CONOCIMIENTO DE LA ENFERMERA EN LA ATENCIÓN A USUARIO CON PRE-ECLAMPSIA Y ECLAMPSIA

Introduction Preeclampsia-eclampsia everywhere in the world continues being one of the main causes of morbidity and perinatal mortality. In Mexico it has been the leading cause of maternal death of the last 20 years, in spite of advances in quality and quantity of prenatal care, delivery assistance and puerperium attention. Objective To identify the level of knowledge of the nursing personnel in Labor and Delivery, as well as Gynecology and Obstetrics caring for people with preeclampsia-eclampsia. Material and methods A study was made of a descriptive survey given to 75 nurses in the General Regional Hospital No.1, in which an instrument of information was elaborated regarding the level of knowledge of the nursing personnel caring for people with preeclampsia-eclampsia. This was validated by two rounds of experts and one test pilot, the measurement scale was also good as it answered correctly from 86% to 100 % of items, fair, from 70% to 85% and poor less than 69%. Results The average age of the nurses was 41 years, with a standard deviation ±7.1. In reference to the level of knowledge of the nursing personnel in the field of preeclampsia-eclampsia caring for patients, the result was deficient even though the time in service was more than three years. Conclusions The level of knowledge of the nursing personnel regarding preeclampsia-eclampsia was low, and there is no connection between experience and level of knowledge.Introducción La preeclampsia-eclampsia continúa siendo una de las principales causas de morbilidad y mortalidad perinatal en todo el mundo. En México ha sido la primera causa de muerte materna en los últimos 20 años a pesar de los avances en calidad y cantidad de control prenatal, de la atención del parto y puerperio. Objetivo Identificar el nivel de conocimiento que tiene el personal de enfermería del área de Tococirugía y Ginecoobstetricia en la atención a usuarias con preeclampsia eclampsia. Material y métodos Se realizó un estudio encuesta descriptiva a 75 enfermeras del Hospital General Regional No. 1, en el cual se elaboró un instrumento de información sobre nivel de conocimientos del personal de enfermería de preeclampsia eclampsia, validado por dos rondas de expertos y una prueba piloto, así mismo la escala de medición fue bueno cuando contestara correctamente del 86 al 100 % de los ítems, regular, del 70 al 85 %, y deficiente, menos de 69 %. Resultados El promedio de edad de las enfermeras fue de 41 años, con una desviación estándar más menos 7.1. Referente al nivel de conocimiento del personal de enfermería sobre preeclampsia eclampsia en el manejo de usuarias el resultado fue deficiente aún cuando la antigüedad en el servicio fue de más de tres años. Conclusiones El nivel de conocimientos del personal de enfermería en preeclampsia eclampsia fue bajo, además no existe congruencia entre la antigüedad en el servicio y el nivel de conocimiento

A922 Sequential measurement of 1 hour creatinine clearance (1-CRCL) in critically ill patients at risk of acute kidney injury (AKI)

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Stroke genetics informs drug discovery and risk prediction across ancestries

Previous genome-wide association studies (GWASs) of stroke - the second leading cause of death worldwide - were conducted predominantly in populations of European ancestry(1,2). Here, in cross-ancestry GWAS meta-analyses of 110,182 patients who have had a stroke (five ancestries, 33% non-European) and 1,503,898 control individuals, we identify association signals for stroke and its subtypes at 89 (61 new) independent loci: 60 in primary inverse-variance-weighted analyses and 29 in secondary meta-regression and multitrait analyses. On the basis of internal cross-ancestry validation and an independent follow-up in 89,084 additional cases of stroke (30% non-European) and 1,013,843 control individuals, 87% of the primary stroke risk loci and 60% of the secondary stroke risk loci were replicated (P < 0.05). Effect sizes were highly correlated across ancestries. Cross-ancestry fine-mapping, in silico mutagenesis analysis(3), and transcriptome-wide and proteome-wide association analyses revealed putative causal genes (such as SH3PXD2A and FURIN) and variants (such as at GRK5 and NOS3). Using a three-pronged approach(4), we provide genetic evidence for putative drug effects, highlighting F11, KLKB1, PROC, GP1BA, LAMC2 and VCAM1 as possible targets, with drugs already under investigation for stroke for F11 and PROC. A polygenic score integrating cross-ancestry and ancestry-specific stroke GWASs with vascular-risk factor GWASs (integrative polygenic scores) strongly predicted ischaemic stroke in populations of European, East Asian and African ancestry(5). Stroke genetic risk scores were predictive of ischaemic stroke independent of clinical risk factors in 52,600 clinical-trial participants with cardiometabolic disease. Our results provide insights to inform biology, reveal potential drug targets and derive genetic risk prediction tools across ancestries.</p

