7 research outputs found
Signaling pathways modulated by fish oil in salt-sensitive hypertension
- Author
- Publication venue
- 'American Physiological Society'
- Publication date
- Field of study
Shared decision making between physicians and patients
- Author
- Publication venue
- BMJ Publishing Group
- Publication date
- Field of study
No abstract as this is a letter to the edito
n-3 Fatty acids block TNF-α-stimulated MCP-1 expression in rat mesangial cells
- Author
- Publication venue
- American Physiological Society
- Publication date
- Field of study
Monocyte chemoattractant protein 1 (MCP-1) is a CC cytokine that fundamentally contributes to the pathogenesis of inflammatory renal disease. MCP-1 is highly expressed in cytokine-stimulated mesangial cells in vitro and following glomerular injury in vivo. Interventions to limit MCP-1 expression are commonly effective in assorted experimental models. Fish oil, an abundant source of n-3 fatty acids, has anti-inflammatory properties, the basis of which remains incompletely defined. We examined potential mechanisms whereby fish oil reduces MCP-1 expression and thereby suppresses inflammatory responses to tissue injury. Cultured mesangial cells were treated with TNF-α in the presence of the n-3 fatty acids docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA); equimolar concentrations of the n-6 fatty acids LA and OA served as controls. MCP-1 mRNA expression was assessed by Northern blotting, and transcriptional activity of the MCP-1 promoter was assessed by transient transfection. The involvement of the ERK and NF-κB pathways was evaluated through transfection analysis and the use of the MEK inhibitor U0126. DHA and EPA decreased TNF-α-stimulated MCP-1 mRNA expression by decreasing transcription of the MCP-1 gene. DHA and EPA decreased p-ERK expression and nuclear translocation of NF-κB, both of which are necessary for TNF-α-stimulated MCP-1 expression. Both NF-κB and AP-1 sites were involved in transcriptional regulation of the MCP-1 gene by DHA and EPA. We conclude that DHA and EPA inhibit TNF-α-stimulated transcription of the MCP-1 gene through interaction of signaling pathways involving ERK and NF-κB. We speculate that such effects may contribute to the salutary effect of fish oil in renal and vascular disease
The impact of treatment with avacopan on health-related quality of life in antineutrophil cytoplasmic antibody-associated vasculitis: a post-hoc analysis of data from the ADVOCATE trial
- Author
- Agraz Pamplona Irene
- Al Jayyousi Reem
- Alberici Federico
- Amin Tania
- Andrews Jacqueline
- Anton Jordi
- Arndt Fabian
- Atsumi Tatsuya
- Au Peh Chen
- Augusto Jean-Francois
- Baines Laura Anne
- Barbour Sean
- Barrio Lucia Vicente
- Becvar Radim
- Bekker Pirow
- Belilos Elise
- Belot Alexandre
- Benck Urs Tobias
- Bergner Raoul
- Bomback Andrew S.
- Bovy Christophe
- Brachemi Soumeya
- Brogan Paul
- Bruchfeld Annette
- Brunetta Enrico
- Burnier Michel
- Burton James
- Busch Martin
- Carlin Jeffrey
- Chakera Aron
- Chang Chen Lin Yih
- Chauveau Dominique
- Chester Wasko Mary
- Chua Ignatius
- Ciggaran Secundino
- Cinta Cid Maria
- Clarkson Michael
- Collins Michael
- Cooper Bruce
- Cornec Divi
- Cournoyer Serge
- Dagna Lorenzo
- Daikeler Thomas
- Dasgupta Bhaskar
- De Vita Salvatore
- de Zoysa Janak
- Demoulin Nathalie
- Derebail Vimal K.
- Diaz Encarnacion Montserrat
- Dieperink Hans
- Dobashi Hiroaki
- Doulton Timothy William Ronald
- Dragoi Serban
- Dua Anisha
- Dudler Jean
- Emmi Giacomo
- Ficheux Maxence
- Floege Juergen
- Flossmann Oliver
- Forbess Lindsy
- Fujimoto Shoichi
- Fulladosa Oliveras Xavier
- Gabrielli Armando
- Garibotto Giacomo
- Geetha Duvuru
- Gipson Patrick
- Girard Louis-Philippe
- Gohh Reginald
- Greenwood Gregory Todd
- Gregersen Jon Waarst
- Grevbo Bard-Waldum
- Griffin Sian V.
- Grundmann Franziska
- Hagino Noboru
- Halbritter Jan
- Haller Hermann
- Harigai Masayoshi
- Harper Janice Marian
- Harper Lorraine
- Haubitz Marion
- Hauser Thomas
- Hellemans Rachel
- Hellmich Bernhard
- Henes Joerg Christoph
- Hohenstein Bernd
- Horak Pavel
- Horomanski Audra
- Hougardy Jean-Michel
- Hugenberg Steven T.
- Hugo Christian
- Ihata Atsushi
- Iking-Konert Christof
- Ivarsen Per
- Jayne David R W
- Jimenez Richard A. H.
