31 research outputs found
Reliability Evaluation of Wind Turbine Systems’ Components
The increasing use of wind generation requests modifications in the electric power systems planning conception, because it includes one more uncertainty component, which needs to be studied properly and modeled. Understanding the failures rates and downtimes of wind turbines is difficult not only because of the considerable range of designs and sizes that are now in service worldwide but also since studies are conducted independently under various operating conditions in different countries. The fault tree method (FTA) has been used to study the reliability of many different power generation systems. This paper now applies that method to a wind turbine system to estimate the reliability of wind turbines. In the implementations, several types of wind turbines were considered in order to analyze the system’s reliability. The effectiveness of the proposed method is revealed through several case studies
Prediction of the Thromboembolic Syndrome: an Application of Artificial Neural Networks in Gene Expression Data Analysis
The aim of this study was to propose a method for improving the power of recognition and classification of thromboembolic syndrome based on the analysis of ‎ gene expression data using artificial neural networks. The studied method was performed on a dataset which contained data about 117 patients admitted to a hospital in Durham in 2009. Of all the studied patients, 66 patients were suffering from thromboembolic syndrome and 51 people were enrolled in the study as the control group. The gene expression level of 22277 was measured for all the samples and was entered into the model as the main variable. Due to the high number of variables, principal components analysis and auto-encoder neural network methods were used in order to reduce the dimension of data. The results showed that when using auto-encoder networks, the classification accuracy was 93.12. When using the PCA method to reduce the size of the data, the obtained accuracy was 78.26, and hence a significant difference in the accuracy of classification was observed. If auto-encoder network method is used, the sensitivity and specificity will be 92.58 and 93.68 and when PCA method is used, they will be 0.77 and 0.78 respectively. The results suggested that auto-encoder networks, compared with the PCA method, had a higher level of accuracy for the classification of thromboembolic syndrome status
Effects of gamma rays on rat testis tissue according to the morphological parameters and immunohistochemistry: radioprotective role of silymarin.
OBJECTIVE
To determine the radioprotective effects of Silymarin in adult male Sprague-Dawley rats irradiated with γ-rays.
METHODS
The present experimental study was performed in Tehran University of Medical Sciences, Tehran, Iran from December 2009 to March 2010. The study was performed on 40 rats, which were randomly and equally divided into four groups: 1) control group: neither received Silymarin nor irradiated with γ-rays; 2) γ-irradiation group: testis region exposed to 2Gy of γ-rays; 3) Silymarin & γ-irradiation: rats received 100 mg/kg of Silymarin 24hrs before exposure to 2Gy of γ-rays; 4) Silymarin & γ-irradiation: rats received 200 mg/kg of Silymarin 24hrs before exposure to 2Gy of γ-rays. After animal experiments and preparing the tissue sections, different histological and histomorphological parameters of seminiferous tubules and the biological characteristics of Leydig cells were evaluated applying quantitative assessment, Johnson scoring, and Leydig cell apoptosis assay by TUNEL method. The data were analyzed applying ANOVA and Tukey's post hoc test, using SPSS software (V.19).
RESULTS
Irradiation of 2 Gy γ-rays to the testis of the rats significantly affected the frequency of spermatogonia, primary spermatocyte, round spermatid, spermatozoa, seminiferous tube and lumen diameters, thickness of the epithelium, Leydig cell nuclear diameter and volume, epithelium height, and apoptotic cells (p<0.05). However, administration of Silymarin improved the mentioned parameters specifically in 200 mg/kg of dosage.
CONCLUSION
Silymarin could act as a potent radioprotector and it can be used in modulation as well as improvement to radiation therapy to prevent male reproductive function, specifically seminiferous tubules in an animal model; however, its molecular mechanism is still not clear and needs more molecular researches
Knowledge, attitude and practice of urban and ruarl households towards principles of nutrition in Iran: results of NUTRIKAP Survey.
Background:
The aim of this study was to assess knowledge, attitude and practice of urban and rural households toward principles of nutrition in Iran.
Methods:
The study population was Iranian households who live in rural and urban areas in all provinces of the country. The sampling method at households’ level in each province was single stage cluster sampling with equal size clusters. The incumbent data was collected by a structured questionnaire and through the interview with the eligible subject in each household.
Results:
A total of 14,136 Iranian households were selected as total sample size, 9,149 urban households, and 4,987 rural households. Around 57.2% of urban and 49.5% of rural households was aware of food groups. Respectively in urban and rural households, about 35.1% and 39.7% had correct knowledge toward roles of food groups. Approximately 41.5% and 39.9% of households had accurate knowledge about reason of food eating in urban and rural areas, respectively. The results showed that 79.6% of them had favorable attitudes.
The most of the households consumed red meat and poultry weekly whereas fish was eaten rarely. Fruits, vegetables and dairy were consumed daily in the most of households. Sugar intake was daily in the most of households and cream and butter intake was weekly.
Conclusion:
The most of households had moderate knowledge and good attitudes. Practice of families about food consumption was good. The results of this study can be used for proper intervention for improving of health society
Reliability Evaluation of Wind Turbine Systems' Components
The increasing use of wind generation requests modifications in the electric power systems planning conception, because it includes one more uncertainty component, which needs to be studied properly and modeled. Understanding the failures rates and downtimes of wind turbines is difficult not only because of the considerable range of designs and sizes that are now in service worldwide but also since studies are conducted independently under various operating conditions in different countries. The fault tree method (FTA) has been used to study the reliability of many different power generation systems. This paper now applies that method to a wind turbine system to estimate the reliability of wind turbines. In the implementations, several types of wind turbines were considered in order to analyze the system's reliability. The effectiveness of the proposed method is revealed through several case studies
Nanoparticles of Conjugated Methotrexate-Human Serum Albumin: Preparation and Cytotoxicity Evaluations
Methotrexate-human serum albumin conjugates were developed by a simple carbodiimide reaction. Methotrexate-human serum albumin conjugates were then crosslinked with 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide HCl (EDC) to form nanoparticles. The size of nanoparticles determined by laser light scattering and TEM was between 90–150 nm. Nanoparticles were very stable at physiologic conditions (PBS pH 7.4, 37∘C) and after incubation with serum. The effect of amount of EDC used for crosslinking on the particle size and free amino groups of nanoparticles was examined. The amount of crosslinker showed no significant effect on the size of nanoparticles but free amino groups of nanoparticles were decreased by increasing the crosslinker. The physicochemical interactions between methotrexate and human serum albumin were investigated by differential scanning calorimetry (DSC). Nanoparticles were more cytotoxic on T47D cells compared to free methotrexate. Moreover, methotrexate-human serum albumin nanoparticles decreased the IC50 value of methotrexate on T47D cells in comparison with free methotrexate