The role of chrononutrition in obesity

47 p.INTRODUCCIÓN Y OBEJTIVOS: La prevalencia del sobrepeso y la obesidad han aumentado de forma alarmante en los últimos años. Además de la dieta, los horarios de alimentación irregulares o el elevado consumo de “snacks” pueden inducir cronodisrrupción. Los objetivos han sido revisar la evidencia sobre la crononutrición y su implicación en la obesidad; conocer las implicaciones de la crononutrición en la regulación de los ritmos circadianos; identificar las consecuencias de la cronodisrrupción en el estado metabólico y conocer la evidencia de la cronodieta en la prevención y tratamiento de la obesidad. MATERIAL Y MÉTODOS: Se ha realizado una revisión bibliográfica narrativa de la evidencia científica disponible en los últimos 5 años. Se han incluido 58 registros. RESULTADOS: En gran parte de los estudios se ha visto que consumir la mayor parte de la energía de día en la mañana temprano se ha asociado a un mejor estado metabólico, una mayor termogénesis inducida por los alimentos y mejor control del peso. No se ha observado consenso entre la relación del horario de la comida y la calidad de esta. CONCLUSIONES: La ingesta de alimentos es el principal sincronizador de los relojes periféricos, por lo que limitar la ingesta de alimentos a determinadas horas del día puede tener implicación en el funcionamiento fisiológico del organismo. La evidencia sugiere que realizar comidas en un horario más temprano durante el día y de forma regular se asocia a una disminución del peso corporal y un mejor perfil metabólico en comparación con los horarios tardíos.INTRODUCTION: The prevalence of overweight and obesity has increased alarmingly in recent years. In addition to diet, irregular eating schedules or high consumption of snacks may induce chronodisruption. The objectives were to review the evidence on chronodieting and its implication in obesity; to know the implications of chronodieting in the regulation of circadian rhythms; to identify the consequences of chronodisruption on metabolic status; and to know the evidence of chronodieting in the prevention and treatment of obesity. MATERIAL AND METHODS: A narrative literature review of the scientific evidence available in the last 5 years was carried out. 58 records were included. RESULTS: Most studies have found that consuming most of the day's energy in the early morning has been associated with better metabolic state, greater food-induced thermogenesis and better weight control. There is no consensus on the relationship between meal timing and meal quality. CONCLUSION: Food intake is the main synchroniser of peripheral clocks, so limiting food intake at certain times of the day may have implications for the physiological functioning of the body. Evidence suggests that eating meals earlier in the day and on a regular basis is associated with a decrease in body weight and a better metabolic profile compared to later in the day.Grado en Medicin

P050 Oral inflammatory changes associated with inflammatory bowel disease in spondyloarthritis associated with early endoscopic findings

BACKGROUND: Spondyloarthritis (SpA) is a heterogeneous group of chronic autoinflammatory disorders that can present extra-articular gastrointestinal manifestations. Among them is mainly inflammatory bowel disease (IBD). Although IBD mainly affects the intestinal tract, it can include early manifestations evident in the oral cavity. No comparative data on these oral manifestations in patients with SpA were found in the literature. OBJECTIVE: To identify oral clinical manifestations due to changes in the oral mucosa associated with IBD in patients with SpA without a diagnosis of IBD and associate them with endoscopic and histological findings. METHODS: 80 patients with SpA and 52 healthy controls were evaluated. They were assessed intra- and extra-orally, following the modified World Health Organization guideline. In addition, by clinical parameters of rheumatological, gastrointestinal and laboratory activity. Ileocolonoscopy was performed with digital chromoendoscopy with magnification and histological analysis. Comparative analyzes were performed by Chi square tests, Fisher's exact tests, confirmed by univariate regression and discriminant analysis of multiple correspondences. Institutional ethics committee approval cod-2017-023. RESULTS: The patients with SpA had 56% male gender, mean age of 42.8 years (SD ± 10.4) and a BMI in the range of 23.9 - 28.4. The healthy controls, 54% of the male gender with an average age of 41 years (SD ± 13.6) and a body mass index-BMI in the range of 22.9 - 27.6. The patients reported smoking only in 6.2%, however as a smoking history in 31% and passive smokers (15%), the majority employed (41%), married (56%) and professionals (49%). Of the healthy controls, they smoked (15%), with a history of smoking (31%), passive smokers (21%), the majority employed (77%), with their own home (67%), and professionals (54%). The patients with SpA reported a greater presence of some signs and symptoms of gastrointestinal origin 69%, while in the controls it was 7.7% (p = 0.001). Forty one of them were referred to colonoscopy with magnification being in 17.1 % changes in the mucosa of the rectum and in the same frequency changes in the mucosa of the sigmoid colon. Regarding the ileum, changes in the mucosa were evidenced in 41.5% of the cases. The presence of oral lesions was evident and predominated in them (63%) compared to controls p = 0.050. The main oral lesions associated with IBD were gingivitis (55%) (p = 0.001), followed by aphthous stomatitis (3.8%), angular cheilitis (2.6%) and perioral erythema with scaling (1.3%). 100% of the patients who presented alteration of the colonic mucosa presented oral lesions associated with IBD (p = 0039), which was also significantly associated with the presence of gingivitis/aphthous stomatitis (p = 0.029). CONCLUSION: Patients with SpA without a diagnosis of IBD have more oral signs and symptoms compared to healthy controls. Gingivitis is important given its association with early endoscopic and histological findings. Manifestations in the oral cavity can precede intestinal manifestations, therefore the clinical assessment by the oral pathologist in conjunction with gastroenterology and rheumatology allows a timely referral to gastroenterology and an endoscopic and histological evaluation, impacting the quality of life of patients

