A Streamlined Strategy for Aglycone Assembly and Glycosylation

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/102108/1/ange_201307680_sm_miscellaneous_information.pdfhttp://deepblue.lib.umich.edu/bitstream/2027.42/102108/2/13892_ftp.pd

A Streamlined Strategy for Aglycone Assembly and Glycosylation

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/102092/1/13647_ftp.pdfhttp://deepblue.lib.umich.edu/bitstream/2027.42/102092/2/anie_201307680_sm_miscellaneous_information.pd

Orthopaedic provider perceptions of virtual care : which providers prefer virtual care?

AIMS: The purpose of our study was to determine which groups of orthopaedic providers favour virtual care, and analyze overall orthopaedic provider perceptions of virtual care. We hypothesize that providers with less clinical experience will favour virtual care, and that orthopaedic providers overall will show increased preference for virtual care during the COVID-19 pandemic and decreased preference during non-pandemic circumstances. METHODS: An orthopaedic research consortium at an academic medical system developed a survey examining provider perspectives regarding orthopaedic virtual care. Survey items were scored on a 1 to 5 Likert scale (1 = strongly disagree , 5 = strongly agree ) and compared using nonparametric Mann-Whitney U test. RESULTS: Providers with less experience were more likely to recommend virtual care for follow-up visits (3.61 on the Likert scale (SD 0.95) vs 2.90 (SD 1.23); p = 0.006) and feel that virtual care was essential to patient wellbeing (3.98 (SD 0.95) vs 3.00 (SD 1.16); p \u3c 0.001) during the pandemic. Less experienced providers also viewed virtual visits as providing a similar level of care as in-person visits (2.41 (SD 1.02) vs 1.76 (SD 0.87); p = 0.006) and more time-efficient than in-person visits (3.07 (SD 1.19) vs 2.34 (SD 1.14); p = 0.012) in non-pandemic circumstances. During the pandemic, most providers viewed virtual care as effective in providing essential care (83.6%, n = 51) and wanted to schedule patients for virtual care follow-up (82.2%, n = 50); only 10.9% (n = 8) of providers preferred virtual visits in non-pandemic circumstances. CONCLUSION: Orthopaedic providers with less clinical experience seem to favourably view virtual care both during the pandemic and under non-pandemic circumstances. Providers in general appear to view virtual care positively during the pandemic but are less accommodating towards it in non-pandemic circumstances

Manufacturing Workers Have a Higher Incidence of Carpal Tunnel Syndrome

OBJECTIVE: It is unclear whether clerical or labor-type work is more associated with risk for developing work-related carpal tunnel syndrome (WrCTS). METHODS: National employment, demographic, and injury data were examined from the Bureau of Labor Statistics databases for the years 2003 to 2018. Injuries for clerical and labor industries were compared using linear regression, two-group t test, and one-way analysis of variance (ANOVA) analysis. RESULTS: WrCTS injuries are decreasing over time (B = -1002.62, P \u3c 0.001). The labor industry demonstrated a significantly higher incidence of WrCTS when compared with the clerical industries (P \u3c 0.001). Within labor industries, the manufacturing industry had the highest incidence of WrCTS over time (P \u3c 0.001). CONCLUSIONS: Our study showed WrCTS injuries have declined over time. Additionally, our findings may suggest that the labor industry has a stronger association with WrCTS than the clerical industry

Are orthopaedic providers willing to work overtime to address COVID-19-related patient backlogs and financial deficits?