Stroke genetics informs drug discovery and risk prediction across ancestries

Previous genome-wide association studies (GWASs) of stroke — the second leading cause of death worldwide — were conducted predominantly in populations of European ancestry1,2. Here, in cross-ancestry GWAS meta-analyses of 110,182 patients who have had a stroke (five ancestries, 33% non-European) and 1,503,898 control individuals, we identify association signals for stroke and its subtypes at 89 (61 new) independent loci: 60 in primary inverse-variance-weighted analyses and 29 in secondary meta-regression and multitrait analyses. On the basis of internal cross-ancestry validation and an independent follow-up in 89,084 additional cases of stroke (30% non-European) and 1,013,843 control individuals, 87% of the primary stroke risk loci and 60% of the secondary stroke risk loci were replicated (P < 0.05). Effect sizes were highly correlated across ancestries. Cross-ancestry fine-mapping, in silico mutagenesis analysis3, and transcriptome-wide and proteome-wide association analyses revealed putative causal genes (such as SH3PXD2A and FURIN) and variants (such as at GRK5 and NOS3). Using a three-pronged approach4, we provide genetic evidence for putative drug effects, highlighting F11, KLKB1, PROC, GP1BA, LAMC2 and VCAM1 as possible targets, with drugs already under investigation for stroke for F11 and PROC. A polygenic score integrating cross-ancestry and ancestry-specific stroke GWASs with vascular-risk factor GWASs (integrative polygenic scores) strongly predicted ischaemic stroke in populations of European, East Asian and African ancestry5. Stroke genetic risk scores were predictive of ischaemic stroke independent of clinical risk factors in 52,600 clinical-trial participants with cardiometabolic disease. Our results provide insights to inform biology, reveal potential drug targets and derive genetic risk prediction tools across ancestries

Knowlwedge of the nurse attending a person with pre-eclampsia and eclampsia.

Introducción La preeclampsia-eclampsia continúa siendo una de las principales causas de morbilidad y mortalidad perinatal en todo el mundo. En México ha sido la primera causa de muerte materna en los últimos 20 años a pesar de los avances en calidad y cantidad de control prenatal, de la atención del parto y puerperio. (1-2). Objetivo Identificar el nivel de conocimiento que tiene el personal de enfermería del área de Tococirugía y Ginecoobstetricia en la atención a usuarias con preeclampsia eclampsia. Material y métodos Se realizó un estudio encuesta descriptiva a 75 enfermeras del Hospital General Regional No. 1, en el cual se elaboró un instrumento de información sobre nivel de conocimientos del personal de enfermería de preeclampsia eclampsia, validado por dos rondas de expertos y una prueba piloto, así mismo la escala de medición fue bueno cuando contestara correctamente del 86 al 100 % de los ítems, regular, del 70 al 85 %, y deficiente, menos de 69 %. Resultados El promedio de edad de las enfermeras fue de 41 años, con una desviación estándar más menos 7.1. Referente al nivel de conocimiento del personal de enfermería sobre preeclampsia eclampsia en el manejo de usuarias el resultado fue deficiente aún cuando la antigüedad en el servicio fue de más de tres años. Conclusiones El nivel de conocimientos del personal de enfermería en preeclampsia eclampsia fue bajo, además no existe congruencia entre la antigüedad en el servicio y el nivel de conocimiento.SUMMARY Introduction Preeclampsia-eclampsia everywhere in the world continues being one of the main causes of morbidity and perinatal mortality. In Mexico it has been the leading cause of maternal death of the last 20 years, in spite of advances in quality and quantity of prenatal care, delivery assistance and puerperium attention. (1-2) Objective To identify the level of knowledge of the nursing personnel in Labor and Delivery, as well as Gynecology and Obstetrics caring for people with preeclampsia-eclampsia. Material and methods A study was made of a descriptive survey given to 75 nurses in the General Regional Hospital No.1, in which an instrument of information was elaborated regarding the level of knowledge of the nursing personnel caring for people with preeclampsia-eclampsia. This was validated by two rounds of experts and one test pilot, the measurement scale was also good as it answered correctly from 86% to 100 % of items, fair, from 70% to 85% and poor less than 69%. Results The average age of the nurses was 41 years, with a standard deviation ±7.1. In reference to the level of knowledge of the nursing personnel in the field of preeclampsia-eclampsia caring for patients, the result was deficient even though the time in service was more than three years. Conclusions The level of knowledge of the nursing personnel regarding preeclampsia-eclampsia was low, and there is no connection between experience and level of knowledge