On the symmetric 2-(v,k,λ) designs with a flag-transitive point-imprimitive automorphism group

The symmetric 2-(v,k,λ) designs with k>λ(λ−3)/2 admitting a flag-transitive point-imprimitive automorphism group are completely classified: they are the known 2-designs with parameters (16,6,2),(45,12,3),(15,8,4) or (96,20,4)

Mitigation of environmental damage by monitoring chemical biological indices of disturbed soil

The Soil Biodiversity platform has invited researchers, politicians, decision-makers, industries, and states to seriously consider soil biodiversity conservation, including all kinds of microorganisms: ‘The maintenance of soil biodiversity is essential to both the environment and agricultural industries.’ Moreover, since 2015, the ‘Cross-Sector Biodiversity Initiative (CSBI)’ has presented a platform for the development and sharing of ‘good practices’ to be implemented concerning the protection and restoration of ‘biodiversity’ in extractive activities. This platform is a collaborative tool to access the knowledge and collective experience of experts in the sector. It provides practical guidance, innovative approaches, and examples to support mitigation operationalizing. In addition, CSBI has developed some guides to limit, as far as possible, the negative impacts on the biodiversity of development projects and activate the processes of mitigating the damage and recovery of biodiversity. Our study aimed to assess the severity of soil disturbance in an industrial area using chemical-biological indicators and to suggest mitigation and restoration activities. For soil quality restoration, it was necessary to encourage land management practices to increase the levels of organic matter and soil biodiversity. In particular, minimum soil tillage and no-tillage practices to maintain soil cover, improve its structure, maintenance, and increase of perennial plants, and finally, careful/limited use of fertilizers. The chemical-biological indices after one year have highlighted a clear improvement in the state of health of the soil in chemical-physical, microbiological, and entomo-fauna terms. The soil and its entire community of living beings can adapt and react to difficultie

Robotization of the IR-Thermographic technique – impact on the visualisation quality and considerations on the data workflow

Quality control automation is becoming increasingly popular in industrial production lines. Active thermography techniques are well-regarded for their adaptability, providing fast, non-contact, and full-field non-destructive evaluation. Automating thermographic evaluation can increase assessment speed and repeatability without sacrificing inspection accuracy. By using a robot arm to manipulate the thermographic setup, it becomes possible to inspect large components and refine scans on suspicious zones, even in parts with complex geometries. In this study, the performance of a new thermographic inspection platform is compared with a conventional setup to showcase the potential improvements. A plastic curved-shaped sample with artificial flat bottom hole defects is used as a benchmark for the comparison. The advantages and disadvantages of robotizing the infrared non-destructive setup are analyzed, and the impact of the data workflow and future research activities are also discussed

Mechanical properties of carbon nanotube fibres: St Venant's principle at the limit and the role of imperfections

Carbon nanotube (CNT) fibres, especially if perfect in terms of purity and alignment, are of extreme anisotropy. With their high axial strength but ready slippage between the CNTs, there is utmost difficulty in transferring the force applied uniformly. Finite element analysis is used to predict the stress distribution in CNT fibres loaded by grips attached to their surface, along with the resulting tensile stress-strain curves. This study demonstrates that in accordance with St Venant’s principle very considerable length-to-diameter ratios (~ 103) are required before the stress becomes uniform across the fibre, even at low strains. It is proposed that lack of perfect orientation and presence of carbonaceous material between bundles greatly enhances the stress transfer, thus increasing the load it can carry before failing by shear. It is suggested that a very high strength batch of fibres previously observed experimentally had an unusually high concentration of internal particles, meaning that the pressure exerted by the grips would assist stress transfer between the layers. We conclude, that the strength of CNT fibres depends on the specific testing geometries and that imperfections, whether by virtue of less-than-perfect orientation or of embedded impurities, are actually major positive contributors to the observed strength.The authors are grateful to USN ONR GLOBAL for the provision of funding under award number N62909-14-1-N200. Any opinions, findings, and conclusions or recommendations expressed in this material are those of the author(s) and do not necessarily reflect the views of the Office of Naval Research.This is the accepted manuscript. The final version is available at http://www.sciencedirect.com/science/article/pii/S0008622315004728

Quantum dot opto-mechanics in a fully self-assembled nanowire

We show that fully self-assembled optically-active quantum dots (QDs) embedded in MBE-grown GaAs/AlGaAs core-shell nanowires (NWs) are coupled to the NW mechanical motion. Oscillations of the NW modulate the QD emission energy in a broad range exceeding 14 meV. Furthermore, this opto-mechanical interaction enables the dynamical tuning of two neighboring QDs into resonance, possibly allowing for emitter-emitter coupling. Both the QDs and the coupling mechanism -- material strain -- are intrinsic to the NW structure and do not depend on any functionalization or external field. Such systems open up the prospect of using QDs to probe and control the mechanical state of a NW, or conversely of making a quantum non-demolition readout of a QD state through a position measurement.Comment: 20 pages, 6 figure

Sterile Inflammation Fuels Gastric Cancer

Constitutively activated NF-κB signaling has long been known to be oncogenic. In this issue of Immunity, O’Reilly et al. (2018) unveil a link between loss of NF-κB1, aberrant STAT1 signaling, sterile inflammation, and the increased expression of immune checkpoint molecules as cancer drivers

Testing the Dispersion of Nanoparticles in a Nanocomposite with an Ultra-Low Fill Content Using a Novel Non-Destructive Evaluation Technique

