Effects of pot fishing on the physical condition of snow crab (Chionoecetes opilio) and southern Tanner crab (Chionoecetes bairdi)

The effects of commercial fishing with crab pots on the physical condition of the snow crab (Chionoecetes opilio) and southern Tanner crab (C. bairdi) were investigated in the Bering Sea and in Russian waters of the Sea of Okhotsk. In crabs that were subjected to pot hauling, the presence of gas embolism and the deformation of gill lamellae were found in histopathological investigations. Crab vitality, which was characterized subjectively through observation of behavioral responses, depended on not only the number of pot hauls but also the time between hauls. Immediately after repeated pot hauls at short time intervals (≤3 days), we observed a rapid decline in vitality of crabs. When hauling intervals were increased to >3 days, the condition of crabs did not significantly change. After repeated pot hauls, concentration of the respiratory pigment hemocyanin ([Hc]) was often lower in the hemolymph of crabs than in the hemolymph of freshly caught animals. Our research indicated that changes in [Hc] in crabs after repeated pot hauls were caused by the effects of decompression and not by starvation of crabs in pots or exposure of crabs to air. We suggest that the decrease in [Hc] in hemolymph of snow and southern Tanner crabs was a response to the adverse effects of decompression and air-bubble disease. The decrease in [Hc] in affected crabs may be a result of mechanisms that regulate internal pressure in damaged gills to optimize respiratory circulation

Multi-service resource queue with the multy-component Poisson arrivals

In many papers devoted to telecommunication systems, multiservice queueing models with heterogeneous customer arrivals are given. As a rule, there is streaming traffic, corresponding to the audio and video conference, and elastic traffic, corresponding to the data and file transmission. Different types of traffic require different quality of service, therefore the multi-service systems are also differentiated service systems. Such papers are aimed at developing a framework for estimating the quality of service indicators in new generation multi-service networks. This paper considers a multiservice resource queueing system with three Poisson arrivals, one of which is splitting. The equation for the probabilities distribution of the total resource amounts on the system blocks is compiling by the dynamic screening method, and using the characteristic function of the stationary distribution, the solution is obtaining. The numerical characteristics of the system performance are obtained by the method of moments using characteristic function. A numerical example shows that arrivals intensity growing increases optimal total resource amounts on system blocks in the system with limited resources, and the splitting arrivals affect the correlation between total resource amounts

Contrasting metacognitive profiles and their association with negative symptoms in groups with schizophrenia, early psychosis and depression in a Russian sample

Research has suggested that negative symptoms in psychotic disorders may be in part fueled by deficits in metacognition or the ability to form integrated ideas about oneself and others. One limitation of this work is that it has largely come from North America and Western Europe. To further the literature, we assessed symptoms using the Positive and Negative Syndrome Scale and Metacognition using the Metacognitive Assessment Scale - Abbreviated in a sample of outpatients with prolonged schizophrenia (n = 41), early episode psychosis (n = 37) and major depression (n = 30) gathered in Moscow, Russia. Verbal memory was assessed for use as a potential covariate. ANOVA revealed the two groups with psychosis had significantly poorer metacognitive function in terms of self-reflectivity and awareness of the other, than the group with depression. In both psychosis groups negative symptoms were more robustly related to metacognition than other forms of symptoms after controlling for neurocognition. Results support the possibility that metacognitive deficits are a psychological factor which cross culturally contributes to negative symptoms and point to metacognition as a potentially important target for intervention

