Comparative pharmacological evaluation of ocimum sanctum and imipramine for antidepressant activity

The present study was undertaken to evaluate the comparative antidepressant activity of Ocimum sanctum (OS) and imipramine using animal models of depression. Imipramine (15 mg/kg/i.p) and herbal extract of OS (500 mg/kg/p.o) were subjected for its antidepressant activity using four different animal models of depression, viz: Forced Swimming Test (FST), Reserpine Reversal Test (RRT), Haloperidol-Induced Catalepsy (HIC), and Pentobarbitone Sleeping Time (PST) in male Wistar rats. The study after single administration of OS and imipramine revealed a statistically significant reduction in immobility time in FST, RRT, and protection against HIC, compared to control respectively. However there was no significant potentiation of PST. The antidepressant activity of OS was comparable to that of standard drug imipramine. The results of the present study indicate the potential for use of OS as an adjuvant in the treatment of depression.Colegio de Farmacéuticos de la Provincia de Buenos Aire

Comparative pharmacological evaluation of Hypericum perforatum and Rosmarinus officinalis for anti-depressant activity

The comparative antidepressant activity of the extracts of Hypericum perforatum and Rosmarinus officinalis using animal models of depression were evaluated. The herbal extracts of Hypericum perforatum (20 mg/kg/p.o.), Rosmarinus officinalis (500 mg/kg/p.o.) were subjected for its antidepressant activity using four different animal models of depression, viz: Forced Swimming Test (FST), Reserpine Reversal Test (RRT), Haloperidol-Induced Catalepsy (HIC), and Pentobarbitone Sleeping Time (PST) in male Wistar rats. The study after single oral administration of Hypericum perforatum and Rosmarinus officinalis extracts revealed a statistically significant reduction in immobility time in FST, RRT, and protection against HIC, compared to control respectively. However, there was no significant potentiation of PST. The results of our study demonstrate the extracts of Hypericum perforatum and Rosmarinus officinalis proved to have a promising antidepressant potential.Colegio de Farmacéuticos de la Provincia de Buenos Aire

Influence of ACE inhibitors on the ECG of acute renal hypertension induced rats

The present study was designed to assess the influence of ACE inhibitors on the electrocardiograph of acute renal hypertensive rats. Acute Renal Hypertension (ARH) was induced in healthy Wistar male rats by clamping/occluding the left renal artery for 4 h. The ECG of the control (normotensive), sham-Operated, hypertensive and ARH Induced rats, treated with ramipril (2.5 mg/kg b.w. p.o) and captopril (4 mg/kg b.w. p.o.) were recorded using the computerized ECG recording system (NIVIQURE). The RR intervals in hypertensive rats were increased significantly when compared to control group. Ramipril increased the RR interval significantly (P < 0.001). However, captopril did not show statistically significant decrease in RR interval. The amplitude of the QRS complex in the hypertensive group was increased when compared to control group. There was a significant decrease in the amplitude of the QRS complex with ramipril and captopril (P < 0.001) treated ARH rats, when compared with hypertensive group. Blockade of the RAAS system is highly effective in preventing both hypertension and changes in the generation of impulse in the pacemaker and its conduction of the cardiac impulses, which is attributed by the deflections of ECG: P, QRS and T waves.Colegio de Farmacéuticos de la Provincia de Buenos Aire

Penyembuhan cara sufi

viii, 300 hlm. ;21 c

Evaluation of the anti–depressant activity of Myristica fragrans (Nutmeg) in male rats

Objective: The present study was undertaken to evaluate anti-depressant activity of Myristica fragrans(MS). Materials and Methods: Male Wistar rats were subjected to imipramine and herbal extract ofMS for their antidepressant activity using Forced Swimming Test (FST), Reserpine Reversal Test (RRT), Haloperidol-Induced Catalepsy (HIC), and Pentobarbitone Sleeping Time (PST). Results: Administration of MS and imipramine revealed a statistically significant reduction in immobility time in FST, RRT, and protection against HIC, compared to the control group. However, there was no significant potentiation of PST. Conclusion: Our study demonstrated the potential antidepressant activity of MS

Mechanistic insights of Sn-based non-chemically-amplified resists under EUV irradiation

