Pigmented Lesion on the Cheek: A Quiz

International audienceQui

Harmonized clinical trial methodologies for localized cutaneous leishmaniasis and potential for extensive network with capacities for clinical evaluation

International audienceINTRODUCTION: Progress with the treatment of cutaneous leishmaniasis (CL) has been hampered by inconsistent methodologies used to assess treatment effects. A sizable number of trials conducted over the years has generated only weak evidence backing current treatment recommendations, as shown by systematic reviews on old-world and new-world CL (OWCL and NWCL).MATERIALS AND METHODS: Using a previously published guidance paper on CL treatment trial methodology as the reference, consensus was sought on key parameters including core eligibility and outcome measures, among OWCL (7 countries, 10 trial sites) and NWCL (7 countries, 11 trial sites) during two separate meetings.RESULTS: Findings and level of consensus within and between OWCL and NWCL sites are presented and discussed. In addition, CL trial site characteristics and capacities are summarized.CONCLUSIONS: The consensus reached allows standardization of future clinical research across OWCL and NWCL sites. We encourage CL researchers to adopt and adapt as required the proposed parameters and outcomes in their future trials and provide feedback on their experience. The expertise afforded between the two sets of clinical sites provides the basis for a powerful consortium with potential for extensive, standardized assessment of interventions for CL and faster approval of candidate treatments

Diagnosis of Fucosidosis through Cutaneous Manifestations

El objetivo central de este trabajo es analizar la crítica al naturalismo formulada por la corriente denominada feminismo materialista francés (FMF). Mostraremos que la crítica que dicha corriente elabora permite desmontar tempranamente, desde principios de la década de 1970, diversos biologicismos, tanto en el campo del marxismo como del feminismo teórico. De este modo, demostraremos que el FMF provee un marco epistémico alternativo al sistema sexo/género, tal como era desarrollado por la misma época en la literatura anglófona (a partir de los trabajos de Ann Oakley y Gayle Rubin) y que permite pensar "antes del género y más allá de él" (tomamos prestada la expresión de Falquet, 2018). Esta investigación se despliega a la luz de una inquietud general: la necesidad de recuperar líneas de pensamiento que quedan ocultas bajo la sedimentación de las narrativas hegemónicas. En este caso, se trata de abordar teorías que se encuentran fuera del feminismo mainstream, con clara preeminencia estadounidense. Es por esto que en este trabajo, retomamos la propuesta benjaminiana de construir una historia a contrapelo que descubra, entre las diferentes capas o estratos del relato hegemónico, los restos de otros relatos. El feminismo materialista francés, que surge al fragor de los tumultuosos años sesenta y principios de los setenta, quedará sepultado en los años posteriores. ¿Cuáles son los motivos de esta invisibilización? ¿Por qué el FMF pasó desapercibido durante tanto tiempo, e incluso hoy, cómo es que casi no conocemos los nombres de estas autoras: Christine Delphy, Colette Guillaumin, Paola Tabet y Nicole-Claude Mathieu? Para abordar estos interrogantes, proponemos un análisis del feminismo materialista francés desde una nueva perspectiva: aquella que aportan los estudios contemporáneos sobre la división académica del conocimiento global, desde una perspectiva situada en el Sur, para contribuir tanto a los estudios feministas como al gran campo de saberes sobre la circulación internacional de teorías.Universidad Nacional de La Plat

Segmental phenolization for the treatment of Ingrown toenails: technique report, follow up of 146 patients, and review of the literature

Background: Ingrown toenail is a common problem causing significant morbidity. Various procedures used for treating this painful condition were discussed in the literature.Objetctive: Through a prospective study we aimed to evaluate in a long-term follow-up the efficacy of partial nail plate avulsion combined with phenolic chemical matricectomy for the treatment of Ingrown toenails.Methods: We recruited outpatient from January 2006 to December 2009; all treated by phenol matricectomy and assured a regular follow up.Results: Consecutive 146 patients with a total of 171 Ingrown toenails were enrolled. There was no significant morbidity and the procedure was tolerated well by all patients. The short-term results were excellent. No severe complications occurred during the 21-month follow-up period. The overall recurrence was 2.7 %.Conclusion: Phenol cauterization compared with other surgical ablation techniques may be the treatment of choice of Ingrown toenails. It’s an effective technique for the treatment of Ingrown toenails accompanied by less morbidity and lower recurrence rates