Ressenyes

Index de les obres ressenyades: Patrizia DALLA ROSA ; Bianca Maria DA RIF, Un gigante trascurato 1988-2008 : vent'anni di promozione di studi dell'Associazione Internazionale Dino Buzzat

Magnetism and structure of LixCoO2 and comparison to NaxCoO2

The magnetic properties and structure of LixCoO2 for x between 0.5 and 1.0 are reported. Co4+ is found to be high-spin in LixCoO2 for x between 0.94 and 1.0 and low-spin for x between 0.50 and 0.78. Weak antiferromagnetic coupling is observed, increasing in strength as more Co4+ is introduced. At an x value of about 0.65, the temperature-independent contribution to the magnetic susceptibility and the electronic contribution to the specific heat are largest. Neutron diffraction analysis reveals that the lithium oxide layer expands perpendicular to the basal plane and the Li ions displace from their ideal octahedral sites with decreasing x. A comparison of the structures of the NaxCoO2 and LixCoO2 systems reveals that the CoO2 layer changes substantially with alkali content in the former but is relatively rigid in the latter. Further, the CoO6 octahedra in LixCoO2 are less distorted than those in NaxCoO2. We postulate that these structural differences strongly influence the physical properties in the two systems

Evolution of physical training in football

En el ámbito del deporte, ha venido siendo demostrado, que uno de los factores más importantes para que el deportista pueda rendir en las mejores condiciones es el de tener una buena preparación física. Independientemente del perfeccionamiento técnico, apoyo médico, nutrición, nuevos materiales, etc. La preparación física ha experimentado en los últimos años una evolución extraordinaria, tanto en cantidad como en calidad. En las últimas décadas las ciencias del deporte han evolucionado enormemente, producto de ello son los avances aparecidos en la preparación física en el fútbol a todos sus niveles. En este artículo se analizan las principales tendencias que históricamente han venido empleándose para la mejora de las diferentes cualidades físicas que implican la práctica de este deporte, con el objetivo de alcanzar el mejor rendimiento posible

Caveolin-1 Modulates Mechanotransduction Responses to Substrate Stiffness through Actin-Dependent Control of YAP

The transcriptional regulator YAP orchestrates many cellular functions, including tissue homeostasis, organ growth control, and tumorigenesis. Mechanical stimuli are a key input to YAP activity, but the mechanisms controlling this regulation remain largely uncharacterized. We show that CAV1 positively modulates the YAP mechanoresponse to substrate stiffness through actin-cytoskeleton-dependent and Hippo-kinase-independent mechanisms. RHO activity is necessary, but not sufficient, for CAV1-dependent mechanoregulation of YAP activity. Systematic quantitative interactomic studies and image-based small interfering RNA (siRNA) screens provide evidence that this actin-dependent regulation is determined by YAP interaction with the 14-3-3 protein YWHAH. Constitutive YAP activation rescued phenotypes associated with CAV1 loss, including defective extracellular matrix (ECM) remodeling. CAV1-mediated control of YAP activity was validated in vivo in a model of pancreatitis-driven acinar-to-ductal metaplasia. We propose that this CAV1-YAP mechanotransduction system controls a significant share of cell programs linked to these two pivotal regulators, with potentially broad physiological and pathological implications. Moreno-Vicente et al. report that CAV1, a key component of PM mechanosensing caveolae, mediates adaptation to ECM rigidity by modulating YAP activity through the control of actin dynamics and phosphorylation-dependent interaction of YAP with the 14-3-3-domain protein YWHAH. Cav1-dependent YAP regulation drives two pathophysiological processes: ECM remodeling and pancreatic ADM. © 2018 The Author