621 research outputs found
Vlaamse riddermonniken in de verf gezet?
Collective identities and transnational networks in medieval and early modern Europe, 1000-180
Het klooster Groendijk in Sneek en de familie Harinxma (II)
Collective identities and transnational networks in medieval and early modern Europe, 1000-180
The deiodination of thyroid hormone in rat liver
As mentioned in the preceding paragraphs, enzymatic deiodination of T4
is the most important route for the production of the biologically active
thyroid hormone, T3• The liver is regarded as the principal site for the
peripheral production of T3. Besides deiodination the liver is also most active in the conjugation of the different iodothyronines with either
glucuronic acid or sulfuric acid. Chapter II deals with a review of recent
literature concerning cellular uptake and enzymatic deiodination of
iodochyronines from experiments with cultured rat hepatocytes or
subcellular. fractions. The regulation and nature of the enzymatic
deiodination in the liver will be compared with deiodinases found in other
tissues. In order to gain more insight in the mechanism of enzymatic
deiodination, attempts have been made to purify the deiodinating enzyme of
rat liver and kidneys. Our efforts towards deiodinase purification will be
discussed in conjunction with data available from the literature. Finally,
some remarks will be made concerning the importance of the liver in thyroid
hormone metabolism.
The following chapters describe investigations related to the mechanism
of rat liver iodothyronine deiodinase. Chapters III and IV concern the
development of convenient methods for the chemical synthesis of
iodothyronine sulfate esters and sulfamates, and the subsequent study of
the deiodination of these compounds, especially T4 sulfate ester. The
chemical modification of the iodothyronine deiodinase by
diethylpyrocarbonate or photo-oxidation with Rose Bengal is reported in
chapter v. These results strongly suggest the presence of an active site
histidine residue. Chapter VI describes the use of N-bromoacetyl-T3 as an
affinity label for the deiodinase, while chapters VII and VLII deal with
the partial purification of the enzyme from rat liver microsomal fraction.
Basic knowledge of the deiodinating enzymes will help us to understand the
alterations of serum iodothyronine concentrations in health and disease
Het klooster Groendijk in Sneek en de familie Harinxma (I)
Collective identities and transnational networks in medieval and early modern Europe, 1000-180
The Frisians as a chosen people: religious-patriotic historiography in fifteenth-century Frisia
Collective identities and transnational networks in medieval and early modern Europe, 1000-180
Gerkesklooster en zijn ontginningsactiviteit in Langewold omstreeks 1300
Collective identities and transnational networks in medieval and early modern Europe, 1000-180
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