AIMS: COVID-19-related patient care delays have resulted in an unprecedented patient care backlog in the field of orthopaedics. The objective of this study is to examine orthopaedic provider preferences regarding the patient care backlog and financial recovery initiatives in response to the COVID-19 pandemic. METHODS: An orthopaedic research consortium at a multi-hospital tertiary care academic medical system developed a three-part survey examining provider perspectives on strategies to expand orthopaedic patient care and financial recovery. Section 1 asked for preferences regarding extending clinic hours, section 2 assessed surgeon opinions on expanding surgical opportunities, and section 3 questioned preferred strategies for departmental financial recovery. The survey was sent to the institution\u27s surgical and nonoperative orthopaedic providers. RESULTS: In all, 73 of 75 operative (n = 55) and nonoperative (n = 18) providers responded to the survey. A total of 92% of orthopaedic providers (n = 67) were willing to extend clinic hours. Most providers preferred extending clinic schedule until 6pm on weekdays. When asked about extending surgical block hours, 96% of the surgeons (n = 53) were willing to extend operating room (OR) block times. Most surgeons preferred block times to be extended until 7pm (63.6%, n = 35). A majority of surgeons (53%, n = 29) believe that over 50% of their surgical cases could be performed at an ambulatory surgery centre (ASC). Of the strategies to address departmental financial deficits, 85% of providers (n = 72) were willing to work extra hours without a pay cut. CONCLUSION: Most orthopaedic providers are willing to help with patient care backlogs and revenue recovery by working extended hours instead of having their pay reduced. These findings provide insights that can be incorporated into COVID-19 recovery strategies. Level of Evidence: II

Upper-Extremity Injuries are the 2nd Most Common Workplace Injuries from 1992 to 2018

Musculoskeletal injuries occur frequently in the workplace, yet it is unclear whether upper-extremity, lower-extremity, or trunk injuries are the most prevalent. We hypothesize that: (1) trunk injuries are the most common in the overall workplace, and (2) upper-extremity injuries are more common in labor-based industries than non-labor industries. Workplace related injury data from 1992 to 2018 was collected from the Bureau of Labor Statistics “Workplace Injuries & Illnesses” database. Occurrence of trunk, upper-extremity, and lower-extremity injuries in major industries (agriculture, construction, manufacturing, and healthcare) were aggregated during this time period and compared. Overall workplace related injury occurrence in major industries from 1992 to 2018 for the following body regions were tabulated as follows: upper-extremity (4,471,340 cases), lower-extremity (3,296,547 cases), and trunk (5,889,940 cases) (p\u3c.05). Upper-extremity injury incidence was observed to be significantly higher than lower-extremity injury incidence in the manufacturing industry (p\u3c.001) and significantly lower than trunk injury incidence in the healthcare industry (p\u3c.001). However, differences between upper-extremity injury incidence and both lower-extremity and trunk injury incidence were not significant for the other industries. When comparing the occurrence of upper-extremity injuries across industries from 1992 to 2018, significant differences were determined between all industries except for healthcare (p\u3c.001). When identifying changes in injury occurrence in each respective industry across this time span, manufacturing was shown to have the largest decrease (x=-5,432, r=-.91) followed by construction (x=-966, r=-.87) and then agriculture (x=-270, r=-.79). Weak correlation was observed for healthcare (x=118, r=.15)

Point processes in arbitrary dimension from fermionic gases, random matrix theory, and number theory

It is well known that one can map certain properties of random matrices, fermionic gases, and zeros of the Riemann zeta function to a unique point process on the real line. Here we analytically provide exact generalizations of such a point process in d-dimensional Euclidean space for any d, which are special cases of determinantal processes. In particular, we obtain the n-particle correlation functions for any n, which completely specify the point processes. We also demonstrate that spin-polarized fermionic systems have these same n-particle correlation functions in each dimension. The point processes for any d are shown to be hyperuniform. The latter result implies that the pair correlation function tends to unity for large pair distances with a decay rate that is controlled by the power law r^[-(d+1)]. We graphically display one- and two-dimensional realizations of the point processes in order to vividly reveal their "repulsive" nature. Indeed, we show that the point processes can be characterized by an effective "hard-core" diameter that grows like the square root of d. The nearest-neighbor distribution functions for these point processes are also evaluated and rigorously bounded. Among other results, this analysis reveals that the probability of finding a large spherical cavity of radius r in dimension d behaves like a Poisson point process but in dimension d+1 for large r and finite d. We also show that as d increases, the point process behaves effectively like a sphere packing with a coverage fraction of space that is no denser than 1/2^d.Comment: 40 pages, 11 figures, 1 table, iopart; corrected mislabeled section numbers and minor typographical issues; minor text change