SELECTION OF OPTIMAL RISK ASSESSMENT OF ISCHEMIC HEART DISEASE FOR GENERAL PRACTITIONER

Цель исследования: анализ и установление простой и корректной лабораторной оценки риска развития ишемической болезни сердца для врача-лечебника в лечебно-профилактических учреждениях со слабым материально-техническим оснащением.Материалы и методы: выполнен ретроспективный анализ 960 лабораторных показателей пациентов клинико-диагностической лаборатории Ростовского государственного медицинского университета по обращению за период с 2015 по 2017 годы в возрасте от 25 до 78 лет.В анализ включены показатели глюкозы, креатинина, мочевины, аспартатаминотрансферазы, аланинаминотрансфераза и липидограммы (холестерин, триацилглицериды, липопротеины высокой плотности, коэффициент атерогенности). Выборка осуществлялась на основании наличия полного соответствия показателей у каждого конкретного пациента ввиду того, что не у всех пациентов был полный спектр исследований. В итоге выборка корреляционного диапазона для: глюкозы и липидограммы составила 450 показателей, для глюкозы, аспартатаминотрансферазы, аланинаминотрансфераза, креатинина и липидограммы 309 показателей, для глюкозы, аспартатаминотрансферазы, аланинаминотрансфераза, креатинина, мочевины и липидограммы 186 показателей.Группировка показателей липидограммы проводилась в направлениях:– по признаку связанного повышенного показателя глюкозы (≥6,1), как вероятного эквивалентного маркёра ишемической болезни сердца, у группы А и нормального (<6,1) у группы Б из диапазона глюкозы и липидограммы.– по признаку связанного повышенного абсолютного показателя аспартатаминотрансферазы (≥37), как вероятного маркёра ишемической болезни сердца, у группы №1 и нормального (<37) у группы №2 из диапазона глюкозы, аспартатаминотрансферазы, аланинаминотрансфераза, креатинина и липидограммы.– по признаку связанного повышенного показателя коэффициента атерогенности (≥3) с индексом триациглицериды\глюкоза у группы 1а и низкого (<3) у группы 2б из диапазона данных глюкозы, аспартатаминотрансферазы, аланинаминотрансфераза, креатинина и липидограммы.Результаты: при сравнении двух групп показателей липидограммы по признаку связанного повышенного и нормального показателя глюкозы получили для холестерина, триацилглицеридов, липопротеинов высокой плотности t=0,3, v≈956, p=0,76; t=4,2, v≈355, p=0,00003; t=0,2, v≈8, р=0,84 соответственно. Так удаётся отвергнуть нулевую гипотезу (H0) только для показателей триацилглицеридов.При сравнении двух групп показателей липидограммы в спектре признака повышенного и нормального АСТ не удалось отвергнуть H0 для холестерина, триацилглицеридов, липопротеинов высокой плотности при t=0,73, v≈876, p=0,47; t=1,14, v≈481, p=0,25; t=0,54, v≈9, р=0,6 соответственно. Это значит, что по отношению к признаку повышенного показателя аспартатаминотрансферазы не обнаружилось статистически значимой разности связанного липидного профиля с липидным профилем нормального показателя аспартатаминотрансферазы, при изначально установленном условии, что исследуемые показатели не имели выраженной корреляционной связи между собой.При сравнении двух групп показателей индекса триациглицериды/глюкоза в спектре повышенного и сниженного коэффициента атерогенности удалось отвергнуть H0 при t=3,8, v≈192, p=0,0001. Следовательно, при установленном лабораторно риске наличия атеросклероза у исследуемой группы с повышенным коэффициентом атерогенности статистически значимо возрастает уровень показателя триациглицериды/глюкоза.Заключение: таким образом, из исследования удалось:1) установить наибольшую клиническую значимость глюкозы, коэффициента атерогенности и триацилглицеридов из всех лабораторных маркёров, которые учитывались в выборке для диагностики ишемической болезни сердца;2) подобрать оптимальный лабораторный тест, состоящий из двух анализов показателей: глюкозы и триацилглицеридов, которые соответствуют главному оценочному критерию «доступность»;3) обозначить рекомендацию электрокардиограммы и лабораторного теста на анализ глюкозы, коэффициента атерогенности и триацилглицеридов, как достаточного, чтобы верифицировать диагноз ишемической болезни сердца для врача-лечебника в лечебно-профилактических учреждениях со слабым материально-техническим оснащением.The purpose of the study: analysis and establishment of a simple and valid laboratory test for diagnosis of coronary heart disease for doctors in medical institutions with poor material and technical equipment.Materials and methods: we performed a retrospective analysis of 960 laboratory parameters of patients the clinical diagnostic laboratory of Rostov state medical university for the treatment period from 2015 to 2017 and aged 25 to 78 years.The analysis included indices of glucose, creatinine, urea, aspartate aminotransferase, alanine aminotransferase and dyslipidemia panel. Sampling was carried out on the basis of full compliance with the indicators in each patient in view of the fact that not all patients had full range of research. In the end, the sample correlation range: glucose and dyslipidemia panel was 450 indicators for glucose, aspartate aminotransferase, alanine aminotransferase, creatinine and lipid 309 indicators for glucose, aspartate aminotransferase, alanine aminotransferase, creatinine, urea, and dyslipidemia panel 186 indicators.The grouping of lipid indicators was carried out in the following directions:– on the basis of the associated increased rate of glucose (≥6,1) as a probable equivalent of the marker in coronary artery disease group and normal (<6,1) the group B of the range of glucose and lipid profile.– on the basis of the associated high absolute increased aspartate aminotransferase (≥37) as the likely marker of coronary artery disease, group 1 and normal (<37), the group 2 of the range glucose, aspartate aminotransferase, alanine aminotransferase, creatinine and lipid profile.– on the basis of the associated high rate atherogenic coefficient (≥3) iTyG the group 1а and lowest (<3), the group 2в of the data range of glucose, aspartate aminotransferase, alanine aminotransferase, creatinine and lipid profile.Results: when comparing the two groups of indicators of lipid profile on the basis of the associated high and normal rate of glucose was obtained for cholesterol, triglycerides, low density lipoproteins t=0.3 mm, v≈956, p=0,76; t=4,2 v≈355, p=0,00003; t=0,2, v≈8, p=0,84, respectively. This way it is possible to reject the null hypothesis (H0) - only indicators triglycerides.When comparing the two groups of indicators of lipid profile in a spectrum characteristic of high and normal aspartate aminotransferase failed to reject H0 for cholesterol, triglycerides and low density lipoproteins at t=0,73, v≈876, p=0,47; t=1.14 and v≈481, p=0.25; t=0,54, v≈9, p=0.6, respectively. It means that relatively to the basis of the increased rate of aspartate aminotransferase statistically significant difference between associated lipid profile and lipid profile of normal increased aspartate aminotransferase, when initially provided that the investigated parameters had no correlation between them.When comparing two groups of indicators index triacylglyceride/glucose in the spectrum of high and reduced atherogenic coefficient failed to reject H0 when t=3,8, v≈192, p=0.0001. Consequently, when the prescribed laboratory is a risk of presence of atherosclerosis in the study group with elevated atherogenic coefficient significantly increases the level of the index triacylglyceride/glucose.Conclusion: thus, the study gave the opportunity:1) to establish the highest clinical significance of glucose, atherogenic index and triglycerides of all the laboratory markers included in the sample for the diagnosis of coronary artery disease;2) to choose the best laboratory test consisting of two test indicators: glucose and triglycerides, which correspond to the main “accessibility”;3) to indicate the recommendation of the electrocardiogram and laboratory test analysis of glucose, atherogenic index and triglycerides, as sufficient to verify a diagnosis of coronary heart disease for doctors in medical institutions with poor material and technical equipment

Proinflammatory cytokines IL-6, IL-1β, TNF-α in infective endocarditis

Aim. To study the features of macrophages in the tissues of resected valves in operated patients with infective endocarditis (IE), their significance and interaction with inflammatory markers to improve the effectiveness of IE diagnosis. Materials and methods. Prospectively the research included 25 adult patients with active IE (Duke criteria 2015) and 24 patients with heart defects without IE, hospitalized in a cardiosurgical hospital in Moscow (2021–2022). A standard laboratory and instrumental examination was carried out for the diagnosis of IE, including etiological diagnosis with microbiological and molecular biological methods, and echocardiographic examination of heart. Additionally, the neutrophil-to-lymphocyte ratio (NLR) was calculated. The study of macrophages was carried out in the tissues of resected valves with the determination of the expression of pro- and anti-inflammatory cytokine genes, macrophage markers (CD 68+) using real-time PCR. Results. Increased expression of proinflammatory cytokines IL-1β, TNF-α and IL-6 was revealed in the group of operated patients with IE with significant differences in IL-1β (CI [IQR] 0.00367 [0.00047–0.01553] vs 0.00018 [0.00012–0.00262]; p0.05) and IL-6 (CI [IQR] 0.00367 [0.00047–0.01553] vs 0.00018 [0.00012–0.00262]; p0.05) and IL-6 (CI [IQR] 0.00338 [0.00066–0.01674] vs 0.00054 [0.00044–0.00378]; p0.05). The expression of anti-inflammatory cytokines in valve tissues prevailed in the control group without significant differences from patients with IE. The macrophage marker CD 68+ was revealed in all examined patients with a significant quantitative predominance in the group of patients with IE. There were no differences in the expression of pro- and anti-inflammatory cytokines depending on the presence of embolic events, intracardiac complications, etiological affiliation to S. aureus, as well as hospital mortality and combined endpoint (death from all causes or recurrence of IE 6 months after surgery) in patients with IE with or without events. Cytokines IL-1β and IL-6 positively correlated with each other, with leukocytes and NLR. ROC analysis determined that IL-1β and NLR had the most favorable features for the diagnosis of IE [IL-1β AUC 0.816 (p=0.02), NLR AUC 0.807 (p=0.03)]. IL-6 did not show a diagnostic value in IE. The threshold value for IL-1β was 0.00029 (sensitivity 86.4%, specificity 60.0%, prognostic value of negative result 75.0% and positive 76.0%, AUC 0.761; p=0.008). Conclusion. The valve macrophages of patients with IE express elevated levels of proinflammatory cytokines IL-1β and IL-6, regardless of etiological affiliation or complicated course of IE. IL-1β has a high diagnostic value for determining the inflammatory activity in IE

