10 research outputs found
Evaluation of the Multi-Attribute Prioritisation Tool for Total Joint Replacement
- Publication venue
- 'Elsevier BV'
- Publication date
- 31/01/2018
- Field of study
© 2018 Prof. PK Surendran Memorial Education Foundation. Published by Elsevier, a division of RELX India, Pvt. Ltd. All rights reserved.
This manuscript version is made available under the CC-BY-NC-ND 4.0 license: http://creativecommons.org/licenses/by-nc-nd/4.0/
This author accepted manuscript is made available following 12 month embargo from date of publication (March 2018) in accordance with the publisher’s archiving policyRationale, aims and objectives
The demand for arthroplasty is increasing and will continue to rise with an ageing population. Obesity and lengthy waiting time for Total Joint Replacement (TJR) have been associated with poorer outcomes postoperatively. This study aimed to evaluate the Multi-Attribute Prioritisation Tool (MAPT) for TJR patients. The primary objective was to explore if patients prioritised by the MAPT had an improvement in score post-operative. Further to identify any relationship between MAPT score and length of time on the waiting list or obesity.
Method
This retrospective cohort study included 308 patients undergoing total hip (n = 114) or total knee (n = 194) arthroplasty. We examined preoperative and postoperative MAPT scores of patients who had total hip or total knee arthroplasty. After assessing the difference between postoperative and preoperative MAPT scores, patients scores were compared to BMI and waiting time classes. BMI was allocated to less than 30, 30–35, 35–40 and greater than 40. Duration of time on the waiting list was allocated to less than 6 months and greater than 6 months.
Results
THA and TKA patients MAPT scores improved from a preoperative score of 71.39–5.26 postoperative and 54.11 to 7.13 respectively. Patients whose MAPT scores placed them in the high priority category had a significant relationship with length of time on the waiting list (p < 0.01). There were no significant differences between length of time on the waiting list and improvement scores for low priority and middle priority patients. BMI had minimal effect on patients improvement score postoperative.
Conclusion
TJR patients prioritised by the MAPT questionnaire do experience pain relief as portrayed by a reduction in postoperative MAPT score. A longer length of time on the waiting list seems to effect the improvement a high priority patient can have postoperative
Evaluating the Effects of SARS-CoV-2 Spike Mutation D614G on Transmissibility and Pathogenicity.
- Author
- Aanensen David M
- Abudahab Khalil
- Acheson Erwan
- Adams Alexander
- Adams Helen
- Adriaenssens Evelien M
- Afifi Safiah
- Aggarwal Dinesh
- Ahmad Shazaad SY
- Alam Mohammad T
- Alcolea-Medina Adela
- Alderton Alex
- Alikhan Nabil-Fareed
- Allan John
- Allara Elias
- Amato Roberto
- Andersson Monique
- Angyal Adrienn
- Aranday-Cortes Elihu
- Ariani Cristina
- Asad Hibo
- Asamaphan Patawee
- Ashworth Jordan
- Atkinson Laura
- Attwood Stephen
- Auckland Cressida
- Awan Ali R
- Aydin Alp
- Baker David J
- Baker Paul
- Balcazar Carlos E
- Ball Jonathan
- Barton Edward
- Bashton Matthew
- Batra Rahul
- Baxter Laura
- Beale Mathew A
- Beaver Charlotte
- Beckett Angela
- Beer Robert
- Beggs Andrew
- Bell Andrew
- Bellis Katherine L
- Berger Duncan J
- Berriman Matt
- Berry Lisa
- Berry Louise
- Betancor Gilberto
- Betteridge Emma
- Bewshea Claire M
- Bibby David
- Bicknell Kelly
- Birchley Alec
- Bird Paul
- Bishop Chloe
- Blane Beth
- Bolt Frances
- Bonsall David
- Boswell Tim
- Bosworth Andrew
- Bourgeois Yann
- Boyd Olivia
- Boyes John
- Bradley Declan T
- Bradshaw Daniel
- Breen Cassie
- Bresner Catherine
- Breuer Judith
- Bridgewater Hannah E
- Brooks Tony T
- Broos Alice
- Brown Julianne Rose
- Brown Paul E
- Brown Rebecca
- Brunker Kirstyn
- Bucca Giselda
- Buck David
- Buddenborg Sarah K
- Bull Matthew
- Bull Matthew
- Burton-Fanning Shirelle
- Butcher Ethan
- Caddy Sarah L
- Caller Laura G
- Campbell Sharon
- Carlile Matthew
- Carmichael Stephen N
- Casey Anna
- Castellano Sergi
- Chalker Vicki
- Chand Meera
- Chapman Michael R
- Chappell Joseph G
- Charalampous Themoula
- Charles Ian G
- Chaudhry Yasmin
- Chauhan Anoop J
- Cheng Jeffrey KJ
- Churcher Carol M
- Clark Gemma
- Coll Francesc
- Collins Jennifer
- Colquhoun Rachel
- Colquhoun Rachel M
- Connor Thomas R
- Connor Thomas R
- Constantinidou Chrystala
- Coombes Jason
- Corden Sally
- Cormie Claire
- Cortes Nicholas
- Cortes Nick
- Cottrell Simon
- Coupland Lindsay J
- Cowell Angela
- Cox Alison
- Craine Noel
- Cronin Michelle
- Crooke Derrick
- Curran Martin D
- Curran Tanya
- da Silva Filipe Ana
- da Silva Filipe Ana
- Dabrera Gavin
- Danesh John
- Darby Alistair C
- Davidson Rose K
- Davies Alisha
- Davis Thomas
- de Cesare Mariateresa
- De Lacy Elen
- de Oliveira Martins Leonardo
- de Silva Thushan I
- Debebe Johnny
- Dervisevic Samir
- Dewar Rebecca
- Dias Joana
- Diaz Maria
- Dibling Thomas
- Dorman Matthew J
- Downing Fatima
- Drury Eleanor
- du Plessis Louis
- Duckworth Nichola
- Dyal Patricia L
- Eccles Richard
- Edgeworth Jonathan
- Edwards Sue
- Eldirdiri Sahar
- Ellaby Nicholas
- Ellard Sian
- Elliott Scott
- Eltringham Gary
- Elumogo Ngozi
- Essex Sarah
- Evans Cariad
- Evans Johnathan M
- Eyre David
- Fairley Derek J
- Fallon Karlie
- Farbos Audrey
- Farr Ben
- Feltwell Theresa
- Fina Laia
- Findlay Jacqueline
- Fisher Chloe L
- Fleming Vicki M
- Forrest Leysa M
- Forrest Sally
- Foulser Luke
- Francois Sarah
- Fraser Christophe
- Freeman Timothy M
- Frost Lucy R
- Fuller William
- Gallagher Eileen
- Gallagher Michael D
- Garcia-Casado Maria V
- Gaskin Amy
- Gatica-Wilcox Bree
- Gavriil Artemis
- Geidelberg Lily
- Geidelberg Lily
- Gemmell Matthew
- Georgana Iliana
- George Ryan P
- Gifford Laura
- Gilbert Lauren
- Gill Harmeet K
- Gilroy Rachel AJ
- Girgis Sophia T
- Glaysher Sharon
- Golubchik Tanya
- Goncalves Sonia
- Goodfellow Ian
- Goodfellow Ian G
- Goodwin Scott
- Graham Clive
- Graham Lee
- Grammatopoulos Dimitris
- Green Angie
- Green Luke R
- Greenaway Jane
- Gregory Richard
- Griffith Luke
- Groves Danielle C
- Groves Natalie
- Guest Martyn
- Gulliver Huw
- Gutierrez Ana Victoria
- Hadjirin Nazreen F
- Haldenby Sam T
- Hale Antony D
- Hall Grant
- Halstead Fenella
- Hamilton William L
- Haque Tanzina
- Harper Katherine L
- Harris Kathryn Ann
- Harrison Ewan M
- Harrison Ian
- Harrison James W
- Hartman Hassan
- Hattersley Andrew
- Heaney Judith
- Helmer Thomas
- Hesketh Andrew R
- Heyburn David
- Higginson Ellen E
- Hill Verity
- Hill Verity
- Hilvers Ember
- Hiscox Julian A
- Holden Matthew TG
- Holmes Alison
- Holmes Christopher
- Holmes Nadine
- Hoosdally Sarah
- Hopes Richard
- Hosmillo Myra
- Houldcroft Charlotte J
- Howe Robin
- Howson-Wells Hannah C
- Hubb Jonathan
- Hughes Joseph
- Hughes Margaret
- Hunter Adam D
- Hutchings Stephanie
- Impey Robert
- Irish-Tavares Dianne
- Iturriza-Gomara Miren
- Jackson Ben
- Jackson Ben
- Jackson David A
- Jackson David K
- Jackson Kathryn A
- Jahun Aminu S
- James Keith
- Jamrozy Dorota
- Jarrett Ruth
- Jeffries Aaron R
- Jesudason Natasha
- Jesudason Natasha G
- John Michaela
- Johnson Kate
- Johnson Natasha
- Johnson Rob
- Johnson Robert
- Johnston Ian
- Jones Hannah
- Jones Katie
- Jones Rachel
- Jones Sophie
- Jorgensen David
- Jorgensen David
- Joseph Amelia
- Justice Anita
- Kane Leanne
- Kay Gemma L
- Kay Sally
- Keatley Jon-Paul
- Keeley Alexander J
- Kenyon Anita
- Kermack Leanne M
- Khakh Manjinder
- Khokhar Fahad A
- Kidd Stephen
- Kingsley Robert A
- Kitchen Christine
- Knight Bridget A
- Kolyva Anastasia
- Koshy Cherian
- Kraemer Moritz
- Kristiansen Mark
- Kumziene-Summerhayes Sara
- Kwiatkowski Dominic
- Lackenby Angie
- Langford Cordelia
- Lawniczak Mara
- Le-Viet Thanh
- Lee David
- Lee Jack CD
- Letchford Laura
- Levene Nick
- Levett Lisa J
- Li Kathy
- Li Kathy K
- Liggett Steven
- Lindsey Benjamin B
- Lister Michelle M
- Livett Rich
- Lloyd Allyson
- Lo Stephanie
- Loh Joshua
- Loman Nicholas J
- Loman Nicholas J
- Loose Matthew W
- Loveson Katie F
- Lowe Hannah
- Lucaci Anita O
- Ludden Catherine
- Lynch Jessica
- Lyons Ronan A
- Macfarlane-Smith Louissa R
- Machin Nicholas W
- MacIntyre-Cockett George
- Madona Pinglawathee
- Maes Mailis
- Mahungu Tabitha W
- Mair Daniel
- Maksimovic Joshua
- Manesis Nikos
- Manley Robin
- Manso Carmen
- Marchbank Angela
- Martincorena Inigo
- Martinez-Nunez Rocio T
- Masoli Jane AH
- Mason Jenifer
- Mather Alison E
- Mbisa Tamyo
- McCluggage Kathryn
- McClure Patrick C
- McCrone John T
- McCrone JT
- McGuigan Samantha
- McHugh Martin P
- McKenna James P
- McKerr Caoimhe
- McMinn Liz
- McMurray Claire
- Meader Emma J
- Meadows Lizzie
- Menegazzo Mirko
- Meredith Luke W
- Merrick Ian
- Mestek-Boukhibar Lamia
- Miah Shahjahan
- Michell Stephen L
- Michelsen Michelle L
- Molnar Zoltan
- Monaghan Lynn
- Mookerjee Siddharth
- Moore Catherine
- Moore Catrin
- Moore Christopher
- Moore Nathan
- Morgan Mari
- Morgan Sian
- Mori Matilde
- Moses Samuel
- Muir Peter
- Munn Robert
- Myers Richard
- Nascimento Fabricia F
- Nascimento Fabricia F
- Naydenova Plamena
- Neaverson Alexandra S
- Nebbia Gaia
- Nelson Andrew
- Nelson Charlotte
- Nelson Rachel
- Nicholls Sam
- Nicholls Samuel M
- Nichols Jenna
- Niebel Marc O
- Niola Paola
- Nomikou Kyriaki
- O'Toole Elaine
- O'Toole Áine
- Orton Richard J
- Osman Husam
- Ott Sascha
- O’Grady Justin
- O’Toole Áine
- Pacchiarini Nicole
- Pacchiarini Nicole
- Padgett Debra
- Page Andrew J
- Palmer Sophie
- Palmer Steve
- Panchbhaya Yasmin N
- Pandey Sarojini
- Park Naomi
- Parker Matthew D
- Parmar Surendra
- Parr Yasmin A
- Parsons Paul J
- Partridge David G
- Pascall David J
- Patel Gaurang
- Patel Minal
- Patel Vineet
- Paterson Steve
- Payne Brendan AI
- Peacock Sharon J
- Pearson Clare
- Perry Malorie
- Peto Timothy
- Pinckert Malte L
- Platt Steven
- Plimmer Amy
- Poplawski Radoslaw
- Potter Will
- Prakash Reenesh
- Prestwood Liam
- Price Anna
- Price Anna
- Price James
- Puethe Christoph
- Pybus Oliver
- Pybus Oliver G
- Pymont Hannah M
- Quail Mike
- Quick Joshua
- Raghwani Jayna
- Ragonnet-Cronin Manon
- Rainbow Lucille
- Rajatileka Shavanthi
- Rambaut Andrew
- Rambaut Andrew
- Ramsay Mary
- Randell Paul A
- Raviprakash Veena
- Raza Mohammad
- Resende Silva Paola C
- Rey Sara
- Rey Sara M
- Reynolds Nicola
- Richter Alex
- Robertson David L
- Robertson David L
- Robinson Esther
- Robinson Trevor I
- Robson Samuel C
- Rogers Hazel A
- Rooke Stefan
- Rowan Aileen
- Rowe Will
- Roy Sunando
- Rudder Steven
- Ruis Chris
- Ryan Felicity
- Sambles Christine M
- Sang Fei
- Scarlett Garry P
- Schaefer Ulf
- Scher Emily
- Scott Carol
- Scott Garren
- Sethi Dheeraj K
- Shaaban Sharif
- Shah Divya
- Shah Rajiv
- Shah Rajiv N
- Shankar Giri
- Shaw Robert
- Shepherd James
- Shepherd James G
- Sheriff Nicola
- Shirley Lesley
- Signell Adrian W
- Sillitoe John
- Simpson David A
- Singer Joshua B
- Sivaprakasam Venkat
- Siveroni Igor
- Siveroni Igor
- Sloan Tim J
- Sluga Graciela
- Smith Christen
- Smith Colin P
- Smith Darren L
- Smith Nikki
- Smith Wendy
- Smollett Katherine L
- Snell Luke B
- Souster Emily
- Southgate Joel
- Southgate Joel
- Spellman Karla
- Spencer-Chapman Michael
- Sridhar Sushmita
- Stanley Rachael
- Stanton Thomas D
- Starinskij Igor
- Stark Richard
- Stockton Joanne
- Stuart Claire
- Studholme David J
- Swindells Emma
- Swingler Tracey
- Taha Yusri
- Tang Julian
- Taylor Ben EW
- Taylor Graham P
- Taylor Sarah
- Taylor-Joyce Grace
- Tedim Ana P
- Temperton Ben
- Templeton Kate E
- Thompson Thomas
- Thomson Emma C
- Thomson Emma C
- Thomson Nicholas M
- Thornton Alicia
- Thurston Scott
- Todd John A
- Tong Lily
- Tonkin-Hill Gerry
- Torok M Estee
- Trebes Amy
- Trotter Alexander J
- Tsoleridis Theocharis
- Tucker Rachel M
- Turtle Lance
- Tutill Helena J
- Underwood Anthony P
- Unnikrishnan Meera
- Vamos Edith E
- Vasylyeva Tetyana
- Vattipally Sreenu
- Vipond Ian B
- Volz Erik
- Volz Erik M
- Wain John
- Walsh Sarah
- Wang Dennis
- Wantoch Michelle
- Warne Ben
- Warwick-Dugdale Joanna
- Wastenge Elizabeth
- Watkins Joanne
- Watts Joanne
- Waugh Sheila
- Webber Mark A
- Weeks Sam
- Weldon Danni
- Whitehead Mark
- Williams Charlotte A
- Williams Chris
- Williams David
- Williams Rachel J
- Williams Rebecca
- Williams Thomas
- Williamson Kathleen A
- Willingham Iona
- Wilson Harry D
- Wise Emma
- Workman Trudy
- Wright Victoria
- Wyles Matthew
- Wyllie Sarah
- Yakovleva Anna
- Yasir Muhammad
- Yeats Corin A
- Yew Wen C
- Young Gregory R
- Young Jamie
- Yu Xiaoyu
- Zarebski Alex
- Publication venue
- Cell
- Publication date
- 01/09/2020
- Field of study
Global dispersal and increasing frequency of the SARS-CoV-2 spike protein variant D614G are suggestive of a selective advantage but may also be due to a random founder effect. We investigate the hypothesis for positive selection of spike D614G in the United Kingdom using more than 25,000 whole genome SARS-CoV-2 sequences. Despite the availability of a large dataset, well represented by both spike 614 variants, not all approaches showed a conclusive signal of positive selection. Population genetic analysis indicates that 614G increases in frequency relative to 614D in a manner consistent with a selective advantage. We do not find any indication that patients infected with the spike 614G variant have higher COVID-19 mortality or clinical severity, but 614G is associated with higher viral load and younger age of patients. Significant differences in growth and size of 614G phylogenetic clusters indicate a need for continued study of this variant