Hepatitis C virus seroprevalence in the general female population from 8 countries

Background: Hepatitis C virus (HCV) infection is a significant global health issue because it is widespread and persistent and can cause serious liver diseases. Objectives: The aim of this study is to estimate HCV prevalence in women from the general population in different geographical areas worldwide and to assess the potential role of sexual behaviour in the virus transmission. Study design: Each participating centre recruited a random sample of women from the general population aged from less than 20 to more than 75 years. The study included 8130 women from 8 countries with information on sociodemographic factors, reproductive and sexual behaviour, smoking habit and HPV DNA through individual interviews. A blood sample was also collected to perform serological tests. We estimated the prevalence ratios associated to HCV to evaluate the effect of sexual behaviour in viral transmission. Results: Women were reactive to a minimum of two HCV antigens, including at least one non structural protein were considered as positive (33% of the samples were classified as positive, 40% as negative, and 27% as indeterminate (N = 402), that were considered as not positive). The age-adjusted HCV seroprevalence varied significantly by regions (0.3% in Argentina to 21.1% in Nigeria). We found no association between HCV prevalence and age, educational level, smoking habit and any of the available variables for sexual behaviour and reproductive history. Conclusions: This large study showed heterogeneous distribution of HCV seroprevalence in female and provides evidence of the null impact of sexual behaviour in HCV transmission. (C) 2015 Elsevier B.V. All rights reserved

Actualizar el sistema de gestión de calidad en la empresa ERFOLG ingeniería S.A.S de acuerdo a los requisitos expuestos en los numerales 4, 5 y 6 de la norma ISO 9001:2015, para el alcance “estudios y diseños de distritos y sistemas de riego”