- Jose Soler Maria
- Jourde-Chiche Noemie
- Kalstad Synove
- Kaname Shinya
- Kaneko Yuko
- Karras Alexandre
- Kaskas Marwan Omar
- Katagiri Akira
- Katayama Masao
- Kermani Tanaz
- Kidder Dana
- Kirino Yohei
- Kitagawa Kiyoki
- Kivitz Alan J.
- Klein Alexandre
- Klocke Rainer
- Koening Curry
- Komatsuda Atsushi
- Kono Hajime
- Kotter Ina
- Krarup Elizabeth
- Kronbichler Andreas
- Kubacki T
- Kurasawa Takahiko
- Kurtkoti Jagadeesh
- Lamprecht Peter
- Langford Carol A.
- Langguth Daman
- Lanyon Peter Charles
- Laurin Louis-Philippe
- Levidiotis Vicki
- Lhotta Karl
- Liang Patrick
- Lindner Tom
- Little Mark
- Luqmani Raashid
- Luxton Grant
- Lyngsoe Cecilie
- Makanjuola David Osagie
- Manenti Lucio
- Marco Rusinol Helena
- Marder Galina
- Matsumura Ryutaro
- Maurier Francois
- McCann Liza
- McLaren John Stuart
- Mehling Heidrun
- Merkel Peter A
- Mesbah Rafik
- Mimura Toshihide
- Mohamed Amr Ahmed El-Huesseini
- Molloy Eamonn
- Monach Paul
- Moranne Olivier
- Morinobu Akio
- Mount Peter
- Mudge David
- Murakawa Yohko
- Nandagudi Anupama C.
- Naniwa Taio
- Nanki Toshihiro
- Neel Antoine
- Neumann Thomas
- Neyra Nilda Roxana
- Niemer Gregory W.
- Niles John
- Noble Euan
- O'Riordan Edmond
- Obi Reginald
- Ogawa Noriyoshi
- Oshima Hisaji
- Owens Charles
- Pagnoux Christian
- Parks Deborah L.
- Patel Mumtaz
- Patel Rajan Kantilal
- Philibert David
- Phoon Richard
- Pieruzzi Federico
- Podoll Amber S.
- Praga Manuel
- Pusey Charles Dickson
- Quemeneur Thomas
- Quintana Porras Luis
- Rabindranath Kannaiyan
- Rajakariar Ravindra
- Ranganathan Dwarakanathan
- Rigothier Claire
- Ritchie Angus
- Robson Joanna C.
- Robson Michael
- Roccatello Dario
- Rosenkranz Alexander
- Rovin Brad
- Rutgers Abraham
- Ryan Jessica
- Rychlik Ivan
- Saadoun David
- Sada Kenei
- Salama Alan David
- Salvarani Carlo
- Sam R
- Schaier Matthias
- Schönermarck Ulf
- Seeger Harald
- Segarra Alfons
- Segelmark Marten
- Selvan Shilpa
- Shergy William Julius
- Silva Arnold Lawrence
- Smyth Lucy
- Soveri Inga
- Specks Ulrich
- Spiera Robert
- Sprangers Ben
- Springer Jason M.
- Sreih Antonie G.
- Strand Vibeke
- Striebich Christopher Charles
- Sugiyama Eiji
- Suranyi Michael
- Svensson My Hanna Sofia
- Swarup Areena
- Sznajd Jan
- Szombati Istvan
- Szpirt Wladimir
- Szucs Gabriella
- Takeuchi Tohru
- Taki Hirofumi
- Tamura Naoto
- Taylor Joanne
- Teng Y. K. Onno
- Terrier Benjamin
- Tesar Vladimir
- Thakar Surabhi
- Thomaidi Eleni
- Tiliakos Athan N.
- Tsai Yong
- Tsukamoto Tatsuo
- van Daele Paulus Leon Arthur
- Venhoff Nils
- Vielhauer Volker
- Vogt Bruno
- Waguespack Dia R.
