Sünder und Heilige, Tisci und Givenchy

Für diesen Beitrag ist leider kein Abstract verfügbar. ----------URN: urn:nbn:de:hbz:6:3-201403148

Andys Erbe. Über das Verhältnis von Mode und Kunst am Beispiel der Künstlerkollaborationen des Luxuslabels Louis Vuitton

This paper is concerned with cooperations between artists and fashion designers on a common product. It centers on the case specific analysis of the collaborations between the luxury fashion label Louis Vuitton, and the artists Takashi Murakami and Richard Prince. Between 2003 and 2008, they designed handbag collections in limited editions with Vuitton's creative director Marc Jacobs. On the one hand, the cooperations are identified as a marketing strategy that obtains an increase in profit by the attribution of artistic prestige on fashion items. On the other hand, I argue that there is a relationship between the collaborations with Vuitton and the artistic practices of Murakami, and Prince, their positioning towards the commercialization of their work, and the conception of their role as artists. This relationship will be scrutinized with regard to the transformations of the artistic field caused by the Pop Art Movement in the 1960s

CATECHOL-O-METHYLTRANSFERASE GENOTYPE MODIFIES EXECUTIVE FUNCTIONING AND PREFRONTAL FUNCTIONAL CONNECTIVITY IN WOMEN WITH ANOREXIA NERVOSA.

Background: Anorexia nervosa (AN) is characterised by high levels of perseveration and inflexibility which interfere with successful treatments. Dopamine signalling seems to play a key role in modulating the prefrontal cortex, since both dopamine deficiency and excess negatively influences the efficiency of cognitive functions. The present study explores the effect of a functional polymorphism (Val158Met) in the catechol-O-methyltransferase gene on the set-shifting abilities and prefrontal functional connectivity of patients with AN. Methods: All subjects of the study (166 subjects with DSM-IV lifetime AN and 140 healthy women) performed the Wisconsin Card Sorting Task, and a subsample (33 AN patients and 30 controls) underwent resting-state functional magnetic resonance imaging scanning. Results: Both underweight and weight-recovered AN patients showed high levels of perseveration, but only in the underweight group did the Val158Met polymorphism affect cognitive performance, showing the U-shaped curve characteristic of increased dopamine signalling in the prefrontal cortex. Underweight AN patients who are Met homozygotes had significantly higher levels of perseveration and increased prefrontal functional connectivity, indicating abnormal regional cortical processing. Limitations: Although our data show that grey matter reduction in starving AN did not explain our findings, the cross-sectional design of the present study did not allow to distinguish between the effects of starvation and those of low estrogen levels. Conclusions: Starvation affects dopamine release in the prefrontal cortex of AN patients with different effects on executive functioning and prefrontal functional connectivity according to catechol-O-methyltransferase genotype. This observation has several therapeutic implications that need to be addressed by future studies

Changing rate of serious infections in biologic-exposed rheumatoid arthritis patients : data from South American registries BIOBADABRASIL and BIOBADASAR

Most reports on serious infections (SI) in rheumatoid arthritis (RA) patients treated with biological disease-modifying antirheumatic drugs (bDMARDs) are from the USA and Western Europe. Data from other regions are largely missing. We report data from South American countries with different backgrounds and health-care systems but similar registries. We merged 2010-2016 data from two registries, BIOBADABRASIL (Brazil) and BIOBADASAR (Argentina), which share the same protocol, online platform and data monitoring process. Patients with active RA were included when they began the first bDMARD or a conventional synthetic DMARD (csDMARD, control group). The SI incidence rate (IR) per 1000 patient/years and adjusted IR ratio (aIRR) were estimated for bDMARDs and csDMARDs. Data were analysed for 3717 RA patients with an exposure of 13,380 patient/years. The 2591 patients treated with bDMARDs (64% tumour necrosis factor-alpha inhibitors (TNFi)) had a follow-up of 9300years, and the 1126 treated with csDMARDs had an exposure of 4081 patient/years. The SI IR was 30.54 (CI 27.18-34.30) for all bDMARDs and 5.15 (CI 3.36-7.89) for csDMARDs. The aIRR between the two groups was 2.03 ([1.05, 3.9] p=0.034) for the first 6months of treatment but subsequently increased to 8.26 ([4.32, 15.76] p<0.001). The SI IR for bDMARDs decreased over time in both registries, dropping from 36.59 (28.41-47.12) in 2012 to 7.27 (4.79-11.05) in 2016. While SI remains a major concern in South American patients with RA treated with bDMARDs, a favourable trend toward a reduction was observed in the last years3882129213