Hoy en día con el crecimiento empresarial que se ha dado en todo el mundo, ha hecho necesario implementar nuevas metodologías que permitan a las organizaciones ser más competitivas en el mercado, tomando como primera instancia la satisfacción de sus clientes. De acuerdo a lo anterior surge la necesidad de estar siempre preparados ante las exigencias que tienen día a día, ya sea al adquirir algún tipo de bien o servicio, donde se requiere que las empresas cuenten con muchos fundamentos que los hagan competitivos ante las demás y así dar cumplimiento a esto; se ha determinado una serie de normas que demuestran la capacidad de una organización de estar bien fundamentada como las herramientas que tiene el ICONTEC, la cual nos ofrece una serie de normas y requisitos que logran establecer una empresa bien diseñada y fundamentada para la prestación de un servicio. ERFOLG INGENIERÍA S.A.S es una empresa comprometida en la prestación de servicios ha estado mostrando siempre interés por cumplir con los requisitos del Sistema de Gestión de Calidad, logrando obtener la certificación de la ISO 9001:2008 hace dos años. Debido a los cambios que presenta día a día también las normas y sus requisitos que son exigidos por el ICONTEC, quien ha desarrollado una trayectoria al pasar de los años con la NTC ISO 9001. Por tal motivo dicha empresa prestadora de servicios desea obtener la certificación en calidad de acuerdo a los parámetros establecidos en la NTC ISO 9001:2015; es por esto que nuestro trabajo está enfocado en la actualización de tres numerales 4, 5,6. El numeral 4 hace referencia al contexto de la organización donde se elaboró una matriz DOFA teniendo en cuenta estrategias organizacionales y el enfoque que este brinda para la gestión del riesgo, a partir de unas cuestiones externas e internas. El numeral 5 trata sobre el liderazgo y compromiso organizacional y por último el numeral 6, en el cual se evalúan los riesgos y oportunidades que tiene la organización reflejados mediante una matriz de riesgo basados en la NTC ISO 31000:2011, permitiendo la prevención de la materialización de estos, a través de la definición de controles, e implementado acciones preventivas cuando estos controles no sean suficientes.Nowadays, with the business growth that has taken place all over the world, it has become necessary to implement new methodologies that allow organizations to be more competitive in the market, taking as a first instance the satisfaction of their customers. According to the above, there is a need to always be prepared for the demands they have every day, either when acquiring some type of good or service, where companies are required to have many fundamentals that make them competitive with others and thus comply with this; A series of standards has been determined that demonstrate the ability of an organization to be well founded as the tools that ICONTEC has, which offers us a series of standards and requirements that establish a well-designed and grounded company for the provision of a service. ERFOLG INGENIERÍA S.A.S is a company committed to the provision of services has always been showing interest in complying with the requirements of the Quality Management System, obtaining the certification of ISO 9001: 2008 two years ago. Due to the changes that the standards and requirements that are demanded by ICONTEC also presents every day, who has developed a trajectory over the years with the NTC ISO 9001. For this reason, said service provider wishes to obtain quality certification according to the parameters established in NTC ISO 9001: 2015; This is why our work is focused on updating three numerals 4, 5,6. Numeral 4 refers to the context of the organization where a DOFA matrix was developed taking into account organizational strategies and the approach it provides for risk management, based on external and internal issues. Numeral 5 is about leadership and organizational commitment and finally numeral 6, which evaluates the risks and opportunities that the organization has reflected through a risk matrix based on NTC ISO 31000: 2011, allowing the prevention of materialization of these, through the definition of controls, and implemented preventive actions when these controls are not sufficient.Introducción. -- 1. Reseña histórica. -- 2. Justificación. -- 3. Planteamiento del problema. -- 3.1. Descripción del problema. -- 3.2. Formulación del problema. -- 4. Objetivos. -- 4.1. Objetivo general. -- 4.2. Objetivos específicos. -- 5. Marco teórico. -- 6. Desarrollo del proyecto. -- 6.1. Matriz de correlación. -- 6.2. Diagnóstico de la situación actual. -- 6.2.1. Plan de acción. -- 6.3. Planeación estratégica. -- 6.3.1. Misión. -- 6.3.2. Visión. -- 6.3.3. Política. -- 6.3.4. Objetivos de calidad. -- 6.3.5. Identificación de las necesidades y expectativas de las partes interesadas. -- 6.3.6. Alcance. -- 6.3.7. Sistema de gestión de la calidad y sus procesos. -- 6.3.7.1. Mapa de procesos. -- 6.3.7.2. Caracterización de los procesos. -- .3.7.3. Proceso gestión gerencial. -- 6.3.7.4. Proceso de gestión comercial. -- 6.3.7.5. Proceso de gestión financiera. -- 6.3.7.6. Proceso de recursos humanos. -- 6.3.7.7. Proceso gestión de compras. -- 6.3.7.8. Proceso de gestión de mantenimiento. -- 6.3.7.9. Proceso de estudios, diseños distritos y sistemas de riego. -- 6.3.7.10. Proceso de construcción de distritos y sistemas de riego. -- 6.3.7.11. Proceso mejora continua. -- 6.3.8. Recursos necesarios para los procesos y su disponibilidad. -- 6.3.9. Matriz de responsabilidades y autoridades. -- 6.4. Liderazgo. -- 6.4.1. Enfoque al cliente. -- 6.4.2. Política de calidad. -- 6.5. Roles, responsabilidad y autoridades. -- 6.5.1. Matriz de responsabilidades y autoridades. -- 6.5.2. Organigrama. -- 7. Gestión del riesgo. -- 7.1. Metodología para la identificación, análisis y gestión del riesgo. -- 7.2. Riesgos identificados y gestionados. -- 7.3. Objetivos de calidad. -- 7.4. Gestión del cambio. -- 8. Conclusiones. -- Recomendaciones. -- Bibliografí[email protected]