- Walker Robert
- Walsh Michael
- Westman Kerstin
- Wissing Karl Martin
- Witzke Oliver
- Yamagata Kunihiro
- Yamamura Masahiro
- Yue Huibin
- Zaoui Philippe
- Publication venue
- Publication date
- 01/01/2023
- Field of study
Sparsentan in patients with IgA nephropathy: a prespecified interim analysis from a randomised, double-blind, active-controlled clinical trial
- Author
- Aaron Fearday
- Abdallah Geara
- Adam Morris
- Adriana Fernandes
- Adriana Sierra Ochoa
- Aejin Kim
- Agata Winiarska
- Aine Maire De Bhailis
- Ajay Dhaygude
- Alastair Gillies
- Alba Atenza
- Alberto Ortiz Arduan
- Alejandro Soria Villen
- Alessia Fornoni
- Alex Mercer PhD g
- Alexandre Buffet
- Alexandre Karras
- Alfred Rodriguez
- Ali Assefi
- Allister Williams
- Allyson Medina
- Alvaro Vaz
- Alvita Vickiene
- Amanda Hall
- Amanda Mather
- Amanda Siriwardana
- Amar Mahdi
- Amy Henderson
- Amy Hudson
- An Vanacker
- Ana Avila Bernabeu
- Ana Carolina Figueiredo
- Ana Cortesão Costa
- Ana Farinha
- Ana Marta Gomes
- Ana Messias
- Ana Natario
- Ana Perez de Jose
- Ana Savuk
- Ana Vilar Gimeno
- Andrea Cavalli
- Andrea Solazzo
- Andrew Bomback
- Andrew Henderson
- Andrew McNally
- Angel Forcen
- Angel Sevillano
- Angus Ritchie
- Angus Turnbull
- Anna Benesova
- Anna Jander
- Anna Ricchiuto
- Anne Blanchard
- Anne-Elisabeth Heng
- Annegret Koch
- Annette Girardet
- Annie Reynolds
- Annika Adoberg
- Anoushka Krishnan
- Anthony Ting Pong Chan
- Antolina Moreno
- Antonio Galan Serrano
- Aparna Padiyar
- Archana Gautam
- Arksarapuk Jittirat
- Arnold Silva
- Aron Chakera
- Artashes Patrikyan
- Arun Gopu
- Arunima Jain
- Arvind Ponnusamy
- Asghar Chaudhry
- Asha Bailey
- Ashik Hayat
- Ashraf Mikhail
- Asta Auerbach
- Asta Stankuviene
- Aurore Labat
- Bamidele Ajayi
- Bang-Gee Hsu
- Barbara Greco
- Bart Maes
- Bassam Alchi
- Belen Vizcaino Castillo
- Bernd Hohenstein
- Bert Vandewiele
- Bertrand Dussol
- Bhadran Bose
- Bhavna Pandya
- Biruh Workeneh
- Bogna Kwella
- Bojan Jelakovic
- Brad Rovin
- Bradley Nelson
- Brendon Neuen
- Brian Snow
- Britt Newsome
- Brittany Sheridan
- Bruce Baker
- Bruce Cooper
- Bruce Julian
- Bruce Spinowitz
- Camille Lanaret
- Caridad Martinez Villanueva
- Carlos Arias
- Carlos Gonzalez
- Carlotta Federica Zizzi
- Carmelita Marcantoni
- Carmen Sivo
- Carol Pollock
- Carole Philipponnet
- Caroline Dudreuilh
- Cassandra Kimber
- Catalina Martín Cleary
- Catarina Abrantes
- Catarina Almeida
- Catarina Teixeira
- Caterina Vita
- Catherine Janko
- Catherine Masset
- Cathylee Sly
- Celine Foote
- Chaim Charytan
- Chee Kay Cheung
- Chen Peh
- Cheng-Hsu Chen
- Cheuk Chun Szeto
- Chi Kwan Darwin Lam
- Chi-Chih Hung
- Chia-Tien Hsu
- Chiara Cogno
- Chien-Liang Chen
- Chien-Wei Huang
- Chih-Hsien Wang
- Chih-Yang Hsu
- Chii Yeap
- Christian Broyet
- Christian Combe
- Christiane Kettner
- Christine Ayvazyan
- Christophe Mariat
- Christopher Goldsmith
- Christopher Keller
- Chukwuma Chukwu
- Ciro Esposito
- Claire Rigothier
- Clara Barrios
- Clara Garcia Carro
- Clara Pardinhas
- Clarisse Greze
- Clement Dumond
- Clementine Nicolo
- Colin Geddes
- Constantina Chrysochou
- Cristina Medrano Villarroya
- Cyril Garrouste
- Damien Thibaudin
- Dan Pugh
- Dana Kim
- Dana Rizk
- Daniela Lopes
- Dariush Arfaania
- Dariusz Aksamit
- David Fouassier
- David Packham
- David Semple
- Davide Bolignano
- Davide Catucci
- Davina Ngoi Wah Lie
- Daw-Yang Hwang
- Dawn Caster
- Didem Tez
- Diliana Draganova
- Dimitrios Moutzouris
- Dita Maixnerova
- Djuro Plavljanic
- Dominik Cieniawski
- Donald Brandon
- Donald Brandon
- Dong Wan Chae
