111,635 research outputs found
Method for predicting pump cavitation performance
Method requires the availability of two sets of appropriate data for each pump to be analyzed. At least one set of the data must provide measurable thermodynamic effects of cavitation
Archaeologists and Aborigines
Aboriginal hostility to archaeological work in Australia seem to be due mainly to lack of public understanding of what archaeology is all about. For this archaeologists themselves are chiefly to blame, because of their general disinclination or inability to communicate in a popular wa
Open loop digital frequency multiplier
An open loop digital frequency multiplier is described which has a multiplied output synchronized to low frequency clock pulse. The system includes a multistage digital counter which provides a pulse output as a function of an integer divisor. The integer divisor and the timing or counting cycle of the counter are interrelated to the frequency of a clock input. The counting cycle is controlled by a one shot multivibrator which, in turn, is driven by a reference frequency input
Computer design of extension springs
Computer program speeds up design process of tension springs and simultaneously optimizes the design by varying the input
Solar Ultraviolet Spectral Irradiance Monitor (SUSIM)
The solar ultraviolet spectral irradiance monitor (SUSIM) measures the ultraviolet flux from the entire Sun with high absolute accuracy over the wavelength range 120 to 400 nm with a resolution of 0.1 nm. SUSIM consists of two identical double dispersion scanning spectrometers with 5 photodiodes, 2 photon counters, and a deuterium lamp calibration source, all sealed in a canister pressurized to 1.1 atmosphere of argon. One spectrometer is used almost continuously during sunlight, the other is used once per day as a calibration check. The observations will yield improved absolute measurements of the ultraviolet solar fluxes, provide an accurate reference for studies of variability of the solar fluxes on the time scales of the solar cycle and longer, and measure shorter term changes as well. These measurements complement the ACR measurements of the total solar irradiance. The data will be used to study the physical behavior of the Sun and the Earth's atmosphere, weather, and climate
Telomeric NAP1L4 and OSBPL5 of the KCNQ1 cluster, and the DECORIN gene are not imprinted in human trophoblast stem cells
Background: Genomic imprinting of the largest known cluster, the Kcnq1/KCNQ1 domain on mChr7/hChr11, displays significant differences between mouse and man. Of the fourteen transcripts in this cluster, imprinting of six is ubiquitous in mice and humans, however, imprinted expression of the other eight transcripts is only found in the mouse placenta. The human orthologues of the latter eight transcripts are biallelically expressed, at least from the first trimester onwards. However, as early development is less divergent between species, placental specific imprinting may be present in very early gestation in both mice and humans.
Methodology/Principal Findings: Human embryonic stem (hES) cells can be differentiated to embryoid bodies and then to trophoblast stem (EB-TS) cells. Using EB-TS cells as a model of post-implantation invading cytotrophoblast, we analysed allelic expression of two telomeric transcripts whose imprinting is placental specific in the mouse, as well as the ncRNA KCNQ1OT1, whose imprinted expression is ubiquitous in early human and mouse development. KCNQ1OT1 expression was monoallelic in all samples but OSBPL5 and NAP1L4 expression was biallelic in EB-TS cells, as well as undifferentiated hES cells and first trimester human fetal placenta. DCN on hChr12, another gene imprinted in the mouse placenta only, was also biallelically expressed in EB-TS cells. The germline maternal methylation imprint at the KvDMR was maintained in both undifferentiated hES cells and EB-TS cells.
Conclusions/Significance: The question of placental specific imprinting in the human has not been answered fully. Using a model of human trophoblast very early in gestation we show a lack of imprinting of two telomeric genes in the KCNQ1 region and of DCN, whose imprinted expression is placental specific in mice, providing further evidence to suggest that humans do not exhibit placental specific imprinting. The maintenance of both differential methylation of the KvDMR and monoallelic expression of KCNQ1OT1 indicates that the region is appropriately regulated epigenetically in vitro. Human gestational load is less than in the mouse, resulting in reduced need for maternal resource competition, and therefore maybe also a lack of placental specific imprinting. If genomic imprinting exists to control fetal acquisition of maternal resources driven by the placenta, placenta-specific imprinting may be less important in the human than the mouse
Soft X-ray telescope (SXRT)
The soft X-ray telescope (SXRT) will provide direct images of the solar corona with spatial resolution of about 1 arcsecond. These images will show the global structure of the corona, the location and area of coronal holes, and the presence of even the smallest active regions and flares. The good spatial resolution will show the fine scale magnetic structure and changes in these phenomena. These observations are essential for monitoring, predicting, and understanding the solar magnetic cycle, coronal heating, solar flares, coronal mass ejections, and the solar wind. These observations complement those of the White Light Coronagraph and Ultra-Violet Coronal Spectrometer; the SXRT will detect active regions and coronal holes near the east limb, thereby giving a week or more of advanced warning for disturbed geomagnetic conditions at Earth. The instrument consists of a grazing incidence collecting mirror with a full-disk film camera at the primary focus, and a secondary relay optic that feeds a CCD camera with a field of view about the size of an average active region
Active Cavity Radiometer (ACR)
The active cavity radiometer (ACR) measures the total solar irradiance to determine the magnitude and direction of variations in the total solar radiative output. The ACR is an electrically self calibrating cavity pyroheliometer capable of measuring the total solar irradiance with an absolute accuracy better than 0.2% and capable of detecting changes in the total irradiance smaller than 0.001%. The data will be used to study the physical behavior of the Sun and the Earth's climate
Balanced Topological Field Theories
We describe a class of topological field theories called ``balanced
topological field theories.'' These theories are associated to moduli problems
with vanishing virtual dimension and calculate the Euler character of various
moduli spaces. We show that these theories are closely related to the geometry
and equivariant cohomology of ``iterated superspaces'' that carry two
differentials. We find the most general action for these theories, which turns
out to define Morse theory on field space. We illustrate the constructions with
numerous examples. Finally, we relate these theories to topological
sigma-models twisted using an isometry of the target space.Comment: 40 pages, harvmac, references added, to appear in Commun. Math. Phy
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