Effects of Liposomes Contained in Thermosensitive Hydrogels as Biomaterials Useful in Neural Tissue Engineering

Indexación: Scopus.Advances in the generation of suitable thermosensitive hydrogels for the delivery of cells in neural tissue engineering demonstrate a delicate relationship between physical properties and capabilities to promote cell proliferation and differentiation. To improve the properties of these materials, it is possible to add liposomes for the controlled release of bioactive elements, which in turn can affect the physical and biological properties of the hydrogels. In the present investigation, different hydrogels based on Pluronic F127 have been formulated with the incorporation of chitosan and two types of liposomes of two different sizes. The rheological and thermal properties and their relation with the neurite proliferation and growth of the PC12 cell line were evaluated. Our results show that the incorporation of liposomes modifies the properties of the hydrogels dependent on the concentration of chitosan and the lipid type in the liposomes, which directly affect the capabilities of the hydrogels to promote the viability and differentiation of PC12 cells. © 2017 by the authors.http://www.mdpi.com/1996-1944/10/10/112

Non-linear Dependence of L(B) on L(FIR) and M(H2) among Spiral Galaxies and Effects of Tidal Interaction

Through the study of a carefully selected sample of isolated spiral galaxies, we have established that two important global physical quantities for tracing star forming activities, L(FIR) and M(H2), have non-linear dependence on another commonly cited global quantity L(B). Furthermore we show that simple power law relations can effectively describe these non-linear relations for spiral galaxies spanning four orders of magnitude in FIR and M(H2) and nearly three orders of magnitude in L(B). While the existence of non-linear dependence of M(H2) (assuming a constant CO-to-H2 conversion) and L(FIR) on optical luminosity L(B) has been previously noted in the literature, an improper normalization of simple scaling by L(B) has been commonly used in many previous studies to claim enhanced molecular gas content and induced activities among tidally interacting and other types of galaxies. We remove these non-linear effects using the template relations derived from the isolated galaxy sample and conclude that strongly interacting galaxies do not have enhanced molecular gas content, contrary to previous claims. With these non-linear relations among L(B), L(FIR) and M(H2) properly taken into account, we confirm again that the FIR emission and the star formation efficiency L(FIR)/M(H2) are indeed enhanced by tidal interactions. Virgo galaxies show the same level of M(H2) and L(FIR) as isolated galaxies. We do not find any evidence for enhanced star forming activity among barred galaxies.Comment: 19 pages and 5 figures, requires AAS style files, ApJ, accepte

Hemi-Synthesis and Anti-Oomycete Activity of Analogues of Isocordoin

Indexación: Web of Science; Scopus.An efficient synthesis of a series of 4-oxyalkyl-isocordoin analogues (2–8) is reported for the first time. Their structures were confirmed by1H-NMR,13C-NMR, and HRMS. Their anti-oomycete activity was evaluated by mycelium and spores inhibition assay against two selected pathogenic oomycetes strains: Saprolegnia parasitica and Saprolegnia australis. The entire series of isocordoin derivatives (except compound 7) showed high inhibitory activity against these oomycete strains. Among them, compound 2 exhibited strong activity, with minimum inhibitory concentration (MIC) and minimum oomyceticidal concentration (MOC) values of 50 µg/mL and 75 µg/mL, respectively. The results showed that 4-oxyalkylated analogues of isocordoin could be potential anti-oomycete agents.http://www.mdpi.com/1420-3049/22/6/96

Spectra of sparse non-Hermitian random matrices: an analytical solution

We present the exact analytical expression for the spectrum of a sparse non-Hermitian random matrix ensemble, generalizing two classical results in random-matrix theory: this analytical expression forms a non-Hermitian version of the Kesten-Mckay law as well as a sparse realization of Girko's elliptic law. Our exact result opens new perspectives in the study of several physical problems modelled on sparse random graphs. In this context, we show analytically that the convergence rate of a transport process on a very sparse graph depends upon the degree of symmetry of the edges in a non-monotonous way.Comment: 5 pages, 5 figures, 12 pages supplemental materia

Glassy transition in the three-dimensional random field Ising model

The high temperature phase of the three dimensional random field Ising model is studied using replica symmetry breaking framework. It is found that, above the ferromagnetic transition temperature T_f, there appears a glassy phase at intermediate temperatures T_f<T<T_b while the usual paramagnetic phase exists for T>T_b only. Correlation length at T_b is computed and found to be compatible with previous numerical results.Comment: 7 pages, LaTeX file, preprint 1014 - Rome

Comportamiento del cáncer colorectal en pacientes menores de 40 años de dos hospitales universitarios en medellín y neiva entre 1980-2000

Determinar el comportamiento del CCR en pacientes menores de 40 años, diagnosticados en el HUHMP y HUSVP desde 1980 hasta el año 2000, para observar la frecuencia y justificar de manera epidemiológica la importancia de desarrollar nuevos proyectos en el país en esta área

Percolation in three-dimensional random field Ising magnets

The structure of the three-dimensional random field Ising magnet is studied by ground state calculations. We investigate the percolation of the minority spin orientation in the paramagnetic phase above the bulk phase transition, located at [Delta/J]_c ~= 2.27, where Delta is the standard deviation of the Gaussian random fields (J=1). With an external field H there is a disorder strength dependent critical field +/- H_c(Delta) for the down (or up) spin spanning. The percolation transition is in the standard percolation universality class. H_c ~ (Delta - Delta_p)^{delta}, where Delta_p = 2.43 +/- 0.01 and delta = 1.31 +/- 0.03, implying a critical line for Delta_c < Delta <= Delta_p. When, with zero external field, Delta is decreased from a large value there is a transition from the simultaneous up and down spin spanning, with probability Pi_{uparrow downarrow} = 1.00 to Pi_{uparrow downarrow} = 0. This is located at Delta = 2.32 +/- 0.01, i.e., above Delta_c. The spanning cluster has the fractal dimension of standard percolation D_f = 2.53 at H = H_c(Delta). We provide evidence that this is asymptotically true even at H=0 for Delta_c < Delta <= Delta_p beyond a crossover scale that diverges as Delta_c is approached from above. Percolation implies extra finite size effects in the ground states of the 3D RFIM.Comment: replaced with version to appear in Physical Review

Tricritical Points in the Sherrington-Kirkpatrick Model in the Presence of Discrete Random Fields

The infinite-range-interaction Ising spin glass is considered in the presence of an external random magnetic field following a trimodal (three-peak) distribution. The model is studied through the replica method and phase diagrams are obtained within the replica-symmetry approximation. It is shown that the border of the ferromagnetic phase may present first-order phase transitions, as well as tricritical points at finite temperatures. Analogous to what happens for the Ising ferromagnet under a trimodal random field, it is verified that the first-order phase transitions are directly related to the dilution in the fields (represented by $p_{0}$). The ferromagnetic boundary at zero temperature also exhibits an interesting behavior: for $0<p_{0}<p_{0}^{*} \approx 0.30856$, a single tricritical point occurs, whereas if $p_{0}>p_{0}^{*}$ the critical frontier is completely continuous; however, for $p_{0}=p_{0}^{*}$, a fourth-order critical point appears. The stability analysis of the replica-symmetric solution is performed and the regions of validity of such a solution are identified; in particular, the Almeida-Thouless line in the plane field versus temperature is shown to depend on the weight $p_{0}$.Comment: 23pages, 7 ps figure