- Doris Chan
- Dorota Zielinska
- Drasko Pavlovic
- Dubravka Trajbar Kentric
- Dunja Barisic
- Dunja Vujcic
- Durga Kanigicherla
- Eamon Mahdi
- Eddie Tan
- Edgar Almeida
- Eduardo Gutierrez Martinez
- Eduardo Parra Moncasi
- Eduardo Verde Moreno
- Egle Asakiene
- Elaine Phua
- Elder Mendoza
- Elena Boaglio
- Elena Goma
- Elena Gutierrez Solis
- Eleni Stamellou
- Elizabeth Curry
- Elizabeth Hendren
- Elizabeth Stallworthy
- Ellen McCarthy
- Elsa Sofia Quadrado Soares
- Elviira Seppet
- Elzbieta Felicjanczuk
- Emily McQuarrie
- Emma Calatayud Aristoy
- Emma Diletta Stea
- Emma O'Lone
- Eric Alamartine
- Eric Firre
- Eric Koester
- Eric Thervet
- Erica Daina
- Erika Perez
- Esther Tamarit
- Eswari Vilayur
- Euan Noble
- Euan Noble
- Eva Rodriguez Garcia
- Evangelina Merida Herrero
- Ewa Satora
- Fabiola Alonso Garcia
- Fahameedah Kamal
- Faisal Fakih
- Faisal Fakih
- Farah Latif
- Farid Ghalli
- Federica Di Maio
- Federica Papadia
- Federica Urciuolo
- Fernando Eduardo Barbosa Nolasco
- Fernando Nolasco
- Figen Cakiroglu
- Filipa Cardoso
- Fiona Chapman
- Flavia Capaccio
- Francesca Annese
- Francesca Deodato
- Francesco Giaroni
- Francisco de la Prada Alvarez
- Franziska Sarnow
- Gabriel Contreras
- Gabriel Doctor
- Gabriele Donati
- Gaia Coppock
- Gary Chi Wang Chan
- Gemma Patella
- Georg Schlieper
- Georgina Irish
- Gerald Appel
- Gerald Waters
- Gert Meeus
- Giuseppe Remuzzi
- Grant Luxton
- Guillaume Claisse
- Guillaume Jeantet
- Gunjan Garg
- Gunter Wolf
- Gustavo Andres Useche Bonilla
- Hajeong Lee
- Han Ro
- Hanna Augustyniak-Bartosik
- Hans Schmidt-Guertler
- Haresh Selvaskandan
- Harold Giles
- Heather Green
- Helen Pilmore
- Helena Marco Rusinol
- Helena Sousa
- Helena Sá
- Helmut Reichel
- Hernán Trimarchi MD b l
- Hesham Mohey
- Hon Tang
- Hon-Yen Wu
- Hoon Young Choi
- Howard Lifland
- Hsien-Fu Chiu
- Hsin-Yu Chen
- Hua-Chang Fang
- Hung-Chun Chen
- Hung-Tien Kuo
- Hung-Yuan Chen
- Hye Ryoun Jang
- Hyeong Cheon Park
- Hyung Wook Kim
- Hyung-seok Lee
- HyunHee Lee
- Ian Chiu
- Ian Dittmer
- Ian Fraser
- Iara Da Silva Santos
- Indranil Dasgupta
- Inga Arune Bumblyte'
- Ingrid Masson
- Ingrid Prkacin
- Irene Agraz Pamplona
- Irina Suyumova
- Isabella Abbasciano
- Isabelle Ayoub
- Ivan Durlen
- Ivan Kruljac
- Ivan Rychlik
- Ivana Mikacic
- Ivica Horvatic
- Ivon Maritza Bobadilla Rico
- Ivon Maritza Bobadilla Rico
- Jae Hyun Chang
- Jafar Ahmed
- Jai Radhakrishnan
- James Sullivan
- James Tumlin
- Jana Uhlinova
- Jane Waugh
- Jane Waugh
- Janson Leung
- Javad Mojarrab
- Jean-Emmanuel Serre
- Jeffrey Glaze
- Jeffrey Tsun Kit Ha
- Jer-Chia Tsai
- Jerko Barbic
- Jerry Meng
- Ji Yong Jung
- Jigar Kadakia
- Jihyun Yang
- Joana de Sousa Soares Felgueiras
- Joana Gameiro
- Joana Marques
- Johann Konstantin Herfurth
- Jonathan Ayling-Smith
- Jonathan Barratt
- Jonathan Erlich
- Jonathan Hogan
- Jonay Pantoja Perez
- Jong Cheol Jeong
- Jorge Enrique Monroy Avella
- Jose Antonio Lopes
- Jose Ballarin
- Jose Carlos de Jesus Barreto
- Jose Luño Fernandez
- Jose Nuno de Almeida Agapito Fonseca
- Josep Miquel Blasco Pelicano
- Joshua Storrar
- João Carlos Fernandes
- Ju-Yeh Yang
- Juan Carbonell
- Jula Inrig MD f
- Julia Piel
- Julita Gontarek-Kacprzak
- Jung Tak Park
- JungEun Lee
- Junseok Jeon
- Jurgen Floege
- Jusmin Patel
- Justyna Zbrzezniak
- Jwa-Kyung Kim
- Ka Fai Yim
- Ka Shun Samuel Fung
- Ka Yeong Chun
- Kadri Lilienthal
- Kadri Telling
- Kai-Hsiang Shu
- Kang-Ju Chou
- Kannaiyan Rabindranath
- Karen Brown
- Karen Wilder
- Karolina Kratka
- Karolina Majstorovic Barac
- Kassem Khalil
- Kathryn Klamm