Hospital admission and emergency care attendance risk for SARS-CoV-2 delta (B.1.617.2) compared with alpha (B.1.1.7) variants of concern: a cohort study
- Author
- Aanensen David
- Abudahab Khalil
- Acheson Erwan
- Adams Alexander
- Adams Helen
- Afifi Safiah
- Aggarwal Dinesh
- Ahmad Shazaad
- Aigrain Louise
- Alam Mohammad
- Alcolea-Medina Adela
- Alderton Alex
- Aliabadi Shirin
- Alikhan Nabil-Fareed
- Allara Elias
- Amato Roberto
- Andersson Monique
- Angyal Adrienn
- Aranday-Cortes Elihu
- Ariani Cristina
- Asad Hibo
- Asamaphan Patawee
- Ash Amy
- Ashcroft Fiona
- Atkinson Laura
- Attwood Stephen
- Auckland Cressida
- Awan Ali
- Aydin Alp
- Baker David
- Baker Paul
- Balcazar Carlos
- Ball Jonathan
- Barrett Jeff
- Barton Edward
- Bashton Matthew
- Bassett Andrew
- Batra Rahul
- Baxter Laura
- Bayzid Nadua
- Beale Mathew
- Beaver Charlotte
- Beckett Angela
- Bedford Luke
- Beer Robert
- Beggs Andrew
- Bellis Katherine
- Berry Lisa
- Berry Louise
- Best Angus
- Betancor Gilberto
- Betteridge Emma
- Bewshea Claire
- Bibby David
- Bicknell Kelly
- Birchley Alec
- Bird Paul
- Bishop Chloe
- Blacow Rachel
- Blakey Victoria
- Blane Beth
- Bolt Frances
- Bonfield James
- Bonner Stephen
- Bonsall David
- Boswell Tim
- Bosworth Andrew
- Bourgeois Yann
- Boyd Olivia
- BoYes John
- Bradley Amanda
- Bradley Declan
- Bradshaw Daniel
- Breen Cassie
- Bresner Catherine
- Breuer Judith
- Bridgewater Hannah
- Bronner Iraad
- Brooks Ellena
- Broos Alice
- Brown Julianne
- Brown Paul
- Brown Rebecca
- Bucca Giselda
- Buck David
- Bull Matthew
- Burton-Fanning Shirelle
- Campbell Sharon
- Carabelli Alessandro
- Carden Holli
- Carlile Matthew
- Carmichael Stephen
- Casey Anna
- Cerda Alberto
- Chalker Vicki
- Chand Meera
- Chapman Michael
- Chappell Joseph
- Charalampous Themoula
- Charlett Andre
- Chatterton Wendy
- Chaudhry Yasmin
- Chauhan Anoop
- Cheng Jeffrey
- Churcher Carol
- Clark Gemma
- Cogger Benjamin
- Coll Francesc
- Collins Jennifer
- Connor Thomas
- Constantinidou Chrystala
- Cook Kate
- Coombes Jason
- Corden Sally
- Cormie Claire
- Cortes Nick
- Cotic Marius
- Cottrell Simon
- Coupland Lindsay
- Cowell Angela
- Cox Alison
- Craine Noel
- Crawford Liam
- Cronin Michelle
- Crook Derrick
- Cumley Nicola
- Curran Martin
- Curran Tanya
- da Silva Filipe Ana
- Dabrera Gavin
- Dabrera Gavin
- Dadrah Ashok
- Danesh John
- Darby Alistair
- Davidson Rose
- Davies Alisha
- Davies Robert
- Davis Thomas
- De Angelis Daniela
- de Cesare Mariateresa
- De Lacy Elen
- de Oliveira Martins Leonardo
- de Silva Thushan
- Debebe Johnny
- Dent Hannah
- Dervisevic Samir
- Dewar Rebecca
- Dias Joana
- Dorman Matthew
- Downing Fatima
- Drury Eleanor
- du Plessis Louis
- Duckworth Nichola
- Durham Jillian
- Eccles Richard
- Edgeworth Jonathan
- Edwards Sue
- Eldirdiri Sahar
- Ellaby Nicholas
- Ellard Sian
- Elliott Scott
- Eltringham Gary
- Ensell Leah
- Escalera Zamudio Marina
- Essex Sarah
- Evans Cariad
- Evans Johnathan
- Eyre David
- F. Nascimento Fabricia
- Fairley Derek
- Fallon Karlie
- Farbos Audrey
- Farr Ben
- Fearn Christopher
- Fenton Melisa
- Fina Laia
- Fisher Chloe
- Flaviani Flavia
- Fleming Vicki
- Forrest Sally
- Foulser Luke
- Francois Sarah
- Fraser Christophe
- Freeman Timothy
- Frost Lucy
- Fuller William
- Galai Katerina
- Gallagher Eileen
- Gallagher Eileen
- Gallagher Michael
- Gallis Marta
- Gaskin Amy
- Gatica-Wilcox Bree
- Geidelberg Lily
- Gemmell Matthew
- Georgana Iliana
- George Ryan
- Gifford Laura
- Gilbert Lauren
- Gill Harmeet
- Girgis Sophia
- Glaysher Sharon
- Golubchik Tanya
- Goncalves Sonia
- Goodfellow Ian
- Goodwin Scott
- Goudarzi Salman
- Gourtovaia Marina
- Graham Clive
- Graham Lee
- Grammatopoulos Dimitris
- Green Angie
- Green Luke
- Greenaway Jane
- Gregory Richard
- Groves Danielle
- Groves Natalie
- Guest Martyn
- Gulliver Huw
- Gunson Rory
- Gupta Ravi
- Gutierrez Bernardo
- Hadjirin Nazreen
- Haldenby Sam
- Hale Antony
- Hall Grant
- Halstead Fenella
- Hamilton William
- Haque Tanzina
- Harper Katherine
- Harris Kathryn
- Harris Ross J
- Harrison Ewan
- Harrison Ian
- Harrison James
- Hart Jennifer
- Hartley John
- Hartman Hassan
- Hassan-Ibrahim Mohammed
- Heaney Judith
- Helmer Thomas
- Hesketh Andrew
- Heyburn David
- Higginson Ellen
- Hill Verity
- Hilvers Ember
- Hiscox Julian
- Hogsden Wendy
- Holden Matthew
- Holmes Alison
- Holmes Christopher
- Holmes Nadine
- Hope Russell
- Hopes Richard
- Hosmillo Myra
- Howe Robin
- Howson-Wells Hannah
- Hubb Jonathan
- Hughes Joseph
- Hughes Margaret
- Hutchings Stephanie
- Illingworth Chris
- Impey Robert
- Irish-Tavares Dianne
- Iturriza-Gomara Miren
- Jackson Chris
- Jackson David
- Jackson Kathryn
- Jackson Leigh
- Jahun Aminu
- James Keith
- Jamrozy Dorota
- Jannoo Riaz
- Jeffries Aaron
- Jeremiah Sarah
- Jesudason Natasha
- John Michaela
- Johnson Kate
- Johnson Natasha
- Johnson Rob
- Johnston Ian
- Jones Carl
- Jones Christopher
- Jones Hannah
- Jones Katie
- Jones Rachel
- Jones Sophie
- Jorgensen David
- Joseph Amelia
- Justice Anita
- Kane Leanne
- Karamani Angeliki
- Kay Gemma
- Kay Sally
- Keatley Jon-Paul
- Keeley Alexander
- Kenyon Anita
- Kermack Leanne
- Khakh Manjinder
- Kidd Stephen
- Kitchen Christine
- Knight Bridget
- Koshy Cherian
- Kraemer Moritz
- Kristiansen Mark
- Kumziene-SummerhaYes Sara
- Kwiatkowski Dominic
- Lackenby Angie
- Langford Cordelia
- Lawniczak Mara
- Le-Viet Thanh
- Ledesma Juan
- Lee David
- Lee Jack
- Leek Danielle
- Lensing Stefanie
- Leonard Steven
- Letchford Laura
- Levene Nick
- Levett Lisa
- Lewis Kevin
- Li Kathy
- Liddle Jennifier
- Liggett Steven
- Lindsey Benjamin
- Lister Michelle
- Livett Rich
- Lloyd Allyson
- Lo Stephanie
- Loman Nicholas
- Loose Matthew
- Lopez-Bernal Jamie
- Louka Stavroula
- Loveson Katie
- Lowe Hannah
- Lowe Helen
- Lucaci Anita
- Ludden Catherine
- Lynch Jessica
- Lyons Ronan
- Macfarlane-Smith Louissa
- Machin Nicholas
- MacIntyre-Cockett George
- Maclean Alasdair
- Madona Pinglawathee
- Maes Mailis
- Mahanama Adhyana
- Mahungu Tabitha
- Mair Daniel
- Maksimovic Joshua
- Makunin Alex
- Malone Cassandra
- Manesis Nikos
- Manley Robin
- Manso Carmen
- Marchbank Angela
- Martincorena Inigo
- Martinez Nunez Rocio
- Masoli Jane
- Mason Jenifer
- Mather Alison
- Mayhew Megan
- Mbisa Tamyo
- McCann Clare
- McCarthy Shane
- McCluggage Kathryn
- McClure Patrick
- McGuigan Samantha
- McHugh Martin
- McKenna James
- McKerr Caoimhe
- McManus Georgina
- McMurray Claire
- McNally Alan
- Meader Emma
- Meadows Lizzie
- Megram Oliver
- Menegazzo Mirko
- Merrick Ian
- Merrill Tammy
- Miah Shahjahan
- Michell Stephen
- Michelsen Michelle
- Mirza Jeremy
- Moles-Garcia Emma
- Moll Robin
- Mollett Guy
- Molnar Zoltan
- Monaghan Lynn
- Mookerjee Siddharth
- Moore Catherine
- Moore Christopher
- Moore Jonathan
- Moore Nathan
- Morgan Mari
- Morgan Sian
- Mori Matilde
- Moses Samuel
- Muir Peter
- Munn Robert
- Myers Richard
- Nebbia Gaia
- Nelson Andrew
- Nelson Charlotte
- Nelson Rachel
- Nicholls Sam
- Nichols Jenna
- Nickbakhsh Seema
- Niebel Marc
- Nomikou Kyriaki
- Nyberg Tommy
- O'Brien Sarah
- O'Grady Justin
- O'Toole Elaine
- O'Toole Áine
- Oliver Karen
- Orton Richard
- Osman Husam
- Ott Sascha
- Pacchiarini Nicole
- Padgett Debra
- Page Andrew
- Palmer Sophie
- Palmer Steve
- Pandey Sarojini
- Park Naomi
- Parker Matthew
- Parmar Surendra
- Parsons Paul
- Partridge David
- Patel Amita
- Patel Minal
- Patel Vineet
- Paterson Steve
- Paul Hannah
- Payne Brendan
- Peacock Sharon
- Pearson Clare
- Pelosi Emanuela
- Percival Benita
- Perry Malorie
- Peto Timothy
- Pinckert Malte
- Platt Steven
- Plimmer Amy
- Poplawski Radoslaw
- Presanis Anne M
- Prestwood Liam
- Price Anna
- Price James
- Prieto Jacqui
- Puethe Christoph
- Pusok Monika
- Pybus Oliver
- Pymont Hannah
- Quail Michael
- Quick Joshua
- Raghwani Jayna
- Ragonnet-Cronin Manon
- Rainbow Lucille
- Rajan Diana
- Rajatileka Shavanthi
- Rambaut Andrew
- Ramsay Mary
- Randell Paul
- Ratcliffe Liz
- Raviprakash Veena
- Raza Mohammad
- Redshaw Nicholas
- Rey Sara
- Reynolds Nicola
- Richter Alex
- Robertson David
- Robinson Esther
- Robinson Trevor
- Robson Samuel
- Rooke Stefan
- Rowan Aileen
- Rowe Will
- Roy Sunando
- Rudder Steven
- Ruis Chris
- Rushton Steven
- Saeed Kordo
- Saluja Tranprit
- Samaraweera Buddhini
- Sambles Christine
- Sang Fei
- Scarlett Garry
- Schaefer Ulf
- Scott Carol
- Scott Garren
- Seaman Shaun R
- Shaaban Sharif
- Shah Divya
- Shah Rajiv
- Shankar Giri
- Shepherd James
- Sheriff Nicola
- Shirley Lesley
- Signell Adrian
- Sillitoe John
- Silveira Siona
- Simpson David
- Singer Joshua
- Sinnathamby Mary A
- Sivaprakasam Venkat
- Siveroni Igor
- Sloan Tim
- Sluga Graciela
- Smith Colin
- Smith Darren
- Smith Kim
- Smith Louise
- Smith Nikki
- Smith Wendy
- Smollett Katherine
- Snell Luke
- Southgate Joel
- Spellman Karla
- Spencer Chapman Michael
- Sridhar Sushmita
- Stanley Rachael
- Stanton Thomas
- Starinskij Igor
- Stark Richard
- Stockton Joanne
- Stonehouse Susanne
- Storey Nathaniel
- Studholme David
- Swindells Emma
- Symmonds Amanda
- Taha Yusri
- Tang Julian
- Taylor Ben
- Taylor Graham
- Taylor Sarah
- Taylor-Joyce Grace
- Temperton Ben
- Templeton Kate
- Thelwall Simon
- Thompson Thomas
- Thomson Emma
- Thornton Alicia
- Thurston Scott
- Todd John
- Tong Lily
- Tonkin-Hill Gerry
- Torok M. Estee
- Tovar-Corona Jaime
- Trebes Amy
- Trotter Alexander
- Tsoleridis Theocharis
- Tucker Rachel
- Turtle Lance
- Twohig Katherine
- Twohig Katherine A
- Underwood Anthony
- Unnikrishnan Meera
- Vamos Edith
- Vasylyeva Tetyana
- Vattipally Sreenu
- Vernet Gabrielle
- Vipond Ian
- Volz Erik
- Walsh Sarah
- Wang Dennis
- Wantoch Michelle
- Warne Ben
- Warwick-Dugdale Joanna
- Wastenge Elizabeth
- Watkins Joanne
- Watts Joanne
- Waugh Sheila
- Webster Hermione
- Weldon Danni
- Westhorpe Adam
- Whitehead Mark
- Whiteley Max
- Whitwham Andrew
- Wierzbicki Claudia
- Williams Charlotte
- Williams Chris
- Williams David
- Williams Lesley-Anne
- Williams Rachel
- Williams Rebecca
- Williams Thomas
- Williamson Kathleen
- Willingham Iona
- Wilson Harry
- Wilson Rebekah
- Wilson-Davies Eleri
- Wise Emma
- Witele Eric
- Workman Trudy
- Wright Victoria
- Wyatt Tim
- Wyles Matthew
- Wyllie Sarah
- Xu-McCrae Li
- Yeats Corin
- Yew Wen
- Young Gregory
- Young Jamie
- Zaidi Asad
- Zarebski Alex
- Zhang Peijun
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2022
- Field of study
Background:
The SARS-CoV-2 delta (B.1.617.2) variant was first detected in England in March, 2021. It has since rapidly become the predominant lineage, owing to high transmissibility. It is suspected that the delta variant is associated with more severe disease than the previously dominant alpha (B.1.1.7) variant. We aimed to characterise the severity of the delta variant compared with the alpha variant by determining the relative risk of hospital attendance outcomes.
Methods:
This cohort study was done among all patients with COVID-19 in England between March 29 and May 23, 2021, who were identified as being infected with either the alpha or delta SARS-CoV-2 variant through whole-genome sequencing. Individual-level data on these patients were linked to routine health-care datasets on vaccination, emergency care attendance, hospital admission, and mortality (data from Public Health England's Second Generation Surveillance System and COVID-19-associated deaths dataset; the National Immunisation Management System; and NHS Digital Secondary Uses Services and Emergency Care Data Set). The risk for hospital admission and emergency care attendance were compared between patients with sequencing-confirmed delta and alpha variants for the whole cohort and by vaccination status subgroups. Stratified Cox regression was used to adjust for age, sex, ethnicity, deprivation, recent international travel, area of residence, calendar week, and vaccination status.
Findings:
Individual-level data on 43 338 COVID-19-positive patients (8682 with the delta variant, 34 656 with the alpha variant; median age 31 years [IQR 17–43]) were included in our analysis. 196 (2·3%) patients with the delta variant versus 764 (2·2%) patients with the alpha variant were admitted to hospital within 14 days after the specimen was taken (adjusted hazard ratio [HR] 2·26 [95% CI 1·32–3·89]). 498 (5·7%) patients with the delta variant versus 1448 (4·2%) patients with the alpha variant were admitted to hospital or attended emergency care within 14 days (adjusted HR 1·45 [1·08–1·95]). Most patients were unvaccinated (32 078 [74·0%] across both groups). The HRs for vaccinated patients with the delta variant versus the alpha variant (adjusted HR for hospital admission 1·94 [95% CI 0·47–8·05] and for hospital admission or emergency care attendance 1·58 [0·69–3·61]) were similar to the HRs for unvaccinated patients (2·32 [1·29–4·16] and 1·43 [1·04–1·97]; p=0·82 for both) but the precision for the vaccinated subgroup was low.
Interpretation:
This large national study found a higher hospital admission or emergency care attendance risk for patients with COVID-19 infected with the delta variant compared with the alpha variant. Results suggest that outbreaks of the delta variant in unvaccinated populations might lead to a greater burden on health-care services than the alpha variant.
Funding:
Medical Research Council; UK Research and Innovation; Department of Health and Social Care; and National Institute for Health Research
Evaluating the Effects of SARS-CoV-2 Spike Mutation D614G on Transmissibility and Pathogenicity
- Author
- Aanensen David M.
- Abudahab Khalil
- Acheson Erwan
- Adams Alexander
- Adams Helen
- Adriaenssens Evelien M.
