Evolución y aplicación del marketing cultural en los museos

Many cultural institutions, especially museums, have still to introduce specialized marketing into their practices. Very often governing bodies and consultancies apply concepts of marketing that are based on the classical definition which is well suited to a certain kind of cultural industry, but not to museums or similar institutions. We describe the background and evolution of cultural marketing, which was born in the US in the late 1960s, and propose the application of a conceptual model which facilitates its introduction and evaluation in the museum context. We analyse the special situation of museums with regard to their market, bearing in mind the specific evolution of marketing techniques in museum institutions. Finally, we stress the importance of the museum’s website as a key part in this strategic planning

Plan de infraestructuras aeronáuticas

Presentación realizada en el XII Foro de Usuarios Aeronáuticos, celebrado de forma telemática el 15 de marzo de 2022

Evolución y aplicación del marketing cultural en los museos

Many cultural institutions, especially museums, have still to introduce specialized marketing into their practices. Very often governing bodies and consultancies apply concepts of marketing that are based on the classical definition which is well suited to a certain kind of cultural industry, but not to museums or similar institutions. We describe the background and evolution of cultural marketing, which was born in the US in the late 1960s, and propose the application of a conceptual model which facilitates its introduction and evaluation in the museum context. We analyse the special situation of museums with regard to their market, bearing in mind the specific evolution of marketing techniques in museum institutions. Finally, we stress the importance of the museum’s website as a key part in this strategic planning

Diversas herramientas para la predicción aeronáutica de área

Ponencia presentada en: V Simposio Nacional de Predicción, celebrado en 2001 en Madrid.En el Centro Nacional de Predicción se elaboran diariamente diversos productos que incluyen la predicción de fenómenos tales como el engelamiento, la turbulencia y las ondas de montaña, cuya ocurrencia incide sobre la operación de aeronaves comerciales, militares o particulares. Para la localización temporal y espacial de estos fenómenos se han desarrollado diversas aplicaciones Mcidas que hacen uso de variables obtenidas en formato de rejilla, directamente o mediante postproceso, de modelos de predicción numérica. Estas herramientas son presentadas en esta exposición, ilustrando diversas situaciones ejemplo, mostrando en que forma pueden ser de utilidad a los predictores y haciendo hincapié en sus limitaciones

Web browsers and Web 2.0

Web 2.0 and browsers are two very closely connected concepts. The reason is that browsers are the user agents that are needed to make navigating web 2.0 a reality. Within a very short span of time, new versions have been issued by the top three web browsers: Explorer, Firefox and Opera. In this article we examine and compare the new capabilities and functions of these three browsers in terms of the new web

Servicios meteorológicos para la navegación aérea en el Plan Mundial de Navegación Aérea de OACI: Escenario Europeo

Presentación realizada en el Foro de Usuarios Aeronáuticos, celebrado el 9 de diciembre de 2014 en los Servicios Centrales de AEMET en Madri

Acrobat 8: Adobe’s new technological wager for business document management

The PDF format, developed by Adobe and since converted to an open, multiplatform standard, gets a new boost from version 8 of Acrobat, produced by the same company. A review is offered of the main characteristics and functionality of this new application that most likely will have a great impact on electronic document management for business

The aggregation of alpha-synuclein and its disaggregation by the Hsp70 disaggregation machinery

Neurodegenerative disorders are characterised by the deposition of proteinaceous aggregates in the brain. In the case of synucleinopathies, such as Parkinson’s disease, the aggregates are mainly composed of α-synuclein (αSyn). The aggregation process of αSyn is toxic for neurons but the cause of the toxicity remains elusive. In vitro, the constitutively expressed cytosolic heat shock 70 protein, Hsc70, together with two cochaperones, the J-domain protein DNAJB1 and the nucleotide exchange factor Apg2, can disassemble αSyn amyloid fibres and small oligomers. However, the model is incomplete, lacking structural as well as mechanistic details. To address these two issues (αSyn aggregation in cells and the incomplete model of αSyn disaggregation in vitro), I have used electron and fluorescence microscopy and biochemical assays. Correlating fluorescence images and cryo tomograms, I have investigated the structure of αSyn aggregates in a yeast model. αSyn colocalises at the plasma membrane and forms cytosolic inclusions rich in vesicles and lipid droplets. Using cryo electron microscopy (cryo-EM) and tomography, I have shown that recombinant αSyn does not form large oligomers on the surface of tubulated liposomes. Using single particle cryo-EM, I have studied the complex formed of αSyn amyloid fibres and a mutant of DNAJB1 lacking the J-domain and G/F linker (ΔJ-DNAJB1). A low-resolution reconstruction of the complex was generated in which horseshoe-like densities, identified as ΔJ-DNAJB1, surrounded the fibre. I also produced a high-resolution map of the αSyn fibre showing a new conformation. Lastly, using cryo-EM, fluorescence microscopy and biochemical assays, I have investigated the function of Apg2 in disaggregation. Unexpectedly, Apg2 enhances Hsc70 recruitment to the fibres, preferentially at one end. This Apg2-induced recruitment regulates the disaggregation activity. The work in this thesis provides new information about αSyn aggregation, its toxicity and its disaggregation by the Hsc70 system

Nutrition, bioenergetics, and metabolic syndrome

According to the World Health Organization (WHO), the global nutrition report shows that whilst part of the world's population starves, the other part suffers from obesity and associated complications. A balanced diet counterparts these extreme conditions with the proper proportion, composition, quantity, and presence of macronutrients, micronutrients, and bioactive compounds. However, little is known on the way these components exert any influence on our health. These nutrients aiming to feed our bodies, our tissues, and our cells, first need to reach mitochondria, where they are decomposed into CO2 and H2O to obtain energy. Mitochondria are the powerhouse of the cell and mainly responsible for nutrients metabolism, but they are also the main source of oxidative stress and cell death by apoptosis. Unappropriated nutrients may support mitochondrial to become the Trojan horse in the cell. This review aims to provide an approach to the role that some nutrients exert on mitochondria as a major contributor to high prevalent Western conditions including metabolic syndrome (MetS), a constellation of pathologic conditions which promotes type II diabetes and cardiovascular risk. Clinical and experimental data extracted from in vitro animal and cell models further demonstrated in patients, support the idea that a balanced diet, in a healthy lifestyle context, promotes proper bioenergetic and mitochondrial function, becoming the best medicine to prevent the onset and progression of MetS. Any advance in the prevention and management of these prevalent complications help to face these challenging global health problems, by ameliorating the quality of life of patients and reducing the associated sociosanitary burden