- Kay Kyaw
- Kellyn McMahon
- Kenneth Yong
- Kerri McGreal
- Kevin Schulte
- Kieran McCafferty
- Kit Chung Jack Ng
- Klara Drinovska
- Kook-Hwan Oh
- Kristi Veermae
- Kristin Unt
- Kshama Mehta
- Kuei-Ting Tung
- Kulli Kolvald
- Kumaradevan Mahadevan
- Kumaradevan Mahadevan
- Kyu-Beck Lee
- Lai Wan Chan
- Lana Gellineo
- Lathika Raakesh
- Laura Ann Kooienga
- Laure Burguet
- Lauren Floyd
- Lauren Heath
- Laurence Solomon
- Lavinia Negrea
- Lea Weiland
- Leila Chenine
- Leticia Perez Lluna
- Lida Maria Rodas Marin
- Liesbeth Viaene
- Liisi Leis
- Liliana Cunha
- Lina Santockiene
- Lisa Schulz
- Lisa Willcocks
- Loredana Colla
- Loreto Gesualdo
- Lorraine Pui Yuen Kwan
- Lothar Wolf
- Louise DaSilva
- Luc Radermacher
- Lucia Del Vecchio
- Lucia Parreira
- Luigi Biancone
- Luis F Quintana
- Luis Pedro Falcao Goncalves
- Machaiah Madhrira
- Madis Ilmoja
- Magdalena Krajewska
- Maggie Ming Yee Mok
- Mai Rosenberg
- Malgorzata Stanczyk
- Mandy Schlosser
- Mangalee Fernando
- Manual Praga
- Manuel Burdese
- Manuel Pereira de Vicente
- Marc Decupere
- Marcin Tkaczyk
- Marco Colucci
- Marcus Moeller
- Margo Laute
- Margret Patecki
- Mari Sargsyan
- Maria Angeles Goicoechea Diezhandino
- Maria Antonia Munar Vila
- Maria Antonia Munar Vila
- Maria Antonieta Azancot Rivero
- Maria Arena
- Maria Dolores Sánchez de la Nieta
- Maria Menezes
- Marija Stankovic
- Marina Reis
- Marine Livrozet
- Mario Cozzolino
- Mario Gois
- Mario Raimundo
- Mario Ruiz
- Marius Miglinas
- Mark Lagatta
- Mark Lambie
- Mark Thomas
- Marta Calvo Arevalo
- Martial Moonen
- Martin Busch
- Martin Drinkovic
- Martin Gallagher
- Martin Nitschke
- Martina Milicevic
- María Vanessa Pérez Gómez
- Massimo Torreggiani
- Matias Trillini
- Matthew Sayer
- Matthias Cassia
- May Tan
- Meera Patel Suthar
- Meg Jardine
- Mei-Chuan Kuo
- Mei-Fen Pai
- Melissa Cheetham
- Mercedes Gonzalez Moya
- Mercedes Salgueira Lazo
- Mercedes Velo Plaza
- Michael Collins
- Michael Germain
- Michel Zakari
- Michela Musolino
- Michelle N Rheault MD i
- Michelle O'Shaughnessy
- Ming-Ju Wu
- Ming-Shan Chang
- Mingyao Ma
- Mirco Belingheri
- Mirela Dobre
- Miriana Dinic
- Mohamad Kassem
- Mohammad Ali
- Mohammad Rony
- Mona Razavian
- Mona Wahba
- Monica Bordoli
- Monica Furlano
- Monica Limardo
- Montserrat Diaz Encarnacion
- Moon Hyoung Lee
- Muh Geot Wong
- Muh Geot Wong PhD m n
- Muralikrishna Gangadharan
- Myung-Gyu Kim
- Narae Joo
- Natalia Allende Burgos
- Natalia Allende Burgos
- Natalia Ramos Terrades
- Nathan Lorde
- Nayan Gowda
- Nazareno Carullo
- Neeraj Dhaun
- Neil Boudville
- Nicholas Gray
- Nick Mansfield
- Nicolas Maillard
- Nicole Douthit
- Nicolino Comi
- Nikhil Thyagarajan
- Nikolaus Wirtz
- Nisha Clement
- Nishigandha Pradhan
- Nishita Parikh
- Noemie Chiche-Jourde
- Norbert Kwella
- Norberto Perico
- Nuno Fonseca
- Olga Gracia Garcia
- Oliver Flossmann
- Olivia Wickens
- Olivier Schockaert
- Omar Sherin Ibrahim Ragy
- Paolo Randone
- Paramit Chowdhury
- Patricia Alves
- Patricia Valerio Santos
- Patrick Hamilton
- Patrick Mark
- Patrizia Passerini
- Paul Manley
- Pedro Okoh
- Peter Doubel
- Peter Hollett
- Peter Hollett
- Peter Sizeland
- Philip Clayton
- Philippe Zaoui
- Phillip Madonia
- Piergiorgio Messa
- Pierre-Louis Carron
- Pietro Canetta
- Pietro Napodano
- Piotr Jaskowski
- Po-Tsang Lee
- Po-Yu Tseng
- Pradip Chowdhury
- Praveena Jyothinagaram
- Priscilla Smith
- Prof Brad Rovin MD j
- Prof Charles E Alpers MD d
- Prof Hiddo J L Heerspink PhD a b
- Prof Howard Trachtman MD k
- Prof Irene L Noronha MD h
- Prof Jai Radhakrishnan MD c