Effects of Dietary Energy Concentration and Feed Intake on Growth Performance of Newly Received Growing Cattle Fed Diets Based on Corn and Corn Co-Products

Objective:This study’s focus was to evaluate if feeding equal amounts of energy from a high-energy limit-fed diet has an effect on growth performance of growing beef cattle when compared to traditional high-roughagead libitumdiets. Study Description:A total of 392 crossbred heifers were fed one of four experimental diets for a 70-day receiving period. Treatments included a high-roughage diet formulated to provide 45 Mcal of net energy for gain (NEg) per 100 lb of dry matter (DM) and fed forad libitumintake (AL) or a high-energy diet formulated to provide 60 Mcal of NEgper 100 lb of DM and fed at 75% (LIM-75), 80% (LIM-80), or 85% (LIM-85) ofad libitumintake. Treatments were designed to equalize for energy intake between calves assigned to AL and LIM-75. The Bottom Line:Restricting feed intake while maintaining energy intake does not negatively influence growth performance of newly received growing beef cattle. In times of high forage cost or shortened growing periods producers could program gains based on their own financial and personal needs

Identification of rare-disease genes using blood transcriptome sequencing and large control cohorts.

It is estimated that 350 million individuals worldwide suffer from rare diseases, which are predominantly caused by mutation in a single gene1. The current molecular diagnostic rate is estimated at 50%, with whole-exome sequencing (WES) among the most successful approaches2-5. For patients in whom WES is uninformative, RNA sequencing (RNA-seq) has shown diagnostic utility in specific tissues and diseases6-8. This includes muscle biopsies from patients with undiagnosed rare muscle disorders6,9, and cultured fibroblasts from patients with mitochondrial disorders7. However, for many individuals, biopsies are not performed for clinical care, and tissues are difficult to access. We sought to assess the utility of RNA-seq from blood as a diagnostic tool for rare diseases of different pathophysiologies. We generated whole-blood RNA-seq from 94 individuals with undiagnosed rare diseases spanning 16 diverse disease categories. We developed a robust approach to compare data from these individuals with large sets of RNA-seq data for controls (n = 1,594 unrelated controls and n = 49 family members) and demonstrated the impacts of expression, splicing, gene and variant filtering strategies on disease gene identification. Across our cohort, we observed that RNA-seq yields a 7.5% diagnostic rate, and an additional 16.7% with improved candidate gene resolution

I Spy Transits and Pulsations: Empirical Variability in White Dwarfs Using Gaia and the Zwicky Transient Facility

We present a novel method to detect variable astrophysical objects and transient phenomena using anomalous excess scatter in repeated measurements from public catalogs of Gaia DR2 and Zwicky Transient Facility (ZTF) DR3 photometry. We first provide a generalized, all-sky proxy for variability using only Gaia DR2 photometry, calibrated to white dwarf stars. To ensure more robust candidate detection, we further employ a method combining Gaia with ZTF photometry and alerts. To demonstrate the efficacy, we apply this latter technique to a sample of roughly $12,100$ white dwarfs within 200 pc centered on the ZZ Ceti instability strip, where hydrogen-atmosphere white dwarfs are known to pulsate. Through inspecting the top $1\%$ samples ranked by these methods, we demonstrate that both the Gaia-only and ZTF-informed techniques are highly effective at identifying known and new variable white dwarfs, which we verify using follow-up, high-speed photometry. We confirm variability in all 33 out of 33 ($100\%$) observed white dwarfs within our top $1\%$ highest-ranked candidates, both inside and outside the ZZ Ceti instability strip. In addition to dozens of new pulsating white dwarfs, we also identify five white dwarfs highly likely to show transiting planetary debris; if confirmed, these systems would more than triple the number of white dwarfs known to host transiting debris.Comment: 30 pages, 14 figures, revised and accepted to ApJ on March 11, 202