- Afifi Safiah
- Aggarwal Dinesh
- Ahmad Shazaad S.Y.
- Alam Mohammad T.
- Alcolea-Medina Adela
- Alderton Alex
- Alikhan Nabil-Fareed
- Allan John
- Allara Elias
- Amato Roberto
- Andersson Monique
- Angyal Adrienn
- Aranday-Cortes Elihu
- Ariani Cristina
- Asad Hibo
- Asamaphan Patawee
- Ashworth Jordan
- Atkinson Laura
- Attwood Stephen
- Auckland Cressida
- Awan Ali R.
- Aydin Alp
- Baker David J.
- Baker Paul
- Balcazar Carlos E.
- Ball Jonathan
- Barton Edward
- Bashton Matthew
- Batra Rahul
- Baxter Laura
- Beale Mathew A.
- Beaver Charlotte
- Beckett Angela
- Beer Robert
- Beggs Andrew
- Bell Andrew
- Bellis Katherine L.
- Berger Duncan J.
- Berriman Matt
- Berry Lisa
- Berry Louise
- Betancor Gilberto
- Betteridge Emma
- Bewshea Claire M.
- Bibby David
- Bicknell Kelly
- Birchley Alec
- Bird Paul
- Bishop Chloe
- Blane Beth
- Bolt Frances
- Bonsall David
- Boswell Tim
- Bosworth Andrew
- Bourgeois Yann
- Boyd Olivia
- Boyes John
- Bradley Declan T.
- Bradshaw Daniel
- Breen Cassie
- Bresner Catherine
- Breuer Judith
- Bridgewater Hannah E.
- Brooks Tony T.
- Broos Alice
- Brown Julianne Rose
- Brown Paul E.
- Brown Rebecca
- Brunker Kirstyn
- Bucca Giselda
- Buck David
- Buddenborg Sarah K.
- Bull Matthew
- Bull Matthew
- Burton-Fanning Shirelle
- Butcher Ethan
- Caddy Sarah L.
- Caller Laura G.
- Campbell Sharon
- Carlile Matthew
- Carmichael Stephen N.
- Casey Anna
- Castellano Sergi
- Chalker Vicki
- Chand Meera
- Chapman Michael R.
- Chappell Joseph G.
- Charalampous Themoula
- Charles Ian G.
- Chaudhry Yasmin
- Chauhan Anoop J.
- Cheng Jeffrey K.J.
- Churcher Carol M.
- Clark Gemma
- Coll Francesc
- Collins Jennifer
- Colquhoun Rachel
- Colquhoun Rachel M.
- Connor Thomas R.
- Connor Thomas R.
- Constantinidou Chrystala
- Coombes Jason
- Corden Sally
- Cormie Claire
- Cortes Nicholas
- Cortes Nick
- Cottrell Simon
- Coupland Lindsay J.
- Cowell Angela
- Cox Alison
- Craine Noel
- Cronin Michelle
- Crooke Derrick
- Curran Martin D.
- Curran Tanya
- da Silva Filipe Ana
- da Silva Filipe Ana
- Dabrera Gavin
- Danesh John
- Darby Alistair C.
- Davidson Rose K.
- Davies Alisha
- Davis Thomas
- de Cesare Mariateresa
- De Lacy Elen
- de Oliveira Martins Leonardo
- de Silva Thushan I.
- Debebe Johnny
- Dervisevic Samir
- Dewar Rebecca
- Dias Joana
- Diaz Maria
- Dibling Thomas
- Dorman Matthew J.
- Downing Fatima
- Drury Eleanor
- du Plessis Louis
- Duckworth Nichola
- Dyal Patricia L.
- Eccles Richard
- Edgeworth Jonathan
- Edwards Sue
- Eldirdiri Sahar
- Ellaby Nicholas
- Ellard Sian
- Elliott Scott
- Eltringham Gary
- Elumogo Ngozi
- Essex Sarah
- Evans Cariad
- Evans Johnathan M.
- Eyre David
- Fairley Derek J.
- Fallon Karlie
- Farbos Audrey
- Farr Ben
- Feltwell Theresa
- Fina Laia
- Findlay Jacqueline
- Fisher Chloe L.
- Fleming Vicki M.
- Forrest Leysa M.
- Forrest Sally
- Foulser Luke
- Francois Sarah
- Fraser Christophe
- Freeman Timothy M.
- Frost Lucy R.
- Fuller William
- Gallagher Eileen
- Gallagher Michael D.
- Garcia-Casado Maria V.
- Gaskin Amy
- Gatica-Wilcox Bree
- Gavriil Artemis
- Geidelberg Lily
- Geidelberg Lily
- Gemmell Matthew
- Georgana Iliana
- George Ryan P.
- Gifford Laura
- Gilbert Lauren
- Gill Harmeet K.
- Gilroy Rachel A.J.
- Girgis Sophia T.
- Glaysher Sharon
- Golubchik Tanya
- Goncalves Sonia
- Goodfellow Ian
- Goodfellow Ian G.
- Goodwin Scott
- Graham Clive
- Graham Lee
- Gramatopoulos Dimitris
- Green Angie
- Green Luke R.
- Greenaway Jane
- Gregory Richard
- Griffith Luke
- Groves Danielle C.
- Groves Natalie
- Guest Martyn
- Gulliver Huw
- Gutierrez Ana Victoria
- Hadjirin Nazreen F.
- Haldenby Sam T.
- Hale Antony D.
- Hall Grant
- Halstead Fenella
- Hamilton William L.
- Haque Tanzina
- Harper Katherine L.
- Harris Kathryn Ann
- Harrison Ewan M.
- Harrison Ian
- Harrison James W.
- Hartman Hassan
- Hattersley Andrew
- Heaney Judith
- Helmer Thomas
- Hesketh Andrew R.
- Heyburn David
- Higginson Ellen E.
- Hill Verity
- Hill Verity
- Hilvers Ember
- Hiscox Julian A.
- Holden Matthew T.G.
- Holmes Alison
- Holmes Christopher
- Holmes Nadine
- Hoosdally Sarah
- Hopes Richard
- Hosmillo Myra
- Houldcroft Charlotte J.
- Howe Robin
- Howson-Wells Hannah C.
- Hubb Jonathan
- Hughes Joseph
- Hughes Margaret
- Hunter Adam D.
- Hutchings Stephanie
- Impey Robert
- Irish-Tavares Dianne
- Iturriza-Gomara Miren
- Jackson Ben
- Jackson Ben
- Jackson David A.
- Jackson David K.
- Jackson Kathryn A.
- Jahun Aminu S.
- James Keith
- Jamrozy Dorota
- Jarrett Ruth
- Jeffries Aaron R.
- Jesudason Natasha
- Jesudason Natasha G.
- John Michaela
- Johnson Kate
- Johnson Natasha
- Johnson Rob
- Johnson Robert
- Johnston Ian
- Jones Hannah
- Jones Katie
- Jones Rachel
- Jones Sophie
- Jorgensen David
- Jorgensen David
- Joseph Amelia
- Justice Anita
- Kane Leanne
- Kay Gemma L.
- Kay Sally
- Keatley Jon-Paul
- Keeley Alexander J.
- Kenyon Anita
- Kermack Leanne M.
- Khakh Manjinder
- Khokhar Fahad A.
- Kidd Stephen
- Kingsley Robert A.
- Kitchen Christine
- Knight Bridget A.
- Kolyva Anastasia
- Koshy Cherian
- Kraemer Moritz
- Kristiansen Mark
- Kumziene-Summerhayes Sara
- Kwiatkowski Dominic
- Lackenby Angie
- Langford Cordelia
- Lawniczak Mara
- Le-Viet Thanh
- Lee David
- Lee Jack C.D.
- Letchford Laura
- Levene Nick
- Levett Lisa J.
- Li Kathy
- Li Kathy K.
- Liggett Steven
- Lindsey Benjamin B.
- Lister Michelle M.
- Livett Rich
- Lloyd Allyson
- Lo Stephanie
- Loh Joshua
- Loman Nicholas J.
- Loman Nicholas J.
- Loose Matthew W.
- Loveson Katie F.
- Lowe Hannah
- Lucaci Anita O.
- Ludden Catherine
- Lynch Jessica
- Lyons Ronan A.
- Macfarlane-Smith Louissa R.
- Machin Nicholas W.
- MacIntyre-Cockett George
- Madona Pinglawathee
- Maes Mailis
- Mahungu Tabitha W.
- Mair Daniel
- Maksimovic Joshua
- Manesis Nikos
- Manley Robin
- Manso Carmen
- Marchbank Angela
- Martincorena Inigo
- Martinez-Nunez Rocio T.
- Masoli Jane A.H.
- Mason Jenifer
- Mather Alison E.
- Mbisa Tamyo
- McCluggage Kathryn
- McClure Patrick C.
- McCrone J.T.
- McCrone John T.
- McGuigan Samantha
- McHugh Martin P.
- McKenna James P.
- McKerr Caoimhe
- McMinn Liz
- McMurray Claire
- Meader Emma J.
- Meadows Lizzie
- Menegazzo Mirko
- Meredith Luke W.
- Merrick Ian
- Mestek-Boukhibar Lamia
- Miah Shahjahan
- Michell Stephen L.
- Michelsen Michelle L.
- Molnar Zoltan
- Monaghan Lynn
- Mookerjee Siddharth
- Moore Catherine
- Moore Catrin
- Moore Christopher
- Moore Nathan
- Morgan Mari
- Morgan Sian
- Mori Matilde
- Moses Samuel
- Muir Peter
- Munn Robert
- Myers Richard
- Nascimento Fabricia F.
- Nascimento Fabricia F.
- Naydenova Plamena
- Neaverson Alexandra S.
- Nebbia Gaia
- Nelson Andrew
- Nelson Charlotte
- Nelson Rachel
- Nicholls Sam
- Nicholls Samuel M.
- Nichols Jenna
- Niebel Marc O.
- Niola Paola
- Nomikou Kyriaki
- O'Toole Elaine
- O'Toole Áine
- Orton Richard J.
- Osman Husam
- Ott Sascha
- O’Grady Justin
- O’Toole Áine
- Pacchiarini Nicole
- Pacchiarini Nicole
- Padgett Debra
- Page Andrew J.
- Palmer Sophie
- Palmer Steve
- Panchbhaya Yasmin N.
- Pandey Sarojini
- Park Naomi
- Parker Matthew D.
- Parmar Surendra
- Parr Yasmin A.
- Parsons Paul J.
- Partridge David G.
- Pascall David J.
- Patel Gaurang
- Patel Minal
- Patel Vineet
- Paterson Steve
- Payne Brendan A.I.
- Peacock Sharon J.
- Pearson Clare
- Perry Malorie
- Peto Timothy
- Pinckert Malte L.
- Platt Steven
- Plimmer Amy
- Poplawski Radoslaw
- Potter Will
- Prakash Reenesh
- Prestwood Liam
- Price Anna
- Price Anna
- Price James
- Puethe Christoph
- Pybus Oliver
- Pybus Oliver G.
- Pymont Hannah M.
- Quail Mike
- Quick Joshua
- Raghwani Jayna
- Ragonnet-Cronin Manon
- Rainbow Lucille
- Rajatileka Shavanthi
- Rambaut Andrew
- Rambaut Andrew
- Ramsay Mary
- Randell Paul A.
- Raviprakash Veena
- Raza Mohammad
- Resende Silva Paola C.
- Rey Sara
- Rey Sara M.
- Reynolds Nicola
- Richter Alex
- Robertson David L.
- Robertson David L.
- Robinson Esther
- Robinson Trevor I.
- Robson Samuel C.
- Rogers Hazel A.
- Rooke Stefan
- Rowan Aileen
- Rowe Will
- Roy Sunando
- Rudder Steven
- Ruis Chris
- Ryan Felicity
- Sambles Christine M.
- Sang Fei
- Scarlett Garry P.
- Schaefer Ulf
- Scher Emily
- Scott Carol
- Scott Garren
- Sethi Dheeraj K.
- Shaaban Sharif
- Shah Divya
- Shah Rajiv
- Shah Rajiv N.
- Shankar Giri
- Shaw Robert
- Shepherd James
- Shepherd James G.
- Sheriff Nicola
- Shirley Lesley
- Signell Adrian W.
- Sillitoe John
- Simpson David A.
- Singer Joshua B.
- Sivaprakasam Venkat
- Siveroni Igor
- Siveroni Igor
- Sloan Tim J.
- Sluga Graciela
- Smith Christen
- Smith Colin P.
- Smith Darren
- Smith Nikki
- Smith Wendy
- Smollett Katherine L.
- Snell Luke B.
- Souster Emily
- Southgate Joel
- Southgate Joel
- Spellman Karla
- Spencer-Chapman Michael
- Sridhar Sushmita
- Stanley Rachael
- Stanton Thomas D.
- Starinskij Igor
- Stark Richard
- Stockton Joanne
- Stuart Claire
- Studholme David J.
- Swindells Emma
- Swingler Tracey
- Taha Yusri
- Tang Julian
- Taylor Ben E.W.
- Taylor Graham P.
- Taylor Sarah
- Taylor-Joyce Grace
- Tedim Ana P.
- Temperton Ben
- Templeton Kate E.
- Thompson Thomas
- Thomson Emma C.
- Thomson Emma C.
- Thomson Nicholas M.
- Thornton Alicia
- Thurston Scott
- Todd John A.
- Tong Lily
- Tonkin-Hill Gerry
- Torok M. Estee
- Trebes Amy
- Trotter Alexander J.
- Tsoleridis Theocharis
- Tucker Rachel M.
- Turtle Lance
- Tutill Helena J.
- Underwood Anthony P.
- Unnikrishnan Meera
- Vamos Edith E.
- Vasylyeva Tetyana
- Vattipally Sreenu
- Vipond Ian B.
- Volz Erik
- Volz Erik M.
- Wain John
- Walsh Sarah
- Wang Dennis
- Wantoch Michelle
- Warne Ben
- Warwick-Dugdale Joanna
- Wastenge Elizabeth
- Watkins Joanne
- Watts Joanne
- Waugh Sheila
- Webber Mark A.
- Weeks Sam
- Weldon Danni
- Whitehead Mark
- Williams Charlotte A.
- Williams Chris
- Williams David
- Williams Rachel J.
- Williams Rebecca
- Williams Thomas
- Williamson Kathleen A.
- Willingham Iona
- Wilson Harry D.
- Wise Emma
- Workman Trudy
- Wright Victoria
- Wyles Matthew
- Wyllie Sarah
- Yakovleva Anna
- Yasir Muhammad
- Yeats Corin A.
- Yew Wen C.
- Young Gregory R.
- Young Jamie
- Yu Xiaoyu
- Zarebski Alex
- Publication venue
- Elsevier
- Publication date
- 07/01/2021
- Field of study
Global dispersal and increasing frequency of the SARS-CoV-2 spike protein variant D614G are suggestive of a selective advantage but may also be due to a random founder effect. We investigate the hypothesis for positive selection of spike D614G in the United Kingdom using more than 25,000 whole genome SARS-CoV-2 sequences. Despite the availability of a large dataset, well represented by both spike 614 variants, not all approaches showed a conclusive signal of positive selection. Population genetic analysis indicates that 614G increases in frequency relative to 614D in a manner consistent with a selective advantage. We do not find any indication that patients infected with the spike 614G variant have higher COVID-19 mortality or clinical severity, but 614G is associated with higher viral load and younger age of patients. Significant differences in growth and size of 614G phylogenetic clusters indicate a need for continued study of this variant
Changes in symptomatology, reinfection, and transmissibility associated with the SARS-CoV-2 variant B.1.1.7: an ecological study
- Author
- Aanensen David M
- Abudahab Khalil
- Acheson Erwan
- Adams Alexander
- Adams Helen
- Afifi Safiah
- Aggarwal Dinesh
- Ahmad Shazaad S Y
- Aigrain Louise
- Alam Mohammad T.
- Alcolea-Medina Adela
- Alderton Alex
- Alikhan Nabil-Fareed
- Allara Elias
- Amato Roberto
- Andersson Monique
- Angyal Adrienn
- Antonelli Michela
- Aranday-Cortes Elihu
- Ariani Cristina V
- Asad Hibo
- Asamaphan Patawee
- Ash Amy
- Ashcroft Fiona
- Atkinson Laura
- Attwood Stephen W
- Auckland Cressida
- Awan Ali R
- Aydin Alp
- Baker David J
- Baker Paul
- Balcazar Carlos E
- Ball Jonathan
- Barrett Jeff
- Barton Edward
- Bashton Matthew
- Bassett Andrew R
- Batra Rahul
- Baxter Laura
- Bayzid Nadua
- Beale Mathew A
- Beaver Charlotte
- Beckett Angela H
- Bedford Luke
- Beer Robert
- Beggs Andrew
- Bellis Katherine L
- Berry Lisa
- Berry Louise
- Best Angus
- Betancor Gilberto
- Betteridge Emma
- Bewshea Claire M
- Bibby David
- Bicknell Kelly
- Birchley Alec
- Bird Paul
- Bishop Chloe
- Blacow Rachel
- Blakey Victoria
- Blane Beth
- Bolt Frances
- Bonfield James
- Bonner Stephen
- Bonsall David
- Boswell Tim
- Bosworth Andrew
- Bourgeois Yann
- Boyd Olivia
- BoYes John
- Bradley Amanda
- Bradley Declan T
- Bradshaw Daniel
- Breen Cassie
- Bresner Catherine
- Breuer Judith
- Bridgewater Hannah E.