Los videojuegos como estrategia lúdica a través de la gamificación para mejorar la comprensión lectora en los estudiantes de grado sexto del Colegio Gimnasio Modelia Real

En la presente propuesta se plantea como estrategia lúdica la implementación de los videojuegos a través de la gamificación para mejorar la comprensión lectora de los estudiantes de grado sexto del Colegio Gimnasio Modelia Real y, como eje transversal se tuvo en cuenta la literatura y la filosofía. Los instrumentos de investigación utilizados fueron la encuesta y el pretest, a partir de estos se identificó el preocupante desinterés de los estudiantes por leer de manera autónoma ya que, percibían la lectura como un medio obligado para acceder a una nota. Por lo tanto, se evidencia la necesidad de transformar las dinámicas de enseñanza aprendizaje y las prácticas pedagógicas mediadas por las TIC para intentar solucionar la problemática en mención. Para este propósito se tuvo en cuenta el enfoque cualitativo en la medida en que permite realizar una aproximación real con los participantes a partir de preguntas e hipótesis antes, durante y después de la recolección y el análisis de los datos como afirman Hernández, Fernández y Baptista. A partir de la implementación de la propuesta se evidenció el interés del grupo de estudiantes frente al tema de los videojuegos y la posibilidad de utilizarlos con estrategias lúdicas para promover la lectura, el análisis simbólico y mejorar la comprensión. También, se verificó que han tenido acceso a diferentes dispositivos que les han permitido desarrollar capacidades y habilidades básicas como: comunicación, adaptabilidad, creatividad, persistencia y pensamiento crítico. Además, se logró observar que los videojuegos a través de la gamificación favorecen el desarrollo de habilidades de pensamiento complejo. La estrategia de intervención cuyo título es: “Leo, me divierto y aprendo con el dios de la guerra” se aplicará en el año 2021 como proyecto de largo alcance. (apartes del texto)In this following proposal paper, it is proposed as a playful strategy, the implementation of video games through gamification to improve the reading comprehension skills of sixth grade students of the Gimnasio Modelia Real school and, as a transversal thrust literature and philosophy were reached. The research instruments used were the questionnaire and the pretest, based on these, the worrying disinterest of the students in reading autonomously was identified, since they perceived reading as an obligatory means to achieve a grade. Therefore, is evident necessity of transforming the teaching-learning dynamics and the pedagogical practices mediated by ICT for trying to solve the problem mentioned. For this purpose, the qualitative approach was taken into account insofar as it allows a real approach to the participants based on questions and hypotheses before, during and after the data collection and the analysis, as stated by Hernández, Fernández and Baptista. From the implementation of the proposal, it was evidenced the interest of the group of students in the subject of video games and the possibility of using them with playful strategies to promote reading, symbolic analysis and improve understanding. Furthermore, it was verified that they have had access to different devices that have allowed them to develop basic abilities and skills such as: communication, adaptability, creativity, persistence and critical thinking. Additionally, it was observed that video games through gamification stimulate the development of complex thinking skills. The intervention strategy whose title is: "I read, I have fun and I learn with the god of war" will be applied in the year 2021 as a classroom project in order to turn learning into a meaningful and fun experience.Fundación Universitaria Los Libertadore

Development of a rapid colorimetric multiplex PCR-reverse line blot for the detection and typing of 14 Chlamydia trachomatis genovars

