10 research outputs found
1989 Texas DTPA Reform: Closing the DTPA Loophole in the 1987 Tort Reform Laws and the Ongoing Quest for Fairer DTPA Laws.
Abstract Forthcoming
IL-6-mediated hepatocyte production is the primary source of plasma and urine neutrophil gelatinase associated lipocalin during acute kidney injury
Neutrophil gelatinase associated lipocalin (NGAL, Lcn2) is the most widely studied biomarker of acute kidney injury (AKI). Previous studies have demonstrated that NGAL is produced by the kidney and released into the urine and plasma. Consequently, NGAL is currently considered a tubule specific injury marker of AKI. However, the utility of NGAL to predict AKI has been variable suggesting that other mechanisms of production are present. IL-6 is a proinflammatory cytokine increased in plasma by two hours of AKI and mediates distant organ effects. Herein, we investigated the role of IL-6 in renal and extra-renal NGAL production. Wild type mice with ischemic AKI had increased plasma IL-6, increased hepatic NGAL mRNA, increased plasma NGAL, and increased urine NGAL; all reduced in IL-6 knockout mice. Intravenous IL-6 in normal mice increased hepatic NGAL mRNA, plasma NGAL and urine NGAL. In mice with hepatocyte specific NGAL deletion (Lcn2hep-/-) and ischemic AKI, hepatic NGAL mRNA was absent, and plasma and urine NGAL were reduced. Since urine NGAL levels appear to be dependent on plasma levels, the renal handling of circulating NGAL was examined using recombinant human NGAL. After intravenous recombinant human NGAL administration to mice, human NGAL in mouse urine was detected by ELISA during proximal tubular dysfunction, but not in pre-renal azotemia. Thus, during AKI, IL-6 mediates hepatic NGAL production, hepatocytes are the primary source of plasma and urine NGAL, and plasma NGAL appears in the urine during proximal tubule dysfunction. Hence, our data change the paradigm by which NGAL should be interpreted as a biomarker of AKI
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[Letter from John T. Montford to Jack Davis, April 5, 1993]
Photocopy of a letter from John T. Montford, Member of the Texas Senate Twenty-Eight District, to Jack Davis, co-director of North Texas Institute for Educators on the Visual Arts. In regards to Davis's letter which informed Montford about North Texas Institute for Educators on the Visual Arts. Montford writes that he is a supporter of the arts in education and of arts programs in general, and has introduced SB 778, designed to provide more funding source for the Texas Commission on the Arts. Montford writes that be believe the bill's chances of passage and thanks Davis again for his letter
Bioinformatics: a multidisciplinary approach for the life sciences
Volume: 186Start Page: 1End Page:
Bioinformatics, museums and society: integrating biological data for knowledge-based decisions
Volume: 187Start Page: 1End Page: