Sediment budget in a deep-sea core from the central equatorial Pacific

Stratigraphic, mineralogic, chemical, and geochronologic measurements on a core from 8°20\u27N, 153°W show that sediment has been accumulating at a rate of 160 g/cm2/106 years. Of this, 125 g is fresh Quaternary sediment while the remainder is lower and middle Tertiary material eroded from nearby outcrops...

Lakes of the Huron basin: their record of runoff from the laurentide ice sheet

The 189,000 km2 Huron basin is central in the catchment area of the present Laurentian Great Lakes that now drain via the St. Lawrence River to the North Atlantic Ocean. During deglaciation from 21-7.5 ka BP, and owing to the interactions of ice margin positions, crustal rebound and regional topography, this basin was much more widely connected hydrologically, draining by various routes to the Gulf of Mexico and Atlantic Ocean, and receiving overflows from lakes impounded north and west of the Great Lakes-Hudson Bay drainage divide.Early ice-marginal lakes formed by impoundment between the Laurentide Ice Sheet and the southern margin of the basin during recessions to interstadial positions at 15.5 and 13.2 ka BP. In each of these recessions, lake drainage was initially southward to the Mississippi River and Gulf of Mexico. In the first recession, drainage subsequently switched eastward along the ice margin to the North Atlantic Ocean. In the second recession, drainage continued southward through the Michigan basin, and later, eastward via the Ontario basin and Mohawk River valley to the North Atlantic Ocean. During the final retreat of ice in the Huron basin from 13 to 10 ka BP, proglacial lake drainage switched twice from the Michigan basin and the Mississippi River system to the North Atlantic via the Ontario basin and Mohawk River valley, finally diverting to the Champlain Sea in the St. Lawrence River valley at about 11.6 ka BP.New seismo- and litho-stratigraphic information with ostracode data from the offshore lacustrine sediments were integrated with the traditional data of shorelines, uplift histories of outlets, and radio-carbon-dated shallow-water evidence of transgressions and regressions to reconstruct the water level history and paleolimnological record for the northern Huron basin for the 11-7 ka BP period. Negative excursions in the [delta]18O isotopic composition of ostracodes and bivalves in southern Lake Michigan, southwestern Lake Huron and eastern Lake Erie indicate an influx of water from ice-marginal Lake Agassiz in central North America about 11 ka BP. A major decline in water levels of the Huron basin after 10.5 ka BP followed the high-level Main Lake Algonquin phase as ice receded and drainage was established through the North Bay area to Ottawa River valley. During the subsequent Mattawa-Stanley phase, the lake level history was dominated by fluctuations of tens of meters. Highstands of the earliest oscillations, whose origin is not clear, might be related to some of the well known Post Algonquin shorelines. After 9.6 ka BP, it is suggested that large inflows from Lake Agassiz and hydraulic damming in downstream outlets were the likely cause of the Lake Mattawa highstands. A lowstand at 9.3-9.1 ka BP occurred when these inflows were diverted, or impeded by an ice advance in the Nipigon basin area, while undiluted meltwater continued to enter the Huron basin. Assemblages and isotopic composition of the ostracode fauna indicate very dilute meltwater during the lowstands as late as 7.5 ka BP, and precipitation runoff with comparatively higher dissolved solids during the highstands. We speculate that the water composition of the Lake Mattawa highstands was dominated by the Agassiz inflows; by that time, much of Lake Agassiz was remote from ice-marginal environments, and the inflows were drawn from surface water of the southern sector of the lake, which was largely supplied by runoff and dissolved solids from the exposed land area of western Canada. Major inflows apparently ended about 8 ka BP, but northern proglacial lakes apparently continued as meltwater persisted in the Huron basin until about 7.5 ka BP. The cessation of major inflows initiated the final lowstand in the Huron basin and the present hydrological regime of local runoff.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/31942/1/0000895.pd

Allosteric Modulation of the HIV-1 gp120-gp41 Association Site by Adjacent gp120 Variable Region 1 (V1) N-Glycans Linked to Neutralization Sensitivity