EPMA-World Congress 2015: Bonn, Germany. 3-5 September 2015

Table of contents A1 Predictive and prognostic biomarker panel for targeted application of radioembolisation improving individual outcomes in hepatocellular carcinoma Jella-Andrea Abraham, Olga Golubnitschaja A2 Integrated market access approach amplifying value of “Rx-CDx” Ildar Akhmetov A3 Disaster response: an opportunity to improve global healthcare Russell J. Andrews, Leonidas Quintana A4 USA PPPM: proscriptive, profligate, profiteering medicine-good for 1 % wealthy, not for 99 % unhealthy Russell J. Andrews A5 The role of IDO in a murine model of gingivitis: predictive and therapeutic potentials Babak Baban, Jun Yao Liu, Xu Qin, Tailing Wang, Mahmood S. Mozaffari A6 Specific diets for personalised treatment of diabetes type 2 Viktoriia V. Bati, Tamara V. Meleshko, Olga B. Levchuk, Nadiya V. Boyko A7 Towards personalized physiotherapeutic approach Joanna Bauer, Ewa Boerner, Halina Podbielska A8 Cells, animal, SHIME and in silico models for detection and verification of specific biomarkers of non-communicable chronic diseases Alojz Bomba, Viktor O. Petrov, Volodymyr G. Drobnych, Rostyslav V. Bubnov, Oksana M. Bykova, Nadiya V. Boyko A9 INTERACT-chronic care model: Self-treatment by patients with decision support e-Health solution Hans-Peter Brunner-La Rocca, Lutz Fleischhacker, Olga Golubnitschaja, Frank Heemskerk, Thomas Helms, Tiny Jaarsma, Judita Kinkorova, Jan Ramaekers, Peter Ruff, Ivana Schnur, Emilio Vanoli, Jose Verdu A10 PPPM in cardiovascular medicine in 2015 Hans-Peter Brunner-La Rocca A11 Magnetic resonance imaging of nanoparticles in mice, potential for theranostic and contrast media development – pilot results Rostyslav V. Bubnov, Sergiy A. Grabovetskyi, Olena M. Mykhalchenko, Natalia O. Tymoshok, Oleksandr B. Shcherbakov, Igor P. Semeniv, Mykola Y. Spivak A12 Ultrasound diagnosis for diabetic neuropathy - comparative study Rostyslav V. Bubnov, Tetyana V. Ostapenko A13 Ultrasound for stratification patients with diabetic foot ulcers for prevention and personalized treatment - pilot results Rostyslav V. Bubnov, Nazarii M. Kobyliak, Nadiya M. Zholobak, Mykola Ya. Spivak A14 Project ImaGenX – designing and executing a questionnaire on environment and lifestyle risk of breast cancer John Paul Cauchi A15 Genomics – a new structural brand of predictive, preventive and personalized medicine or the new driver as well? Dmitrii Cherepakhin, Marina Bakay, Artem Borovikov, Sergey Suchkov A16 Survey of questionnaires for evaluation of the quality of life in various medical fields Barbara Cieślik, Agnieszka Migasiewicz, Maria-Luiza Podbielska, Markus Pelleter, Agnieszka Giemza, Halina Podbielska A17 Personalized molecular treatment for muscular dystrophies Sebahattin Cirak A18 Secondary mutations in circulating tumour DNA for acquired drug resistance in patients with advanced ALK + NSCLC Marzia Del Re, Paola Bordi, Valentina Citi, Marta Palombi, Carmine Pinto, Marcello Tiseo, Romano Danesi A19 Recombinant species-specific FcεRI alpha proteins for diagnosis of IgE-mediated allergies in dogs, cats and horses Lukas Einhorn, Judit Fazekas, Martina Muhr, Alexandra Schoos, Lucia Panakova, Ina Herrmann, Krisztina Manzano-Szalai, Kumiko Oida, Edda Fiebiger, Josef Singer, Erika Jensen-Jarolim A20 Global methodology for developmental neurotoxicity testing in humans and animals early and chronically exposed to chemical contaminants Arpiné A. Elnar, Nadia Ouamara, Nadiya Boyko, Xavier Coumoul, Jean-Philippe Antignac, Bruno Le Bizec, Gauthier Eppe, Jenny Renaut, Torsten Bonn, Cédric Guignard, Margherita Ferrante, Maria Liusa Chiusano, Salvatore Cuzzocrea, Gerard O'Keeffe, John Cryan, Michelle Bisson, Amina Barakat, Ihsane Hmamouchi, Nasser Zawia, Anumantha Kanthasamy, Glen E. Kisby, Rui Alves, Oscar Villacañas Pérez, Kim Burgard, Peter Spencer, Norbert Bomba, Martin Haranta, Nina Zaitseva, Irina May, Stéphanie Grojean, Mathilde Body-Malapel, Florencia Harari, Raul Harari, Kristina Yeghiazaryan, Olga Golubnitschaja, Vittorio Calabrese, Christophe Nemos, Rachid Soulimani