3,311 research outputs found
New Measurement of the Relative Scintillation Efficiency of Xenon Nuclear Recoils Below 10 keV
Liquid xenon is an important detection medium in direct dark matter
experiments, which search for low-energy nuclear recoils produced by the
elastic scattering of WIMPs with quarks. The two existing measurements of the
relative scintillation efficiency of nuclear recoils below 20 keV lead to
inconsistent extrapolations at lower energies. This results in a different
energy scale and thus sensitivity reach of liquid xenon dark matter detectors.
We report a new measurement of the relative scintillation efficiency below 10
keV performed with a liquid xenon scintillation detector, optimized for maximum
light collection. Greater than 95% of the interior surface of this detector was
instrumented with photomultiplier tubes, giving a scintillation yield of 19.6
photoelectrons/keV electron equivalent for 122 keV gamma rays. We find that the
relative scintillation efficiency for nuclear recoils of 5 keV is 0.14, staying
constant around this value up to 10 keV. For higher energy recoils we measure a
value around 20%, consistent with previously reported data. In light of this
new measurement, the XENON10 experiment's results on spin-independent
WIMP-nucleon cross section, which were calculated assuming a constant 0.19
relative scintillation efficiency, change from cm to
cm for WIMPs of mass 100 GeV/c, and from
cm to cm for WIMPs of mass 30
GeV/c.Comment: 8 pages, 8 figure
3D Position Sensitive XeTPC for Dark Matter Search
The technique to realize 3D position sensitivity in a two-phase xenon time
projection chamber (XeTPC) for dark matter search is described. Results from a
prototype detector (XENON3) are presented.Comment: Presented at the 7th UCLA Symposium on "Sources and Detection of Dark
Matter and Dark Energy in the Universe
pH-dependent redox and CO binding properties of chelated protoheme-L-histidine and protoheme-glycyl-L-histidine complexes
The pH dependence of redox properties, spectroscopic features and CO binding kinetics for the chelated protohemin-6(7)-L-histidine methyl ester (heme-H) and the chelated protohemin-6(7)-glycyl-L-histidine methyl ester (heme-GH) systems has been investigated between pH 2.0 and 12.0. The two heme systems appear to be modulated by four protonating groups, tentatively identified as coordinated H2O, one of heme's propionates, N epsilon of the coordinating imidazole, and the carboxylate of the histidine residue upon hydrolysis of the methyl ester group (in acid medium). The pK(a) values are different for the two hemes, thus reflecting structural differences. In particular, the different strain at the Fe-N-epsilon bond, related to the different length of the coordinating arm, results in a dramatic alteration of the bond strength, which is much smaller in heme-H than in heme-GH. It leads to a variation in the variation of the pKa for the protonation of the N-epsilon of the axial imidazole as well as in the proton-linked behavior of the other protonating groups, envisaging a cross-talk communication mechanism among different groups of the heme, which can be operative and relevant also in the presence of the protein matrix
Constraints on inelastic dark matter from XENON10
It has been suggested that dark matter particles which scatter inelastically
from detector target nuclei could explain the apparent incompatibility of the
DAMA modulation signal (interpreted as evidence for particle dark matter) with
the null results from CDMS-II and XENON10. Among the predictions of
inelastically interacting dark matter are a suppression of low-energy events,
and a population of nuclear recoil events at higher nuclear recoil equivalent
energies. This is in stark contrast to the well-known expectation of a falling
exponential spectrum for the case of elastic interactions. We present a new
analysis of XENON10 dark matter search data extending to E keV
nuclear recoil equivalent energy. Our results exclude a significant region of
previously allowed parameter space in the model of inelastically interacting
dark matter. In particular, it is found that dark matter particle masses
GeV are disfavored.Comment: 8 pages, 4 figure
First Results from the XENON10 Dark Matter Experiment at the Gran Sasso National Laboratory
The XENON10 experiment at the Gran Sasso National Laboratory uses a 15 kg
xenon dual phase time projection chamber (XeTPC) to search for dark matter
weakly interacting massive particles (WIMPs). The detector measures
simultaneously the scintillation and the ionization produced by radiation in
pure liquid xenon, to discriminate signal from background down to 4.5 keV
nuclear recoil energy. A blind analysis of 58.6 live days of data, acquired
between October 6, 2006 and February 14, 2007, and using a fiducial mass of 5.4
kg, excludes previously unexplored parameter space, setting a new 90% C.L.
