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V803 Centauri: Helium Dwarf Nova Mimicking a WZ Sge-Type Superoutburst

We observed long-term behavior of the helium dwarf nova V803 Cen, and clarified the existence of at least two distinct states (state with 77-d supercycles and standstill-like state) which interchangeably appeared with a time-scale of 1--2 yr. We also conducted a time-resolved CCD photometry campaign during the bright outburst in 2003 June. The overall appearance of the outburst closely resemble that of the late stage of the 2001 outburst of WZ Sge, consisting of the initial peak stage (superoutburst plateau), the dip, and the oscillating (rebrightening) states. During the initial peak stage, we detected large-amplitude superhump-type variation with a period of 0.018686(4) d = 1614.5(4) s, and during the oscillation stage, we detected variations with a period of 0.018728(2) d = 1618.1(2) s. We consider that the former period better represents the superhump period of this system, and the latter periodicity may be better interpreted as arising from late superhumps. The overall picture of the V803 Cen outburst resembles that of a WZ Sge-type outburst, but apparently with a higher mass-transfer rate than in hydrogen-rich WZ Sge-type stars. We suggest that this behavior may be either the result of difficulty in maintaining the hot state in a helium disk, or the effect of an extremely low tidal torque resulting from the extreme mass ratio.Comment: 13 pages, 11 figures, to appear in PAS

Endogenous protease nexin-1 protects against cerebral ischemia.

The serine protease thrombin plays a role in signalling ischemic neuronal death in the brain. Paradoxically, endogenous neuroprotective mechanisms can be triggered by preconditioning with thrombin (thrombin preconditioning, TPC), leading to tolerance to cerebral ischemia. Here we studied the role of thrombin's endogenous potent inhibitor, protease nexin-1 (PN-1), in ischemia and in tolerance to cerebral ischemia induced by TPC. Cerebral ischemia was modelled in vitro in organotypic hippocampal slice cultures from rats or genetically engineered mice lacking PN-1 or with the reporter gene lacZ knocked into the PN-1 locus PN-1HAPN-1-lacZ/HAPN-1-lacZ (PN-1 KI) exposed to oxygen and glucose deprivation (OGD). We observed increased thrombin enzyme activity in culture homogenates 24 h after OGD. Lack of PN-1 increased neuronal death in the CA1, suggesting that endogenous PN-1 inhibits thrombin-induced neuronal damage after ischemia. OGD enhanced β-galactosidase activity, reflecting PN-1 expression, at one and 24 h, most strikingly in the stratum radiatum, a glial cell layer adjacent to the CA1 layer of ischemia sensitive neurons. TPC, 24 h before OGD, additionally increased PN-1 expression 1 h after OGD, compared to OGD alone. TPC failed to induce tolerance in cultures from PN-1(-/-) mice confirming PN-1 as an important TPC target. PN-1 upregulation after TPC was blocked by the c-Jun N-terminal kinase (JNK) inhibitor, L-JNKI1, known to block TPC. This work suggests that PN-1 is an endogenous neuroprotectant in cerebral ischemia and a potential target for neuroprotection

Inverse anisotropic diffusion from power density measurements in two dimensions

This paper concerns the reconstruction of an anisotropic diffusion tensor $\gamma=(\gamma_{ij})_{1\leq i,j\leq 2}$ from knowledge of internal functionals of the form $\gamma\nabla u_i\cdot\nabla u_j$ with $u_i$ for $1\leq i\leq I$ solutions of the elliptic equation $\nabla \cdot \gamma \nabla u_i=0$ on a two dimensional bounded domain with appropriate boundary conditions. We show that for I=4 and appropriately chosen boundary conditions, $\gamma$ may uniquely and stably be reconstructed from such internal functionals, which appear in coupled-physics inverse problems involving the ultrasound modulation of electrical or optical coefficients. Explicit reconstruction procedures for the diffusion tensor are presented and implemented numerically.Comment: 27 pages, 6 figure

The Peculiar 2004 Superoutburst in the Helium Dwarf Nova, 2003aw

We conducted a time-resolved photometric campaign of the helium dwarf nova, 2003aw in 2004 May--June. 2003aw stayed at 14.7--15.7 mag for the first several days during this campaign, which is the plateau phase of this superoutburst. This variable then rapidly decayed to $\sim$18.0 mag, still brighter by about 2 mag than its quiescence magnitude, and maintained this brightness for about 20 days, having short flares of $\sim$2 mag. A long fading tail followed it. We detected superhumps with a period of 0.02357(4) d [= 2036(3) s] during the plateau phase. The whole light curve of the superoutburst in 2003aw, taking into account the present data and those in the literature, perfectly resembles that of the 1996-1997 superoutburst of the peculiar WZ Sge-type hydrogen-rich dwarf nova, EG Cnc.Comment: 5 pages, 4 figures, PASJ Letter in pres

