B and Bs semileptonic decay form factors with NRQCD/HISQ quarks

We discuss our ongoing effort to calculate form factors for several B and Bs semileptonic decays. We have recently completed the first unquenched calculation of the form factors for the rare decay B -> K ll. Extrapolated over the full kinematic range of q^2 via model-independent z expansion, these form factor results allow us to calculate several Standard Model observables. We compare with experiment (Belle, BABAR, CDF, and LHCb) where possible and make predictions elsewhere. We discuss preliminary results for Bs -> K l nu which, when combined with anticipated experimental results, will provide an alternative exclusive determination of |Vub|. We are exploring the possibility of using ratios of form factors for this decay with those for the unphysical decay Bs -> eta_s as a means of significantly reducing form factor errors. We are also studying B -> pi l nu, form factors for which are combined with experiment in the standard exclusive determination of |Vub|. Our simulations use NRQCD heavy and HISQ light valence quarks on the MILC 2+1 dynamical asqtad configurations.Comment: 7 pages, 5 figures, presented at the 31st International Symposium on Lattice Field Theory (Lattice 2013), 29 July - 3 August 2013, Mainz, German

Bs→DsℓνB_s \to D_s \ell \nu Form Factors and the Fragmentation Fraction Ratio fs/fdf_s/f_d

We present a lattice quantum chromodynamics determination of the scalar and vector form factors for the $B_s \rightarrow D_s \ell \nu$ decay over the full physical range of momentum transfer. In conjunction with future experimental data, our results will provide a new method to extract $|V_{cb}|$, which may elucidate the current tension between exclusive and inclusive determinations of this parameter. Combining the form factor results at non-zero recoil with recent HPQCD results for the $B \rightarrow D \ell \nu$ form factors, we determine the ratios $f^{B_s \rightarrow D_s}_0(M_\pi^2) / f^{B \rightarrow D}_0(M_K^2) = 1.000(62)$ and $f^{B_s \rightarrow D_s}_0(M_\pi^2) / f^{B \rightarrow D}_0(M_\pi^2) = 1.006(62)$. These results give the fragmentation fraction ratios $f_s/f_d = 0.310(30)_{\mathrm{stat.}}(21)_{\mathrm{syst.}}(6)_{\mathrm{theor.}}(38)_{\mathrm{latt.}}$ and $f_s/f_d = 0.307(16)_{\mathrm{stat.}}(21)_{\mathrm{syst.}}(23)_{\mathrm{theor.}}(44)_{\mathrm{latt.}}$, respectively. The fragmentation fraction ratio is an important ingredient in experimental determinations of $B_s$ meson branching fractions at hadron colliders, in particular for the rare decay ${\cal B}(B_s \rightarrow \mu^+ \mu^-)$. In addition to the form factor results, we make the first prediction of the branching fraction ratio $R(D_s) = {\cal B}(B_s\to D_s\tau\nu)/{\cal B}(B_s\to D_s\ell\nu) = 0.301(6)$, where $\ell$ is an electron or muon. Current experimental measurements of the corresponding ratio for the semileptonic decays of $B$ mesons disagree with Standard Model expectations at the level of nearly four standard deviations. Future experimental measurements of $R(D_s)$ may help understand this discrepancy.Comment: 21 pages, 15 figure

B and B-s meson decay constants from lattice QCD

We present a new determination of the B and B-s meson decay constants using nonrelativistic quantum chromodynamics (NRQCD) b-quarks, highly improved staggered quark (HISQ) light and strange valence quarks and the MILC collaboration N-f = 2 + 1 lattices. The new calculations improve on HPQCD\u27s earlier work with NRQCD b-quarks by replacing AsqTad with HISQ valence quarks, by including a more chiral MILC fine ensemble in the analysis, and by employing better tuned quark masses and overall scale. We find f (B) = 0.191(9) GeV, f (Bs) = 0.228(10) GeV and f (Bs)/f (B) = 1.188(18). Combining the new value for f (Bs)/f (B) with a recent very precise determination of the B-s meson decay constant based on HISQ b-quarks, f (Bs) = 0.225(4) GeV, leads to f (B) = 0.189(4) GeV. With errors of just 2.1% this represents the most precise f (B) available today

Form factor ratios for Bs→K ℓ νB_s \rightarrow K \, \ell \, \nu and Bs→Ds ℓ νB_s \rightarrow D_s \, \ell \, \nu semileptonic decays and ∣Vub/Vcb∣|V_{ub}/V_{cb}|

We present a lattice quantum chromodynamics determination of the ratio of the scalar and vector form factors for two semileptonic decays of the $B_s$ meson: $B_s \rightarrow K \ell \nu$ and $B_s \rightarrow D_s \ell \nu$. In conjunction with future experimental data, our results for these correlated form factors will provide a new method to extract $|V_{ub}/V_{cb}|$, which may elucidate the current tension between exclusive and inclusive determinations of these Cabibbo-Kobayashi-Maskawa mixing matrix parameters. In addition to the form factor results, we determine the ratio of the differential decay rates, and forward-backward and polarization asymmetries, for the two decays.Comment: 16 pages, 9 figures. Version published in PRD: minor typos fixed and two figures updated. arXiv admin note: text overlap with arXiv:1703.0972