upper limit for the WIMP-nucleon spin-independent cross-section of 8.8 x
10^{-44} cm^2 for a WIMP mass of 100 GeV/c^2, and 4.5 x 10^{-44} cm^2 for a
WIMP mass of 30 GeV/c^2. This result further constrains predictions of
supersymmetric models.Comment: accepted for publication in Phys. Rev. Let
A search for light dark matter in XENON10 data
We report results of a search for light (<10 GeV) particle dark matter with
the XENON10 detector. The event trigger was sensitive to a single electron,
with the analysis threshold of 5 electrons corresponding to 1.4 keV nuclear
recoil energy. Considering spin-independent dark matter-nucleon scattering, we
exclude cross sections \sigma_n>3.5x10^{-42} cm^2, for a dark matter particle
mass m_{\chi}=8 GeV. We find that our data strongly constrain recent elastic
dark matter interpretations of excess low-energy events observed by CoGeNT and
CRESST-II, as well as the DAMA annual modulation signal.Comment: Manuscript identical to v2 (published version) but also contains
erratum. Note v3==v2 but without \linenumber
A longitudinal study on the information needs and preferences of patients after an acute coronary syndrome
Background: Research has shown that the provision of pertinent health information to patients with cardiovascular disease is associated with better adherence to medical prescriptions, behavioral changes, and enhanced perception of control over the disease. Yet there is no clear knowledge on how to improve information pertinence. Identifying and meeting the information needs of patients and their preferences for sources of information is pivotal to developing patient-led services. This prospective, observational study was aimed at exploring the information needs and perceived relevance of different information sources for patients during the twenty-four months following an acute coronary syndrome. Methods: Two hundred and seventeen newly diagnosed patients with acute coronary syndrome were enrolled in the study. The patients were primarily men (83.41 %) with a mean age of 57.28 years (range 35-75; SD = 7.98). Patients' needs for information and the perceived relevance of information sources were evaluated between 2 and 8 weeks after hospitalization (baseline) and during three follow-ups at 6, 12 and 24 months after baseline. Repeated measures ANOVA, Bonferroni post hoc tests and Cochran's Q Test were performed to test differences in variables of interest over time. Results: Results showed a reduction in information needs, but this decrease was significant only for topics related to daily activities, behavioral habits, risk and complication. At baseline, the primary sources of information were specialists and general practitioners, followed by family members and information leaflets given by physicians. Relevance of other sources changed differently over time. Conclusion: The present longitudinal study is an original contribution to the investigation of changes in information needs and preferences for sources of information among patients who are diagnosed with acute coronary syndrome. One of the main results of this study is that information on self-disease management is perceived as a minor theme for patients even two years after the event. Knowledge on how patients' information needs and perceived relevance of information sources change over time could enhance the quality of chronic disease management, leading health-care systems to move toward more patient-tailored care
The Audiological Follow-Up of Children with Symptomatic Congenital Cytomegalovirus Infection: An Experience in Two Italian Centers
Background: Congenital cytomegalovirus (cCMV) infection is the leading cause of non-hereditary sensorineural hearing loss in children. While about 10% of children reportedly display symptoms at birth, 85-90% of cCMV infection cases are asymptomatic. However, 10-15% of these asymptomatic infants may later develop hearing, visual, or neurodevelopmental impairments. This study aimed to evaluate the impact of cCMV infection on newborns' hearing function with a particular emphasis on progressive and late-onset cases. Methods: This study is a retrospective chart analysis with longitudinal character and was conducted in two Italian centers: Center 1 (from 1 November 2007 to 31 December 2021) and Center 2 (from 1 January 2012 to 31 December 2021). Data collected included newborn hearing screening results, characterization of hearing loss (unilateral/bilateral, degree of impairment), and audiological follow-up. Results: The cohort consisted of 103 children (42% males, 58% females). In total, 28 children presented with hearing impairment; 71.4% (20 out of 28) of the cases of hearing loss were severe/profound, with 35.7% of the cases due to unilateral hearing loss. Out of twenty-eight, six experienced progression of hearing loss and four had late-onset hearing loss. Conclusions: In the absence of universal cCMV screening, hearing screening at birth for cCMV remains a critical factor for early diagnosis. A significant percentage of children affected by cCMV with normal audiological evaluations at birth is easily lost to follow-up. Close collaboration between neonatologists, pediatricians, and audiological services is fundamental to ensure timely diagnosis and treatment of cCMV-related hearing loss
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