive conditions such that
quantum walks defined on this graph must have infinite hitting times for some
initial states. In the case of the discrete walk, if this condition is
satisfied the walk will have infinite hitting times for any choice of a coin
operator, and we give a class of graphs with infinite hitting times for any
choice of coin. Hitting times are not very well-defined for continuous time
quantum walks, but we show that the idea of infinite hitting-time walks
naturally extends to the continuous time case as well.Comment: 28 pages, 3 figures in EPS forma
Quantum walks on quotient graphs
A discrete-time quantum walk on a graph is the repeated application of a
unitary evolution operator to a Hilbert space corresponding to the graph. If
this unitary evolution operator has an associated group of symmetries, then for
certain initial states the walk will be confined to a subspace of the original
Hilbert space. Symmetries of the original graph, given by its automorphism
group, can be inherited by the evolution operator. We show that a quantum walk
confined to the subspace corresponding to this symmetry group can be seen as a
different quantum walk on a smaller quotient graph. We give an explicit
construction of the quotient graph for any subgroup of the automorphism group
and illustrate it with examples. The automorphisms of the quotient graph which
are inherited from the original graph are the original automorphism group
modulo the subgroup used to construct it. We then analyze the behavior of
hitting times on quotient graphs. Hitting time is the average time it takes a
walk to reach a given final vertex from a given initial vertex. It has been
shown in earlier work [Phys. Rev. A {\bf 74}, 042334 (2006)] that the hitting
time can be infinite. We give a condition which determines whether the quotient
graph has infinite hitting times given that they exist in the original graph.
We apply this condition for the examples discussed and determine which quotient
graphs have infinite hitting times. All known examples of quantum walks with
fast hitting times correspond to systems with quotient graphs much smaller than
the original graph; we conjecture that the existence of a small quotient graph
with finite hitting times is necessary for a walk to exhibit a quantum
speed-up.Comment: 18 pages, 7 figures in EPS forma
Management of diarrhea in patients with HER2-positive breast cancer treated with neratinib: A case series and summary of the literature
INTRODUCTION: Neratinib and neratinib-based combinations have demonstrated efficacy for treatment of human epidermal growth factor receptor 2-positive (HER2+) early-stage and metastatic breast cancers. However, diarrhea has been reported as a common adverse event leading to neratinib discontinuation. Results from the CONTROL trial suggest that proactive diarrhea management with antidiarrheal prophylaxis or dose escalation of neratinib from a lower starting dose to the full FDA-approved dose of 240 mg/day can reduce the incidence, duration, and severity of neratinib-associated diarrhea in patients with early-stage breast cancer. Dose escalation has been included in the FDA-approved label for both early-stage and metastatic HER2+âbreast cancer since June 2021.
CASE SERIES: This series of five cases details real-world clinical implementation of strategies for management of neratinib-induced diarrhea in patients with early-stage and metastatic HER2+âbreast cancer, including a patient with a pre-existing gastrointestinal disorder.
MANAGEMENT AND OUTCOME: In four of five cases, diarrhea was managed with neratinib dose escalation, and antidiarrheal prophylaxis with loperamide plus colestipol was used in the remaining case. Management of diarrhea allowed all patients to remain on therapy.
DISCUSSION: This case series shows that neratinib-associated diarrhea can be managed effectively with neratinib dose escalation from a lower initial starting dose and/or prophylactic antidiarrheal medications in a real-world clinical setting. The findings highlight the importance of patient-provider communication in proactive management of adverse events. Widespread implementation of the strategies described here may improve adherence and thereby clinical outcomes for patients with HER2+âbreast cancer treated with neratinib
Social determinants of health and cancer screening implementation and outcomes in the USA: A systematic review protocol
BACKGROUND: Improving the delivery, uptake, and implementation of cancer screening to meet evidence-based recommendations is needed to reduce persistent cancer health disparities in the USA. Current national public health targets emphasize the role of social determinants of health (SDOH) on cancer screening. However, there remains a need to explicate these linkages, toward the goal of identifying and implementing effective interventions that target and address SDOH to reduce inequities in cancer screening.