- Prof Jonathan Barratt PhD e
- Prof Vlado Perkovic MD b ofor the PROTECT Investigators† Author links open overlay panelEric Alarmartine
- Przemyslaw Miarka
- Rachel Jones
- Radko Komers MD f
- Radu Jacob
- Raffi Minasian
- Rajan Patel
- Rajdeep Gadh
- Ramachandra Patak
- Ranjit Dhelaria
- Rathika Krishnasamy
- Rathika Krishnasamy
- Raul Fernandez Prado
- Richard Lafayette
- Rishi Pruthi
- Ritesh Raichoudhury
- Robert Carroll
- Robert Davidson
- Robert Haws
- Robert Malecki
- Roberta Aliotta
- Rocco Baccaro
- Roderick Comunale
- Roderick Comunale
- Roger Wyndham
- Rouzbeh Afsari
- Roxane Gaisset
- Rui Barata
- Sadia Jahan
- Saif Al Chalabi
- Salem Almaani
- Salia Virxinia Pol Heres
- Sam Daneshvari
- Samir Parikh
- Sandra Karanovic
- Sang-Kyung Jo
- Sapna Shah
- Sara Fernandes
- Sara Goncalves
- Sara Ombelet
- Sara Vigano
- Sarah Ashley Ford Sightler
- Sarah Lawman
- Sarah Quinn
- Sarah Roxburgh
- Saravanan Balamuthusamy
- Se Joong Kim
- Sebahat Sat
- Secundino Cigarran Guldris
- Selena Longhi
- Serena Ponti
- Seung Hyeok Han
- SeWon Oh
- Shamik Bhadra
- Shang-Feng Tsai
- Shang-Jyh Hwang
- Sharon Adler
- Shaundeep Sen
- Sheng Kuo
- Shih-Hsiang Ou
- Shih-Ping Hsu
- Shilpanjali Jesudason
- Sian Griffin
- Siddhartha Kattamanchi
- Silja Sanden
- Silvia Malvica
- Simon Mucha
- Simon Roger
- Simone Accarino
- Simone Kulka
- Siu Fai Cheung
- Smeeta Sinha
- Sofia Jorge
- Sofie Jamar
- Songuk Yoon
- Sradha Kotwal
- Sreedhar Mandayam
- Stacy Martinez
- Stefan Weiner
- Stefanie Stangenberg
- Stefano Costanzi
- Stephan Christian Werth
- Stephane Burtey
- Stephane Roueff
- Stephen McDonald
- Stewart Bieler BA a
- Sui Kon
- Suneel Udani
- Sunggyun Kim
- Susan Crail
- Susan Wan
- Suzanne Forbes
- Sven Heinrichs
- Sydney Chi Wai Tang
- Syeda Ahmad
- Sze Ho Sunny Wong
- Szu-Yu Pan
- Sónia Silva
- Tae-Hyun Yoo
- Tak Tai Andrew Yue
- Tamara Malek Marin
- Tania Salehi
- Teresa Furtado
- Theodoros Kasimatis
- Thida Maung Maung Myint
- Thilo Krueger
- Thomas Bucknall
- Thomas Malfait
- Thomas Powell
- Thomas Weinreich
- Thu Nguyen
- Tiane Dai
- Toby Coates
- Tomasz Stompor
- Tung-Min Yu
- Tze Goh
- Tzung-Yo Ho
- Ulrich Kunzendorf
- Ulysses Diva PhD f
- Unnikrishnan Pillai
- Unnikrishnan Pillai
- Ursula Verdalles Guzman
- Urte Zakauskiene
- Usha Peri
- Valentin Mayet
- Valérie de Précigout
- Veronica Viramontes
- Victor Fernandez
- Victoria Campbell
- Victoria Campbell
- Vidu Wijeratne
- Viet Nguyen
- Viet Nguyen
- Vittoria Esposito
- Vladmir Tesar
- Wai Lim
- Wai Ping Law
- Wan-Chuan Tsai
- Wanja Bernhardt
- Wenceslao Adrian Aguilera Morales
- William Paxton
- William Rote PhD f
- Wim Lemahieu
- Wladyslaw Sulowicz
- Wooin Ahn
- Wookyung Chung
- Xavier Warling
- Yahsou Delmas
- Yan Li
- Yelena Drexler
- Yen-Ling Chiu
- Yeong Hoon Kim
- Yi-Wen Chiu
- Yick Hei Wong
- Yonatan Peleg
- Young Rim Song
- YoungYoul Hyun
- Yu-Sen Peng
- Yunmi Kim
- Yusuf Eqbal
- Yusuf Eqbal
- Yvonne Shen
- Zivka Dika
- Zoltan Endre
- Zvonimir Sitas
- Publication venue
- Publication date
- 01/01/2023
- Field of study
Background: Sparsentan is a novel, non-immunosuppressive, single-molecule, dual endothelin and angiotensin receptor antagonist being examined in an ongoing phase 3 trial in adults with IgA nephropathy. We report the prespecified interim analysis of the primary proteinuria efficacy endpoint, and safety. Methods: PROTECT is an international, randomised, double-blind, active-controlled study, being conducted in 134 clinical practice sites in 18 countries. The study examines sparsentan versus irbesartan in adults (aged ≥18 years) with