General morphology, classification and biology of Cerambycidae

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A Knot in the Line: Sea Turtle Bycatch Reduction Problems in the United States Atlantic Pelagic Longline Fishery

Part I of this Comment describes the problem of sea turtle bycatch, focusing on the direct impacts on sea turtles, ineffective laws, and poor reporting. Part II describes the U.S. Atlantic pelagic longline fishing industry by discussing longline fishing methodology, the historical background of the industry, the fish species harvested, and the areas covered by the fishery. Part III describes the current laws and regulations designed to protect sea turtles from becoming bycatch in the U.S. Atlantic pelagic longline fishery. Finally, Part IV provides recommendations for reducing sea turtle bycatch in the future

Diseases caused by mutations in mitochondrial carrier genes SLC25: A review

In the 1980s, after the mitochondrial DNA (mtDNA) had been sequenced, several diseases resulting from mtDNA mutations emerged. Later, numerous disorders caused by mutations in the nuclear genes encoding mitochondrial proteins were found. A group of these diseases are due to defects of mitochondrial carriers, a family of proteins named solute carrier family 25 (SLC25), that transport a variety of solutes such as the reagents of ATP synthase (ATP, ADP, and phosphate), tricarboxylic acid cycle intermediates, cofactors, amino acids, and carnitine esters of fatty acids. The disease-causing mutations disclosed in mitochondrial carriers range from point mutations, which are often localized in the substrate translocation pore of the carrier, to large deletions and insertions. The biochemical consequences of deficient transport are the compartmentalized accumulation of the substrates and dysfunctional mitochondrial and cellular metabolism, which frequently develop into various forms of myopathy, encephalopathy, or neuropathy. Examples of diseases, due to mitochondrial carrier mutations are: combined D-2-and L-2-hydroxyglutaric aciduria, carnitine-acylcarnitine carrier deficiency, hyperornithinemia-hyperammonemia-homocitrillinuria (HHH) syndrome, early infantile epileptic encephalopathy type 3, Amish microcephaly, aspartate/glutamate isoform 1 deficiency, congenital sideroblastic anemia, Fontaine progeroid syndrome, and citrullinemia type II. Here, we review all the mitochondrial carrier-related diseases known until now, focusing on the connections between the molecular basis, altered metabolism, and phenotypes of these inherited disorders

A structural view of egg coat architecture and function in fertilization.

Species-restricted interaction between gametes at the beginning of fertilization is mediated by the extracellular coat of the egg, a matrix of cross-linked glycoprotein filaments called the zona pellucida (ZP) in mammals and the vitelline envelope in nonmammals. All egg coat subunits contain a conserved protein-protein interaction module-the "ZP domain"-that allows them to polymerize upon dissociation of a C-terminal propeptide containing an external hydrophobic patch (EHP). Recently, the first crystal structures of a ZP domain protein, sperm receptor ZP subunit zona pellucida glycoprotein 3 (ZP3), have been reported, giving a glimpse of the structural organization of the ZP at the atomic level and the molecular basis of gamete recognition in vertebrates. The ZP module is divided in two related immunoglobulin-like domains, ZP-N and ZP-C, that contain characteristic disulfide bond patterns and, in the case of ZP-C, also incorporate the EHP. This segment lies at the interface between the two domains, which are connected by a long loop carrying a conserved O-glycan important for binding to sperm in vitro. The structures explain several apparently contradictory observations by reconciling the variable disulfide bond patterns found in different homologues of ZP3 as well as the multiple ZP3 determinants alternatively involved in gamete interaction. These findings have implications for our understanding of ZP subunit biogenesis; egg coat assembly, architecture, and interaction with sperm; structural rearrangements leading to postfertilization hardening of the ZP and the block to sperm binding; and the evolutionary origin of egg coats

Fluvial piracies in the NE sector of the Sierra de Aconquija (Tafí Valley, NW Argentina)

The Sierra de Aconquija is a recently uplifted mountain chain in NW Argentina. The NE side of the sierra is drained by the Munoz and Los Alisos rivers - whose base level is the Las Carreras Depression that is located to the SW of the Taft valley. Two of the major headwaters of the Munoz River suffered during its Holocene development from piracy by the Los Alisos River. These piracies had important consequences on the size of both basins and the functioning of their alluvial fans. The main causes of the captures were changes in river dynamics during Lateglacial and Holocene glacial events. Neotectonic activation does not seem to be the most determining factor, although there are active Holocene faults nearby (Las Carreras Fault 2). Geomorphological and human occupation data recovered from the alluvial fans enables us to estimate that the most recent capture was produced during the Late Holocene

Online negotiation. Theoretical proposal

The latest changes due to by the pandemic situation have caused that, on the one hand, audiovisual communication technologies through the Internet have rapidly developed to cover communication needs, allowing not only the participation of several users in a session but also different configurations to adapt to educational, personal and professional needs, such as teleworking. On the other hand, the adaptation of people, due to the need of utilizing these communication tools, both in the personal and professional fields, have resulted in the integration of these technologies very quickly and with a global reach. With the term online negotiation, we refer to any long-distance negotiation process, without physical contact and using audiovisual communication tools, mainly connected to the Internet, which allow immediate and technically fluent communication, but with certain limitations and differences with face-to-face negotiations. Online negotiations are here to stay, and it is therefore, necessary to analyze the changes and define a practical learning methodology with direct application to the professional contex

Tracking Down the ZP Domain: From the Mammalian Zona Pellucida to the Molluscan Vitelline Envelope

Oocytes from virtually all organisms are surrounded by at least one coat. This specialized extracellular matrix, called the zona pellucida (ZP) in mammals and the vitelline envelope (VE) in nonmammals, has a structural function and plays essential roles in oogenesis, fertilization, and early development. During the last 15 years, compelling evidence has accumulated that all ZP/VE subunits polymerize using a conserved sequence, the ZP domain, so that the basic structural features of egg coat matrices have been maintained through evolution. Moreover, ZP domains have been identified in many other polymeric extracellular proteins from eukaryotes. This review compares the ultrastructure and molecular composition of egg coats from mollusc to human, suggests a common mechanism for assembly of ZP/VE proteins, and discusses alternative models of how these could be arranged within filaments

Introduction into Nigeria of a Distinct Genotype of Avian Influenza Virus (H5N1)

Genetic characterization of highly pathogenic avian influenza viruses (H5N1) isolated in July 2008 in Nigeria indicates that a distinct genotype, never before detected in Africa, reached the continent. Phylogenetic analysis showed that the viruses are genetically closely related to European and Middle Eastern influenza A (H5N1) isolates detected in 2007