- Bronner Iraad F
- Brooks Ellena
- Broos Alice
- Brown Julianne Rose
- Brown Paul E
- Brown Rebecca
- Bucca Giselda
- Buck David
- Bull Matthew
- Burton-Fanning Shirelle
- Campbell Sharon
- Canas Liane S
- Capdevila Joan
- Carabelli Alessandro M
- Carden Holli
- Carlile Matthew
- Carmichael Stephen N
- Casey Anna
- Cerda Alberto C
- Chalker Vicki
- Chan Andrew T
- Chand Meera
- Chapman Michael R
- Chappell Joseph G
- Charalampous Themoula
- Chatterton Wendy
- Chaudhry Yasmin
- Chauhan Anoop J
- Cheng Jeffrey K.J.
- Churcher Carol M
- Clark Gemma
- Cogger Benjamin J
- Coll Francesc
- Collins Jennifer
- Connor Thomas R
- Constantinidou Chrystala
- Cook Kate
- Coombes Jason
- Corden Sally
- Cormie Claire
- Cortes Nick
- Cotic Marius
- Cottrell Simon
- Coupland Lindsay
- Cowell Angela
- Cox Alison
- Craine Noel
- Crawford Liam
- Cronin Michelle
- Crook Derrick
- Cumley Nicola
- Curran Martin D
- Curran Tanya
- da Silva Filipe Ana
- Dabrera Gavin
- Dadrah Ashok
- Danesh John
- Darby Alistair C
- Davidson Rose K
- Davies Alisha
- Davies Robert
- Davis Thomas
- de Cesare Mariateresa
- De Lacy Elen
- de Oliveira Martins Leonardo
- de Silva Thushan I
- Debebe Johnny
- Dent Hannah
- Dervisevic Samir
- Dewar Rebecca
- Dias Joana
- Dorman Matthew J
- Downing Fatima
- Drew David A
- Drury Eleanor
- du Plessis Louis
- Duckworth Nichola
- Durham Jillian
- Eccles Richard
- Edgeworth Jonathan
- Edwards Sue
- Eldirdiri Sahar
- Ellaby Nicholas
- Ellard Sian
- Elliott Scott
- Eltringham Gary
- Ensell Leah
- Escalera Zamudio Marina
- Essex Sarah
- Evans Cariad
- Evans Johnathan M
- Eyre David
- Fairley Derek J
- Fallon Karlie
- Farbos Audrey
- Farr Ben W
- Fearn Christopher
- Fenton Melisa Louise
- Fina Laia
- Fisher Chloe L
- Flaviani Flavia
- Fleming Vicki M
- Forrest Sally
- Foulser Luke
- Francois Sarah
- Fraser Christophe
- Freeman Timothy M
- Frost Lucy R.
- Fuller William
- Galai Katerina
- Gallagher Eileen
- Gallagher Michael D
- Gallis Marta
- Gaskin Amy
- Gatica-Wilcox Bree
- Geidelberg Lily
- Gemmell Matthew
- Georgana Iliana
- George Ryan P
- Gifford Laura
- Gilbert Lauren
- Gill Harmeet K
- Girgis Sophia T
- Glaysher Sharon
- Golubchik Tanya
- Goncalves Sonia
- Goodfellow Ian G
- Goodwin Scott
- Goudarzi Salman
- Gourtovaia Marina
- Graham Clive
- Graham Lee
- Graham Mark S
- Grammatopoulos Dimitris
- Green Angie
- Green Luke R
- Greenaway Jane
- Gregory Richard
- Groves Danielle C
- Groves Natalie
- Guest Martyn
- Gulliver Huw
- Gunson Rory N
- Gupta Ravi Kumar
- Gutierrez Bernardo
- Hadjirin Nazreen F
- Haldenby Sam T
- Hale Antony D
- Hall Grant
- Halstead Fenella
- Hamilton William L
- Hammers Alexander
- Haque Tanzina
- Harper Katherine L
- Harris Kathryn Ann
- Harrison Ewan M
- Harrison Ian
- Harrison James W
- Hart Jennifer
- Hartley John A
- Hartman Hassan
- Hassan-Ibrahim Mohammed O
- Heaney Judith
- Helmer Thomas
- Hesketh Andrew R
- Heyburn David
- Higginson Ellen E
- Hill Verity
- Hilvers Ember
- Hiscox Julian A
- Hogsden Wendy
- Holden Matthew T.G.
- Holmes Alison
- Holmes Christopher
- Holmes Nadine
- Hopes Richard
- Hosmillo Myra
- Howe Robin
- Howson-Wells Hannah C
- Hu Christina
- Hubb Jonathan
- Hughes Joseph
- Hughes Margaret
- Hutchings Stephanie
- Illingworth Chris J
- Impey Robert
- Irish-Tavares Dianne
- Iturriza-Gomara Miren
- Jackson Chris
- Jackson David K
- Jackson Kathryn A
- Jahun Aminu S
- James Keith
- Jamrozy Dorota
- Jannoo Riaz
- Jeffries Aaron R
- Jeremiah Sarah
- Jesudason Natasha G
- John Michaela
- Johnson Kate
- Johnson Natasha
- Johnson Rob
- Johnston Ian
- Jones Carl
- Jones Christopher R
- Jones Hannah
- Jones Katie
- Jones Rachel
- Jones Sophie
- Jorgensen David
- Joseph Amelia
- Justice Anita
- Kane Leanne
- Karamani Angeliki
- Kay Gemma L
- Kay Sally
- Keatley Jon-Paul
- Keeley Alexander J
- Kenyon Anita
- Kermack Leanne M
- Khakh Manjinder
- Kidd Stephen
- Kitchen Christine
- Kläser Kerstin
- Knight Bridget A
- Koshy Cherian
- Kraemer Moritz UG
- Kristiansen Mark
- Kumziene-SummerhaYes Sara
- Kwiatkowski Dominic
- Lackenby Angie
- Langford Cordelia F
- Lawniczak Mara
- Le-Viet Thanh
- Ledesma Juan
- Lee David
- Lee Jack CD
- Leek Danielle
- Lensing Stefanie V
- Leonard Steven
- Letchford Laura
- Levene Nick
- Levett Lisa J
- Lewis Kevin
- Li Kathy K
- Liddle Jennifier
- Liggett Steven
- Lindsey Benjamin B
- Lister Michelle M
- Livett Rich
- Lloyd Allyson
- Lo Stephanie
- Loman Nicholas J
- Loose Matthew W
- Louka Stavroula F
- Loveson Katie F
- Lowe Hannah
- Lowe Helen L
- Lucaci Anita O
- Ludden Catherine
- Lynch Jessica
- Lyons Ronan A
- Macfarlane-Smith Louissa R
- Machin Nicholas W
- MacIntyre-Cockett George
- Maclean Alasdair
- Madona Pinglawathee
- Maes Mailis
- Mahanama Adhyana I.K
- Mahungu Tabitha W
- Mair Daniel
- Maksimovic Joshua
- Makunin Alex
- Malone Cassandra S
- Manesis Nikos
- Manley Robin
- Manso Carmen
- Marchbank Angela
- Martincorena Inigo
- Martinez Nunez Rocio T
- Masoli Jane AH
- Mason Jenifer
- Mather Alison E
- May Anna
- Mayhew Megan
- Mbisa Tamyo
- McCann Clare
- McCarthy Shane
- McCluggage Kathryn
- McClure Patrick C
- McGuigan Samantha
- McHugh Martin P
- McKenna James P
- McKerr Caoimhe
- McManus Georgina M
- McMurray Claire
- McNally Alan
- Meader Emma J
- Meadows Lizzie
- Megram Oliver
- Menegazzo Mirko
- Merrick Ian
- Merrill Tammy V
- Miah Shahjahan
- Michell Stephen L
- Michelsen Michelle L
- Mirza Jeremy
- Modat Marc
- Moles-Garcia Emma
- Moll Robin J
- Mollett Guy
- Molnar Zoltan
- Molteni Erika
- Monaghan Lynn
- Mookerjee Siddharth
- Moore Catherine
- Moore Christopher
- Moore Jonathan
- Moore Nathan
- Morgan Mari
- Morgan Sian
- Mori Matilde
- Moses Samuel
- Muir Peter
- Munn Robert
- Murray Benjamin
- Myers Richard
- Nascimento Fabricia F.
- Nebbia Gaia
- Nelson Andrew
- Nelson Charlotte
- Nelson Rachel
- Nguyen Long H
- Nicholls Sam
- Nichols Jenna
- Nickbakhsh Seema
- Niebel Marc O
- Nomikou Kyriaki
- O'Brien Sarah
- O'Grady Justin
- O'Toole Elaine
- O'Toole Áine
- Oliver Karen
- Orton Richard J
- Osman Husam
- Ott Sascha
- Ourselin Sebastien
- Pacchiarini Nicole
- Padgett Debra
- Page Andrew J
- Palmer Sophie
- Palmer Steve
- Pandey Sarojini
- Park Naomi R
- Parker Matthew D
- Parmar Surendra
- Parsons Paul J
- Partridge David G
- Patel Amita
- Patel Minal
- Patel Vineet
- Paterson Steve
- Paul Hannah
- Payne Brendan AI
- Peacock Sharon J
- Pearson Clare
- Pelosi Emanuela
- Percival Benita
- Perry Malorie
- Peto Timothy
- Pinckert Malte L
- Platt Steven
- Plimmer Amy
- Polidori Lorenzo
- Poplawski Radoslaw
- Prestwood Liam
- Price Anna
- Price James
- Prieto Jacqui A
- Puethe Christoph
- Pusok Monika
- Pybus Oliver G
- Pymont Hannah M
- Quail Michael A
- Quick Joshua
- Raghwani Jayna
- Ragonnet-Cronin Manon
- Rainbow Lucille
- Rajan Diana
- Rajatileka Shavanthi
- Rambaut Andrew
- Ramsay Mary
- Randell Paul Anthony
- Ratcliffe Liz
- Raviprakash Veena
- Raza Mohammad
- Redshaw Nicholas M
- Rey Sara
- Reynolds Nicola
- Richter Alex
- Robertson David L
- Robinson Esther
- Robinson Trevor I
- Robson Samuel C
- Rooke Stefan
- Rowan Aileen
- Rowe Will
- Roy Sunando
- Rudder Steven
- Ruis Chris
- Rushton Steven
- Saeed Kordo
- Saluja Tranprit
- Samaraweera Buddhini
- Sambles Christine M
- Sang Fei
- Scarlett Garry P
- Schaefer Ulf
- Scott Carol
- Scott Garren
- Selvachandran Somesh
- Shaaban Sharif
- Shah Divya
- Shah Rajiv N
- Shankar Giri
- Shepherd James G
- Sheriff Nicola
- Shirley Lesley
- Signell Adrian W
- Sillitoe John
- Silveira Siona
- Simpson David A
- Singer Joshua B
- Sivaprakasam Venkat
- Siveroni Igor
- Sloan Tim J
- Sluga Graciela
- Smith Colin P
- Smith Darren
- Smith Kim S
- Smith Louise
- Smith Nikki
- Smith Wendy
- Smollett Katherine L
- Snell Luke B
- Southgate Joel
- Spector Tim D
- Spellman Karla
- Spencer Chapman Michael H
- Sridhar Sushmita
- Stanley Rachael
- Stanton Thomas D
- Starinskij Igor
- Stark Richard
- Steves Claire J
- Stockton Joanne
- Stonehouse Susanne
- Storey Nathaniel
- Studholme David J
- Sudre Carole H
- Swindells Emma
- Symmonds Amanda
- Taha Yusri
- Tang Julian
- Taylor Ben EW
- Taylor Graham P
- Taylor Sarah
- Taylor-Joyce Grace
- Temperton Ben
- Templeton Kate E
- Thompson Thomas
- Thomson Emma C
- Thornton Alicia
- Thurston Scott AJ
- Todd John A
- Tong Lily
- Tonkin-Hill Gerry
- Torok M. Estee
- Tovar-Corona Jaime M
- Trebes Amy
- Trotter Alexander J
- Tsoleridis Theocharis
- Tucker Rachel M
- Turtle Lance
- Twohig Katherine A
- Underwood Anthony P
- Unnikrishnan Meera
- Vamos Edith E
- Varsavsky Thomas
- Vasylyeva Tetyana I
- Vattipally Sreenu
- Vernet Gabrielle
- Vipond Ian B
- Volz Erik M
- Walsh Sarah
- Wang Dennis
- Wantoch Michelle
- Warne Ben
- Warwick-Dugdale Joanna
- Wastenge Elizabeth
- Watkins Joanne
- Watts Joanne
- Waugh Sheila
- Webster Hermione J
- Weldon Danni
- Westhorpe Adam P
- Whitehead Mark
- Whiteley Max
- Whitwham Andrew
- Wierzbicki Claudia
- Williams Charlotte A
- Williams Chris
- Williams David
- Williams Lesley-Anne
- Williams Rachel J
- Williams Rebecca
- Williams Thomas
- Williamson Kathleen A
- Willingham Iona
- Wilson Harry D
- Wilson Rebekah E
- Wilson-Davies Eleri
- Wise Emma
- Witele Eric
- Wolf Jonathan
- Workman Trudy
- Wright Victoria
- Wyatt Tim
- Wyles Matthew
- Wyllie Sarah
- Xu-McCrae Li
- Yeats Corin A
- Yew Wen C
- Young Greg
- Young Jamie
- Zarebski Alex E
- Zhang Peijun
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/05/2021
- Field of study
Background
The SARS-CoV-2 variant B.1.1.7 was first identified in December, 2020, in England. We aimed to investigate whether increases in the proportion of infections with this variant are associated with differences in symptoms or disease course, reinfection rates, or transmissibility.
Methods
We did an ecological study to examine the association between the regional proportion of infections with the SARS-CoV-2 B.1.1.7 variant and reported symptoms, disease course, rates of reinfection, and transmissibility. Data on types and duration of symptoms were obtained from longitudinal reports from users of the COVID Symptom Study app who reported a positive test for COVID-19 between Sept 28 and Dec 27, 2020 (during which the prevalence of B.1.1.7 increased most notably in parts of the UK). From this dataset, we also estimated the frequency of possible reinfection, defined as the presence of two reported positive tests separated by more than 90 days with a period of reporting no symptoms for more than 7 days before the second positive test. The proportion of SARS-CoV-2 infections with the B.1.1.7 variant across the UK was estimated with use of genomic data from the COVID-19 Genomics UK Consortium and data from Public Health England on spike-gene target failure (a non-specific indicator of the B.1.1.7 variant) in community cases in England. We used linear regression to examine the association between reported symptoms and proportion of B.1.1.7. We assessed the Spearman correlation between the proportion of B.1.1.7 cases and number of reinfections over time, and between the number of positive tests and reinfections. We estimated incidence for B.1.1.7 and previous variants, and compared the effective reproduction number, Rt, for the two incidence estimates.
Findings
From Sept 28 to Dec 27, 2020, positive COVID-19 tests were reported by 36 920 COVID Symptom Study app users whose region was known and who reported as healthy on app sign-up. We found no changes in reported symptoms or disease duration associated with B.1.1.7. For the same period, possible reinfections were identified in 249 (0·7% [95% CI 0·6–0·8]) of 36 509 app users who reported a positive swab test before Oct 1, 2020, but there was no evidence that the frequency of reinfections was higher for the B.1.1.7 variant than for pre-existing variants. Reinfection occurrences were more positively correlated with the overall regional rise in cases (Spearman correlation 0·56–0·69 for South East, London, and East of England) than with the regional increase in the proportion of infections with the B.1.1.7 variant (Spearman correlation 0·38–0·56 in the same regions), suggesting B.1.1.7 does not substantially alter the risk of reinfection. We found a multiplicative increase in the Rt of B.1.1.7 by a factor of 1·35 (95% CI 1·02–1·69) relative to pre-existing variants. However, Rt fell below 1 during regional and national lockdowns, even in regions with high proportions of infections with the B.1.1.7 variant.
Interpretation
The lack of change in symptoms identified in this study indicates that existing testing and surveillance infrastructure do not need to change specifically for the B.1.1.7 variant. In addition, given that there was no apparent increase in the reinfection rate, vaccines are likely to remain effective against the B.1.1.7 variant.
Funding
Zoe Global, Department of Health (UK), Wellcome Trust, Engineering and Physical Sciences Research Council (UK), National Institute for Health Research (UK), Medical Research Council (UK), Alzheimer's Society
Genomic assessment of quarantine measures to prevent SARS-CoV-2 importation and transmission
- Author
- Aanensen David M.
- Abudahab Khalil
- Acheson Erwan
- Adams Alexander
- Adams Helen
- Afifi Safiah
- Aggarwal Dinesh
- Aggarwal Dinesh
- Ahmad Shazaad S. Y.
- Aigrain Louise
- Alam Mohammad T.
- Alcolea-Medina Adela
- Alderton Alex
- Alikhan Nabil-Fareed
- Allara Elias
- Amato Roberto
- Andersson Monique
- Angyal Adrienn
- Aranday-Cortes Elihu
- Ariani Cristina V.
- Asad Hibo
- Asamaphan Patawee
- Ash Amy
- Ashcroft Fiona
- Atkinson Laura
- Attwood Stephen W.
- Auckland Cressida
- Awan Ali R.
- Aydin Alp
- Baker David J.
- Baker Paul
- Balcazar Carlos E.
- Ball Jonathan
- Barrett Jeff
- Barton Edward
- Bashton Matthew
- Bassett Andrew R.
- Batra Rahul
- Baxter Laura
- Bayzid Nadua
- Beale Mathew A.
- Beaver Charlotte
- Beckett Angela H.
- Bedford Luke
- Beer Robert
- Beggs Andrew
- Bellis Katherine L.