biopsy-proven IgA nephropathy and proteinuria of 1·0 g/day or higher despite maximised renin-angiotensin system inhibitor treatment for at least 12 weeks. Participants were randomly assigned in a 1:1 ratio to receive sparsentan 400 mg once daily or irbesartan 300 mg once daily, stratified by estimated glomerular filtration rate at screening (30 to 1·75 g/day). The primary efficacy endpoint was change from baseline to week 36 in urine protein-creatinine ratio based on a 24-h urine sample, assessed using mixed model repeated measures. Treatment-emergent adverse events (TEAEs) were safety endpoints. All endpoints were examined in all participants who received at least one dose of randomised treatment. The study is ongoing and is registered with ClinicalTrials.gov, NCT03762850. Findings: Between Dec 20, 2018, and May 26, 2021, 404 participants were randomly assigned to sparsentan (n=202) or irbesartan (n=202) and received treatment. At week 36, the geometric least squares mean percent change from baseline in urine protein-creatinine ratio was statistically significantly greater in the sparsentan group (-49·8%) than the irbesartan group (-15·1%), resulting in a between-group relative reduction of 41% (least squares mean ratio=0·59; 95% CI 0·51-0·69; p<0·0001). TEAEs with sparsentan were similar to irbesartan. There were no cases of severe oedema, heart failure, hepatotoxicity, or oedema-related discontinuations. Bodyweight changes from baseline were not different between the sparsentan and irbesartan groups. Interpretation: Once-daily treatment with sparsentan produced meaningful reduction in proteinuria compared with irbesartan in adults with IgA nephropathy. Safety of sparsentan was similar to irbesartan. Future analyses after completion of the 2-year double-blind period will show whether these beneficial effects translate into a long-term nephroprotective potential of sparsentan. Funding: Travere Therapeutics
Analysis of Outcomes in Ischemic vs Nonischemic Cardiomyopathy in Patients With Atrial Fibrillation A Report From the GARFIELD-AF Registry
- Author
- A'Court Christine
- Abdel-Qader Muwafeg
- Abe Masahiko
- Abe Masatake
- Abe Mitsunori
- Abe Sumihisa
- Abe Yukihiko
- Abhayaratna Walter
- Accogli Michele
- Adachi Susumu
- Adachi Toru
- Adak Dhriti
- Adam Matthew
- Adriaansen Henk
- Aegerter Emanuel
- Ageta Masato
- Aggarwala Anil
- Agnelli Giancarlo
- AgnieszkaMetzgier-Gumiela AgnieszkaMetzgier-Gumiela
- Ahlmark Hakan
- Ahmad Kamran
- Ahmad Shahid
- Ahmed Fayzal
- Ahn Jung Joo
- Akers Lori
- Akiyama Masahiro
- Al Mahmeed Wael
- Al-Khalili Faris
- Alberts Mark
- Alborough Elizabeth
- Aldegather Jehad
- Aleksandrova Elena
- Alexandre Almeida Carlos
- Ali Amar
- Ali Gholam
- Alia Pilar Montero
- Allasia Bartolomeo
- Alonso Carmela
- Alonso Concepcion
- Altun Armagan
- Alunni Massimo
- Alvarez Garcia Pere
- Alvarez Douglas
- Alvarez Miguel
- Alzogaray Maria Fernanda
- Amarenco Pierre
- Amaro Marisol
- Ambicka Monika
- Ambrosino Pasquale
- Ambrosio Giuseppe
- Amin Joseph
- Amrhein Diana
- Amstutz Daniela
- An Hae Jung
- Andere Natalia
- Andersson Agneta
- Andersson Lisbeth
- Ando Hiroshi
- Ando Shinichi
- Andrzejewski Dariusz
- Angaran Paul
- Ansoult Nadege
- Antonova Petra
- Antonsen Hege
- Aoki Kenji
- Aoyama Takuma
- Appleby Nigel
- Appleby Nigel
- Aracil Villar Joaquin
- Arai Hidekazu
- Araminowicz Joanna
- Aras Funda
- Arcocha Torres Maria Fe
- Argena Antonio
- Arima Shinichi
- Armangau Pauline
- Arstall Margaret
- Asafu-Adjaye Nana
- Asano Hiroshi
- Asano Taku
- Ashraf M. Javed
- Assagay Maharajh S.