Absolute Fluorescence Spectrum and Yield Measurements for a wide range of experimental conditions

For the JEM-EUSO CollaborationThe fluorescence yield is a key ingredient in cosmic ray energy determination. It is sensitive to pressure, temperature and humidity. Up to now the fluorescence yield of the brightest line at 337 nm has been measured in an absolute way in one set of conditions, whereas fluorescence yields at the other wavelengths have been relatively measured for different conditions. Thus, absolute calibration for all the lines is unclear. We will do all measurements at once using the same apparatus: all the lines will be measured absolutely and not relatively for all conditions. For that we will use the 3-5 MeV electron beam of the PHIL accelerator (Photon Injector at LAL), shooting in a box filled with air at varying pressures, temperatures and humidity. Delta rays resulting from the beam collisions with Nitrogen are responsible for the light yield. The light detection probability should be independent of its emission point especially at the delta ray stopping point. The idea is to use an integrating sphere, encapsulated in a vessel where pressure, temperature and humidity can be varied. This sphere will have two ports for the beam (in and out), one more port dedicated to a NIST photodiode for calibration and another port feeding optical fibers going to: A) a grating spectrometer equipped with cooled CCD. B) a photomultiplier with BG3 filters to measure directly the integrated yield. Calibrations at the percent level, will give each line spectrum yields with a precision between 2 to 5%. A special issue will be to estimate the leakage due to "high energy" delta rays. Thus, we the air density will be increased, the beam energy will be lowered until the beam stops inside the sphere. Then, the energy loss will be precisely derived from the Bethe-Bloch formula. We will present the set-up

Synthesis and evaluation of new designed multiple ligands directed towards both peroxisome proliferator-activated receptor-γ and angiotensin II type 1 receptor

Because of the complex biological networks, many pathologic disorders fail to be treated with a molecule directed towards a single target. Thus, combination therapies are often necessary, but they have many drawbacks. An alternative consists in building molecules intended to interact with multiple targets, called designed multiple ligands. We followed such a strategy in order to treat metabolic syndrome, by setting up molecules directed towards both type 1 angiotensin II (AT1) receptor and peroxisome proliferator-activated receptor-γ (PPAR-γ). For this purpose, many molecules were prepared by merging both pharmacophores following three different strategies. Their ability to activate PPAR-γ and to block AT1 receptors were evaluated in vitro. This strategy led to the preparation of many new PPAR-γ activating and AT1 blocking molecules. Among them, some exhibited both activities, highlighting the convenience of this approach

Constraints on the Progenitor of SN 2016gkg From Its Shock-Cooling Light Curve

SN 2016gkg is a nearby Type IIb supernova discovered shortly after explosion. Like several other Type IIb events with early-time data, SN 2016gkg displays a double-peaked light curve, with the first peak associated with the cooling of a low-mass extended progenitor envelope. We present unprecedented intranight-cadence multi-band photometric coverage of the first light-curve peak of SN 2016gkg obtained from the Las Cumbres Observatory Global Telescope network, the Asteroid Terrestrial-impact Last Alert System, the Swift satellite and various amateur-operated telescopes. Fitting these data to analytical shock-cooling models gives a progenitor radius of ~25-140 solar radii with ~2-30 x 10^-2 solar masses of material in the extended envelope (depending on the model and the assumed host-galaxy extinction). Our radius estimates are broadly consistent with values derived independently (in other works) from HST imaging of the progenitor star. However, the shock-cooling model radii are on the lower end of the values indicated by pre-explosion imaging. Hydrodynamical simulations could refine the progenitor parameters deduced from the shock-cooling emission and test the analytical models.Comment: Accepted by ApJ

Discovery of Variability of the Progenitor of SN 2011dh in M51 Using the Large Binocular Telescope

We show that the candidate progenitor of the core-collapse SN 2011dh in M51 (8 Mpc away) was fading by 0.039 +- 0.006 mag/year during the three years prior to the supernova, and that this level of variability is moderately unusual for other similar stars in M 51. While there are uncertainties about whether the true progenitor was a blue companion to this candidate, the result illustrates that there are no technical challenges to obtaining fairly high precision light curves of supernova progenitors using ground based observations of nearby (<10 Mpc) galaxies with wide field cameras on 8m-class telescopes. While other sources of variability may dominate, it is even possible to reach into the range of evolution rates required by the quasi-static evolution of the stellar envelope. For M 81, where we have many more epochs and a slightly longer time baseline, our formal 3 sigma sensitivity to slow changes is presently 3 millimag/year for a M_V ~= -8 mag star. In short, there is no observational barrier to determining whether the variability properties of stars in their last phases of evolution (post Carbon ignition) are different from earlier phases.Comment: 17 pages, 5 figures, submitted to Ap