Formulating high sensitivity and resolution in Extreme Ultraviolet (EUV) resists is a serious concern regarding the adaptation of EUV lithography. The incorporation of a high optical density Sn compound in MAPDST-co-ADSM (4-(methacryloyloxy)phenyl) dimethylsulfoniumtrifluoromethane sulfonate-co-acetyldibutylstannyl methacrylate, a non-CAR photoresist, exhibits lithography resolution for sub-15 nm node when patterned under e-beam and Helium ion irradiation. The synthesized resists were irradiated at 103.5 eV (~92 eV) using monochromatic synchrotron radiation. After EUV irradiation and oxidation, the resists were investigated using XPS, NEXAFS and by theoretical calculations (FEFF9 modeling program). It was observed significant changes in the labile CF3SO3 – moiety, but interestingly its total dissociation or desorption was not observed after long exposure times. Bonds rearrangements of formation of SnO2 and new S–C/C–F functionalities after irradiation were detected. Those complex processes suggested the existence of important sinks for the high photon energy absorbed, which in turn increased the lithography resolution. The present results highlight the importance of the incorporation of a heavy metal covalently linked to the main polymer structure. The enhanced resolution observed in the MAPDST-co-ADSM resist formulation using standard processing conditions, establishes its potential candidature as a EUVL resist for rapid prototyping of semiconductor devices.Fil: Belmonte, Guilherme K.. Universidade Federal do Rio Grande do Sul; BrasilFil: Cendron, Suelen W.. Universidade Federal do Rio Grande do Sul; BrasilFil: Guruprasad Reddy, Pulikanti. Indian Institute Of Technology Mandi; IndiaFil: Moura, Cleverson A.S.. Universidade Federal do Rio Grande do Sul; BrasilFil: Ghulam Moinuddin, Mohamad. Indian Institute Of Technology Mandi; IndiaFil: Peter, Jerome. Indian Institute Of Technology Mandi; IndiaFil: Sharma, Satinder K.. Indian Institute Of Technology Mandi; IndiaFil: Lando, Gabriela. Universidade Federal do Rio Grande do Sul; BrasilFil: Puiatti, Marcelo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Físico-química de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Instituto de Investigaciones en Físico-química de Córdoba; ArgentinaFil: Gonsalves, Kenneth E.. Indian Institute Of Technology Mandi; IndiaFil: Weibel, Daniel E.. Universidade Federal do Rio Grande do Sul; Brasi

Wear characteristics of patterned and un-patterned tetrahedral amorphous carbon film in the presence of synthetic and bio based lubricants

In this article, wear performance of patterned and non-patterned tetrahedral carbon thin film (ta-C) is compared in the presence of various lubricants. For this purpose, wear tests were conducted at temperatures (40 °C-125 °C) which are normally found during automotive engine operation. Wear test were conducted at 100 N load and 120 min. The results showed that bio-based lubricant show better wear performance at 40 and 80 °C compared to PAO lubricant for both laser patterned and non-patterned ta-C thin film. However, at the temperature of 125 °C, PAO showed better wear performance than palm based TMP ester. This can be because of unstable film formation at higher temperatures in case of bio-based lubricant. It was also found that patterned ta-C thin films shows higher wear resistance than non-patterned thin film. This can be because of micro pores which can provide lubricant, capture micro and nano wear particle and behave as micro hydrodynamic bearings

Experimental investigation of tribological properties of laser textured tungsten doped diamond like carbon coating under dry sliding conditions at various loads.

Laser micro texturing technique has shown its potential in reducing friction and wear at various mechanical interfaces such as automotive and cutting tools etc.. Automotive parts are coated with Diamond-like Carbon (DLC) coatings to enhance their performance. Due to stringent condition at the automotive contacts and demand for performance enhancement, increase in performance of DLC coatings is required. In this study laser micro texturing is being combined with tungsten doped DLC coating. In order to analyze the benefits of laser micro texturing on tungsten doped DLC coating. Tribological testing was conducted on a reciprocating test rig at various loading conditions. The results indicated that laser textured tungsten doped DLC coating showed the lower coefficient of friction compared to un-textured tungsten doped DLC coating at a load of 15 N, 25 N and 35 N. Higher graphitization was observed in the case of un-textured coating at 35 N load