Purpose. Chlamydiatrachomatis is responsible for trachoma-associated blindness as well as the most common sexually transmitted bacterial infection worldwide, although the genovars for the former are typically A-C, whilst for the latter they are D-K and for the uncommon infection lymphogranuloma venereum they are L1-3. Nucleotide variations within the ompA gene facilitate the identification of C. trachomatis genovars. This study describes a colorimetric multiplex PCR/RLB typing assay (mPCR-RLB) directed to the VD2 region of the ompA gene for general C. trachomatis positivity and the identification of 14 individual C. trachomatis genovars. Methodology. The assay was validated by analysing 40 blinded samples that included reference strains of C. trachomatis genovars and other non-chlamydial micro-organisms that had been analysed previously using quantitative PCR (qPCR). Ninety clinical samples that had previously been found to be C. trachomatis-positive by qPCR were also evaluated using the mPCR-RLB assay. Results. The mPCR-RLB assay showed 100% agreement with the qPCR in the detection of C. trachomatis reference strains and no cross-reaction of non-chlamydial micro-organisms was observed. In the analysis of the chlamydial clinical samples, 97.8% were C. trachomatis-positive by mPCR/RLB assay and there was a 96.6% concordance with the qPCR at the group identification level and a 92.2% concordance at the genovar level. Conclusion. The mPCR-RLB assay is a rapid and sensitive methodology for the identification of C. trachomatis genovars associated with urogenital infections, trachoma or lymphogranuloma venereum diseases that can be implemented in clinical settings, helping to identify reinfections and treatment failures and establish the appropriate treatment course

Novel predictive biomarkers for cervical cancer prognosis

International audienceHigh hypoxic, glycolytic and acidosis metabolisms characterize cervical cancer tumors and have been described to be involved in chemoradioresistance mechanisms. Based on these observations, the present study assessed four selected novel biomarkers on the prognosis of locally advanced cervical carcinoma. A total of 66 patients with stage IIB/IIIB cervical cancer were retrospectively included. The protein expression levels of glucose transporter 1 (GLUT1), carbonic anhy-drase 9 (CAIX) and hexokinase 1 (HKII) were investigated by immunohistochemistry on tumor biopsies, hemoglobin was measured and the disease outcome was monitored. A total of 53 patients (80.3%) presented a complete response. For these patients, the protein expression levels of GLUT1, CAIX and HKII were overexpressed. A significant difference was observed (P= 0.0127) for hemoglobin levels (≤11 g/dl) in responsive compared with non-responsive patients. The expression of GLUT1 is associated with a lower rate of both overall and disease-free survival, with a trend of decreased risk of 1.1x and 1.5x, respectively. Co-expression of GLUT1 and HKII is associated with a decreased trend risk of 1.6x for overall survival. Patients with hemoglobin levels ≤11 g/dl had a 4.3-fold risk (P=0.02) in decreasing both to the rate of overall and disease-free survival. The presence of anemic hypoxia (hemoglobin ≤11 g/dl) and the expression of GLUT1 and/or HKII influence treatment response and are associated with a lower overall and disease-free survival. The present results demonstrated that these biomarkers may be used as predictive markers and suggested that these metabolic pathways can be used as potential novel therapeutic targets

The coexistence of antiphospholipid syndrome and systemic lupus erythematosus in Colombians.

OBJECTIVES: To examine the prevalence and associated factors related to the coexistence of antiphospholipid syndrome (APS) and systemic lupus erythematosus (SLE) in a cohort of Colombian patients with SLE, and to discuss the coexistence of APS with other autoimmune diseases (ADs). METHOD: A total of 376 patients with SLE were assessed for the presence of the following: 1) confirmed APS; 2) positivity for antiphospholipid (aPL) antibodies without a prior thromboembolic nor obstetric event; and 3) SLE patients without APS nor positivity for aPL antibodies. Comparisons between groups 1 and 3 were evaluated by bivariate and multivariate analysis. RESULTS: Although the prevalence of aPL antibodies was 54%, APS was present in just 9.3% of SLE patients. In our series, besides cardiovascular disease (AOR 3.38, 95% CI 1.11-10.96, p = 0.035), pulmonary involvement (AOR 5.06, 95% CI 1.56-16.74, p = 0.007) and positivity for rheumatoid factor (AOR 4.68, 95%IC 1.63-14.98, p = 0.006) were factors significantly associated with APS-SLE. APS also may coexist with rheumatoid arthritis, Sjögren's syndrome, autoimmune thyroid diseases, systemic sclerosis, systemic vasculitis, dermatopolymyositis, primary biliary cirrhosis and autoimmune hepatitis. CONCLUSIONS: APS is a systemic AD that may coexist with other ADs, the most common being SLE. Awareness of this polyautoimmunity should be addressed promptly to establish strategies for controlling modifiable risk factors in those patients