B-s -\u3e D(s)l nu form factors and the fragmentation fraction ratio f(s)/f(d)

We present a lattice quantum chromodynamics determination of the scalar and vector form factors for the B-s -\u3e D(s)l. decay over the full physical range of momentum transfer. In conjunction with future experimental data, our results will provide a new method to extract vertical bar V-cb vertical bar, which may elucidate the current tension between exclusive and inclusive determinations of this parameter. Combining the form factor results at nonzero recoil with recent HPQCD results for the B -\u3e Dl(v) form factors, we determine the ratios f(0)(Bs -\u3e Ds) (M-pi(2))/f(0)(B -\u3e D) (M-K(2))=1.000(62) and f(0)(Bs -\u3e Ds) (M-pi(2))/f(0)(B -\u3e D)(M-pi(2))=1.006(62). These results give the fragmentation fraction ratios f(s)/f(d) = 0.310(30)(stat)(21)(syst)(6)(theor)(38)(latt) and f(s)/f(d) = 0.307(16)(stat)(21)(syst)(23)(theor)(44)(latt), respectively. The fragmentation fraction ratio is an important ingredient in experimental determinations of Bs meson branching fractions at hadron colliders, in particular for the rare decay B(B-s -\u3emu(+)mu(-). In addition to the form factor results, we make the first prediction of the branching fraction ratio R(D-s) = B(B-s -\u3e D-s tau nu)/B(B-s -\u3e D-s tau nu)= 0.301(6), where l is an electron or muon. Current experimental measurements of the corresponding ratio for the semileptonic decays of B mesons disagree with Standard Model expectations at the level of nearly four standard deviations. Future experimental measurements of R(D-s) may help understand this discrepancy

Cues and knowledge structures used by mental-health professionals when making risk assessments

Background: Research into mental-health risks has tended to focus on epidemiological approaches and to consider pieces of evidence in isolation. Less is known about the particular factors and their patterns of occurrence that influence clinicians’ risk judgements in practice. Aims: To identify the cues used by clinicians to make risk judgements and to explore how these combine within clinicians’ psychological representations of suicide, self-harm, self-neglect, and harm to others. Method: Content analysis was applied to semi-structured interviews conducted with 46 practitioners from various mental-health disciplines, using mind maps to represent the hierarchical relationships of data and concepts. Results: Strong consensus between experts meant their knowledge could be integrated into a single hierarchical structure for each risk. This revealed contrasting emphases between data and concepts underpinning risks, including: reflection and forethought for suicide; motivation for self-harm; situation and context for harm to others; and current presentation for self-neglect. Conclusions: Analysis of experts’ risk-assessment knowledge identified influential cues and their relationships to risks. It can inform development of valid risk-screening decision support systems that combine actuarial evidence with clinical expertise

A Phase I and Pharmacologic Study of Weekly Gemcitabine in Combination with Infusional 5-fluorodeoxyuridine and Oral Calcium Leucovorin

Purpose: Since preclinical studies have shown more than additive cytotoxicity and DNA damage with the combination of gemcitabine and 5-fluoro-2′-deoxyuridine (FUDR), we studied this combination in a phase I trial. Methods: Gemcitabine alone was given in cycle 1 as a 24-h, 2-h or 1-h i.v. infusion weekly for 3 of 4 weeks; if tolerated, a 24-h i.v. infusion of FUDR was added with oral leucovorin. The cycle was aborted for grade 3 thrombocytopenia, grade 4 neutropenia, and grade 2 or worse nonhematologic toxicity. Results: During cycle 1, six of eight patients who received 150 or 100 mg/m2 over 24 h had dose-limiting neutropenia, thrombocytopenia, fatigue or mucositis. Six of seven patients treated with 1000 mg/m2 over 2 h required a gemcitabine dose reduction for cycle 2 (thrombocytopenia, neutropenia, fatigue). Of 25 assessable patients who received gemcitabine 1000 mg/m2 over 1 h, 7 did not complete cycle 1 due to thrombocytopenia (n = 6) or diarrhea (n = 1). Of 42 patients entered, 27 received at least one course of gemcitabine/FUDR (5-19.5 mg/m2 over 24 h) without appreciable toxicity. Due to a shortage of FUDR, the protocol was closed early. Gemcitabine plasma concentrations averaged 0.061 μM (24 h), 16.3 μM (2 h), and 31.9 μM (1 h). In 21 paired bone marrow mononuclear cell samples obtained before treatment and during FUDR infusion, thymidylate synthase ternary complex was only seen during FUDR infusion. Conclusions: Gemcitabine 100-150 mg/m2 over 24 h was poorly tolerated, whereas toxicity was acceptable with 800-1000 mg/m2 over 1 h. Inhibition of the target enzyme was demonstrated at all FUDR doses