Anatomy of a Design Regime

Since the European Union adopted uniform sui generis design rights, an increasingly complex system of cumulative and overlapping intellectual property rights has emerged. While such harmonization offers several benefits, analyzing the interpretation and application of narrow legal requirements within the EU Community Design Rights may indicate whether such benefits will actually be realized. This paper examines Regulation 6/2002\u27s definitions of informed user and overall impression as they apply to registered designs. After summarizing relevant case law and considering underlying policy goals of the EU Community design legislation, this paper explores whether these definitions could be more efficient and intellectually honest if both the universe of invalidating prior art-relevant to a design\u27s eligibility for protection-and the corresponding scope of protection were restricted by industrial sectors

The role of advertising agencies on the demand for personalized communications

A personalized campaign allows an agency to utilize its clients\u27 records to reach its audience by sending targeted messages and promotions, which often results in improved business results. This pull is achieved by using detailed databases with a large quantity of information about existing and potential customers. This information, in the form of text, data and sometimes images, is then placed into a document in a way that is easy for customers to locate and act upon. Variable data technology should be embraced by advertising agencies as a definite way to improve response rates and generate more business. But what do advertising agencies actually think of personalized campaigns? Is the technology being embraced by agencies to improve business results? Does the type and size of the agency make a difference in whether or not personalized campaigns are used? Does the agency\u27s client base alter the use of personalization? To find solutions to these questions, a survey was given to a random group of advertising agencies drawn from The Red Books list of agencies. A total of 250 agencies completed the telephone survey. Also, an in depth questionnaire was completed by a direct marketing agency using personalized communications, to complement the survey results. What was found was that an average of only 23% of the work the agencies do actually involves using a form of personalized communications. Seventy-nine percent of clients requesting personalization are small businesses ($100 million or less in annual revenue), 15$101 million to $1 billion in annual revenue), and almost 6$1 billion in annual revenue. Forty-eight percent of clients requesting personalized communications were business-to-business clients. Almost 42% were business-to-consumer clients, and the other 11% were both. To determine if there is a difference in the use of personalization according to the agency type, agencies were grouped into three categories: 1) direct marketing and web agencies, 2) traditional full service agencies, and 3) boutique agencies. Results indicate that there is no significant difference in the use of personalization among these three agency types. Direct marketing and web agencies use the most amount of personalization at 25%, followed closely by traditional full service agencies at 24%. Boutique agencies use the least amount of personalization at 20%. To determine if there is a difference in the use of personalization in relation to agency size, the agencies were classified into three groups according to their annual billings: 1) small agencies with $5 million or less in annual revenue, 2) medium agencies with annual revenue between$5,000,001 and $50 million, and 3) large agencies with annual revenue of$50,000,0001 or more. Results determined that there is no significant difference in the use of personalization among these different agency sizes. Large agencies use the most amount of personalization at 27.6%, followed by medium sized agencies at 26.7% and small agencies at 20.7%. Finally, to determine if there is a difference in the use of personalization in relation to client type, agencies were asked on average, what percentages of their accounts are primarily business-to-business (B2B), business-to-consumer (B2C), and a mixture of both. Results indicate that again, there is no significant difference in the use of personalization among these client types. Agencies that served a mixed array of clients use the highest percentage of personalization at 29.5%, while B2B and B2C clients use almost the same percentage of personalization at 21.5% and 22.1%, respectively

Adrenal suppression due to an interaction between ritonavir and injected triamcinolone: a case report

Two HIV-1 infected patients developed signs and symptoms consistent with adrenal suppression after being exposed to intra-articular triamcinolone acetate while also receiving ritonavir as part of their highly active antiretroviral therapy. Laboratory evaluation confirmed secondary adrenal suppression in both cases. Both patients recovered without the need for chronic replacement steroids. Adrenal suppression has been described as an adverse outcome in patients treated with fluticasone and concomitant ritonavir. In the reported cases, the adrenal suppression likely developed as a result of increased systemic concentrations of triamcinolone due to an inhibition of cytochrome p450 3A4 metabolism. Practitioners of HIV medicine should be aware of the potential negative interaction of injected triamcinolone and ritonavir