- Assouline Serge
- Astridge Penny
- Atar Dan
- Atar Dan
- Ausen Karin
- Austria Aileen
- Aves Theresa
- Avinc Gamze
- Avinc Gamze
- Avinc Gamze
- Axthelm Christoph
- Ayar Ozge
- Aydinlar Ali
- Ayres Bronte
- Azakami Shiro
- Aziz Michael
- Azuma Junya
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- Baglioni Gregorio
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- Barkowski Timothy
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- Barnes Dylan
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- Barraquer Feu Edelmira
- Barreau Angeline
- Barreda Maria
- Barretto Antonio Carlos Pereira
- Barrow Susan
- Barry Lisa
- Bartkowiak Radoslaw
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- Bartnik Jerzy
- Basiak Marcin
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- Bassand Jean-Pierre
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- Belenky Dmitry
- Bengtsberg Daniel
- Bennett James
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- Goldhaber Samuel Z.
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- Kodera Kojiro
- Koeln DrWeber
- Koeniger Georg
- Koeniger Praxis Dr
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- van Zyl Louis
- Vandamme Xavier
- Vandrus Boglarka
- Vangel Sandor
- Vardcentral Sunne
- Vardon Elizabeth
- Vardon Elizabeth
- Varol Sinan
- Vazquez Caamano Maria
- Vazquez Gloria Millan
- Veale Richard
- Vercoe Stephen
- Verheugt Freek W. A.
- Verheugt Freek W. A.
- Vertes Andras
- Vicic Judy
- Vicic Judy
- Vida Gutierrez Manuel
- Vila Alicia Martin
- Villani Rosanna
- Vinolas Xavier
- Vishnevsky Alexander
- Vizel Saul
- Voelkel-Babyesiza Regina
- Voigts Birgit
- Volodicheva Olga
- Volpe Massimo
- Vonbank Alexander
- Vorasettakarnkij Yongkasem
- Vormann Reinhold
- Vorster Mary
- Vorster Mary
- Vue Belle
- Vyhlidalova Veronika
- Wada Masamichi
- Wagner Helga
- Wakeling John
- Wakeman Anne
- Waldman Alla
- Walker Martin
- Walko Bogdan
- Wang Daowen
- Wang Y.
- Wang Yong
- Warke A.
- Wastling Rebecca
- Webster Chelsea
- Wegmayr Claudia
- Wegrzynowska Marta
- Wegrzynowska Marta
- Weichelt Sylvia
- Weiser Ute
- Weitbrecht Luis
- Welker James
- Wesolowska Kamila
- Wielkopolska Sroda
- Wierzbicka Aleksandra
- Wildenauer Cosmas
- Wilford Emily
- Williams Celestine
- Williams Philip
- Wilson Pete
- Wilson Vance
- Winkler Helga
- Winnik Stephan
- Wirdby Alexander
- Wisaratapong Treechada
- Wiswedel Henning
- Wohrer Claudia
- Wolf Thomas
- Wong Bennett
- Wong Mike
- Wongtheptien Andwattana
- Wood Annette
- Wood Kristine
- Woody Jill
- Worthy Vanetta
- Wozakowska-Kaplon Beata
- Wozniak-Skowerska Iwona
- Wright Debbie
- Wurziger Juergen
- Xue Li
- Yagensky Andriy
- Yakupov Eduard
- Yamada Takehiro
- Yamaguchi Hiroshi
- Yamamoto Kenichi
- Yamamoto Kentaro
- Yamamoto Kiichiro
- Yamamoto Kunihiko
- Yamamoto Taku
- Yamasawa Masanori
- Yamaura Makoto
- Yamazoe Masahiro
- Yang Jingshan
- Yang Lingli
- Yang Zhiming
- Yawila Suree
- Yildirim Rifat
- Yilmaz Faruk
- Yilmaz Ozcan
- Yokota Naoto
- Yokoyama Yasuhiro
- Yoon Eunji
- Yoon Jung Han
- Yoshida Keiki
- Yoshida Tetsuro
- Yoshida Tomohiro
- Yoshida Tomoki
- Yoshimura Akira
- Yoshizawa Naoto
- Yu HyunJu
- Yu Ting
- Yusuf Huma
- Yuyang Tan
- Zaatout Eman
- Zaitsu Ryuji
- Zak Jan
- Zakutynska-Kowalczyk Karolina
- Zaluska Roman
- Zaman Kashif
- Zateyshchikov Dmitry
- Zauzig Heinz-Dieter
- Zdrowotnej Zespol Opieki
- Zecca Cinzia
- Zemlianskaia Oksana
- Zhai Hong
- Zhan Qiong
- Zhang Guoshan
- Zhang Huaiqin
- Zhang Ran
- Zhang Yi
- Zhao Yusheng
- Zhuravleva Evgeniya
- Zidek Milan
- Zidkova Eva
- Zika Jiri
- Zillo Mariana
- Zimmett Leon
- Zimny Hans-Hermann
- Zincke Stephanie
- Zinka Elzbieta
- Zinka Elzbieta
- Zotova Irina
- Zubeeva Galina
- Zuber Mathieu
- Zutz Stefan
- Zwenkau Schwarz
- Zyczynska Malgorzata
- Publication venue
- 'American Medical Association (AMA)'
- Publication date
- 01/06/2019
- Field of study
IMPORTANCE Congestive heart failure (CHF) is commonly associated with nonvalvular atrial fibrillation (AF), and their combination may affect treatment strategies and outcomes