A21 Mental indicators at young people with attributes hypertension and pre-hypertension Maria E. Evsevyeva, Elena A. Mishenko, Zurida V. Kumukova, Evgeniy V. Chudnovsky, Tatyana A. Smirnova A22 On the approaches to the early diagnosis of stress-induced hypertension in young employees of State law enforcement agencies Maria E. Evsevyeva, Ludmila V. Ivanova, Michail V. Eremin, Maria V. Rostovtseva A23 Сentral aortic pressure and indexes of augmentation in young persons in view of risk factors Maria E. Evsevyeva, Michail V. Eremin, Vladimir I. Koshel, Oksana V. Sergeeva, Nadesgda M. Konovalova A24 Breast cancer prediction and prevention: Are reliable biomarkers in horizon? Shantanu Girotra, Olga Golubnitschaja A25 Flammer Syndrome and potential formation of pre-metastatic niches: A multi-centred study on phenotyping, patient stratification, prediction and potential prevention of aggressive breast cancer and metastatic disease Olga Golubnitschaja, Manuel Debald, Walther Kuhn, Kristina Yeghiazaryan, Rostyslav V. Bubnov, Vadym M. Goncharenko, Ulyana Lushchyk, Godfrey Grech, Katarzyna Konieczka A26 Innovative tools for prenatal diagnostics and monitoring: improving individual pregnancy outcomes and health-economy in EU Olga Golubnitschaja, Jan Jaap Erwich, Vincenzo Costigliola, Kristina Yeghiazaryan, Ulrich Gembruch A27 Immunohistochemical assessment of APUD cells in endometriosis Vadym M. Goncharenko, Vasyl O. Beniuk, Olga V. Kalenska, Rostyslav V. Bubnov A28 Updating personalized management algorithm of endometrial hyperplasia in pre-menopause women Vadym M. Goncharenko, Vasyl O. Beniuk, Rostyslav V. Bubnov, Olga Melnychuk A29 The personified treatment approach of polimorbid patients with periodontal inflammatory diseases Irina A. Gorbacheva, Lyudmila Y. Orekhova, Vadim V. Tachalov A30 Ukrainian experience in hybrid war – the challenge to update algorithms for personalized care and early prevention of different military injuries Olena I. Grechanyk, Rizvan Ya. Abdullaiev, Rostyslav V. Bubnov A31 Tear fluid biomarkers: a comparison of tear fluid sampling and storage protocols Suzanne Hagan, Eilidh Martin, Ian Pearce, Katherine Oliver A32 The correlation of dietary habits with gingival problems during menstruation Cenk Haytac, Fariz Salimov, Servin Yoksul, Anatoly A. Kunin, Natalia S. Moiseeva A33 Genomic medicine in a contemporary Spanish population of prostate cancer: our experience Bernardo Herrera-Imbroda, Sergio del Río-González, Maria Fernanda Lara, Antonia Angulo, Francisco Javier Machuca Santa-Cruz A34 Challenges, opportunities and collaborations for personalized medicine applicability in uro-oncological disease Bernardo Herrera-Imbroda, Sergio del Río-González, Maria Fernanda Lara A35 Metabolic hallmarks of cancer as targets for a personalized therapy John Ionescu A36 Influence of genetic polymorphism as a predictor of the development of periodontal disease in patients with gastric ulcer and 12 duodenal ulcer Alfiya Z. Isamulaeva, Anatoly A. Kunin, Shamil Sh. Magomedov, Aida I. Isamulaeva A37 Challenges in diabetic macular edema Tatjana Josifova A38 Overview of the EPMA strategies in laboratory medicine relevant for PPPM Marko Kapalla, Juraj Kubáň, Olga Golubnitschaja, Vincenzo Costigliola A39 EPMA initiative for effective organization of medical travel: European concepts and criteria Vincenzo Costigliola, Marko Kapalla, Juraj Kubáň, Olga Golubnitschaja A40 Design and innovation in e-textiles: implications for PPPM Anthony Kent, Tom Fisher, Tilak Dias A41 Biobank in Pilsen as a member of national node BBMRI_CZ Judita Kinkorová, Ondřej Topolčan A42 Big data in personalized medicine: hype and hope Matthias Kohl A43 The 3P approach as the platform of the European Dentistry Department (DPPPD) Anatoly A. Kunin, Natalia S. Moiseeva A44 The endometrium cytokine patterns for predictive diagnosis of proliferation severity and cancer prevention Andrii I. Kurchenko, Vasyl A. Beniuk, Vadym M. Goncharenko, Rostyslav V. Bubnov, Nadiya V. Boyko, Andriy M. Strokan A45 A monocyte-based in-vitro system for testing individual responses