A non-destructive evaluation (NDE) technique capable of testing the dispersion of nanoparticles in a nanocomposite would be of great use to the industry to check the quality of the products made and to ensure compliance with their specifications. Very few NDE techniques found in the literature can evaluate the level of dispersion of the nanoparticles in the whole nanocomposite. Here, a recently developed NDE technique based on pulsed phase thermography (PPT) in transmission mode was used to assess the particle dispersion in ultra-low, less than 0.05 wt%, Ag enriched polymeric based nanocomposite manufactured with an innovative nano-coating fragmentation technique. The phasegrams obtained with the presented technique clearly showed clusters or bundles of Ag nanoparticles when present, down to the size of 6 µm. Therefore, the new NDE approach can be applied to verify that the expected levels of dispersion are met in the production process

DİAZEPAM DEGRADATİON USİNG SOLAR PHOTOCATALYSİS

Benzodiazepine drugs are used all over the world for anxiety disorders, as anticonvulsants and anti-epileptics, and for terminally ill people as part of essential medicines list from the World Health Organisation (WHO). The WHO list includes diazepam, which is frequently found as residual pollutant in secondary effluents from wastewater treatment plants (WWTPs). Aiming at the complete removing of this substance from the aqueous environments, two experiments were carried out using Advanced Oxidation Process (AOPs) by simulated solar irradiation with or without TiO2 as catalyst. Photocatalysis was much efficient (half-life = 6 hours) than photolysis (half-life = 34 hours) giving a series of byproduct that were identified by an LC system coupled to a hybrid linear quadrupole ion trap (LTQ)-Fourier-transform ion cyclotron resonance (FT-ICR) mass spectromete

Adoptive immunotherapy with Cl-IB-MECA-treated CD8+T cells reduces melanoma growth in mice

Cl-IB-MECA is a selective A3 adenosine receptor agonist, which plays a crucial role in limiting tumor progression. In mice, Cl-IB-MECA administration enhances the anti-tumor T cell-mediated response. However, little is known about the activity of Cl-IB-MECA on CD8+ T cells. The aim of this study was to investigate the effect of ex vivo Cl-IB-MECA treatment of CD8+ T cells, adoptively transferred in melanoma-bearing mice. Adoptive transfer of Cl-IB-MECA-treated CD8+ T cells or a single administration of Cl-IB-MECA (20 ng/mouse) inhibited tumor growth compared with the control group and significantly improved mouse survival. This was associated with the release of Th1-type cytokines and a greater influx of mature Langerin+ dendritic cells (LCs) into the tumor microenvironment. CD8+ T cells treated with Cl-IB-MECA released TNF-α which plays a critical role in the therapeutic efficacy of these cells when injected to mice. Indeed, neutralization of TNF-α by a specific monoclonal Ab significantly blocked the anti-tumor activity of Cl-IB-MECA-treated T cells. This was due to the reduction in levels of cytotoxic cytokines and the presence of fewer LCs. In conclusion, these studies reveal that ex vivo treatment with Cl-IB-MECA improves CD8+ T cell adoptive immunotherapy for melanoma in a TNF-α-dependent manner

Projecting Ancient Ancestry in Modern-Day Arabians and Iranians: A Key Role of the Past Exposed Arabo-Persian Gulf on Human Migrations

The Arabian Peninsula is strategic for investigations centered on the early structuring of modern humans in the wake of the out-of-Africa migration. Despite its poor climatic conditions for the recovery of ancient human DNA evidence, the availability of both genomic data from neighboring ancient specimens and informative statistical tools allow modeling the ancestry of local modern populations. We applied this approach to a data set of 741,000 variants screened in 291 Arabians and 78 Iranians, and obtained insightful evidence. The west-east axis was a strong forcer of population structure in the Peninsula, and, more importantly, there were clear continuums throughout time linking western Arabia with the Levant, and eastern Arabia with Iran and the Caucasus. Eastern Arabians also displayed the highest levels of the basal Eurasian lineage of all tested modern-day populations, a signal that was maintained even after correcting for a possible bias due to a recent sub-Saharan African input in their genomes. Not surprisingly, eastern Arabians were also the ones with highest similarity with Iberomaurusians, who were, so far, the best proxy for the basal Eurasians amongst the known ancient specimens. The basal Eurasian lineage is the signature of ancient non-Africans who diverged from the common European-eastern Asian pool before 50,000 years ago, prior to the later interbred with Neanderthals. Our results appear to indicate that the exposed basin of the Arabo-Persian Gulf was the possible home of basal Eurasians, a scenario to be further investigated by searching ancient Arabian human specimens.This work was financed by FEDER-Fundo Europeu de Desenvolvimento Regional funds through COMPETE 2020-Operacional Programme for Competitiveness and Internationalization (POCI), Portugal 2020, by Portuguese funds through FCT-Fundação para a Ciência e a Tecnologia, Ministério da Ciência, Tecnologia e Inovação in the framework of the project “Biomedical anthropological study in Arabian Peninsula based on high-throughput genomics” (POCI-01-0145-FEDER-016609), the Italian Ministry of Education, University and Research project Dipartimenti di Eccellenza Program (2018–2022)—Department of Biology and Biotechnology “L. Spallanzani,” University of Pavia (to A.T.). V.F. has a postdoc grant through FCT (SFRH/BPD/114927/2016). i3S is financed by FEDER-COMPETE 2020, Portugal 2020 and by Portuguese funds through FCT in the framework of the project “Institute for Research and Innovation in Health Sciences” (POCI-01-0145-FEDER-007274). Authors would like to thank Dr Francesco Bertolini for facilitating the research of A.R. in the last stage of the article preparation