Tidal Streams as Probes of the Galactic Potential

We explore the use of tidal streams from Galactic satellites to recover the potential of the Milky Way. Our study is motivated both by the discovery of the first lengthy stellar stream in the halo (\cite{it98}) and by the prospect of measuring proper motions of stars brighter than 20th magnitude in such a stream with an accuracy of $\sim 4\mu as/$yr, as will be possible with the Space Interferometry Mission (SIM). We assume that the heliocentric radial velocities of these stars can be determined from supporting ground-based spectroscopic surveys, and that the mass and phase-space coordinates of the Galactic satellite with which they are associated will also be known to SIM accuracy. Using results from numerical simulations as trial data sets, we find that, if we assume the correct form for the Galactic potential, we can predict the distances to the stars as a consequence of the narrow distribution of energy expected along the streams. We develop an algorithm to evaluate the accuracy of any adopted potential by requiring that the satellite and stars recombine within a Galactic lifetime when their current phase-space coordinates are integrated backwards. When applied to a four-dimensional grid of triaxial logarithmic potentials, with varying circular velocities, axis ratios and orientation of the major-axis in the disk plane, the algorithm can recover the parameters used for the Milky Way in a simulated data set to within a few percent using only 100 stars in a tidal stream.Comment: Revised version - original algorithm generalised to be applicable to any potential shape. LaTeX, 12 pages including 3 figures. To be published in ApJ Letter

Tracing Galaxy Formation with Stellar Halos I: Methods

If the favored hierarchical cosmological model is correct, then the Milky Way system should have accreted ~100-200 luminous satellite galaxies in the past \~12 Gyr. We model this process using a hybrid semi-analytic plus N-body approach which distinguishes explicitly between the evolution of light and dark matter in accreted satellites. This distinction is essential to our ability to produce a realistic stellar halo, with mass and density profile much like that of our own Galaxy, and a surviving satellite population that matches the observed number counts and structural parameter distributions of the satellite galaxies of the Milky Way. Our model stellar halos have density profiles which typically drop off with radius faster than those of the dark matter. They are assembled from the inside out, with the majority of mass (~80%) coming from the \~15 most massive accretion events. The satellites that contribute to the stellar halo have median accretion times of ~9 Gyr in the past, while surviving satellite systems have median accretion times of ~5 Gyr in the past. This implies that stars associated with the inner halo should be quite different chemically from stars in surviving satellites and also from stars in the outer halo or those liberated in recent disruption events. We briefly discuss the expected spatial structure and phase space structure for halos formed in this manner. Searches for this type of structure offer a direct test of whether cosmology is indeed hierarchical on small scales.Comment: 22 pages, 16 figures, submitted to Ap

Linking the Green and Brown Worlds: the Prevalence and Effect of Multichannel Feeding in Food Webs

Recent advances in food‐web ecology highlight that most real food webs (1) represent an interplay between producer‐ and detritus‐based webs and (2) are governed by consumers which are rampant omnivores; feeding on varied prey across trophic levels and resource channels. A possible avenue to unify these advances comes from models demonstrating that predators feeding on distinctly different channels may stabilize food webs. Empirical studies suggest many consumers engage in such behavior by feeding on prey items from both living‐autotroph (green) and detritus‐based (brown) webs, what we term “multichannel feeding,” yet we know little about how common such feeding is across systems and trophic levels, or its effect on system stability. Considering 23 empirical webs, we find that multichannel feeding is equally common across terrestrial, freshwater, and marine systems, with \u3e50% of consumers classified as multichannel consumers. Multichannel feeding occurred most often at the first consumer level, indicating that most taxa at the herbivore/detritivore level are more aptly described as multichannel consumers, and that such feeding is not restricted to predators. We next developed a simple four‐compartment nutrient cycling model for consumers eating both autotrophs and detritus with separate parameter sets to represent aquatic vs. terrestrial ecosystems. Modeling results showed that, across terrestrial and aquatic ecosystems, multichannel feeding is stabilizing at low attack rates on autotrophs or when attack rates are asymmetric (moderate on autotrophs while low on detritus), but destabilizing at high attack rates on autotrophs, compared to herbivory‐ or detritivory‐only models. The set of conditions with stable webs with multichannel consumers is narrower, however, for aquatic systems, suggesting that multichannel feeding may generally be more stabilizing in terrestrial systems. Together, our results demonstrate that multichannel feeding is common across ecosystems and may be a stabilizing force in real webs that have consumers with low or asymmetric attack rates