to the implanted material: future for personalized implant construction Julia Kzhyshkowska, Alexandru Gudima, Ksenia S. Stankevich, Victor D. Filimonov4, Harald Klüter, Evgeniya M. Mamontova, Sergei I. Tverdokhlebov A46 Prediction and prevention of adverse health effects by meteorological factors: Biomarker patterns and creation of a device for self-monitoring and integrated care Ulyana B. Lushchyk, Viktor V. Novytskyy, Igor P. Babii, Nadiya G. Lushchyk, Lyudmyla S. Riabets, Ivanna I. Legka A47 Targeting "disease signatures" towards personalized healthcare Mira Marcus-Kalish, Alexis Mitelpunkt, Tal Galili, Neta Shachar, Yoav Benjamini A48 Influence of the skin imperfection on the personal quality of life and possible tools for objective diagnosis Agnieszka Migasiewicz, Markus Pelleter, Joanna Bauer, Ewelina Dereń, Halina Podbielska A49 The new direction in caries prevention based on the ultrastructure of dental hard tissues and filling materials Natalia S. Moiseeva, Anatoly A. Kunin, Dmitry A. Kunin A50 The use of LED radiation in prevention of dental diseases Natalia S. Moiseeva, Yury A. Ippolitov, Dmitry A. Kunin, Alexei N. Morozov, Natalia V. Chirkova, Nakhid T. Aliev A51 Status of endothelial progenitor cells in diabetic nephropathy: predictive and preventive potentials Mahmood S. Mozaffari, Jun Yao Liu, Babak Baban A52 The status of glucocorticoid-induced leucine zipper protein in salivary gland in Sjögren’s syndrome: predictive and personalized treatment potentials Mahmood S. Mozaffari, Jun Yao Liu, Rafik Abdelsayed, Xing-Ming Shi, Babak Baban A53 Maximal aerobic capacity - important quality marker of health Jaroslav Novák, Milan Štork, Václav Zeman A54 The EMPOWER project: laboratory medicine and Horizon 2020 Wytze P. Oosterhuis, Elvar Theodorsson A55 Personality profile manifestations in patient’s attitude to oral care and adherence to doctor’s prescriptions Lyudmila Y. Orekhova, Tatyana V. Kudryavtseva, Elena R. Isaeva, Vadim V. Tachalov, Ekaterina S. Loboda A56 Results of an European survey on personalized medicine addressed to directions of laboratory medicine Mario Pazzagli, Francesca Malentacchi, Irene Mancini, Ivan Brandslund, Pieter Vermeersch, Matthias Schwab, Janja Marc, Ron H.N. van Schaik, Gerard Siest, Elvar Theodorsson, Chiara Di Resta A57 MCI or early dementia predictive speech based diagnosis techniques Matus Pleva, Jozef Juhar A58 Personalized speech based mobile application for eHealth Matus Pleva, Jozef Juhar A59 Circulating tumor cell-free DNA as the biomarker in the management of cancer patients Jiří Polívka jr., Filip Janků, Martin Pešta, Jan Doležal, Milena Králíčková, Jiří Polívka A60 Complex stroke care – educational programme in Stroke Centre University Hospital Plzen Jiří Polívka, Alena Lukešová, Nina Müllerová, Petr Ševčík, Vladimír Rohan A61 Sleep apnea and sleep fragmentation contribute to brain aging Kneginja Richter, Lence Miloseva, Günter Niklewski A62 Personalised approach for sleep disturbances in shift workers Kneginja Richter, Jens Acker, Guenter Niklewski A63 Medical travel and innovative PPPM clusters: new concept of integration Olga Safonicheva, Vincenzo Costigliola A64 Medical travel and women health Olga Safonicheva A65 Continuity of generations in the training of specialists in the field of reconstructive microsurgery Maxim Sautin, Janna Sinelnikova, Sergey Suchkov A66 Telemonitoring of stroke patients – empirical evidence of individual risk management results from an observational study in Germany Songül Secer, Stephan von Bandemer A67 Women’s increasing breast cancer risk with n-6 fatty acid intake explained by estrogen-fatty acid interactive effect on DNA damage: implications for gender-specific nutrition within personalized medicine Niva Shapira A68 Cytobacterioscopy of the gingival crevicular fluid as a method for preventive diagnosis of periodontal diseases Aleksandr Shcherbakov, Anatoly A. Kunin, Natalia S. Moiseeva A69 Use of specially treated composites in dentistry to avoid violations of aesthetics Bogdan R. Shumilovich, Zhanna Lipkind, Yulia Vorobieva, Dmitry