Derivatization Does Not Influence Antimicrobial and Antifungal Activities of Applanoxidic Acids and Sterols from Ganoderma spp.

Abstract Applanoxidic acids and sterols, isolated from Ganoderma spp., were acetylated and/or methylated. The antibacterial activity against Escherichia coli and Staphylococcus aureus and the antifungal activity against Candida albicans and Trichophyton mentagrophytes of the derivatives were investigated by a microdilution method, and compared with those of the natural products. Both natural and modified compounds exhibited comparable antibacterial and antifungal activities in a range of 1.0 to > 2.0 mg/ml minimal inhibitory concentratio

Bioactive Phenolic Compounds from Aerial Parts of Plinia glomerata

Abstract The present work describes the antinociceptive properties and chemical composition of the aerial parts of Plinia glomerata (Myrtaceae). Both of the extracts evaluated, acetonic and methanolic, showed potent antinociceptive action, when analyzed against acetic acid-induced abdominal constrictions in mice, with calculated ID50 (mg/kg, i. p.) values of 24.8 and 3.3, respectively. Through usual chromatographic techniques with an acetonic extract, the following compounds were obtained: 3,4,3′-trimethoxy flavellagic acid (1), 3,4,3′-trimethoxy flavellagic acid 4′-O-glucoside (3) and quercitrin (4), which were identified based on spectroscopic data. Compounds 1 (ID50 = 3.9 mg/kg, i. p., or 10.8 μmol/kg) and 3 (ID50 = 1.3 mg/kg or 2.5 μmol/kg) were notably more active than some well-known analgesic drugs used here for comparison

Erratum: Lipase-catalyzed regioselective acylation of resorcin[4]arenes (Journal of Molecular Catalysis B: Enzymatic (2002) 16 (24-247) PII: S1381117701000686)

10Immobilized lipase from Mucor miehei (RML) catalyzed the regioselective acylation of the C-2 side-chain of the C-alkyl resorcin[4]arene tetra-alcohol 1 in the 1,2-alternate form in organic solvents using vinyl acetate as acylating reagent. The influence of reaction parameters and solvent choice were also studied. Docking simulations allowed the determination of the binding geometry of 1, revealing the importance of Trp88 residue in stabilizing the Michaelis–Menten complex between enzyme and substrate.reservedmixedBotta, Bruno; Zappia, Giovanni; Tafi, Andrea; Botta, Maurizio; Manetti, Fabrizio; Cernia, Enrico; Milana, Giuliana; Palocci, Cleofe; Soro, Simonetta; Delle Monache, GiulianoBotta, Bruno; Zappia, Giovanni; Tafi, Andrea; Botta, Maurizio; Manetti, Fabrizio; Cernia, Enrico; Milana, Giuliana; Palocci, Cleofe; Soro, Simonetta; Delle Monache, Giulian

Two new O-geranyl coumarins from the resinous exudate of Haplopappus multifolius

From the resinous exudate of leaves of Haplopappus multifolius two new coumarins were isolated and assigned the structures 6-hydroxy-7-(5′- hydroxy-3′,7′-dimethylocta-2′,6′-dien)-oxycoumarin (1) and 6-hydroxy-7-(7′-hydroxy-3′,7′-dimethylocta-2′, 5′-dien)-oxy coumarin (2)

New vismiones from <i>psorospermum tenuifolium</i>

Bu11.Chem.Soc.Ethiop., 1(1), 42-46 (1987)

New vismiones from psorospermum tenuifolium

Bu11.Chem.Soc.Ethiop., 1(1), 42-46 (1987)

Diterpenes from Haplopappus chrysanthemifolius

Three new diterpenes were isolated from the aerial part of Haplopappus chrysanthemifolius and assigned the structures 6α-hydroxy-ent-labd-8(17)-en- 15-oic acid, 3β-acetoxy-ent-labd-8(17)-en-15-oic acid and 18α-acetoxylabd- 8(17)-en-15-oic acid. The structures were elucidated by high field NMR spectroscopy