Robustness of sex-differences in functional connectivity over time in middle-aged marmosets

Nonhuman primates (NHPs) are an essential research model for gaining a comprehensive understanding of the neural mechanisms of neurocognitive aging in our own species. In the present study, we used resting state functional connectivity (rsFC) to investigate the relationship between prefrontal cortical and striatal neural interactions, and cognitive flexibility, in unanaesthetized common marmosets (Callithrix jacchus) at two time points during late middle age (8 months apart, similar to a span of 5-6 years in humans). Based on our previous findings, we also determine the reproducibility of connectivity measures over the course of 8 months, particularly previously observed sex differences in rsFC. Male marmosets exhibited remarkably similar patterns of stronger functional connectivity relative to females and greater cognitive flexibility between the two imaging time points. Network analysis revealed that the consistent sex differences in connectivity and related cognitive associations were characterized by greater node strength and/or degree values in several prefrontal, premotor and temporal regions, as well as stronger intra PFC connectivity, in males compared to females. The current study supports the existence of robust sex differences in prefrontal and striatal resting state networks that may contribute to differences in cognitive function and offers insight on the neural systems that may be compromised in cognitive aging and age-related conditions such as mild cognitive impairment and Alzheimer\u27s disease

Finding common ground: identifying and eilciting metacognition in ePortfolios

Research has suggested ePortfolios reveal and support students’ metacognition, that is, their awareness, tracking, and evaluation of their learning over time. However, due to the wide variety of purposes and audiences for ePortfolios, it has been unclear whether there might be common criteria for identifying and assessing metacognition in ePortfolios across varied contexts. The purpose of this study was to identify evidence of metacognition across ePortfolios of three distinct populations of students: traditional-age undergraduates, graduate Education students, and adults returning to school to complete a bachelor’s degree. We set out to explore if and how ePortfolios could support these different learners’ growth as reflective, intentional learners and professionals. Through a qualitative coding process, we identified four key metacognition markers across students’ ePortfolios in these three populations. We conclude students can be guided to engage in metacognition in ways through thoughtful assignment design and assessment process, no matter their context

Teologija na tržištu

One task intended to measure sensitivity to temporal fine structure (TFS) involves the discrimination of a harmonic complex tone from a tone in which all harmonics are shifted upwards by the same amount in hertz. Both tones are passed through a fixed bandpass filter centered on the high harmonics to reduce the availability of excitation-pattern cues and a background noise is used to mask combination tones. The role of frequency selectivity in this "TFS1" task was investigated by varying level. Experiment 1 showed that listeners performed more poorly at a high level than at a low level. Experiment 2 included intermediate levels and showed that performance deteriorated for levels above about 57 dB sound pressure level. Experiment 3 estimated the magnitude of excitation-pattern cues from the variation in forward masking of a pure tone as a function of frequency shift in the complex tones. There was negligible variation, except for the lowest level used. The results indicate that the changes in excitation level at threshold for the TFS1 task would be too small to be usable. The results are consistent with the TFS1 task being performed using TFS cues, and with frequency selectivity having an indirect effect on performance via its influence on TFS cues. (C) 2015 Acoustical Society of America

現代日本語における敬語の命令形

千葉大学社会文化科学研究科研究プロジェクト報告書第123集『語彙と文法の相関-比較･対照研究の視点から』所