- Berry Lisa
- Berry Louise
- Best Angus
- Betancor Gilberto
- Betteridge Emma
- Bewshea Claire M.
- Bibby David
- Bicknell Kelly
- Birchley Alec
- Bird Paul
- Bishop Chloe
- Blacow Rachel
- Blakey Victoria
- Blane Beth
- Bolt Frances
- Bonfield James
- Bonner Stephen
- Bonsall David
- Boswell Tim
- Bosworth Andrew
- Bourgeois Yann
- Boyd Olivia
- BoYes John
- Bradley Amanda
- Bradley Declan T.
- Bradshaw Daniel
- Breen Cassie
- Bresner Catherine
- Breuer Judith
- Bridgewater Hannah E.
- Bronner Iraad F.
- Brooks Ellena
- Broos Alice
- Brown Julianne R.
- Brown Paul E.
- Brown Rebecca
- Bucca Giselda
- Buck David
- Bull Matthew
- Burton-Fanning Shirelle
- Campbell Sharon
- Carabelli Alessandro M.
- Carden Holli
- Carlile Matthew
- Carmichael Stephen N.
- Casey Anna
- Cerda Alberto C.
- Chalker Vicki
- Chand Meera
- Chapman Michael H. Spencer
- Chapman Michael R.
- Chappell Joseph G.
- Charalampous Themoula
- Chatterton Wendy
- Chaudhry Yasmin
- Chauhan Anoop J.
- Chen Cong
- Cheng Jeffrey K. J.
- Churcher Carol M.
- Clark Gemma
- Cogger Benjamin J.
- Coll Francesc
- Collins Jennifer
- Connor Thomas R.
- Constantinidou Chrystala
- Cook Kate
- Coombes Jason
- Corden Sally
- Cormie Claire
- Cortes Nick
- Cotic Marius
- Cottrell Simon
- Coupland Lindsay
- Cowell Angela
- Cox Alison
- Craine Noel
- Crawford Liam
- Cronin Michelle
- Crook Derrick
- Cumley Nicola
- Curran Martin D.
- Curran Tanya
- da Silva Filipe Ana
- Dabrera Gavin
- Dadrah Ashok
- Danesh John
- Darby Alistair C.
- Davidson Rose K.
- Davies Alisha
- Davies Robert
- Davis Thomas
- de Cesare Mariateresa
- De Lacy Elen
- de Oliveira Martins Leonardo
- de Silva Thushan I.
- Debebe Johnny
- Dent Hannah
- Dervisevic Samir
- Dewar Rebecca
- Dias Joana
- Dorman Matthew J.
- Downing Fatima
- Drury Eleanor
- du Plessis Louis
- Duckworth Nichola
- Durham Jillian
- Eccles Richard
- Edgeworth Jonathan
- Edwards Sue
- Eldirdiri Sahar
- Ellaby Nicholas
- Ellard Sian
- Elliott Scott
- Eltringham Gary
- Ensell Leah
- Essex Sarah
- Evans Cariad
- Evans Johnathan M.
- Eyre David
- Fairley Derek J.
- Fallon Karlie
- Farbos Audrey
- Farr Ben W.
- Fearn Christopher
- Fenton Melisa L.
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- Forrest Sally
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- Fraser Christophe
- Freeman Timothy M.
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- Gallagher Eileen
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- Gallis Marta
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- Gatica-Wilcox Bree
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- Georgana Iliana
- George Ryan P.
- Gifford Laura
- Gilbert Lauren
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- Girgis Sophia T.
- Glaysher Sharon
- Golubchik Tanya
- Goncalves Sonia
- Goodfellow Ian G.
- Goodwin Scott
- Goudarzi Salman
- Gourtovaia Marina
- Graham Clive
- Graham Lee
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- Gregory Richard
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- Hill Verity
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- Holden Matthew T. G.
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- Holmes Christopher
- Holmes Nadine
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- Hosmillo Myra
- Howe Robin
- Howson-Wells Hannah C.
- Hubb Jonathan
- Hughes Gareth J.
- Hughes Joseph
- Hughes Margaret
- Hutchings Stephanie
- Illingworth Chris J.
- Impey Robert
- Irish-Tavares Dianne
- Iturriza-Gomara Miren
- Jackson Chris
- Jackson David K.
- Jackson Kathryn A.
- Jahun Aminu S.
- James Keith
- Jamrozy Dorota
- Jannoo Riaz
- Jeffries Aaron R.
- Jeremiah Sarah
- Jesudason Natasha G.
- John Michaela
- Johnson Kate
- Johnson Natasha
- Johnson Rob
- Johnston Ian
- Jones Carl
- Jones Christopher R.
- Jones Hannah
- Jones Katie
- Jones Rachel
- Jones Sophie
- Jorgensen David
- Joseph Amelia
- Justice Anita
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- Karamani Angeliki
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- Keeley Alexander J.
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- Koshy Cherian
- Kraemer Moritz U. G.
- Kristiansen Mark
- Kumziene-SummerhaYes Sara
- Kwiatkowski Dominic
- Lackenby Angie
- Langford Cordelia F.
- Lawniczak Mara
- Le Viet Thanh
- Le-Viet Thanh
- Ledesma Juan
- Lee David
- Lee Jack C. D.
- Leek Danielle
- Lensing Stefanie V.
- Leonard Steven
- Letchford Laura
- Levene Nick
- Levett Lisa J.
- Lewis Kevin
- Li Kathy K.
- Liddle Jennifier
- Liggett Steven
- Lindsey Benjamin B.
- Lister Michelle M.
- Livett Rich
- Lloyd Allyson
- Lo Stephanie
- Logan Sophie
- Loman Nicholas J.
- Loose Matthew W.
- Louka Stavroula F.
- Loveson Katie F.
- Lowe Hannah
- Lowe Helen L.
- Lucaci Anita O.
- Ludden Catherine
- Lynch Jessica
- Lyons Ronan A.
- Macfarlane-Smith Louissa R.
- Machin Nicholas W.
- MacIntyre-Cockett George
- Maclean Alasdair
- Madona Pinglawathee
- Maes Mailis
- Mahanama Adhyana I. K.
- Mahungu Tabitha W.
- Mair Daniel
- Maksimovic Joshua
- Makunin Alex
- Malone Cassandra S.
- Manesis Nikos
- Manley Robin
- Manso Carmen
- Marchbank Angela
- Martincorena Inigo
- Masoli Jane A. H.
- Mason Jenifer
- Mather Alison E.
- Mayhew Megan
- Mbisa Tamyo
- McCann Clare
- McCarthy Shane
- McCluggage Kathryn
- McClure Patrick C.
- McGuigan Samantha
- McHugh Martin P.
- McKenna James P.
- McKerr Caoimhe
- McManus Georgina M.
- McMurray Claire
- McNally Alan
- Meader Emma J.
- Meadows Lizzie
- Megram Oliver
- Menegazzo Mirko
- Merrick Ian
- Merrill Tammy V.
- Miah Shahjahan
- Michell Stephen L.
- Michelsen Michelle L.
- Mirza Jeremy
- Moles-Garcia Emma
- Moll Robin J.
- Mollett Guy
- Molnar Zoltan
- Monaghan Lynn
- Mookerjee Siddharth
- Moore Catherine
- Moore Christopher
- Moore Jonathan
- Moore Nathan
- Morgan Mari
- Morgan Sian
- Mori Matilde
- Moses Samuel
- Muir Peter
- Munn Robert
- Myers Richard
- Nascimento Fabricia F.
- Nebbia Gaia
- Nelson Andrew
- Nelson Charlotte
- Nelson Rachel
- Nicholls Sam
- Nichols Jenna
- Nickbakhsh Seema
- Niebel Marc O.
- Nomikou Kyriaki
- Nunez Rocio T. Martinez
- Oliver Karen
- Orton Richard J.
- Osman Husam
- Ott Sascha
- O’Brien Sarah
- O’Grady Justin
- O’Toole Elaine
- O’Toole Áine
- Pacchiarini Nicole
- Padgett Debra
- Page Andrew J.
- Palmer Sophie
- Palmer Steve
- Pandey Sarojini
- Park Naomi R.
- Parker Matthew D.
- Parmar Surendra
- Parsons Paul J.
- Partridge David G.
- Patel Amita
- Patel Minal
- Patel Vineet
- Paterson Steve
- Paul Hannah
- Payne Brendan A. I.
- Peacock Sharon J.
- Peacock Sharon J.
- Pearson Clare
- Pelosi Emanuela
- Percival Benita
- Perry Malorie
- Peto Timothy
- Pinckert Malte L.
- Platt Steven
- Plimmer Amy
- Poplawski Radoslaw
- Prestwood Liam
- Price Anna
- Price James
- Prieto Jacqui A.
- Puethe Christoph
- Pusok Monika
- Pybus Oliver G.
- Pymont Hannah M.
- Quail Michael A.
- Quick Joshua
- Raghwani Jayna
- Ragonnet-Cronin Manon
- Rainbow Lucille
- Rajan Diana
- Rajatileka Shavanthi
- Rambaut Andrew
- Ramsay Mary
- Randell Paul A.
- Ratcliffe Liz
- Raviprakash Veena
- Raza Mohammad
- Redshaw Nicholas M.
- Rey Sara
- Reynolds Nicola
- Richter Alex
- Robertson David L.
- Robinson Esther
- Robinson Trevor I.
- Robson Samuel C.
- Rooke Stefan
- Rowan Aileen
- Rowe Will
- Roy Sunando
- Rudder Steven
- Ruis Chris
- Rushton Steven
- Saeed Kordo
- Saluja Tranprit
- Samaraweera Buddhini
- Sambles Christine M.
- Sang Fei
- Savva George M.
- Scarlett Garry P.
- Schaefer Ulf
- Scott Carol
- Scott Garren
- Shaaban Sharif
- Shah Divya
- Shah Rajiv N.
- Shankar Giri
- Shepherd James G.
- Sheriff Nicola
- Shirley Lesley
- Signell Adrian W.
- Sillitoe John
- Silveira Siona
- Simpson David A.
- Singer Joshua B.
- Sivaprakasam Venkat
- Siveroni Igor
- Sloan Tim J.
- Sluga Graciela
- Smith Colin P.
- Smith Darren
- Smith Kim S.
- Smith Louise
- Smith Nikki
- Smith Wendy
- Smollett Katherine L.
- Snell Luke B.
- Southgate Joel
- Spellman Karla
- Sridhar Sushmita
- Stanley Rachael
- Stanton Thomas D.
- Starinskij Igor
- Stark Richard
- Stockton Joanne
- Stonehouse Susanne
- Storey Nathaniel
- Studholme David J.
- Swindells Emma
- Symmonds Amanda
- Taha Yusri
- Tang Julian
- Taylor Ben E. W.
- Taylor Graham P.
- Taylor Sarah
- Taylor-Joyce Grace
- Temperton Ben
- Templeton Kate E.
- The COVID-19 Genomics UK (COG
- Thompson Thomas
- Thomson Emma C.
- Thornton Alicia
- Thurston Scott A. J.
- Todd John A.
- Tong Lily
- Tonkin-Hill Gerry
- Torok M. Estee
- Tovar-Corona Jaime M.
- Trebes Amy
- Trotter Alexander J.
- Tsoleridis Theocharis
- Tucker Rachel M.
- Tumelty Niamh M.
- Turner Charlie
- Turtle Lance
- Twohig Katherine A.
- Underwood Anthony P.
- Unnikrishnan Meera
- Vamos Edith E.
- Vasylyeva Tetyana I.
- Vattipally Sreenu
- Vernet Gabrielle
- Vipond Ian B.
- Volz Erik
- Volz Erik M.
- Walsh Sarah
- Wang Dennis
- Wantoch Michelle
- Warne Ben
- Warwick-Dugdale Joanna
- Wastenge Elizabeth
- Watkins Joanne
- Watts Joanne
- Waugh Sheila
- Webster Hermione J.
- Weldon Danni
- Westhorpe Adam P.
- Whitehead Mark
- Whiteley Max
- Whitwham Andrew
- Wierzbicki Claudia
- Williams Charlotte A.
- Williams Chris
- Williams David
- Williams Lesley-Anne
- Williams Rachel J.
- Williams Rebecca
- Williams Thomas
- Williamson Kathleen A.
- Willingham Iona
- Wilson Harry D.
- Wilson Rebekah E.
- Wilson-Davies Eleri
- Wise Emma
- Witele Eric
- Workman Trudy
- Wright Victoria
- Wyatt Tim
- Wyles Matthew
- Wyllie Sarah
- Xu-McCrae Li
- Yeats Corin A.
- Yew Wen Chyin
- Young Greg
- Young Jamie
- Zamudio Marina Escalera
- Zarebski Alex E.
- Zhang Peijun
- Publication venue
- Nature Publishing
- Publication date
- 01/01/2022
- Field of study
Mitigation of SARS-CoV-2 transmission from international travel is a priority. We evaluated the effectiveness of travellers being required to quarantine for 14-days on return to England in Summer 2020. We identified 4,207 travel-related SARS-CoV-2 cases and their contacts, and identified 827 associated SARS-CoV-2 genomes. Overall, quarantine was associated with a lower rate of contacts, and the impact of quarantine was greatest in the 16–20 age-group. 186 SARS-CoV-2 genomes were sufficiently unique to identify travel-related clusters. Fewer genomically-linked cases were observed for index cases who returned from countries with quarantine requirement compared to countries with no quarantine requirement. This difference was explained by fewer importation events per identified genome for these cases, as opposed to fewer onward contacts per case. Overall, our study demonstrates that a 14-day quarantine period reduces, but does not completely eliminate, the onward transmission of imported cases, mainly by dissuading travel to countries with a quarantine requirement
Genomic epidemiology of SARS-CoV-2 in a UK university identifies dynamics of transmission
- Author
- Aanensen David M.
- Abell Chris
- Abudahab Khalil
- Acheson Erwan
- Adams Alexander
- Adams Helen
- Afifi Safiah
- Aggarwal Dinesh
- Aggarwal Dinesh
- Ahmad Shazaad S. Y.
- Ahmadi-Assalemi Gabriela
- Aigrain Louise
- Alam Mohammad T.
- Alcolea-Medina Adela
- Alderton Alex
- Alikhan Nabil-Fareed
- Allara Elias
- Amato Roberto
- Andersson Monique
- Angelis Daniela De
- Angelis Daniela De
- Angyal Adrienn
- Aranday-Cortes Elihu
- Ariani Cristina V.
- Asad Hibo
- Asamaphan Patawee
- Ash Amy
- Ashcroft Fiona
- Atkinson Laura
- Attwood Stephen W.
- Auckland Cressida
- Awan Ali R.
- Aydin Alp
- Baker David J.
- Baker Paul
- Balcazar Carlos E.
- Ball Jonathan
- Barrett Jeff
- Barton Edward
- Bashton Matthew
- Bassett Andrew R.
- Batra Rahul
- Baxter Laura
- Bayzid Nadua
- Beale Mathew A.
- Beaver Charlotte
- Beckett Angela H.
- Bedford Luke
- Beer Robert
- Beggs Andrew
- Bellis Katherine L.
- Berry Lisa
- Berry Louise
- Berry Sarah
- Best Angus
- Betancor Gilberto
- Betteridge Emma
- Bewshea Claire M.
- Bibby David
- Bicknell Kelly
- Birchley Alec
- Bird Paul
- Bishop Chloe
- Blacow Rachel
- Blakey Victoria
- Blane Beth
- Bolt Frances
- Bonfield James
- Bonner Stephen
- Bonsall David
- Boswell Tim
- Bosworth Andrew
- Bourgeois Yann
- Boyd Olivia
- BoYes John
- Bradley Amanda
- Bradley Declan T.
- Bradshaw Daniel
- Braithwaite Vickie
- Breen Cassie
- Bresner Catherine
- Breuer Judith
- Bridgewater Hannah E.
- Brierley Craig
- Bronner Iraad F.
- Brooks Ellena
- Broos Alice
- Brown Christopher
- Brown Christopher A.
- Brown Julianne R.
- Brown Nicholas M.
- Brown Paul E.
- Brown Rebecca
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- Dhada Maharshi
- Dias Joana
- Dorman Matthew J.
- Dougan Gordon
- Douthwaite Julie
- Downing Fatima
- Drury Eleanor
- du Plessis Louis
- du Plessis Louis
- Duckworth Nichola
- Durham Jillian
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- Glaysher Sharon
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- Goncalves Sonia
- Goodall Robin
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- Goodfellow Ian G.
- Goodwin Scott
- Goudarzi Salman
- Gourtovaia Marina
- Graham Clive
- Graham Lee
- Grammatopoulos Dimitris
- Gransden Lucie
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- Hill Verity
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- Hiscox Julian A.
- Hoensch Steve
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- Holgate Jon
- Hollamby Victoria
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- Hosmillo Myra
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- Izuagbe Rhys
- Jackson Chris
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- Jackson Kathryn A.
- Jahun Aminu
- Jahun Aminu S.
- James Keith
- James Laura
- Jamrozy Dorota
- Jannoo Riaz
- Jeffries Aaron R.
- Jeremiah Sarah
- Jesudason Natasha G.
- John Michaela
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- Raghwani Jayna
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- Rajan Diana
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- Simpson David A.
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- Sivaprakasam Venkat
- Siveroni Igor
- Sloan Tim J.
- Sluga Graciela
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- Smith Darren
- Smith Kim S.
- Smith Louise
- Smith Nikki
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- Snell Luke B.
- Southgate Joel
- Spellman Karla
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- Starinskij Igor
- Stark Richard
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- Stonehouse Susanne
- Storey Nathaniel
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- Temperton Ben
- Templeton Kate E.