METHODS: We will conduct a systematic review of English language peer-reviewed original research articles published between 2010 and 2021 that describe observational (qualitative and quantitative) and intervention studies conducted in the USA. In alignment with Healthy People 2030, we will include studies of breast, cervical, colorectal, and/or lung cancer screening. Guided by multiple SDOH frameworks, we will broadly define SDOH by five domain areas: economic stability, education access and quality, healthcare access and quality, neighborhood and built environment, and social and community context. Following systematic literature searches in five databases (Ovid MEDLINE, Embase, CINAHL, Web of Science, Cochrane Library) and piloting of screening procedures, reviewers will independently screen titles/abstracts for potential relevance. Reviewer pairs will then screen full text articles for eligibility criteria. We will extract data items from included articles, including study characteristics, cancer screening intervention information, and coding of SDOH constructs. We will assess study quality using the Mixed Methods Appraisal Tool and synthesize our findings using narrative, descriptive statistics, tables, and figures. Our approach will adhere to the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) recommendations.
DISCUSSION: By completing this systematic review, we will summarize recent literature on SDOH and cancer screening, identify research gaps for inclusion of SDOH, and propose future opportunities for advancing equity in cancer screening by integrating SDOH as part of the implementation context to promote uptake, sustainability, and scale-up in the implementation of screening guidelines.
SYSTEMATIC REVIEW REGISTRATION: PROSPERO CRD42021276582
Spectral reflectance of whale skin above the sea surface: a proposed measurement protocol
Great whales have been detected using veryâhighâresolution satellite imagery, suggesting this technology could be used to monitor whales in remote areas. However, the application of this method to whale studies is at an early developmental stage and several technical factors need to be addressed, including capacity for species differentiation and the maximum depth of detection in the water column. Both require knowledge of the spectral reflectance of the various whale species just above the sea surface, as when whales bodies break the surface of the water to breath, log or breach, there is, at times, no sea water between the whale's skin and the satellite sensor. Here we tested whether such reflectance could be measured on dead whale tissue. We measured the spectral reflectance of fresh integument collected during the bowhead subsistence harvest, and of thawed integument samples from various species obtained following strandings and stored at â20°C. We show that fresh and thawed samples of whale integument have different spectral properties. The reflectance of fresh samples was higher than the reflectance of thawed samples, as integument appears to darken after death and with time, even under frozen conditions. In this study, we present the first whale reflectance estimates (without the influence of sea water and for dead tissue). These provide a baseline for additional work, needed to advance the use of satellite imagery to monitor whales and facilitate their conservation
NASA's Robotic Lunar Lander Development Program
NASA Marshall Space Flight Center and the Johns Hopkins University Applied Physics Laboratory have developed several mission concepts to place scientific and exploration payloads ranging from 10 kg to more than 200 kg on the surface of the moon. The mission concepts all use a small versatile lander that is capable of precision landing. The results to date of the lunar lander development risk reduction activities including high pressure propulsion system testing, structure and mechanism development and testing, and long cycle time battery testing will be addressed. The most visible elements of the risk reduction program are two fully autonomous lander flight test vehicles. The first utilized a high pressure cold gas system (Cold Gas Test Article) with limited flight durations while the subsequent test vehicle, known as the Warm Gas Test Article, utilizes hydrogen peroxide propellant resulting in significantly longer flight times and the ability to more fully exercise flight sensors and algorithms. The development of the Warm Gas Test Article is a system demonstration and was designed with similarity to an actual lunar lander including energy absorbing landing legs, pulsing thrusters, and flight-like software implementation. A set of outdoor flight tests to demonstrate the initial objectives of the WGTA program was completed in Nov. 2011, and will be discussed
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