The HIV-1 gp120-gp41 complex, which mediates viral fusion and cellular entry, undergoes rapid evolution within its external glycan shield to enable escape from neutralizing antibody (NAb). Understanding how conserved protein determinants retain functionality in the context of such evolution is important for their evaluation and exploitation as potential drug and/ or vaccine targets. In this study, we examined how the conserved gp120-gp41 association site, formed by the N- and Cterminal segments of gp120 and the disulfide-bonded region (DSR) of gp41, adapts to glycan changes that are linked to neutralization sensitivity. To this end, a DSR mutant virus (K601D) with defective gp120-association was sequentially passaged in peripheral blood mononuclear cells to select suppressor mutations. We reasoned that the locations of suppressors point to structural elements that are functionally linked to the gp120-gp41 association site. In culture 1, gp120 association and viral replication was restored by loss of the conserved glycan at Asn136 in V1 (T138N mutation) inconjunction with the L494I substitution in C5 within the association site. In culture 2, replication was restored with deletion of the N139INN sequence, which ablates the overlapping Asn141-Asn142-Ser-Ser potential N-linked glycosylation sequons inV1, in conjunction with D601N in the DSR. The 136 and 142 glycan mutations appeared to exert their suppressive effects by altering the dependence of gp120-gp41 interactions on the DSR residues, Leu593, Trp596 and Lys601. The 136 and/or 142glycan mutations increased the sensitivity of HIV-1 pseudovirions to the glycan-dependent NAbs 2G12 and PG16, and also pooled IgG obtained from HIV-1-infected individuals. Thus adjacent V1 glycans allosterically modulate the distal gp120-gp41 association site. We propose that this represents a mechanism for functional adaptation of the gp120-gp41 association site to an evolving glycan shield in a setting of NAb selection

Evidence-based Kernels: Fundamental Units of Behavioral Influence

This paper describes evidence-based kernels, fundamental units of behavioral influence that appear to underlie effective prevention and treatment for children, adults, and families. A kernel is a behavior–influence procedure shown through experimental analysis to affect a specific behavior and that is indivisible in the sense that removing any of its components would render it inert. Existing evidence shows that a variety of kernels can influence behavior in context, and some evidence suggests that frequent use or sufficient use of some kernels may produce longer lasting behavioral shifts. The analysis of kernels could contribute to an empirically based theory of behavioral influence, augment existing prevention or treatment efforts, facilitate the dissemination of effective prevention and treatment practices, clarify the active ingredients in existing interventions, and contribute to efficiently developing interventions that are more effective. Kernels involve one or more of the following mechanisms of behavior influence: reinforcement, altering antecedents, changing verbal relational responding, or changing physiological states directly. The paper describes 52 of these kernels, and details practical, theoretical, and research implications, including calling for a national database of kernels that influence human behavior

Finishing the euchromatic sequence of the human genome

The sequence of the human genome encodes the genetic instructions for human physiology, as well as rich information about human evolution. In 2001, the International Human Genome Sequencing Consortium reported a draft sequence of the euchromatic portion of the human genome. Since then, the international collaboration has worked to convert this draft into a genome sequence with high accuracy and nearly complete coverage. Here, we report the result of this finishing process. The current genome sequence (Build 35) contains 2.85 billion nucleotides interrupted by only 341 gaps. It covers ∼99% of the euchromatic genome and is accurate to an error rate of ∼1 event per 100,000 bases. Many of the remaining euchromatic gaps are associated with segmental duplications and will require focused work with new methods. The near-complete sequence, the first for a vertebrate, greatly improves the precision of biological analyses of the human genome including studies of gene number, birth and death. Notably, the human enome seems to encode only 20,000-25,000 protein-coding genes. The genome sequence reported here should serve as a firm foundation for biomedical research in the decades ahead

Songbirds are Resilient to Hurricane Disturbed Habitats During Spring Migration

The Gulf of Mexico is a conspicuous feature of the Neotropical-Nearctic bird migration system. Traveling long distances across ecological barriers comes with considerable risks, and mortality associated with intercontinental migration may be substantial, including that caused by storms or other adverse weather events. However, little, if anything, is known about how migratory birds respond to disturbance-induced changes in stopover habitat. Isolated, forested cheniere habitat along the northern coast of the Gulf of Mexico often concentrate migrants, during weather conditions unfavorable for northward movement or when birds are energetically stressed. We expected hurricane induced degradation of this habitat to negatively affect the abundance, propensity to stopover, and fueling trends of songbirds that stopover in coastal habitat. We used spring banding data collected in coastal Louisiana to compare migrant abundance and fueling trends before (1993-1996 and 1998-2005) and after hurricanes Rita (2006) and Ike (2009). We also characterized changes in vegetative structure before (1995) and after (2010) the hurricanes. The hurricanes caused dramatic changes to the vegetative structure, which likely decreased resources. Surprisingly, abundance, propensity to stopover, and fueling trends of most migrant species were not influenced by hurricane disturbance. Our results suggest that: 1) the function of chenieres as a refuge for migrants after completing a trans-Gulf flight may not have changed despite significant changes to habitat and decreases in resource availability, and 2) that most migrants may be able to cope with habitat disturbance during stopover. The fact that migrants use disturbed habitat points to their conservation value along the northern coast of the Gulf of Mexico