- The Cambridge Covid-19 testing Centre
- The COVID-19 Genomics UK (COG-UK) Consortium
- Thompson Thomas
- Thomson Emma C.
- Thornton Alicia
- Thurston Scott A. J.
- Todd John A.
- Tolhurst Jonathan
- Tong Lily
- Tonkin-Hill Gerry
- Torok M. Estee
- Tovar-Corona Jaime M.
- Trebes Amy
- Trotter Alexander J.
- Tsoleridis Theocharis
- Tucker Rachel M.
- Turtle Lance
- Twohig Katherine A.
- Tynan Jo
- Underwood Anthony P.
- University of Cambridge Asymptomatic COVID-19 Screening Programm
- Unnikrishnan Meera
- Valletta Sally
- Vamos Edith E.
- Vasylyeva Tetyana I.
- Vattipally Sreenu
- Vernet Gabrielle
- Vignoles Anna
- Vinnell Martin
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- Volz Erik M.
- Waddell Ian
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- Wang Dennis
- Wantoch Michelle
- Warne Ben
- Warwick-Dugdale Joanna
- Wastenge Elizabeth
- Watkins Emmeline
- Watkins Joanne
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- Waugh Sheila
- Weale Gillian
- Webster Hermione J.
- Weekes Michael P.
- Weldon Danni
- Westhorpe Adam P.
- White Phil
- Whitehead Mark
- Whiteley Max
- Whitwham Andrew
- Wierzbicki Claudia
- Williams Charlotte A.
- Williams Chris
- Williams David
- Williams Lesley-Anne
- Williams Rachel J.
- Williams Rebecca
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- Williamson Kathleen A.
- Williman Jack
- Willingham Iona
- Wills Mark
- Wilson Harry D.
- Wilson Karl
- Wilson Rebekah E.
- Wilson-Davies Eleri
- Winster Jennifer
- Wise Emma
- Witele Eric
- Workman Chris
- Workman Trudy
- Wright Elizabeth
- Wright Elizabeth
- Wright Giles
- Wright Jo
- Wright Victoria
- Wyatt Tim
- Wyles Matthew
- Wyllie Sarah
- Xu-McCrae Li
- Yeats Corin A.
- Yew Wen Chyin
- Young Greg
- Young Jamie
- Zamudio Marina Escalera
- Zarebski Alex E.
- Zhang Peijun
- Publication venue
- Nature Communications
- Publication date
- 08/02/2022
- Field of study
AbstractUnderstanding SARS-CoV-2 transmission in higher education settings is important to limit spread between students, and into at-risk populations. In this study, we sequenced 482 SARS-CoV-2 isolates from the University of Cambridge from 5 October to 6 December 2020. We perform a detailed phylogenetic comparison with 972 isolates from the surrounding community, complemented with epidemiological and contact tracing data, to determine transmission dynamics. We observe limited viral introductions into the university; the majority of student cases were linked to a single genetic cluster, likely following social gatherings at a venue outside the university. We identify considerable onward transmission associated with student accommodation and courses; this was effectively contained using local infection control measures and following a national lockdown. Transmission clusters were largely segregated within the university or the community. Our study highlights key determinants of SARS-CoV-2 transmission and effective interventions in a higher education setting that will inform public health policy during pandemics.</jats:p
Evaluating the Effects of SARS-CoV-2 Spike Mutation D614G on Transmissibility and Pathogenicity
- Author
- Aanensen David M
- Abudahab Khalil
- Acheson Erwan
- Adams Alexander
- Adams Helen
- Adriaenssens Evelien M
- Afifi Safiah
- Aggarwal Dinesh
- Ahmad Shazaad SY
- Alam Mohammad T
- Alcolea-Medina Adela
- Alderton Alex
- Alikhan Nabil-Fareed
- Allan John
- Allara Elias
- Amato Roberto
- Andersson Monique
- Angyal Adrienn
- Aranday-Cortes Elihu
- Ariani Cristina
- Asad Hibo
- Asamaphan Patawee
- Ashworth Jordan
- Atkinson Laura
- Attwood Stephen
- Auckland Cressida
- Awan Ali R
- Aydin Alp
- Baker David J
- Baker Paul
- Balcazar Carlos E
- Ball Jonathan
- Barton Edward
- Bashton Matthew
- Batra Rahul
- Baxter Laura
- Beale Mathew A
- Beaver Charlotte
- Beckett Angela
- Beer Robert
- Beggs Andrew
- Bell Andrew
- Bellis Katherine L
- Berger Duncan J
- Berriman Matt
- Berry Lisa
- Berry Louise
- Betancor Gilberto
- Betteridge Emma
- Bewshea Claire M
- Bibby David
- Bicknell Kelly
- Birchley Alec
- Bird Paul
- Bishop Chloe
- Blane Beth
- Bolt Frances
- Bonsall David
- Boswell Tim
- Bosworth Andrew
- Bourgeois Yann
- Boyd Olivia
- Boyes John
- Bradley Declan T
- Bradshaw Daniel
- Breen Cassie
- Bresner Catherine
- Breuer Judith
- Bridgewater Hannah E
- Brooks Tony T
- Broos Alice
- Brown Julianne Rose
- Brown Paul E
- Brown Rebecca
- Brunker Kirstyn
- Bucca Giselda
- Buck David
- Buddenborg Sarah K
- Bull Matthew
- Bull Matthew
- Burton-Fanning Shirelle
- Butcher Ethan
- Caddy Sarah L
- Caller Laura G
- Campbell Sharon
- Carlile Matthew
- Carmichael Stephen N
- Casey Anna
- Castellano Sergi
- Chalker Vicki
- Chand Meera
- Chapman Michael R
- Chappell Joseph G
- Charalampous Themoula
- Charles Ian G
- Chaudhry Yasmin
- Chauhan Anoop J
- Cheng Jeffrey KJ
- Churcher Carol M
- Clark Gemma
- Coll Francesc
- Collins Jennifer
- Colquhoun Rachel
- Colquhoun Rachel M
- Connor Thomas R
- Connor Thomas R
- Constantinidou Chrystala
- Coombes Jason
- Corden Sally
- Cormie Claire
- Cortes Nicholas
- Cortes Nick
- Cottrell Simon
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- Cowell Angela
- Cox Alison
- Craine Noel
- Cronin Michelle
- Crooke Derrick
- Curran Martin D
- Curran Tanya
- da Silva Filipe Ana
- da Silva Filipe Ana
- Dabrera Gavin
- Danesh John
- Darby Alistair C
- Davidson Rose K
- Davies Alisha
- Davis Thomas
- de Cesare Mariateresa
- De Lacy Elen
- de Oliveira Martins Leonardo
- de Silva Thushan I
- Debebe Johnny
- Dervisevic Samir
- Dewar Rebecca
- Dias Joana
- Diaz Maria
- Dibling Thomas
- Dorman Matthew J
- Downing Fatima
- Drury Eleanor
- du Plessis Louis
- Duckworth Nichola
- Dyal Patricia L
- Eccles Richard
- Edgeworth Jonathan
- Edwards Sue
- Eldirdiri Sahar
- Ellaby Nicholas
- Ellard Sian
- Elliott Scott
- Eltringham Gary
- Elumogo Ngozi
- Essex Sarah
- Evans Cariad
- Evans Johnathan M
- Eyre David
- Fairley Derek J
- Fallon Karlie
- Farbos Audrey
- Farr Ben
- Feltwell Theresa
- Fina Laia
- Findlay Jacqueline
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- Fleming Vicki M
- Forrest Leysa M
- Forrest Sally
- Foulser Luke
- Francois Sarah
- Fraser Christophe
- Freeman Timothy M
- Frost Lucy R
- Fuller William
- Gallagher Eileen
- Gallagher Michael D
- Garcia-Casado Maria V
- Gaskin Amy
- Gatica-Wilcox Bree
- Gavriil Artemis
- Geidelberg Lily
- Geidelberg Lily
- Gemmell Matthew
- Georgana Iliana
- George Ryan P
- Gifford Laura
- Gilbert Lauren
- Gill Harmeet K
- Gilroy Rachel AJ
- Girgis Sophia T
- Glaysher Sharon
- Golubchik Tanya
- Goncalves Sonia
- Goodfellow Ian
- Goodfellow Ian G
- Goodwin Scott
- Graham Clive
- Graham Lee
- Gramatopoulos Dimitris
- Green Angie
- Green Luke R
- Greenaway Jane
- Gregory Richard
- Griffith Luke
- Groves Danielle C
- Groves Natalie
- Guest Martyn
- Gulliver Huw
- Gutierrez Ana Victoria
- Hadjirin Nazreen F
- Haldenby Sam T
- Hale Antony D
- Hall Grant
- Halstead Fenella
- Hamilton William L
- Haque Tanzina
- Harper Katherine L
- Harris Kathryn Ann
- Harrison Ewan M
- Harrison Ian
- Harrison James W
- Hartman Hassan
- Hattersley Andrew
- Heaney Judith
- Helmer Thomas
- Hesketh Andrew R
- Heyburn David
- Higginson Ellen E
- Hill Verity
- Hill Verity
- Hilvers Ember
- Hiscox Julian A
- Holden Matthew TG
- Holmes Alison
- Holmes Christopher
- Holmes Nadine
- Hoosdally Sarah
- Hopes Richard
- Hosmillo Myra
- Houldcroft Charlotte J
- Howe Robin
- Howson-Wells Hannah C
- Hubb Jonathan
- Hughes Joseph
- Hughes Margaret
- Hunter Adam D
- Hutchings Stephanie
- Impey Robert
- Irish-Tavares Dianne
- Iturriza-Gomara Miren
- Jackson Ben
- Jackson Ben
- Jackson David A
- Jackson David K
- Jackson Kathryn A
- Jahun Aminu S
- James Keith
- Jamrozy Dorota
- Jarrett Ruth
- Jeffries Aaron R
- Jesudason Natasha
- Jesudason Natasha G
- John Michaela
- Johnson Kate
- Johnson Natasha
- Johnson Rob
- Johnson Robert
- Johnston Ian
- Jones Hannah
- Jones Katie
- Jones Rachel
- Jones Sophie
- Jorgensen David
- Jorgensen David
- Joseph Amelia
- Justice Anita
- Kane Leanne
- Kay Gemma L
- Kay Sally
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- Keeley Alexander J
- Kenyon Anita
- Kermack Leanne M
- Khakh Manjinder
- Khokhar Fahad A
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- Kitchen Christine
- Knight Bridget A
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- Kristiansen Mark
- Kumziene-Summerhayes Sara
- Kwiatkowski Dominic
- Lackenby Angie
- Langford Cordelia
- Lawniczak Mara
- Le-Viet Thanh
- Lee David
- Lee Jack CD
- Letchford Laura
- Levene Nick
- Levett Lisa J
- Li Kathy
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- Liggett Steven
- Lindsey Benjamin B
- Lister Michelle M
- Livett Rich
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- Lynch Jessica
- Lyons Ronan A
- Macfarlane-Smith Louissa R
- Machin Nicholas W
- MacIntyre-Cockett George
- Madona Pinglawathee
- Maes Mailis
- Mahungu Tabitha W
- Mair Daniel
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- Manesis Nikos
- Manley Robin
- Manso Carmen
- Marchbank Angela
- Martincorena Inigo
- Martinez-Nunez Rocio T
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- Mason Jenifer
- Mather Alison E
- Mbisa Tamyo
- McCluggage Kathryn
- McClure Patrick C
- McCrone John T
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- McKenna James P
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- McMurray Claire
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- Meadows Lizzie
- Menegazzo Mirko
- Meredith Luke W
- Merrick Ian
- Mestek-Boukhibar Lamia
- Miah Shahjahan
- Michell Stephen L
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- Monaghan Lynn
- Mookerjee Siddharth
- Moore Catherine
- Moore Catrin
- Moore Christopher
- Moore Nathan
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- Mori Matilde
- Moses Samuel
- Muir Peter
- Munn Robert
- Myers Richard
- Nascimento Fabricia F
- Nascimento Fabricia F
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- Nebbia Gaia
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- Niola Paola
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- Pacchiarini Nicole
- Padgett Debra
- Page Andrew J
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- Panchbhaya Yasmin N
- Pandey Sarojini
- Park Naomi
- Parker Matthew D
- Parmar Surendra
- Parr Yasmin A
- Parsons Paul J
- Partridge David G
- Pascall David J
- Patel Gaurang
- Patel Minal
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- Paterson Steve
- Payne Brendan AI
- Peacock Sharon J
- Pearson Clare
- Perry Malorie
- Peto Timothy
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- Platt Steven
- Plimmer Amy
- Poplawski Radoslaw
- Potter Will
- Prakash Reenesh
- Prestwood Liam
- Price Anna
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- Puethe Christoph
- Pybus Oliver
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- Pymont Hannah M
- Quail Mike
- Quick Joshua
- Raghwani Jayna
- Ragonnet-Cronin Manon
- Rainbow Lucille
- Rajatileka Shavanthi
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- Rambaut Andrew
- Ramsay Mary
- Randell Paul A
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- Resende Silva Paola C
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- Scott Carol
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- Shirley Lesley
- Signell Adrian W
- Sillitoe John
- Simpson David A
- Singer Joshua B
- Sivaprakasam Venkat
- Siveroni Igor
- Siveroni Igor
- Sloan Tim J
- Sluga Graciela
- Smith Christen
- Smith Colin P
- Smith Darren L
- Smith Nikki
- Smith Wendy
- Smollett Katherine L
- Snell Luke B
- Souster Emily
- Southgate Joel
- Southgate Joel
- Spellman Karla
- Spencer-Chapman Michael
- Sridhar Sushmita
- Stanley Rachael
- Stanton Thomas D
- Starinskij Igor
- Stark Richard
- Stockton Joanne
- Stuart Claire
- Studholme David J
- Swindells Emma
- Swingler Tracey
- Taha Yusri
- Tang Julian
- Taylor Ben EW
- Taylor Graham P
- Taylor Sarah
- Taylor-Joyce Grace
- Tedim Ana P
- Temperton Ben
- Templeton Kate E
- Thompson Thomas
- Thomson Emma C
- Thomson Emma C
- Thomson Nicholas M
- Thornton Alicia
- Thurston Scott
- Todd John A
- Tong Lily
- Tonkin-Hill Gerry
- Torok M Estee
- Trebes Amy
- Trotter Alexander J
- Tsoleridis Theocharis
- Tucker Rachel M
- Turtle Lance
- Tutill Helena J
- Underwood Anthony P
- Unnikrishnan Meera
- Vamos Edith E
- Vasylyeva Tetyana
- Vattipally Sreenu
- Vipond Ian B
- Volz Erik
- Volz Erik M
- Wain John
- Walsh Sarah
- Wang Dennis
- Wantoch Michelle
- Warne Ben
- Warwick-Dugdale Joanna
- Wastenge Elizabeth
- Watkins Joanne
- Watts Joanne
- Waugh Sheila
- Webber Mark A
- Weeks Sam
- Weldon Danni
- Whitehead Mark
- Williams Charlotte A
- Williams Chris
- Williams David
- Williams Rachel J
- Williams Rebecca
- Williams Thomas
- Williamson Kathleen A
- Willingham Iona
- Wilson Harry D
- Wise Emma
- Workman Trudy
- Wright Victoria
- Wyles Matthew
- Wyllie Sarah
- Yakovleva Anna
- Yasir Muhammad
- Yeats Corin A
- Yew Wen C
- Young Gregory R
- Young Jamie
- Yu Xiaoyu
- Zarebski Alex
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2021
- Field of study
Global dispersal and increasing frequency of the SARS-CoV-2 spike protein variant D614G are suggestive of a selective advantage but may also be due to a random founder effect. We investigate the hypothesis for positive selection of spike D614G in the United Kingdom using more than 25,000 whole genome SARS-CoV-2 sequences. Despite the availability of a large dataset, well represented by both spike 614 variants, not all approaches showed a conclusive signal of positive selection. Population genetic analysis indicates that 614G increases in frequency relative to 614D in a manner consistent with a selective advantage. We do not find any indication that patients infected with the spike 614G variant have higher COVID-19 mortality or clinical severity, but 614G is associated with higher viral load and younger age of patients. Significant differences in growth and size of 614G phylogenetic clusters indicate a need for continued study of this variant
Recommended from our members
31st Annual Meeting and Associated Programs of the Society for Immunotherapy of Cancer (SITC 2016): part one: National Harbor, MD, USA. 9-13 November 2016
- Author
- Aarts Craig
- Abdallah Rehab
- Abdul-Alim Siddiq
- Abolhalaj Milad
- Abtin Fereidoun
- Acheson Anupama
- Acquavella Nicolas
- Adams Gregory P.
- Adams Katherine
- Adams Sharon
- Adamus Tomasz
- Adekandi Madhukara
- Adurthi Sreenivas
- Adusumilli Prasad S.
- Aeffner Famke
- Afentoulis Michael
- Ager Casey
- Aggouraki Despoina
- Agrawal Rajendra
- Agrawal Sudhir
- Agrawal Swati
- Ahlers Christoph Matthias
- Ahmed Nabil
- Ahn Myung Ju
- Ahr Katya
- Ai Midan
- Aiba Rachida-Siham Bel
- Aisner Joseph
- Albertini Mark R.
- Albiges Laurence
- Albright Andrew
- Algazi Alain
- Ali Siraj
- Alicea Candido
- Allen Natalie
- Allersdorfer Andrea
- Alva Ajjai
- Amado Rafael
- Amaria Rodabe
- Ameratunga Malaka
- Amin Asim
- Amor Amira Ben
- Amrhein John
- Anagnostou Valsamo
- Andersen Rikke
- André Thierry
- Andtbacka Robert H. I.