A. Kunin, Anastasiia V. Sudareva A70 National eHealth system – platform for preventive, predictive and personalized diabetes care Ivica Smokovski, Tatjana Milenkovic A72 The common energy levels of Prof. Szent-Györgyi, the intrinsic chemistry of melanin, and the muscle physiopathology. Implications in the context of Preventive, Predictive, and Personalized Medicine Arturo Solís-Herrera, María del Carmen Arias-Esparza, Sergey Suchkov A73 Plurality and individuality of hepatocellular carcinoma: PPPM perspectives Krishna Chander Sridhar, Olga Golubnitschaja A74 Strategic aspects of higher medical education reforms to secure newer educational platforms for getting biopharma professionals matures Maria Studneva, Sihong Song, James Creeden, Мark Мandrik, Sergey Suchkov A75 Overview of the strategies and activities of the European Federation of Clinical Chemistry and Laboratory Medicine, (EFLM) Elvar Theodorsson, EFLM A76 New spectroscopic techniques for point of care label free diagnostics Syed A. M. Tofail A77 Tumor markers for personalized medicine and oncology - the role of Laboratory Medicine Ondřej Topolčan, Judita Kinkorová, Ondřej Fiala, Marie Karlíková, Šárka Svobodová, Radek Kučera, Radka Fuchsová, Vladislav Třeška, Václav Šimánek, Ladislav Pecen, Jan Šoupal, Štěpán Svačina2 A78 Modern medical terminology (MMT) as a driver of the global educational reforms Evgeniya Tretyak, Maria Studneva, Sergey Suchkov A79 Juvenile hypertension; the relevance of novel predictive, preventive and personalized assessment of its determinants Francesca M. Trovato, G. Fabio Martines, Daniela Brischetto, Daniela Catalano, Giuseppe Musumeci, Guglielmo M. Trovato A80 Proteomarkers Biotech George Th. Tsangaris, Athanasios K. Anagnostopoulos A81 Proteomics and mass spectrometry based non-invasive prenatal testing of fetal health and pregnancy complications George Th. Tsangaris, Athanasios K. Anagnostopoulos A82 Integrated Ecosystem for an Integrated Care model for Heart Failure (HF) patients including related comorbidities (ZENITH) José Verdú, German Gutiérrez, Jordi Rovira, Marta Martinez, Lutz Fleischhacker, Donna Green, Arthur Garson, Elena Tamburini, Stefano Cuomo, Juan Martinez-Leon, Teresa Abrisqueta, Hans-Peter Brunner-La Rocca, Tiny Jaarsma, Teresa Arredondo, Cecilia Vera, Giuseppe Fico, Olga Golubnitschaja, Fernando Arribas, Martina Onderco, Isabel Vara, on behalf of ZENITH consortium A83 Predictive, preventive and personalized medicine in diabetes onset and complication (MOSAIC project) José Verdú, Francesco Sambo, Barbara Di Camillo, Claudio Cobelli, Andrea Facchinetti, Giuseppe Fico, Riccardo Bellazzi, Lucia Sacchi, Arianna Dagliati, Daniele Segnani, Valentina Tibollo, Manuel Ottaviano, Rafael Gabriel, Leif Groop, Jacqueline Postma, Antonio Martinez, Liisa Hakaste, Tiinamaija Tuomi, Konstantia Zarkogianni, on behalf of MOSAIC consortium A84 Possibilities for personalized therapy of diabetes using in vitro screening of insulin and oral hypoglycemic agents Igor Volchek, Nina Pototskaya, Andrey Petrov A85 The innovative technology for personalized therapy of human diseases based on in vitro drug screening Igor Volchek, Nadezhda Pototskaya, Andrey Petrov A86 Bone destruction and temporomandibular joint: predictive markers, pathogenetic aspects and quality of life Ülle Voog-Oras, Oksana Jagur, Edvitar Leibur, Priit Niibo, Triin Jagomägi, Minh Son Nguyen, Chris Pruunsild, Dagmar Piikov, Mare Saag A87 Sub-optimal health management – global vision for concepts in medical travel Wei Wang A88 Sub-optimal health management: synergic PPPM-TCAM approach Wei Wang A89 Innovative technologies for minimal invasive diagnostics Andreas Weinhäusel, Walter Pulverer, Matthias Wielscher, Manuela Hofner, Christa Noehammer, Regina Soldo, Peter Hettegger, Istvan Gyurjan, Ronald Kulovics, Silvia Schönthaler, Gabriel Beikircher, Albert Kriegner, Stephan Pabinger, Klemens Vierlinger A90 Rare disease diobanks for personalized medicine Ayşe Yüzbaşıoğlu, Meral Özgüç, Member of EuroBioBank - European Network of DNA, Cell and Tissue Banks for Rare Disease

