DESIGN, DEVELOPMENT AND CHARACTERIZATION OF PACLITAXEL LOADED SOLID LIPID NANOPARTICLES AS A COLLOIDAL DRUG CARRIER

Objective: This study was aimed to design and characterize Paclitaxel-loaded Solid Lipid Nanoparticles (SLNs) to achieve site specificity,reduce toxicity and sustained release pattern. Methods: Paclitaxel-loaded solid lipid nanoparticles were fabricated by microemulsion followed by probe sonication technique using stearic acid as lipid and stabilized of the mixture of surfactants. In this study, 32 full factorial design was employed for optimizing the concentration of lipid as stearic acid and surfactant (soya lecithin) for the nanoparticles. The optimization was done by studying the dependent variable of particle size and % entrapment efficiency. Results: The results showed that the paclitaxel-loaded solid lipid nanoparticles prepared with the concentration of 33.31 % stearic acid and 500 mg of soya lecithin were optimum characteristic than other formulations. They showed the average particles size 149±4.10 nm and PDI 250±2.04. The zeta potential, % EE and % drug loading capacity was found to be respectively-29.7, 93.38±1.90 and 0.81±0.01. The optimized batch of Paclitaxel SLNs exhibited spherical shape with smooth surface analyzed by Transmission Electron Microscopy. In vitro study showed sustained release profile and was found to follow Higuchi Kinetics Equation. Conclusion: The SLNs of paclitaxel m et al. l the requirements of a colloidal drug delivery system. They had a particle size in nanosize; their size distribution was narrow and all the particles were in a spherical shape

Reproductive biology of rock oyster, Saccostrea cucullata (Born, 1778) along Aare-Ware rocky shore of Ratnagiri, Maharashtra, India

802-809The present study regarding the reproductive biology of Saccostrea cucullata was carried out from May 2014 to April 2016. The observation has indicated that the peak spawning season is from the month of November to January along the Aare-Ware rocky shore of Ratnagiri. For females, the maximum values of Gonado Somatic Index (GSI) were observed in November 2014 (2.8890) and November 2015 (2.9910), whereas in males, GSI values were maximum in November 2014 (2.1964) and December 2015 (2.1681). During the study, the average male: female sex ratio of 1:1.4 was observed, with a minimum of 1:1 in the month of April 2015 and a maximum (1:1.8) during December 2014, indicating predominance of females in all the months. The size of the first maturity has been estimated to be 22.2 mm which can be utilized for signifying management measures for sustainable utilization of the resource

Reproductive biology of rock oyster, Saccostrea cucullata (Born, 1778) along Aare-Ware rocky shore of Ratnagiri, Maharashtra, India

The present study regarding the reproductive biology of Saccostrea cucullata was carried out from May 2014 to April 2016. The observation has indicated that the peak spawning season is from the month of November to January along the Aare-Ware rocky shore of Ratnagiri. For females, the maximum values of Gonado Somatic Index (GSI) were observed in November 2014 (2.8890) and November 2015 (2.9910), whereas in males, GSI values were maximum in November 2014 (2.1964) and December 2015 (2.1681). During the study, the average male: female sex ratio of 1:1.4 was observed, with a minimum of 1:1 in the month of April 2015 and a maximum (1:1.8) during December 2014, indicating predominance of females in all the months. The size of the first maturity has been estimated to be 22.2 mm which can be utilized for signifying management measures for sustainable utilization of the resource

Physical properties of cinnamon bark

Physical properties of cinnamon (Cinnamomum verum J.Pres) bark (var. Nityashree) were determined by dividing into three grades (I, II & III) according to their size at 10.15% (db) moisture content. The values of length, breadth and thickness for grade I were 48.38 mm, 7.34 mm and 1.37 mm; for grade II were 71.81 mm, 8.45 mm and 1.00 mm; for grade III were 104.95 mm, 8.15 mm and 0.98 mm, respectively. Unit volume and surface area for grade I were 214.80 mm3 and 159.68 mm2; for grade II were 364.92 mm3 and 226.33 mm2; for grade III were 409.85 mm3 and 242.85 mm2, respectively. Bulk density and true density for grade I were 144.56 kg m-3 and 177.60 kg m-3 for grade II were 148.44 kg m-3 and 186.87 kg m-3 for grade III were 132.08 kg m-3 and 202.91 kg m-3, respectively. Porosity, angle of repose for grade I was 14.20% and 40.69°; for grade II were 20.95% and 41.56°; for grade III were 37.72% and 42.30°, respectively. The coefficient of static friction with respect to different surfaces viz., plywood, galvanized iron and aluminum sheet for grade I were 0.86, 0.94 and 0.80; for grade II were 0.84, 0.89 and 0.79; for grade III were 0.80, 0.81 and 0.70, respectively. &nbsp

Physical properties of cinnamon bark

Physical properties of cinnamon (Cinnamomum verum J.Pres) bark (var. Nityashree) were determined by dividing into three grades (I, II & III) according to their size at 10.15% (db) moisture content. The values of length, breadth and thickness for grade I were 48.38 mm, 7.34 mm and 1.37 mm; for grade II were 71.81 mm, 8.45 mm and 1.00 mm; for grade III were 104.95 mm, 8.15 mm and 0.98 mm, respectively. Unit volume and surface area for grade I were 214.80 mm3 and 159.68 mm2; for grade II were 364.92 mm3 and 226.33 mm2; for grade III were 409.85 mm3 and 242.85 mm2, respectively. Bulk density and true density for grade I were 144.56 kg m-3 and 177.60 kg m-3 for grade II were 148.44 kg m-3 and 186.87 kg m-3 for grade III were 132.08 kg m-3 and 202.91 kg m-3, respectively. Porosity, angle of repose for grade I was 14.20% and 40.69°; for grade II were 20.95% and 41.56°; for grade III were 37.72% and 42.30°, respectively. The coefficient of static friction with respect to different surfaces viz., plywood, galvanized iron and aluminum sheet for grade I were 0.86, 0.94 and 0.80; for grade II were 0.84, 0.89 and 0.79; for grade III were 0.80, 0.81 and 0.70, respectively. &nbsp

REVIEW ON THERMAL SEEDS IN MAGNETIC HYPERTHERMIA THERAPY

We present the short review on Magnetic nanoparticle specifically for biomedical application. This study shows the overview on magnetic material properties and its biocompatibility. Moreover focusing on engineering aspect of hyperthermia

Physical properties of turmeric (Curcuma longa L.)

Turmeric (Curcuma longa) rhizome (var. IISR Alleppey Supreme) sample was divided into three grades (I: 25–35 mm, II: 35–45 mm, III: 45–55 mm) according to its major dimension to study its physical properties. The average values of geometric property viz., length (30.38–50.60 mm), breadth (9.77–10.64 mm), thickness (5.18–6.44 mm), arithmetic mean diameter (15.82–21.91 mm), geometric mean diameter (12.77–13.76 mm), square mean diameter (24.24–28.58 mm), equivalent diameter (17.61–21.41 mm), sphericity (0.27–0.42), aspect ratio (0.20–0.35), unit volume (1641–2901 mm3), surface area (771–1265 mm2) and shape factor (1.63–1.77) for grades I, II & III are reported. The gravimetric property viz., bulk density (260–348 kg/m3), true density (1341–1354 kg/m3) and porosity (74.53–80.93%), and frictional property viz., angle of repose (37.57–38.90°) and coefficient of friction with respect to different surface viz., aluminum sheet, mild steel sheet and plywood sheet for grades I, II and III were found to range between of 0.69–0.81, 0.84–0.94, 0.80–0.86, respectively. &nbsp