- Angela Omilian
- Angell Helen K.
- Annels Nicola
- Annunziata Christina M.
- Ansa-Addo Ephraim A
- Ansari Tameem
- Antilla Marjukka
- Antonarakis Emmanuel S.
- Aoki Rhonda
- Armand Philippe
- Armstrong Adam
- Arora Kshitij
- Arreaza Gladys
- Ascierto Paolo A.
- Ashworth-Sharpe Julia
- Askmyr David
- Asmellash Senait
- Assadipour Yasmine
- Assenmacher Mario
- Athelogou Maria
- Atkins Michael B.
- Attaf Meriem
- Au Gough
- Au-Young Janice
- Avery Kendra N.
- Ayers Mark
- Azimi Vahid
- Aznar M. Angela
- Backert Linus
- Backes Floor J.
- Bagg Eleanor A. L.
- Bahjat Keith
- Bajorin Dean
- Bakker Lex
- Balakumaran Arun
- Ballesteros-Merino Carmen
- Bander Neil
- Bang Yung-Jue
- Bannerji Rajat
- Baratelli Felicita E.
- Barbee Susannah D.
- Barlesi Fabrice
- Barrett Carl
- Barrett David
- Barth Carola
- Bartkowiak Todd
- Bartlett Nancy
- Basher Fahmin
- Bassett Roland
- Basu Samik
- Bath Natalie
- Batista Luciana
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- Bauer Todd W.
- Baughman Jan E.
- Bayle J. Henri
- Baylin Stephen
- Beechem Joseph
- Beeson Craig
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- Bellovin David I.
- Beltran Nancy
- Bendell Johanna
- Bender James
- Bennett Alan D.
- Bennett Mark K.
- Bergamaschi Cristina
- Berger Frank
- Berger Sven
- Bergeron Derek
- Berglund Anders
- Berglund Sofia
- Bernatchez Chantale
- Bernett Matthew J.
- Bernstein Donna
- Bessell Catherine A.
- Betts Gareth
- Beyer Sophie
- Bhanot Gyan
- Bhardwaj Nina
- Bhardwaj Rukmini
- Bhatia Shailender
- Bhaumik Srabani
- Bianchi Valentina
- Bielamowicz Kevin
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- Billingsley James M.
- Binder-Scholl Gwendolyn
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- Blazar Bruce R.
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- Borges Luis
- Borkar Rohan N.
- Bornschlegl Svetlana
- Bosch Marnix
- Bose Nandita
- Bossen Bolette
- Bot Adrian
- Botti Gerardo
- Boudadi Karim
- Boussiotis Vassiliki A.
- Brahmer Julie
- Bramson Jonathan
- Brenner Malcolm K.
- Brett Sara
- Brevard Julie
- Brewer Joanna
- Brieu Nicolas
- Brisson Ryan
- Brody Joshua
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- Bshara Wiam
- Bu Xia
- Buchner Alexander
- Bucsek Mark
- Budhani Pratha
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- Burger Michael C.
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- Caux Christophe
- Cecchi Fabiola
- Celis Esteban
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- Chaudhri Apoorvi
- Cheever Martin
- Chen Amanda
- Chen Hui
- Chen Jie Qing
- Chen Lawrence
- Chen Lieping
- Chen Mei
- Chen Mingyi
- Chen Shuming
- Chen Xiufen
- Cheng Jonathan
- Cheng Zhi-jie Jey
- Chikina Maria
- Chin Renee
- Chinnasamy Harshini
- Chlosta Sabine
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- Christian Beth
- Chu Liz
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- Clayburgh Daniel R.
- Clement Amanda
- Clements Erin
- Cohen Lewis
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- Colevas A Dimitrios
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- Couto Joseph
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- Crabill George
- Cristescu Razvan
- Crocker Andrea
- Cui Weiguo
- Culp William
- Cumberbatch Kerwin
- Curran Michael
- Curti Brendan
- Dadey Rebekah
- Daenthanasanmak Anusara
- Dai Zhimin
- Damare Sherri
- Dammassa Ernesta
- Danaher Patrick
- Danforth David
- Daud Adil
- Davar Diwakar
- Davenport Anna
- David Larry
- Davies Bronwyn
- Davies Michael A.
- Davis Tom
- De Bono Johann
- De Macedo Mariana Petaccia
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- Desai Jayesh
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- Deshpande Vikram
- Desjarlais John
- Deveraux Quinn
- DeVito Anna Marie
- Devlin Sean
- Dey Chaitali
- Dhudashia Amit
- di Pietro Alessandra
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- Dietz Allan B.
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- Dougherty Janna
- Downing Sean
- Dragnev Konstanin
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- Dunaway Dwayne
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- Dyson Gregory
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- Fakhrejahani Farhad
- Falchook Gerald
- Fan Aaron
- Fan Frank
- Fang Victoria
- Fantini Massimo
- Fardis Maria
- Faries Mark
- Faroudi Mustapha
- Farrell Michael
- Fast Loren
- Felber Barbara
- Feldman Steven A.
- Feng Dai
- Fernando Ingrid
- Ferris Robert
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- Fieschi Jacques
- Fisher George A.
- Fling Steven
- Flint Paul W.
- Forrest-Hay Alex
- Fosco Dominick
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- Greiff Lennart
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- Grimaldi Antonio
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- Noffsinger Lori
- Norris Christie
- Nosrati Adi
- Nunez-Cruz Selene
- Oaknin Ana
- Obeid Joseph M.
- Ocio Enrique
- Odunsi Kunle
- Ogden Julia
- Oh William
- Ohanian Arpy
- Olencki Thomas
- Omilian Angela R.
- Opat Stephen
- Orford Keith W.
- Osman Iman
- Ott Patrick A.
- Ott Sascha
- Ottoson Nadine
- Overacre Abigail
- Overwijk Willem W.
- O’Connor Alison
- O’Neil Bert
- O’Neill Thomas
- Padda Sukhmani K.
- Page David
- Pagès Franck
- Pal Sumanta
- Pamer Eric
- Pan Fan
- Panda Anshuman
- Pandha Hardev
- Pandite Lini
- Pankov Alex
- Papadopoulos Kyriakos P.
- Pardoll Drew
- Paria Biman
- Parihar Robin
- Park Emily
- Park Jiwon
- Park Johanna
- Parney Ian F.
- Parviainen Suvi
- Pasetto Anna
- Patel Sapna P.
- Patnaik Amita
- Patsoukis Nikolaos
- Patterson James W.
- Paulos Chrystal
- Pavlakis George
- Pavlick Anna C.
- Payabyab Eden
- Pedersen Magnus
- Pegram Mark D.
- Peled Jonathan
- Pelletier Sandy
- Perales Miguel
- Perez-Garcia Arianne
- Perini Rodolfo
- Periyasamy Sankar
- Perlewitz Kelly
- Pestic-Dragovich Lidija
- Petersen Christopher
- Petersen Michael Mørk
- Peterson Tim
- Petroni Gina
- Petruzelka Lubos
- Pfeil Jacob
- Pham Hung
- Piha-Paul Sarina A.
- Pilon-Thomas Shari
- Pinzon-Ortiz Maria
- Piperdi Bilal
- Plimack Elizabeth
- Poehlein Christian
- Poggionovo Cécile
- Polaske Nathan
- Polesso Fanny
- Poplin Elizabeth
- Poplonski Tomasz
- Postow Michael
- Powderly John
- Powell Daniel J.
- Powles Thomas
- Pratte Luke
- Prickett Todd D.
- Pritchard Theresa
- Puhlmann Markus
- Puri Raj K.
- Qi Jingjing
- Qiao Guanxi
- Qin Haiying
- Qin Yong
- Qin Zhen
- Quattrini Adriano
- Quinn David
- Rabinovich Brian
- Racolta Adriana
- Rafelson William
- Rahma Osama E.
- Raje Noopur
- Rajurkar Mihir
- Ramachandra Murali
- Ramachandra Raghuveer
- Ramachandran Indu
- Ramakrishna Venky
- Ramakrishnan Rupal
- Ranheim Erik A.
- Rao Arjun A.
- Rashid Rumana
- Rattray Rogan
- Ravindranathan Sruthi
- Razai Amir S.
- Reagan John L.
- Reckamp Karen
- Reddy Ashok
- Reddy Praveen
- Reeves Jason
- Repasky Elizabeth
- Restifo Nicholas P.
- Reu Simone
- Reuben Alex
- Ribas Antoni
- Ribrag Vincent
- Ricca Jacob
- Richards Allison
- Richards Jon
- Richman Sarah A.
- Rickel Erika
- Riddell Stanley
- Riedlinger Greg
- Riemer Joanne
- Rifkin Robert
- Rimm David
- Rina Hui
- Rini Brian I.
- Rittase William
- Rivas Charlotte
- Rivera Miguel
- Robbins Paul F.
- Robida Mark
- Robinson Matthew K.
- Rocafiguera Albert Oriol
- Roder Heinrich
- Roder Joanna
- Rodriguez Kori Porosnicu
- Rodriguez Luis Paz-Ares
- Rodriguez-Garcia Alba
- Rodriguez-Rodriguez Lorna
- Rodríguez-Otero Paula
- Roen Diana
- Roman Kristin
- Romero Pedro
- Rong Xianhui
- Rooney Cliona M.
- Rosen Frances
- Rosenberg Steven
- Rosenberg Steven A.
- Rosenblum Michael
- Rosner Gary
- Ross Ashley
- Ross Jeffrey
- Rossi John M.
- Rothe Christine
- Royster Erica
- Rubinstein Mark
- Ruella Marco
- Rufer Nathalie
- Rush Elizabeth
- Ruzich Janet
- Rådestad Emelie
- Sabado Rachel
- Sabesan Arvind
- Sachsenmeier Eliot
- Sacris Erlinda
- Sadelain Michel
- Saenger Yvonne
- Saini Manoj
- Salama Sofie
- Salazar Andres M.
- Salazar Rachel
- Salles Gilles
- Samiulla Dodheri
- San-Miguel Jesus
- Sanborn Rachel E.
- Sanchez Katherine
- Sander Cindy
- Sanderson Joseph P.
- Sandhu Shahneen
- Sandoval Juan
- Sankin Alexander
- Santiago Laurelis
- Santos João
- Sanz Laia Masvidal
- Saraf Sanatan
- Sarnaik Amod
- Sasikumar Pottayil
- Sathyanaryanan Sriram
- Saunders Tracie
- Savoldo Barbara
- Schadendorf Dirk
- Schaffer Michael E.
- Schalper Kurt
- Scharping Nicole
- Schauder David
- Schaue Dorthe
- Scheel Birgit
- Schiller Annemarie
- Schjesvold Fredrik
- Schlom Jeffrey
- Schloss Charles
- Schlosser Corinna
- Schmidinger Manuela
- Schmidt Guenter
- Schneck Jonathan
- Schoenberg Mark
- Schoenmeyer Ralf
- Scholler John
- Schreiber Taylor H.
- Schult Silke
- Schvartsman Gustavo
- Schwartz Sarit
- Schüler Julia
- Segal Neil H.
- Seiwert Tanguy
- Sellappan Shankar
- Sethuraman Jyothi
- Sewell Andrew Kelvin
- Sgourakis Nikolaos
- Sha Huizi
- Shafren Darren
- Shah Jatin
- Shah Sumit A.
- Shamsili Setareh
- Shane Olwill A.
- Shankaran Veena
- Sharfman William
- Sharma Prannda
- Sharma Sherven
- Sharon Elad
- Sharpe Alan D.
- Shaw Pamela
- Shayan Gulidanna
- Shekarian Tala
- Shen Yueh-wei
- Sher Xinwei
- Sherman Marika
- Sherry Richard
- Shestova Olga
- Shields Anthony
- Shinners Nicholas
- Shinwari Nabeegha
- Shipp Margaret
- Shortt Jake
- Shree Ankita
- Shu Jenny
- Shukla Sachet A.
- Sidhom John-William
- Siefker-Radtke Arlene
- Sievers Eric
- Signoretti Sabina
- Sikic Branimir I.
- Silk Ann
- Silk Jonathan D.
- Silski Cynthia
- Simard François
- Simpson Guy
- Sirard Cynthia
- Siurala Mikko
- Skalova Helena
- Slawin Kevin
- Slingluff Craig L.
- Small William
- Smith David C.
- Smith Sean G.
- Smolkin Mark E.
- Snzol Mario
- Sodre Andressa
- Sokol Levi
- Somerville Robert
- Sondel Paul M.
- Song James
- Song Yang
- Sonpavde Guru
- Soon-Shiong Patrick
- Sosman Jeffrey
- Spacek Jan
- Speiser Daniel E.
- Spencer Christine
- Spencer David M.
- Spires Vanessa M.
- Sprague Isaac
- Spranger Stefani
- Spreafico Anna
- Srinivasa Sreesha P.
- Srivastava Abhishek
- Staffas Anna
- Stagg John
- Stecha Pete
- Stein Mark
- Steinbach Joachim P.
- Steingrimsson Arni
- Steinmetz Sue
- Stern Joshua
- Stevanovic Sanja
- Stewart John
- Stief Christian
- Storey James
- Stramer Amanda
- Stump Julia
- Sturgill Ian
- Su Nan
- Su Paul
- Su Shu
- Subbiah Vivek
- Sudarshan Naremaddepalli
- Suh Robert
- Suisham Stacey
- Sullivan Ryan J.
- Sun Cheng
- Sun Yongming
- Sundarapandiyan Karuna
- Sundararaman Srividya
- Sundberg Berit
- Supan Dana
- Suryawanshi Satyendra
- Suzuki Akiko
- Svane Inge Marie
- Swaby Ramona F.
- Swann Suzanne
- Swanson Ryan
- Swiderski Piotr
- Szomolay Barbara
- Takimoto Chris H.
- Tan Xuemei
- Tang Lei
- Tang Shande
- Tannir Nizar M.
- Tarhini Ahmad A.
- Taur Ying
- Tawbi Hussein
- Taylor Katrina A.
- Tewari Krishnansu S.
- Teyssier Noam
- Thakur Archana
- Theiss Noah
- Thibault Guillaume
- Thomas Lawrence J.
- Thompson John
- Thompson Lucas
- Thompson Seth
- Throsby Mark
- Thyparambil Sheeno
- Tian Zhigang
- Tilman Rau T.
- Timmer John C.
- Ting David
- To Ka Fai
- Tom Warren
- Tonn Torsten
- Topalian Suzanne
- Toth Kyle
- Tran Ben
- Trebska-McGowan Kasia
- Trehu Elizabeth
- Tribble Nicholas
- Trimble Cornelia L.
- Tsai Katy
- Tsang Kwong
- Tsao Tsu-Shuen
- Tsourkas Andrew
- Tsujikawa Takahiro
- Tufman Amanda
- Tumeh Paul
- Tumeh Paul C.
- Turcotte Simon
- Tykodi Scott
- Uemura Marc
- Uger Robert
- Uhlik Mark
- Uhlin Michael
- Urba Walter
- Uribe Diana
- Vaishampayan Ulka
- Valsesia-Wittmann Sandrine
- van den Brink Marcel R. M.
- Van den Eynde Marc
- van Hoef Vincent
- van Loo Pieter Fokko
- Vandeven Natalie
- Varadarajan Navin
- Varadhachary Gauri R.
- Vasaturo Angela
- Vaske Charles
- Vasselli James
- Veerapathran Anandaraman
- Velcheti Vamsidhar
- Veninga Henrike
- Vetsika E-K
- Vignali Dario
- Villabona Lisa
- Villalobos Victor M.
- Villarroel Patricio Pérez
- Viller Natasja Nielsen
- Vitale Laura A.
- Vocka Michal
- Volkmer Jens-Peter
- Voss Martin
- Vuyyuru Raja
- Wagner Joel P.
- Wakefield Jessica
- Wakelee Heather A.
- Waldmann Anja
- Waldmann Thomas
- Wallace William D.
- Waller Edmund K.
- Walser Tonya C.
- Walsh William
- Wan Ee
- Wang Chichung
- Wang Chun-Wei
- Wang Daqing
- Wang Gerald
- Wang Hao
- Wang Judy S.
- Wang Lai
- Wang Ziming
- Wardell Seth
- Wargo Jennifer
- Warren Sarah
- Wassman Karl
- Watkins Simon
- Webb Tonya J.
- Weber James
- Weber Jeffrey
- Weber Sharon
- Webster Philippa
- Wei Ziewn
- Weidlick Jeffrey
- Weigel Tracey
- Weinberg Andrew
- Weissbrich Bianca
- Weissman Irving L.
- Wels Winfried S.
- Wennerberg Erik
- Wenthe Jessica
- Westergaard Marie Christine Wulff
- Whetstone Ryan
- White Andrew M.
- White Eileen
- Whiting Sam
- Widger Jenifer
- Wiedenmann Alexander
- Wiedermann Guy
- Wiegand Volker
- Wiener Doris
- Wigginton Jon
- William Loging
- Williams Jason B.
- Williams LaTerrica C.
- Winter Hauke
- Withers Sita
- Witjes J. Alfred
- Witt Kristina
- Wolchok Jedd D.
- Wolfson Martin
- Wondyfraw Nebiyu
- Wong Philip
- Wong Ryan
- Woodman Scott
- Woods David
- Workman Creg
- Wu Catherine J.
