ATTITUDES TOWARD GOVERNMENT INVOLVEMENT IN AGRICULTURE: RESULTS OF A NATIONAL SURVEY

This study reports results from a nationwide survey of public attitudes toward agriculture. The study focuses on attitudes toward government involvement in agriculture across regions of the county and residential categories.Political Economy,

Private Food Assistance in a Small Metropolitan Area: Urban Resources and Rural Needs

Food banks and other private feeding programs have become an institutionalized component of the social welfare system in over 190 urban areas in the U.S. More recently, private food assistance has gained importance in rural areas as well. The density and capacity of agencies to serve the poor is higher in urban areas than in sparsely populated rural locales where distance and dispersal tend to be barriers to supplying and accessing donated food. Rural food distribution strategies thus must be qualitatively different than those in larger communities, because of the smaller-scale, more informal distributional system. Little is known about how urban-based nonprofit services stimulate and support food assistance in surrounding rural locales. Based on intensive interviews with food bank stafffood pan try directors, and food pantry clientele, we examine obstacles affecting the use of food pantries and the amelioration of food insecurity. We also provide an assessment of how changes in federal welfare provisions may be affecting the need for private food assistance

Buy Me! Buy Me!

The Fourth Annual Report on Trends in Schoolhouse Commercialism, Year 2000-2001, finds growing resistance to – and acceptance of – commercial activities in schools

HERMIONE: a randomized Phase 2 trial of MM-302 plus trastuzumab versus chemotherapy of physician's choice plus trastuzumab in patients with previously treated, anthracycline-naïve, HER2-positive, locally advanced/metastatic breast cancer.

BackgroundHuman epidermal growth factor receptor 2 (HER2)-positive breast cancer is a particularly aggressive form of the disease, and ultimately progresses in patients with metastases on standard therapies. Anthracyclines, such as doxorubicin, are an effective treatment for HER2-positive breast cancer, particularly when administered in combination with trastuzumab - however, doxorubicin-related cardiotoxicity has limited its use. Many patients are therefore never treated with anthracyclines, even upon disease progression, despite the potential for benefit. MM-302 is a novel, HER2-targeted antibody-liposomal doxorubicin conjugate that specifically targets HER2-overexpressing cells. Preclinical and Phase 1 data suggest that MM-302, as a monotherapy or in combination with trastuzumab, could be effective for managing previously treated, anthracycline-naïve, HER2-positive breast cancer, without the cardiotoxicity observed with free doxorubicin formulations.Methods/designHERMIONE is an open-label, multicenter, randomized (1:1) Phase 2 trial of MM-302 plus trastuzumab versus chemotherapy of physician's choice (gemcitabine, capecitabine, or vinorelbine) plus trastuzumab planned to enroll 250 anthracycline-naïve patients with locally advanced/metastatic HER2-positive breast cancer. Key inclusion criteria are: previous treatment with trastuzumab (with or without pertuzumab) in any setting; refractory or intolerant to pertuzumab (refractory to pertuzumab defined as progression in the locally advanced or metastatic setting, or disease recurrence during or within 12 months of completing pertuzumab-containing neoadjuvant and/or adjuvant therapy); and disease progression on, or intolerant to, ado-trastuzumab emtansine for locally advanced or metastatic disease. The trial is currently being conducted at sites in the USA, Canada, and Western Europe. Treatment will be administered in 21-day cycles, and will be continued until disease progression or unacceptable toxicity. The primary endpoint is independently assessed progression-free survival (PFS). Tumor response will be assessed every 6 weeks, and defined according to RECIST v1.1. Secondary endpoints include investigator-assessed PFS, overall survival (OS), OS rates at 6 months and 1 year, objective response rates, safety and tolerability, quality of life, and the pharmacokinetic profile of MM-302 plus trastuzumab.DiscussionThe HERMIONE study will evaluate the efficacy and safety of MM-302 plus trastuzumab in patients with refractory HER2-positive advanced/metastatic breast cancer for whom there are no standard of care therapies with a proven survival advantage.Trial registrationClinicaltrials.gov identifier: NCT02213744 . Registration date: 06AUG2014

Food Security of Low-Income Single Parents in East Alabama: Use of Private and Public Programs in the Age of Welfare Reform

Despite a strong economy, the use of private, nonprofit food assistance is increasing. To determine how single parenthood affects the use of both public and private food assistance, a sample of food bank clients and low-income, food-needy non-clients in East Alabama was interviewed. Overall, single-parent food-pantry clients indicated higher levels of food insecurity than other groups, but the non-clients who were not single parents also indicated high levels of need. Although 42 percent of food bank clients were single parents, results showed that married couples with children were more highly represented among the food bank clients than among food-needy individuals who do not use the pantry. Single parents were more likely than others to receive food stamp and Temporary Assistance to Needy Families (TANF) benefits, a finding that corresponds to this group\u27s lower incomes and larger family sizes

A Comparative Study of the ReCell® Device and Autologous Spit-Thickness Meshed Skin Graft in the Treatment of Acute Burn Injuries.

Early excision and autografting are standard care for deeper burns. However, donor sites are a source of significant morbidity. To address this, the ReCell® Autologous Cell Harvesting Device (ReCell) was designed for use at the point-of-care to prepare a noncultured, autologous skin cell suspension (ASCS) capable of epidermal regeneration using minimal donor skin. A prospective study was conducted to evaluate the clinical performance of ReCell vs meshed split-thickness skin grafts (STSG, Control) for the treatment of deep partial-thickness burns. Effectiveness measures were assessed to 1 year for both ASCS and Control treatment sites and donor sites, including the incidence of healing, scarring, and pain. At 4 weeks, 98% of the ASCS-treated sites were healed compared with 100% of the Controls. Pain and assessments of scarring at the treatment sites were reported to be similar between groups. Significant differences were observed between ReCell and Control donor sites. The mean ReCell donor area was approximately 40 times smaller than that of the Control (P < .0001), and after 1 week, significantly more ReCell donor sites were healed than Controls (P = .04). Over the first 16 weeks, patients reported significantly less pain at the ReCell donor sites compared with Controls (P ≤ .05 at each time point). Long-term patients reported higher satisfaction with ReCell donor site outcomes compared with the Controls. This study provides evidence that the treatment of deep partial-thickness burns with ASCS results in comparable healing, with significantly reduced donor site size and pain and improved appearance relative to STSG

Constraints on the SZ Power Spectrum on Degree Angular Scales in WMAP Data

The Sunyaev-Zel'dovich (SZ) effect has a distinct spectral signature that allows its separation from fluctuations in the cosmic microwave background (CMB) and foregrounds. Using CMB anisotropies measured in Wilkinson Microwave Anisotropy Probe's five-year maps, we constrain the SZ fluctuations at large, degree angular scales corresponding to multipoles in the range from 10 to 400. We provide upper bounds on SZ fluctuations at multipoles greater than 50, and find evidence for a hemispherically asymmetric signal at ten degrees angular scales. The amplitude of the detected signal cannot be easily explained with the allowed number density and temperature of electrons in the Galactic halo. We have failed to explain the excess signal as a residual from known Galactic foregrounds or instrumental uncertainties such as 1/f-noise.Comment: 14 pages, 3 figures, 2 tables. Simple typos fixe