4,418 research outputs found
Mortality following a brain tumour diagnosis in patients with multiple sclerosis
Objectives: As brain tumours and their treatment may theoretically have a poorer prognosis in inflammatory central nervous system diseases such as multiple sclerosis (MS), all-cause mortality following a brain tumour diagnosis was compared between patients with and without MS. The potential role of age at tumour diagnosis was also examined. Setting: Hospital inpatients in Sweden with assessment of mortality in hospital or following discharge. Participants: Swedish national registers identified 20 543 patients with an MS diagnosis (1969-2005) and they were matched individually to produce a comparison cohort of 204 163 members of the general population without MS. Everyone with a primary brain tumour diagnosis was selected for this study: 111 with MS and 907 without MS. Primary and secondary outcome measures: 5-year mortality risk following brain tumour diagnosis and age at brain tumour diagnosis. Results: A non-statistically significant lower mortality risk among patients with MS (lower for those with tumours of high-grade and uncertain-grade malignancy and no notable difference for low-grade tumours) produced an unadjusted HR (and 95% CI) of 0.75 (0.56 to 1.02). After adjustment for age at diagnosis, grade of malignancy, sex, region of residence and socioeconomic index, the HR is 0.91 (0.67-1.24). The change in estimate was largely due to adjustment for age at brain tumour diagnosis, as patients with MS were on average 4.7 years younger at brain tumour diagnosis than those in the comparison cohort (p<0.001). Conclusions: Younger age at tumour diagnosis may contribute to mortality reduction in those with highgrade and uncertain-grade brain tumours. Survival following a brain tumour is not worse in patients with MS; even after age at brain tumour diagnosis and grade of malignancy are taken into account
Low magnetic Prandtl number dynamos with helical forcing
We present direct numerical simulations of dynamo action in a forced Roberts
flow. The behavior of the dynamo is followed as the mechanical Reynolds number
is increased, starting from the laminar case until a turbulent regime is
reached. The critical magnetic Reynolds for dynamo action is found, and in the
turbulent flow it is observed to be nearly independent on the magnetic Prandtl
number in the range from 0.3 to 0.1. Also the dependence of this threshold with
the amount of mechanical helicity in the flow is studied. For the different
regimes found, the configuration of the magnetic and velocity fields in the
saturated steady state are discussed.Comment: 9 pages, 14 figure
Consanguineous marriage, prepregnancy maternal characteristics and stillbirth risk: A population-based case-control study
Introduction. Consanguineous marriage is associated with increased risks for congenital anomalies, low birthweight, and other adverse perinatal outcomes. In this population-based, case-control study we investigated the association between consanguineous marriage (first-cousin marriage) and stillbirth risk, using prospectively collected information from prepregnancy visits. Material and methods. From 2007 to 2009, we identified 283 stillbirths (cases) and 2088 randomly selected live control births through prepregnancy visits in rural Golestan, Iran. The associations between consanguinity and prepregnancy maternal characteristics and stillbirth risk were examined using multivariate logistic regression. Results. The rate of consanguineous marriage was 19.4% among cases and 13.6% among controls. Consanguinity was associated with increased stillbirth risk [odds ratio (OR) 1.53; 95% CI 1.10-2.14]. The association was significantly increased for preterm stillbirth (< 37 gestational weeks) (OR 2.43; 95% CI 1.46-4.04) but not for term stillbirth (≥ 37 weeks) (OR 1.14; 95% CI 0.75-1.74). Low and high maternal age, underweight, obesity, nulliparity, a history of infertility or miscarriage, previous obstetric complications (preeclampsia, preterm delivery, and stillbirth in previous pregnancies) were also associated with increased stillbirth risks. Conclusions. Consanguineous marriage is associated with increased risk of stillbirth, particularly preterm stillbirth. Findings for other maternal risk factors for stillbirth in rural Iran are consistent with previously reported findings from high-income countries. © 2015 Nordic Federation of Societies of Obstetrics and Gynecology
Needed Research on the Englishes of Appalachia
Information about the 79th annual meeting of the Southeastern Conference on Linguistics (SECOL) organized by Jennifer Cramer at the University of Kentucky on April 2012 in Lexington, Kentucky. Topics discussed at the meeting includes current state of research studies on linguistic processes in Appalachia, traditional dialectological and ethnographic. The meeting also featured panel experts including Bridget L. Anderson, Michael Montgomery and Walt Wolfram
Measuring ^{12}C(&alpha,&gamma)^{16}O from White Dwarf Asteroseismology
During helium burning in the core of a red giant, the relative rates of the
3&alpha and ^{12}C(&alpha,&gamma)^{16}O reactions largely determine the final
ratio of carbon to oxygen in the resulting white dwarf star. The uncertainty in