- Wu Haiyan
- Wu Jennifer
- Wunderlich John
- Wydro Mateusz
- Xiao Christine
- Xiao Weihua
- Xin Gang
- Xu Hui
- Xue Allen
- Yamamoto Tori
- Yanagawa Jane
- Yang James
- Yang Jason
- Yang Richard
- Yearley Jennifer
- Yee Andrew J.
- Yee Cassian
- Yehuda Dina Ben
- Yigitsoy Mehmet
- Yimer Habte
- Yonemitsu Yoshikazu
- Yoshino Takayuki
- Yu Evan Y.
- Yu Wendy
- Yu Xuezhong
- Yu Zhiya
- Yusko Erik
- Zacharakis Nikolaos
- Zaharoff David
- Zamarin Dmitriy
- Zang Xingxing
- Zanhow Cynthia
- Zappasodi Roberta
- Zarour Hassane
- Zavadova Eva
- Zehn Dietmar
- Zeng Gang
- Zeng Xue
- Zha Yuanyuan
- Zhang Bingqing
- Zhang Congcong
- Zhang Hongjun
- Zhang Hua
- Zhang Hui
- Zhang Jian
- Zhang Jinyu
- Zhang Liping
- Zhang Maggie
- Zhang Wenjun
- Zhang Xiaonan
- Zhang Yayan
- Zhao Fei
- Zhao Xingli
- Zhao Zeguo
- Zhong Shi
- Zhu Baogong
- Zhu Cheng
- Zhu Yifei
- Zi Tong
- Zimarino Carlo
- Zinzani Pier Luigi
- Zoon Kathryn C.
- Zuleger Cindy
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 03/01/2017
- Field of study
31st Annual Meeting and Associated Programs of the Society for Immunotherapy of Cancer (SITC 2016): part one
- Author
- Aarts Craig
- Abdallah Rehab
- Abdul-Alim Siddiq
- Abolhalaj Milad
- Abtin Fereidoun
- Acheson Anupama
- Acquavella Nicolas
- Adams Gregory P
- Adams Katherine
- Adams Sharon
- Adamus Tomasz
- Adekandi Madhukara
- Adurthi Sreenivas
- Adusumilli Prasad S
- Aeffner Famke
- Afentoulis Michael
- Ager Casey
- Aggouraki Despoina
- Agrawal Rajendra
- Agrawal Sudhir
- Agrawal Swati
- Ahlers Christoph M
- Ahmed Nabil
- Ahn Myung J
- Ahr Katya
- Ai Midan
- Aiba Rachida-Siham B
- Aisner Joseph
- Albertini Mark R
- Albertini Mark R
- Albiges Laurence
- Albright Andrew
- Albright Andrew
- Algazi Alain
- Ali Siraj
- Alicea Candido
- Allen Natalie
- Allersdorfer Andrea
- Alva Ajjai
- Amado Rafael
- Amaria Rodabe
- Ameratunga Malaka
- Amin Asim
- Amor Amira B
- Amrhein John
- Anagnostou Valsamo
- Andersen Rikke
- Andersen Rikke
- André Thierry
- Andtbacka Robert H I
- Angela Omilian
- Angell Helen K
- Annels Nicola
- Annunziata Christina M
- Ansa-Addo Ephraim A
- Ansari Tameem
- Antilla Marjukka
- Antonarakis Emmanuel S
- Antonarakis Emmanuel S
- Aoki Rhonda
- Armand Philippe
- Armand Philippe
- Armstrong Adam
- Arora Kshitij
- Arreaza Gladys
- Ascierto Paolo A
- Ashworth-Sharpe Julia
- Askmyr David
- Asmellash Senait
- Assadipour Yasmine
- Assenmacher Mario
- Athelogou Maria
- Atkins Michael B
- Atkins Michael B
- Atkins Michael B
- Attaf Meriem
- Au Gough
- Au-Young Janice
- Avery Kendra N
- Avery Kendra N
- Ayers Mark
- Ayers Mark
- Ayers Mark
- Azimi Vahid
- Aznar M. A
- Backert Linus
- Backes Floor J
- Bagg Eleanor A L
- Bahjat Keith
- Bajorin Dean
- Bakker Lex
- Balakumaran Arun
- Balakumaran Arun
- Balakumaran Arun
- Ballesteros-Merino Carmen
- Ballesteros-Merino Carmen
- Ballesteros-Merino Carmen
- Bander Neil
- Bang Yung-Jue
- Bannerji Rajat
- Baratelli Felicita E
- Barbee Susannah D
- Barlesi Fabrice
- Barrett Carl
- Barrett David
- Barth Carola
- Bartkowiak Todd
- Bartlett Nancy
- Basher Fahmin
- Bassett Roland
- Bassett Roland
- Basu Samik
- Bath Natalie
- Batista Luciana
- Bauer Todd
- Bauer Todd M
- Bauer Todd W
- Baughman Jan E
- Bayle J. H
- Baylin Stephen
- Beechem Joseph
- Beechem Joseph
- Beechem Joseph
- Beeson Craig
- Bellmunt Joaquim
- Bellmunt Joaquim
- Bellovin David I
- Beltran Nancy
- Bendell Johanna
- Bender James
- Bender James
- Bender James
- Bennett Alan D
- Bennett Mark K
- Bergamaschi Cristina
- Berger Frank
- Berger Sven
- Bergeron Derek
- Berglund Anders
- Berglund Sofia
- Bernatchez Chantale
- Bernett Matthew J
- Bernett Matthew J
- Bernstein Donna
- Bessell Catherine A
- Betts Gareth
- Beyer Sophie
- Bhanot Gyan
- Bhardwaj Nina
- Bhardwaj Nina
- Bhardwaj Nina
- Bhardwaj Rukmini
- Bhatia Shailender
- Bhatia Shailender
- Bhaumik Srabani
- Bianchi Valentina
- Bielamowicz Kevin
- Bieniarz Christopher
- Bifulco Carlo
- Bifulco Carlo
- Bifulco Carlo
- Bifulco Carlo
- Billingsley James M
- Binder-Scholl Gwendolyn
- Binder-Scholl Gwendolyn
- Binnig Gerd
- Birditt Brian
- Bivalacqua Trinity J
- Black Joshua C
- Black Joshua C
- Black Mary
- Blacklock Hilary
- Blackmon Shauna
- Blackmon Shauna
- Blaskovich Michelle A
- Blaskovich Michelle A
- Blaskovich Michelle A
- Blazar Bruce R
- Blitzer Grace
- Bonzon Christine
- Bonzon Christine
- Borch Troels H
- Borch Troels H
- Borges Luis
- Borkar Rohan N
- Bornschlegl Svetlana
- Bornschlegl Svetlana
- Bosch Marnix
- Bose Nandita
- Bossen Bolette
- Bot Adrian
- Botti Gerardo
- Boudadi Karim
- Boussiotis Vassiliki A
- Brahmer Julie
- Bramson Jonathan
- Bramson Jonathan
- Brenner Malcolm K
- Brett Sara
- Brevard Julie
- Brewer Joanna
- Brieu Nicolas
- Brisson Ryan
- Brody Joshua
- Brunazzi Erin
- Bruno Tullia C
- Bryant Bonita
- Bshara Wiam
- Bu Xia
- Buchner Alexander
- Bucsek Mark
- Budhani Pratha
- Bullock Timothy N
- Bullock Timothy N
- Burger Michael C
- Burgess Melissa
- Burgher Blake
- Burgher Blake
- Burk Chad
- Butterfield Lisa H
- Byrd David
- Byrd John
- Byrd Tiara
- Callahan Margaret K
- Campbell Mary
- Campbell Tracy
- Canter Robert J
- Canter Robert J
- Cao Alexander
- Carmichael Lakeesha
- Caron Christine
- Carpentier Sabrina
- Carpio Cecilia
- Carretero-Iglesia Laura
- Carvajal-Hausdorf Daniel
- Caspell Richard
- Caux Christophe
- Cecchi Fabiola
- Celis Esteban
- Cerkovnik Logan
- Cervera-Carrascón Víctor
- Chacon Jessica
- Chagin Karen
- Chakraborty Paramita
- Champagne Monique
- Chan Anthony T C
- Chan Nancy
- Chan Timothy A
- Chandran Smita
- Chandrasekhar Talapaneni
- Chang Peter
- Chang Serena
- Chao Mark
- Chatterjee Shilpak
- Chaudhri Apoorvi
- Cheever Martin
- Chen Amanda
- Chen Hui
- Chen Jie Q
- Chen Lawrence
- Chen Lieping
- Chen Mei
- Chen Mingyi
- Chen Shuming
- Chen Xiufen
- Cheng Jonathan
- Cheng Jonathan
- Cheng Zhi-jie J
- Chikina Maria
- Chin Renee
- Chinnasamy Harshini
- Chlosta Sabine
- Chlosta Sabine
- Choi Minsig
- Choueiri Toni K
- Choueiri Toni K
- Christian Beth
- Chu Liz
- Chu Seung
- Chu Seung
- Chunduru Srinivas
- Clark Joseph I
- Clayburgh Daniel R
- Clement Amanda
- Clements Erin
- Cohen Lewis
- Cohen Zvi
- Colevas A D
- Collins Jennifer
- Colyer Duncan
- Cong Mei
- Conlin Alison
- Conlon Kevin
- Conrad Valerie
- Conroy Jeff
- Conroy Jeff
- Copeland Larry
- Copploa Domenico
- Cordes Lisa
- Cornfeld Mark
- Cortina Luis
- Coussens Lisa M
- Couto Joseph
- Coveler Andrew L
- Crabill George
- Cristescu Razvan
- Cristescu Razvan
- Crocker Andrea
- Cui Weiguo
- Culp William
- Cumberbatch Kerwin
- Curran Michael
- Curti Brendan
- Curti Brendan
- Curti Brendan
- Curti Brendan
- Dadey Rebekah
- Daenthanasanmak Anusara
- Dai Zhimin
- Damare Sherri
- Dammassa Ernesta
- Danaher Patrick
- Danaher Patrick
- Danforth David
- Daud Adil
- Davar Diwakar
- Davenport Anna
- David Larry
- Davies Bronwyn
- Davies Michael A
- Davies Michael A
- Davis Tom
- De Bono Johann
- De Macedo Mariana P
- de Oliveira Moacyr R
- De Santis Maria
- de Wit Ronald
- Deacon Donna H
- Deacon Donna H
- Deeds Michael
- Del Pilar Estevez Diz Maria
- Delcommenne Marc
- Delgoffe Greg M
- Delgoffe Greg M
- Delgoffe Greg M
- Delismon Judy
- Denisova Galina
- Dennis Lucas
- Dennis Lucas
- Deol Abhinav
- Derakhshandeh Roshanak
- DeRenzo Christopher
- Desai Jayesh
- Desai Niyati
- Deshpande Amit
- Deshpande Amit
- Deshpande Vikram
- Desjarlais John
- Desjarlais John
- Deveraux Quinn
- DeVito Anna M
- Devlin Sean
- Dey Chaitali
- Dhudashia Amit
- di Pietro Alessandra
- Diab Adi
- Diaz Luis A
- Diaz-Lagares Angel
- Dietz Allan B
- Dietz Allan B
- Ding Naiqing
- Ding Wei
- Disis Mary L
- Dobson Jason R
- Docta Roslin
- Dolstra Harry
- Dolton Garry
- Donda Alena
- Donia Marco
- Donia Marco
- Donia Marco
- Donovan Michael J
- doo Chang Young
- Doody Jacqueline
- Dotti Gianpietro
- Dougherty Janna
- Downing Sean
- Dragnev Konstanin
- Drake Charles G
- Drake Charles G
- Dranoff Glenn
- Draper Lindsey M
- Drechsel Katharina
- Dreicer Robert
- Dubay Christopher
- Dubay Christopher
- Dubey Aparajita
- Dubinett Steven M
- Dubois Sigrid
- Duhen Rebekka
- Duhen Thomas
- Dummer Reinhard
- Dunaway Dwayne
- Dunaway Dwayne
- Duncan Brynn
- Dundr Pavel
- Duong MyLinh
- Dutour Aurélie
- Dyson Gregory
- D’Amico Leonard
- Eagan Maribeth A
- Early Brandon
- Eckelman Brendan P
- Egevad Lars
- Ehrmann Jon M
- El Rassi Edward
- Elashoff David A
- Elliott Nathan
- Emens Leisha
- Enblad Gunilla
- Erdag Gulsun
- Erdag Gulsun
- Ernstoff Marc S
- Ernstoff Marc S
- Essand Magnus
- Esteller Manel
- Evans Kathy
- Evans Lawrence
- Eyquem Justin
- Fakhrejahani Farhad
- Falchook Gerald
- Fan Aaron
- Fan Frank
- Fang Victoria
- Fantini Massimo
- Fardis Maria
- Fardis Maria
- Faries Mark
- Faroudi Mustapha
- Farrell Michael
- Fast Loren
- Felber Barbara
- Feldman Steven A
- Feng Dai
- Fernando Ingrid
- Ferris Robert
- Ferris Robert L
- Ferris Robert L
- Fieschi Jacques
- Fisher George A
- Fling Steven
- Fling Steven
- Flint Paul W
- Forrest-Hay Alex
- Fosco Dominick
- Foster Aaron E
- Fotin-Mleczek Mariola
- Fousek Kristen
- Fox Bernard
- Fox Bernard
- Fox Bernard
- Fox Bernard
- Fox Bernard
- Fox Maxine
- Francis Nicole
- Frank Ian
- Frank Ian
- Frankel Melissa
- Fraser Kathryn
- Frayssinet Véronique
- Freeman Gordon J
- Freese Katharina
- Frey Alan
- Friedlander Michael L
- Friedlander Philip
- Friedlander Philip
- Friedlander Philip
- Fritsch Edward
- Fry Terry
- Fu Siqing
- Fujii Rika
- Fulton Ross B
- Gajewski Thomas F
- Gajewski Thomas F
- Gajewski Thomas F
- Galon Jérôme
- Gan Hui
- Gan Jacek
- Ganesan Shridar
- Gangadhar Tara C
- Gangxiong Huang
- Gao Qian
- Gardai Shyra J
- Gardner Mark
- Garon Edward B
- Garon Edward B
- Garrabrant Thomas
- Garrett-Mayer Elizabeth
- Gartner Jared J
- Gartner Jared J
- Gartrell Benjamin
- Garvin Denise
- Gastineau Dennis A
- Gastineau Dennis A
- Gastman Brian
- Gause Christine
- Geib James
- Geiss Gary
- Geller Melissa
- Georgoulias V.
- Gerken Claudia
- Gerry Andrew
- Gerry Andrew
- Gershan Jill
- Gershenson Zack
- Ghaffari Mahsa
- Ghori Razi
- Gianani Roberto
- Gianani Roberto
- Gilden Julia
- Gill Saar
- Gillies Stephen D
- Giralt Sergio
- Giri Rajanish
- Gitlitz Barbara
- Giver Cynthia R
- Glenn Sean
- Glenn Sean
- Glitza Isabella
- Glitza Isabella
- Glod John
- Gnad-Vogt Ulrike
- Goel Sanjay
- Goff Stephanie
- Goff Stephanie L
- Goff Stephanie L
- Gojo Ivana
- Gokuldass Aishwarya
- Gokuldass Aishwarya
- Goldinger Simone
- Goldman Jonathan W
- Goldschmidt Hartmut
- Goldstein Joel
- Gonzalez Denise
- Gonzalez Iliana
- Gonzalez Ricardo
- Gorden Keith
- Gormley Michael
- Gottschalk Stephen
- Gottschalk Stephen
- Gottschalk Stephen
- Govindappa Nagaraja
- Gowda Nagaraj
- Gowda Nagesh
- Graff Jeremy
- Grailer Jamison
- Graziano Robert F
- Green Daniel S
- Gregory Gareth
- Greiff Lennart
- Grilley-Olson Juneko E
- Grimaldi Antonio
- Grose Mark
- Grose Mark
- Gross Matt
- Grossenbacher Steven
- Grossenbacher Steven K
- Grupp Stephan
- Gschwendt Juergen
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- Xiao Christine
- Xiao Weihua
- Xin Gang
- Xu Hui
- Xue Allen
- Yamamoto Tori
- Yanagawa Jane
- Yang James
- Yang Jason
- Yang Richard
- Yearley Jennifer
- Yearley Jennifer
- Yee Andrew J
- Yee Cassian
- Yehuda Dina B
- Yigitsoy Mehmet
- Yimer Habte
- Yonemitsu Yoshikazu
- Yoshino Takayuki
- Yu Evan Y
- Yu Wendy
- Yu Xuezhong
- Yu Zhiya
- Yu Zhiya
- Yusko Erik
- Zacharakis Nikolaos
- Zaharoff David
- Zamarin Dmitriy
- Zang Xingxing
- Zanhow Cynthia
- Zappasodi Roberta
- Zarour Hassane
- Zavadova Eva
- Zehn Dietmar
- Zeng Gang
- Zeng Xue
- Zha Yuanyuan
- Zhang Bingqing
- Zhang Congcong
- Zhang Hongjun
- Zhang Hua
- Zhang Hui
- Zhang Jian
- Zhang Jinyu
- Zhang Liping
- Zhang Maggie
- Zhang Wenjun
- Zhang Xiaonan
- Zhang Yayan
- Zhang Yayan
- Zhao Fei
- Zhao Xingli
- Zhao Zeguo
- Zhong Shi
- Zhu Baogong
- Zhu Cheng
- Zhu Yifei
- Zi Tong
- Zi Tong
- Zimarino Carlo
- Zinzani Pier L
- Zinzani Pier L
- Zoon Kathryn C
- Zuleger Cindy
- Publication venue
- Publication date
- 27/03/2018
- Field of study