Freedom and responsibility as key elements of sustainable development of education

The paper reveals the future teachers’ attitude towards freedom and responsibility in the context of sustainable development of education. Sustainable development seems to be impossible without the new generation of free, dignified, respectful, and responsible individuals. Freedom and responsibility are outlined from a pedagogical point of view. The concepts under study are considered to be of great significance for child’s development. The information obtained during the survey and questionnaire conducted with first-year students of the pedagogical university indicates that future teachers do not yet have sufficient experience to correlate adequately the possibility of revealing school students’ freedom and the need to be in charge of the behavior, actions and thoughts of their own. University students believe that school students generally take responsibility for completing individual assignments rather than common ones. Future teachers do not think that school students’ attitude towards education is responsible and trustworthy, would-be teachers doubt that school students are able to manifest freedom and responsibility to full extent. The empirical data drive to the conclusion that it is necessary to change future teachers’ attitude towards freedom and responsibility in their pedagogical activities. Future teachers are advised to change their attitude to freedom and responsibility in their activities

Interrelation of scientific and folk economics in the prothteconomic concept MONEY

In the paper the concept MONEY is considered to be one in a special class of concepts which we propose to call prothteconomic concepts, as they combine prothtologic (everyday) and academic (economic) elements. The prothtologic element of the concept reveals itself in the common national collective conscience, while the academic component manifests itself in the scientific conscience. The vocabulary used by the common national collective conscience describes the concept under study with different semantic attributes. Proverbs as parameological units fully illustrate the way the common national collective conscience expresses ideas and phenomena. The scientific conscience deals with terminological word stock. The comparison of the prothtologic components of the concept with the economic ones finds out coincidence in the plane of contents. As regards the plane of expression, it differs in a considerable number of instances. So the common national collective conscience has worked out its folk economics which has much in common with scientific economics and is stored in proverbs

Generation and gender factors of the structure of value orientations

A great interest in the study of the value orientations of a person is explained by their decisive role in explaining human behavior. Previous studies have shown that demographic factors influence people's value system. Over the past 20 years, several mass surveys have been conducted with wide geography. Their results showed that in the world there are processes of transformation in the structure of cultural values of different communities of people. The aim of this study was to examine the effects of generation and gender factors on value orientations. The study was based on Schwartz's theoretical model of cultural values. The survey was attended by 384 residents of Chelyabinsk and the Chelyabinsk region (Russia). To collect empirical data, Schwartz's questionnaire in Russian was used. The study found that representatives of the Soviet generation are more oriented towards conservative values, and representatives of the post-Soviet generation more adhere to values reflecting their openness to experience. In this study, men differed from women in a greater commitment to the values of autonomy and power. Considering the values of generations in the context of the gender of respondents, it is found that hedonistic values and the desire for stimulation and power are represented by a U-shaped curve in men and an inverted U-shaped curve in women. This allows us to conclude that in Russia, conditions of economic stabilization lead to increased openness to experience and dominance among men. For women, these conditions make the desire for dominance and high social status less significant