the 3&alpha reaction at stellar energies due to the extrapolation from
high-energy laboratory measurements is relatively small, but this is not the
case for the ^{12}C(&alpha,&gamma)^{16}O reaction. Recent advances in the
analysis of asteroseismological data on pulsating white dwarf stars now make it
possible to obtain precise measurements of the central ratio of carbon to
oxygen, providing a more direct way to measure the ^{12}C(&alpha,&gamma)^{16}O
reaction rate at stellar energies. We assess the systematic uncertainties of
this approach and quantify small shifts in the measured central oxygen
abundance originating from the observations and from model settings that are
kept fixed during the optimization. Using new calculations of white dwarf
internal chemical profiles, we find a rate for the ^{12}C(&alpha,&gamma)^{16}O
reaction that is significantly higher than most published values. The accuracy
of this method may improve as we modify some of the details of our description
of white dwarf interiors that were not accessible through previous
model-fitting methods.Comment: 8 pages, 4 figures, 3 tables, uses emulateapj5.sty, Accepted for
publication in the Astrophysical Journa
Very High Mach Number Electrostatic Shocks in Collisionless Plasmas
The kinetic theory of collisionless electrostatic shocks resulting from the
collision of plasma slabs with different temperatures and densities is
presented. The theoretical results are confirmed by self-consistent
particle-in-cell simulations, revealing the formation and stable propagation of
electrostatic shocks with very high Mach numbers (), well above the
predictions of the classical theories for electrostatic shocks.Comment: 6 pages, submitted to Phys. Rev. Let
Swimming in curved space or The Baron and the cat
We study the swimming of non-relativistic deformable bodies in (empty) static
curved spaces. We focus on the case where the ambient geometry allows for rigid
body motions. In this case the swimming equations turn out to be geometric. For
a small swimmer, the swimming distance in one stroke is determined by the
Riemann curvature times certain moments of the swimmer.Comment: 19 pages 6 figure
Hydrodynamic and magnetohydrodynamic computations inside a rotating sphere
Numerical solutions of the incompressible magnetohydrodynamic (MHD) equations
are reported for the interior of a rotating, perfectly-conducting, rigid
spherical shell that is insulator-coated on the inside. A previously-reported
spectral method is used which relies on a Galerkin expansion in
Chandrasekhar-Kendall vector eigenfunctions of the curl. The new ingredient in
this set of computations is the rigid rotation of the sphere. After a few
purely hydrodynamic examples are sampled (spin down, Ekman pumping, inertial
waves), attention is focused on selective decay and the MHD dynamo problem. In
dynamo runs, prescribed mechanical forcing excites a persistent velocity field,
usually turbulent at modest Reynolds numbers, which in turn amplifies a small
seed magnetic field that is introduced. A wide variety of dynamo activity is
observed, all at unit magnetic Prandtl number. The code lacks the resolution to
probe high Reynolds numbers, but nevertheless interesting dynamo regimes turn
out to be plentiful in those parts of parameter space in which the code is
accurate. The key control parameters seem to be mechanical and magnetic
Reynolds numbers, the Rossby and Ekman numbers (which in our computations are
varied mostly by varying the rate of rotation of the sphere) and the amount of
mechanical helicity injected. Magnetic energy levels and magnetic dipole
behavior are exhibited which fluctuate strongly on a time scale of a few eddy
turnover times. These seem to stabilize as the rotation rate is increased until
the limit of the code resolution is reached.Comment: 26 pages, 17 figures, submitted to New Journal of Physic
On the electrodynamics of moving bodies at low velocities
We discuss the seminal article in which Le Bellac and Levy-Leblond have
identified two Galilean limits of electromagnetism, and its modern
implications. We use their results to point out some confusion in the
literature and in the teaching of special relativity and electromagnetism. For
instance, it is not widely recognized that there exist two well defined
non-relativistic limits, so that researchers and teachers are likely to utilize
an incoherent mixture of both. Recent works have shed a new light on the choice
of gauge conditions in classical electromagnetism. We retrieve Le
Bellac-Levy-Leblond's results by examining orders of magnitudes, and then with
a Lorentz-like manifestly covariant approach to Galilean covariance based on a
5-dimensional Minkowski manifold. We emphasize the Riemann-Lorenz approach
based on the vector and scalar potentials as opposed to the Heaviside-Hertz
formulation in terms of electromagnetic fields. We discuss various applications
and experiments, such as in magnetohydrodynamics and electrohydrodynamics,
quantum mechanics, superconductivity, continuous media, etc. Much of the
current technology where waves are not taken into account, is actually based on
Galilean electromagnetism
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