34 research outputs found
Collective Motion of Cells Mediates Segregation and Pattern Formation in Co-Cultures
Pattern formation by segregation of cell types is an important process during embryonic development. We show that an experimentally yet unexplored mechanism based on collective motility of segregating cells enhances the effects of known pattern formation mechanisms such as differential adhesion, mechanochemical interactions or cell migration directed by morphogens. To study in vitro cell segregation we use time-lapse videomicroscopy and quantitative analysis of the main features of the motion of individual cells or groups. Our observations have been extensive, typically involving the investigation of the development of patterns containing up to 200,000 cells. By either comparing keratocyte types with different collective motility characteristics or increasing cells' directional persistence by the inhibition of Rac1 GTP-ase we demonstrate that enhanced collective cell motility results in faster cell segregation leading to the formation of more extensive patterns. The growth of the characteristic scale of patterns generally follows an algebraic scaling law with exponent values up to 0.74 in the presence of collective motion, compared to significantly smaller exponents in case of diffusive motion
The application of evolutionary medicine principles for sustainable malaria control: a scoping study
Pharmacological Strategies for the Management of Levodopa-Induced Dyskinesia in Patients with Parkinsonâs Disease
On the fossil Remains of Panochthus Burmeister, 1866 (Xenarthra, Cingulata, Glyptodontidae) from the Pleistocene of southern Brazil
Upper molar morphology, homologies and evolutionary patterns of chinchilloid rodents (Mammalia, Caviomorpha)
Chinchilloidea are a clade of caviomorph rodents that includes seven living species, the Dinomyidae Dinomys branickii, the Chinchillidae Lagostomus maximus, two species of Chinchilla and three species of Lagidium. In addition, two extinct families are traditionally considered chinchilloids â Neoepiblemidae and Cephalomyidae. The phylogeny of the Chinchilloidea has so far not been well established and is based on partial analyses. Studying the anatomy and ontogeny of extinct and extant taxa, we propose homologies for the upper molars of Chinchilloidea for which these homologies have not been previously proposed: that is the Chinchillidae Prolagostomus, Lagostomus, Lagidium and Chinchilla, and the Neoepiblemidae Neoepiblema and Phoberomys. We identify patterns of occlusal simplification within Chinchilloidea and evaluate its importance in an evolutionary context. A phylogenetic analysis recovered Dinomyidae, Chinchillidae and Neoepiblemidae as clades. âCephalomyidaeâ have not been not recovered as a monophyletic group and âcephalomyidsâ are closely related to Neoepiblemidae. Branisamys is not included within the Dinomyidae and appears to be a basal chinchilloid.Fil: Rasia, Luciano Luis. Consejo Nacional de Investigaciones CientĂficas y TĂ©cnicas. Centro CientĂfico TecnolĂłgico Conicet - La Plata; Argentina. Universidad Nacional de La Plata. Facultad de Ciencias Naturales y Museo. DivisiĂłn PaleontologĂa Vertebrados; ArgentinaFil: Candela, Adriana Magdalena. Consejo Nacional de Investigaciones CientĂficas y TĂ©cnicas. Centro CientĂfico TecnolĂłgico Conicet - La Plata; Argentina. Universidad Nacional de La Plata. Facultad de Ciencias Naturales y Museo. DivisiĂłn PaleontologĂa Vertebrados; Argentin
Coupling of DSC and Dynamic Mechanical Experiments for Probing Processing-Structure-Property Relationships of Catalyst Modified High Performance Epoxy Matrices
Upper molar morphology, homologies and evolutionary patterns of chinchilloid rodents (Mammalia, Caviomorpha)
A New Pliocene Capybara (Rodentia, Caviidae) from Northern South America (Guajira, Colombia), and its Implications for the Great American Biotic Interchange
One of the most striking components of the modern assemblage of South American mammals is the semiaquatic capybara (Caviidae, Hydrochoerinae), the biggest rodent in the world. The large hydrochoerines are recorded from the middle Miocene to the present, mainly in high latitudes of South America. Although less known, they are also recorded in low latitudes of South America, and in Central and North America. We report the first record of capybaras from the late Pliocene of Colombia, found in deposits of the Ware Formation, Guajira Peninsula in northeastern Colombia. We analyze the phylogenetic position within Caviidae, the possible environmental changes in the Guajira Peninsula, and the implications of this finding for the understanding of the Great American Biotic Interchange. The morphological and phylogenetic analyses indicate that the hydrochoerine of the Guajira Peninsula is a new species, ?Hydrochoeropsis wayuu, and this genus is most closely related to Phugatherium. According to the latest phylogenetic results, this clade is the sister group of the lineage of the recent capybaras (Neochoerus and Hydrochoerus). ?Hydrochoeropsis wayuu is the northernmost South American Pliocene hydrochoerine record and the nearest to the Panamanian bridge. The presence of this hydrochoerine, together with the fluvio-deltaic environment of the Ware Formation, suggests that during the late Pliocene, the environment that dominated the Guajira Peninsula was more humid and with permanent water bodies, in contrast with its modern desert habitats