The UK Foundation Programme : past and present

The two-year Foundation Programme was introduced in the UK in 2005. In this article, the original architects of the programme explain why it was ntroduced, the challenges faced when implementing it across the UK, why the programme is successful and what the future holds for the UK Foundation Programme.peer-reviewe

A satellite-borne radar wind sensor (RAWS)

Modeling global atmospheric circulations and forecasting the weather would improve if worldwide information on winds aloft were available. Accurate prediction of weather is important to agriculture, shipping, air traffic, and many other fields. Global system models of climate are of great importance. Current global atmospheric models use pressure measurements and thermodynamic properties to calculate the effects of wind for use in Numerical Weather Prediction (NWP) models. Inputs to the NWP models are temperature, pressure and wind velocities at different heights. Clearly direct wind measurements could significantly improve the NWP model performance. The RAdar Wind Sounder (RAWS) program at the University of Kansas is a study of the feasibility and the trade-offs in the design of a space-based radar system to measure wind vectors. This can be done by measuring the Doppler shift of cloud and rain returns from three or more points and calculating the components of the wind vector. The RAWS study to date uses the candidate system selected after preliminary study of frequencies and sensitivities. Two frequencies chosen, 10 and 35 GHz, allow higher sensitivity for clouds and more penetration for rain. The past year was devoted to modeling the signal-to-noise ratio (SNR) achievable for the two frequencies. The determination of SNR versus cloud penetration depth used a cloud backscattering and attenuation model in the appropriate radar equation. Calculations assumed reasonable losses in reception and transmission, in addition to the atmospheric attenuation. We discovered that ice clouds provide a higher SNR than previously calculated, but some water clouds give lower SNRs than we calculated before. One of the primary issues in the SNR calculation was the choice of the drop size distribution. Although Xin used several distributions (e.g., log normal, Khrigian and Mazin), this year we used the Deirmendjian cloud model. SNR versus cloud penetration plots were generated to validate the candidate system. Rain, which appears in the cloud models at the lower altitudes, provides ample SNR, as do the higher clouds composed of ice particles. However, in some cloud situations we found the sensitivity for the clouds was marginal or inadequate. At 35 GHz, two of the cloud models characterized by 1 to 2 g/cu m of water content at altitudes extending from 150 to 1500 meters, produced a sufficient SNR. Other models, however, with water contents ranging from 0.5 to 4 g/cu m and altitudes up to 4000 meters, exhibit SNR of -3 to -23 dB, largely because of attenuation in the upper cloud layers. These results coupled with the lower SNR at 10 GHz, led to an investigation of alternate frequencies. The rain present beneath these clouds provides adequate SNR at 10 GHz, and in most cases, at GHz

Bone marrow senescence and the microenvironment of hematological malignancies

Senescence is the irreversible arrest of cell proliferation that has now been shown to play an important role in both health and disease. With increasing age senescent cells accumulate throughout the body, including the bone marrow and this has been associated with a number of age-related pathologies including malignancies. It has been shown that the senescence associated secretory phenotype (SASP) creates a pro-tumoural environment that supports proliferation and survival of malignant cells. Understanding the role of senescent cells in tumor development better may help us to identify new treatment targets to impair tumor survival and reduce treatment resistance. In this review, we will specifically discuss the role of senescence in the aging bone marrow (BM) microenvironment. Many BM disorders are age-related diseases and highly dependent on the BM microenvironment. Despite advances in drug development the prognosis particularly for older patients remains poor and new treatment approaches are needed to improve outcomes for patients. In this review, we will focus on the relationship of senescence and hematological malignancies, how senescence promotes cancer development and how malignant cells induce senescence

Systematic study of effect of cross-drafts and nozzle diameter on shield gas coverage

A shield gas flow rate of 15–20 L min21 is typically specified in metal inert gas welding, but is often adjusted to as high as 36 L min21 by welders in practice. Not only is this overuse of shield gas wasteful, but uncontrolled high gas flows can lead to significant turbulence induced porosity in the final weld. There is therefore a need to understand and control the minimum shield gas flow rate used in practical welding where cross-drafts may affect the coverage. Very low gas coverage or no shielding leads to porosity and spatter development in the weld region. A systematic study is reported of the weld quality achieved for a range of shield gas flow rates, cross-draft speeds and nozzle diameters using optical visualisation and numerical modelling to determine the shield gas coverage. As a consequence of the study, the shield gas flow has been reduced to 12 L min21 in production welding, representing a significant process cost saving and reduced environmental impact with no compromise to the final weld quality

MIG gas shielding : Economic savings without detriment to quality

Over the years a number of claims have been made related to potential savings of the shielding gas used in the MIG process. A number of work streams have been set up to consider such areas from a technical and economic standpoint. The use of small helium additions has particular benefits and despite an increase in unit cost, the overriding benefits are achieved in reduced manhour cost. A similar situation has been established when using a high frequency process to switch shielding gases during welding. The outcome from this was very similar to that already described. Overlaid on these has been the increasing use of a technique that visualises actual gas flow during welding by the use of laser backlighting. Some preliminary work in this area is described particularly related to the effect of drafts on the gas distribution. A recent development on the market place is a piece of equipment, which regulates the gas flow automatically and synchronously with the welding current. Gas savings in the region of 50-60% have been obtained. Data has been produced to illustrate these benefits. The potential benefit of developing a computational fluid dynamic model of the gas flow is also described, and early development stages of the model shown. However, there will always exist the very basic management need to minimise leaks from the gas delivery systems

The impact of group emotion regulation interventions on emotion regulation ability:A systematic review

Emotional regulation (ER) as a concept is not clearly defined, and there is a lack of clarity about how individuals can improve their ability to regulate emotions. Nevertheless, there is increasing evidence of the importance of ER as a transdiagnostic treatment target across mental health problems. This review examines the impact of ER group interventions on ER ability compared with no intervention, other comparable group interventions, or control conditions. A systematic review was conducted, in which 15 studies were included. Although types of ER intervention were mixed, the interventions had a considerable overlap in skills taught and how ER was measured. In all but one study, the ER intervention improved ER ability. ER interventions were superior to waitlist or treatment as usual, but there was limited evidence to suggest they were superior to other active treatments. Data from some studies suggest that improved ER was sustained at follow-up. Across the studies, there was generally poor linking of theory to practice, which hampers understanding of how interventions were constructed and why different skills were included. Although the results need to be interpreted with caution due to issues with methodological quality with the included papers, there is promising evidence that ER group interventions significantly improve ER ability